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21 results for Adami,+Eleonora

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ArticlesPeer ReviewedFull Text
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
Author / Creator:Dong, Jinrui ; Viswanathan, Sivakumar ; Adami, Eleonora ; Singh, Brijesh K. ; Chothani, Sonia P. ; Ng, Benjamin ; Lim, Wei Wen ; Zhou, Jin ; Tripathi, Madhulika ; Ko, Nicole S. J. ; Shekeran, Shamini G. ; Tan, Jessie ; Lim, Sze Yun ; Wang, Mao ; Lio, Pei Min ; Yen, Paul M. ; Schafer, Sebastian ; Cook, Stuart A. ; Widjaja, Anissa A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-01, Vol.12 (1), p.66-15, Article 66
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Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease
Author / Creator:Widjaja, Anissa A. ; Viswanathan, Sivakumar ; Shekeran, Shamini G. ; Adami, Eleonora ; Lim, Wei-Wen ; Chothani, Sonia ; Tan, Jessie ; Goh, Joyce Wei Ting ; Chen, Hui Mei ; Lim, Sze Yun ; Boustany-Kari, Carine M. ; Hawkins, Julie ; Petretto, Enrico ; Hübner, Norbert ; Schafer, Sebastian ; Coffman, Thomas M. ; Cook, Stuart A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-12, Vol.13 (1), p.7497-18, Article 7497
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The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling
Author / Creator:Dong, Jinrui ; Viswanathan, Sivakumar ; Adami, Eleonora ; Schafer, Sebastian ; Kuthubudeen, Fathima F ; Widjaja, Anissa A ; Cook, Stuart A
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2021-08, Vol.10
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IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis
Author / Creator:Ng, Benjamin ; Viswanathan, Sivakumar ; Widjaja, Anissa A. ; Lim, Wei-Wen ; Shekeran, Shamini G. ; Goh, Joyce Wei Ting ; Tan, Jessie ; Kuthubudeen, Fathima ; Lim, Sze Yun ; Xie, Chen ; Schafer, Sebastian ; Adami, Eleonora ; Cook, Stuart A.
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2022-03, Vol.23 (7), p.3549
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Genomic landscape of rat strain and substrain variation
Author / Creator:Hermsen, Roel ; de Ligt, Joep ; Spee, Wim ; Blokzijl, Francis ; Schäfer, Sebastian ; Adami, Eleonora ; Boymans, Sander ; Flink, Stephen ; van Boxtel, Ruben ; van der Weide, Robin H ; Aitman, Tim ; Hübner, Norbert ; Simonis, Marieke ; Tabakoff, Boris ; Guryev, Victor ; Cuppen, Edwin
Publisher:England: BioMed Central Ltd
Journal title:BMC genomics, 2015-05, Vol.16 (1), p.357, Article 357
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A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion
Author / Creator:Witte, Franziska ; Ruiz-Orera, Jorge ; Mattioli, Camilla Ciolli ; Blachut, Susanne ; Adami, Eleonora ; Schulz, Jana Felicitas ; Schneider-Lunitz, Valentin ; Hummel, Oliver ; Patone, Giannino ; Mücke, Michael Benedikt ; Šilhavý, Jan ; Heinig, Matthias ; Bottolo, Leonardo ; Sanchis, Daniel ; Vingron, Martin ; Chekulaeva, Marina ; Pravenec, Michal ; Hubner, Norbert ; van Heesch, Sebastiaan
Publisher:England: BioMed Central Ltd
Journal title:Genome Biology, 2021-06, Vol.22 (1), p.191-191, Article 191
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Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function
Author / Creator:McDermott-Roe, Chris ; Leleu, Marion ; Rowe, Glenn C. ; Palygin, Oleg ; Bukowy, John D. ; Kuo, Judy ; Rech, Monika ; Hermans-Beijnsberger, Steffie ; Schaefer, Sebastian ; Adami, Eleonora ; Creemers, Esther E. ; Heinig, Matthias ; Schroen, Blanche ; Arany, Zoltan ; Petretto, Enrico ; Geurts, Aron M.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-02, Vol.12 (2), p.e0170458
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Rattus norvegicus BN/SHR liver and heart left ventricle ribosomal RNA depleted directional RNA sequencing
Author / Creator:Wyler, Emanuel ; van Heesch, Sebastiaan ; Adami, Eleonora ; Hubner, Norbert ; Landthaler, Markus
Publisher:England: BioMed Central Ltd
Journal title:BMC research notes, 2017-08, Vol.10 (1), p.395-3, Article 395
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Titin-truncating variants affect heart function in disease cohorts and the general population
Author / Creator:Schafer, Sebastian ; de Marvao, Antonio ; Adami, Eleonora ; Fiedler, Lorna R ; Ng, Benjamin ; Khin, Ester ; Rackham, Owen J L ; van Heesch, Sebastiaan ; Pua, Chee J ; Kui, Miao ; Walsh, Roddy ; Tayal, Upasana ; Prasad, Sanjay K ; Dawes, Timothy J W ; Ko, Nicole S J ; Sim, David ; Chan, Laura L H ; Chin, Calvin W L ; Mazzarotto, Francesco ; Barton, Paul J ; Kreuchwig, Franziska ; de Kleijn, Dominique P V ; Totman, Teresa ; Biffi, Carlo ; Tee, Nicole ; Rueckert, Daniel ; Schneider, Valentin ; Faber, Allison ; Regitz-Zagrosek, Vera ; Seidman, Jonathan G ; Seidman, Christine E ; Linke, Wolfgang A ; Kovalik, Jean-Paul ; O'Regan, Declan ; Ware, James S ; Hubner, Norbert ; Cook, Stuart A
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2017-01, Vol.49 (1), p.46-53
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Translational regulation shapes the molecular landscape of complex disease phenotypes
Author / Creator:Schafer, Sebastian ; Adami, Eleonora ; Heinig, Matthias ; Rodrigues, Katharina E. Costa ; Kreuchwig, Franziska ; Silhavy, Jan ; van Heesch, Sebastiaan ; Simaite, Deimante ; Rajewsky, Nikolaus ; Cuppen, Edwin ; Pravenec, Michal ; Vingron, Martin ; Cook, Stuart A. ; Hubner, Norbert
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-05, Vol.6 (1), p.7200-7200, Article 7200
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RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing
Author / Creator:Maatz, Henrike ; Jens, Marvin ; Liss, Martin ; Schafer, Sebastian ; Heinig, Matthias ; Kirchner, Marieluise ; Adami, Eleonora ; Rintisch, Carola ; Dauksaite, Vita ; Radke, Michael H. ; Selbach, Matthias ; Barton, Paul J.R. ; Cook, Stuart A. ; Rajewsky, Nikolaus ; Gotthardt, Michael ; Landthaler, Markus ; Hubner, Norbert
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2014-08, Vol.124 (8), p.3419-3430
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Overturning the paradigm that IL6 signaling drives liver regrowth while shining light on a new therapeutic target for regenerative medicine
Author / Creator:Dong, Jinrui ; Viswanathan, Sivakumar ; Adami, Eleonora ; Schafer, Sebastian ; Kuthubudeen, Fathima F. ; Widjaja, Anissa A. ; Cook, Stuart A.
Publisher:Cold Spring Harbor Laboratory
Journal title:bioRxiv, 2021-04
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Inhibition of an immunometabolic axis of mTORC1 activation extends mammalian healthspan
Author / Creator:Widjaja, Anissa A. ; Lim, Wei-Wen ; Viswanathan, Sivakumar ; Chothani, Sonia ; Corden, Ben ; Goh, Joyce Wei Ting ; Tan, Jessie ; Pua, Chee Jian ; Lim, Radiance ; Singh, Brijesh K. ; Cibi, Dasan Mary ; Weber, Susanne ; Lim, Sze Yun ; Adami, Eleonora ; George, Benjamin L. ; Sweeney, Mark ; Xie, Chen ; Tripathi, Madhulika ; Withers, Dominic J ; Hübner, Norbert ; Schafer, Sebastian ; Ho, Lena ; Gil, Jesus ; Carling, David ; Cook, Stuart A.
Publisher:Cold Spring Harbor Laboratory
Journal title:bioRxiv, 2023-07
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Molecular dissection of pro-fibrotic signaling identifies the mechanism underlying IL11-driven fibrosis gene translation, reveals non-specific effects of STAT3 and suggests a new mechanism of action f...
Author / Creator:Widjaja, Anissa A. ; Viswanathan, Sivakumar ; Jinrui, Dong ; Singh, Brijesh K. ; Tan, Jessie ; Ting, Joyce Goh Wei ; Lamb, David ; Shekeran, Shamini G ; George, Benjamin L ; Schafer, Sebastian ; Carling, David ; Adami, Eleonora ; Cook, Stuart A.
Publisher:Cold Spring Harbor Laboratory
Journal title:bioRxiv, 2021-06
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Trans control of cardiac mRNA translation in a protein length-dependent fashion
Author / Creator:Witte, Franziska ; Ruiz-Orera, Jorge ; Camilla Ciolli Mattioli ; Blachut, Susanne ; Adami, Eleonora ; Schulz, Jana Felicitas ; Schneider-Lunitz, Valentin ; Hummel, Oliver ; Patone, Giannino ; Michael Benedikt Mucke ; Silhavy, Jan ; Heinig, Matthias ; Bottolo, Leonardo ; Sanchis, Daniel ; Vingron, Martin ; Chekulaeva, Marina ; Pravenec, Michal ; Hubner, Norbert ; Sebastiaan Van Heesch
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2020-06
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Reliable detection of translational regulation with Ribo-seq
Author / Creator:Chothani, Sonia ; Adami, Eleonora ; Viswanathan, Sivakumar ; Hubner, Norbert ; Cook, Stuart ; Schafer, Sebastian ; Rackham, Owen
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2017-12
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Fibroblast-specific IL11 signaling is required for lung fibrosis and inflammation
Author / Creator:Ng, Benjamin ; Dong, Jinrui ; Viswanathan, Sivakumar ; Widjaja, Anissa A ; Paleja, Bhairav S ; Adami, Eleonora ; Ko, Nicole Sj ; Wang, Mao ; Lim, Stella ; Tan, Jessie ; Chothani, Sonia P ; Albani, Salvatore ; Schafer, Sebastian ; Cook, Stuart A
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2019-10
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Autocrine IL11 cis-signaling in hepatocytes is an initiating nexus between lipotoxicity and non-alcoholic steatohepatitis
Author / Creator:Dong, Jinrui ; Adami, Eleonora ; Chothani, Sonia ; Viswanathan, Sivakumar ; Ng, Benjamin ; Wei-Wen, Lim ; Singh, Brijesh K ; Zhou, Jin ; Ko, Nicole ; Shekeran, Shamini G ; Tan, Jessie ; Sze Yun Lim ; Wang, Mao ; Lio, Pei Min ; Yen, Paul M ; Schafer, Sebastian ; Cook, Stuart A ; Widjaja, Anissa Anindya
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2020-03
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Translational control of cardiac fibrosis
Author / Creator:Chothani, Sonia ; Schafer, Sebastian ; Adami, Eleonora ; Viswanathan, Sivakumar ; Widjaja, Anissa A ; Langley, Sarah R ; Tan, Jessie ; Jian Pua Chee ; D'agostino, Giuseppe ; Sebastiaan Van Heesch ; Witte, Franziska ; Felkin, Leanne E ; Christodoulou, Eleni G ; Dong, Jinrui ; Blachut, Susanne ; Patone, Giannino ; Barton, Paul Jr ; Hubner, Norbert ; Cook, Stuart A ; Owen Jl Rackham
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2018-10
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Redefining Interleukin 11 as a regeneration-limiting hepatotoxin
Author / Creator:Widjaja, Anissa A ; Jin Rui Dong ; Adami, Eleonora ; Viswanathan, Sivakumar ; Ng, Benjamin ; Singh, Brijesh K ; Wei-Wen, Lim ; Zhou, Jin ; Pakkiri, Leroy S ; Shekeran, Shamini G ; Tan, Jessie ; Sze Yun Lim ; Wang, Mao ; Holgate, Robert ; Hearn, Arron ; Yen, Paul M ; Chothani, Sonia ; Felkin, Leanne ; Dear, James W ; Drum, Chester L ; Schafer, Sebastian ; Cook, Stuart A
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2019-11
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Showing 1 to 20 of 21 results

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Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

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Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease

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The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

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IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis

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Genomic landscape of rat strain and substrain variation

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A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

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Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function

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Rattus norvegicus BN/SHR liver and heart left ventricle ribosomal RNA depleted directional RNA sequencing

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Titin-truncating variants affect heart function in disease cohorts and the general population

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Translational regulation shapes the molecular landscape of complex disease phenotypes

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RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing

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Overturning the paradigm that IL6 signaling drives liver regrowth while shining light on a new therapeutic target for regenerative medicine

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Inhibition of an immunometabolic axis of mTORC1 activation extends mammalian healthspan

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Molecular dissection of pro-fibrotic signaling identifies the mechanism underlying IL11-driven fibrosis gene translation, reveals non-specific effects of STAT3 and suggests a new mechanism of action f...

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Trans control of cardiac mRNA translation in a protein length-dependent fashion

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Reliable detection of translational regulation with Ribo-seq

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Fibroblast-specific IL11 signaling is required for lung fibrosis and inflammation

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Autocrine IL11 cis-signaling in hepatocytes is an initiating nexus between lipotoxicity and non-alcoholic steatohepatitis

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Translational control of cardiac fibrosis

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Redefining Interleukin 11 as a regeneration-limiting hepatotoxin

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