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ArticlesPeer ReviewedFull Text
Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc ‘spacer’ domain in the extracellular moiety of chimeric antigen receptors avoids ‘off-target’ activation and uni...
Author / Creator:Hombach, A ; Hombach, A A ; Abken, H
Publisher:London: Nature Publishing Group UK
Journal title:Gene therapy, 2010-10, Vol.17 (10), p.1206-1213
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A dual chain chimeric antigen receptor (CAR) in the native antibody format for targeting immune cells towards cancer cells without the need of an scFv
Author / Creator:Faitschuk, E ; Nagy, V ; Hombach, A A ; Abken, H
Publisher:London: Nature Publishing Group UK
Journal title:Gene therapy, 2016-10, Vol.23 (10), p.718-726
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CD28 cosignalling does not affect the activation threshold in a chimeric antigen receptor-redirected T-cell attack
Author / Creator:Chmielewski, M ; Hombach, A A ; Abken, H
Publisher:London: Nature Publishing Group UK
Journal title:Gene therapy, 2011-01, Vol.18 (1), p.62-72
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T cells redirected by a CD3ζ chimeric antigen receptor can establish self-antigen-specific tumour protection in the long term
Author / Creator:Chmielewski, M ; Rappl, G ; Hombach, A A ; Abken, H
Publisher:London: Nature Publishing Group UK
Journal title:Gene therapy, 2013-02, Vol.20 (2), p.177-186
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Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity
Author / Creator:Hombach, A A ; Kofler, D ; Rappl, G ; Abken, H
Publisher:London: Nature Publishing Group UK
Journal title:Gene therapy, 2009-09, Vol.16 (9), p.1088-1096
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Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer
Author / Creator:Birkholz, K ; Hombach, A ; Krug, C ; Reuter, S ; Kershaw, M ; Kämpgen, E ; Schuler, G ; Abken, H ; Schaft, N ; Dörrie, J
Publisher:London: Nature Publishing Group UK
Journal title:Gene therapy, 2009-05, Vol.16 (5), p.596-604
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ArticlesPeer ReviewedFull Text
Development of Adoptive Cell Therapy for Cancer: A Clinical Perspective
Author / Creator:Hawkins, Robert E. ; Gilham, David E. ; Debets, Reno ; Eshhar, Zelig ; Taylor, Naomi ; Abken, Hinrich ; Schumacher, Ton N.
Publisher:Larchmont, NY: Liebert
Journal title:Human gene therapy, 2010-06, Vol.21 (6), p.665-672
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ArticlesPeer ReviewedFull Text
Chimäre Antigenrezeptoren (CAR) – universelle Werkzeuge in der zellulären Immuntherapie
Author / Creator:Holzinger, A ; Abken, H
Publisher:Berlin: Springer Nature B.V
Journal title:Onkologie (Heidelberg, Germany), 2021-11, Vol.27 (11), p.1069-1074
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ArticlesPeer ReviewedFull Text
Chimäre Antigenrezeptoren (CAR) – universelle Werkzeuge in der zellulären Immuntherapie
Author / Creator:Holzinger, A. ; Abken, H.
Publisher:Heidelberg: Springer Medizin
Journal title:Best practice onkologie, 2021-09, Vol.16 (9), p.402-407
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An interleukin 12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: anti-inflammatory activity in Crohn’s disease and experimental colitis in vivo
Author / Creator:Stallmach, A ; Marth, T ; Weiß, B ; Wittig, B M ; Hombach, A ; Schmidt, C ; Neurath, M ; Zeitz, M ; Zeuzem, S ; Abken, H
Publisher:London: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title:Gut, 2004-03, Vol.53 (3), p.339-345
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T-cell activation by recombinant immunoreceptors: Impact of the intracellular signalling domain on the stability of receptor expression and antigen-specific activation of grafted T cells
Author / Creator:Heuser, C ; Hombach, A ; Lösch, C ; Manista, K ; Abken, H
Publisher:London: Nature Publishing Group UK
Journal title:Gene therapy, 2003-08, Vol.10 (17), p.1408-1419
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A recombinant anti-carcinoembryonic antigen immunoreceptor with combined CD3ζ-CD28 signalling targets T cells from colorectal cancer patients against their tumour cells
Author / Creator:Hombach, A ; Schlimper, C ; Sievers, E ; Frank, S ; Schild, H H ; Sauerbruch, T ; Schmidt-Wolf, I G H ; Abken, H
Publisher:BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title:Gut, 2006-08, Vol.55 (8), p.1156-1164
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An anti-MUC1-antibody–interleukin-2 fusion protein that activates resting NK cells to lysis of MUC1-positive tumour cells
Author / Creator:Heuser, C ; Ganser, M ; Hombach, A ; Brand, H ; Denton, G ; Hanisch, F-G ; Abken, H
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2003-09, Vol.89 (6), p.1130-1139
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A chimeric receptor that selectively targets membrane-bound carcinoembryonic antigen (mCEA) in the presence of soluble CEA
Author / Creator:Hombach, A ; Koch, D ; Sircar, R ; Heuser, C ; Diehl, V ; Kruis, W ; Pohl, C ; Abken, H
Publisher:Basingstoke: Nature Publishing Group
Journal title:Gene therapy, 1999-02, Vol.6 (2), p.300-304
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ArticlesPeer ReviewedFull Text
Immune Response Manipulation: Recombinant Immunoreceptors Endow T-Cells with Predefined Specificity
Author / Creator:Abken, Hinrich ; Hombach, Andreas ; Heuser, Claudia
Publisher:Hilversum: Bentham Science Publishers Ltd
Journal title:Current pharmaceutical design, 2003-01, Vol.9 (24), p.1992-2001
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ArticlesPeer ReviewedFull Text
Dermal Fibroblasts Sustain Proliferation of Activated T Cells via Membrane-Bound Interleukin-15 upon Long-Term Stimulation with Tumor Necrosis Factor-α
Author / Creator:Kapsokefalou, Anna ; Heuser, Claudia ; Abken, Hinrich ; Rappl, Gunter ; Röβler, Martin ; Ugurel, Selma ; Tilgen, Wolfgang ; Reinhold, Uwe
Publisher:Danvers, MA: Elsevier Inc
Journal title:Journal of investigative dermatology, 2001-01, Vol.116 (1), p.102-109
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T cells engrafted with a recombinant anti-CD30 receptor target autologous CD30+ cutaneous lymphoma cells
Author / Creator:Hombach, A ; Muche, J M ; Gerken, M ; Gellrich, S ; Heuser, C ; Pohl, C ; Sterry, W ; Abken, H
Publisher:Basingstoke: Nature Publishing Group
Journal title:Gene therapy, 2001-06, Vol.8 (11), p.891-895
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ArticlesPeer ReviewedFull Text
T cell activation by recombinant FcεRI γ-chain immune receptors: an extracellular spacer domain impairs antigen-dependent T cell activation but not antigen recognition
Author / Creator:Hombach, A ; Heuser, C ; Gerken, M ; Fischer, B ; Lewalter, K ; Diehl, V ; Pohl, C ; Abken, H
Publisher:Houndmills: Nature Publishing Group
Journal title:Gene therapy, 2000-06, Vol.7 (12), p.1067-1075
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Engineered T cells redirected by 2nd and 3rd generation immunoreceptors - The weal and woe of costimulation
Author / Creator:Abken, H
Journal title:Human gene therapy, 2009-11, Vol.20 (11), p.1360-1360
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S80. Prolongation of T cell response by OX40 co-signalling CARS
Author / Creator:Abken, H
Publisher:London: BMJ Publishing Group LTD
Journal title:Journal for immunotherapy of cancer, 2014-03, Vol.2 (S2), p.I18-I18, Article I18
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Showing 1 to 20 of 56 results

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Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc ‘spacer’ domain in the extracellular moiety of chimeric antigen receptors avoids ‘off-target’ activation and uni...

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A dual chain chimeric antigen receptor (CAR) in the native antibody format for targeting immune cells towards cancer cells without the need of an scFv

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CD28 cosignalling does not affect the activation threshold in a chimeric antigen receptor-redirected T-cell attack

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T cells redirected by a CD3ζ chimeric antigen receptor can establish self-antigen-specific tumour protection in the long term

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Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity

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Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer

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Development of Adoptive Cell Therapy for Cancer: A Clinical Perspective

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Chimäre Antigenrezeptoren (CAR) – universelle Werkzeuge in der zellulären Immuntherapie

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Chimäre Antigenrezeptoren (CAR) – universelle Werkzeuge in der zellulären Immuntherapie

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An interleukin 12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: anti-inflammatory activity in Crohn’s disease and experimental colitis in vivo

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T-cell activation by recombinant immunoreceptors: Impact of the intracellular signalling domain on the stability of receptor expression and antigen-specific activation of grafted T cells

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A recombinant anti-carcinoembryonic antigen immunoreceptor with combined CD3ζ-CD28 signalling targets T cells from colorectal cancer patients against their tumour cells

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An anti-MUC1-antibody–interleukin-2 fusion protein that activates resting NK cells to lysis of MUC1-positive tumour cells

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A chimeric receptor that selectively targets membrane-bound carcinoembryonic antigen (mCEA) in the presence of soluble CEA

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Immune Response Manipulation: Recombinant Immunoreceptors Endow T-Cells with Predefined Specificity

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Dermal Fibroblasts Sustain Proliferation of Activated T Cells via Membrane-Bound Interleukin-15 upon Long-Term Stimulation with Tumor Necrosis Factor-α

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T cells engrafted with a recombinant anti-CD30 receptor target autologous CD30+ cutaneous lymphoma cells

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T cell activation by recombinant FcεRI γ-chain immune receptors: an extracellular spacer domain impairs antigen-dependent T cell activation but not antigen recognition

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Engineered T cells redirected by 2nd and 3rd generation immunoreceptors - The weal and woe of costimulation

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S80. Prolongation of T cell response by OX40 co-signalling CARS

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