Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD t...
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
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Author / Creator
Dong, Jinrui , Viswanathan, Sivakumar , Adami, Eleonora , Singh, Brijesh K. , Chothani, Sonia P. , Ng, Benjamin , Lim, Wei Wen , Zhou, Jin , Tripathi, Madhulika , Ko, Nicole S. J. , Shekeran, Shamini G. , Tan, Jessie , Lim, Sze Yun , Wang, Mao , Lio, Pei Min , Yen, Paul M. , Schafer, Sebastian , Cook, Stuart A. and Widjaja, Anissa A.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
IL11 is important for fibrosis in non-alcoholic steatohepatitis (NASH) but its role beyond the stroma in liver disease is unclear. Here, we investigate the role of IL11 in hepatocyte lipotoxicity. Hepatocytes highly express IL11RA and secrete IL11 in response to lipid loading. Autocrine IL11 activity causes hepatocyte death through NOX4-derived ROS...
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Full title
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
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TN_cdi_doaj_primary_oai_doaj_org_article_ce2b5ee017d5453ea86274564e8eb24f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ce2b5ee017d5453ea86274564e8eb24f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-20303-z
