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ArticlesPeer ReviewedFull Text
Strong upregulation of inflammatory genes accompanies photoreceptor demise in canine models of retinal degeneration
Author / Creator:Appelbaum, Tatyana ; Santana, Evelyn ; Aguirre, Gustavo D
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-05, Vol.12 (5), p.e0177224
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Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement
Author / Creator:Cideciyan, Artur V. ; Jacobson, Samuel G. ; Beltran, William A. ; Sumaroka, Alexander ; Swider, Malgorzata ; Iwabe, Simone ; Roman, Alejandro J. ; Olivares, Melani B. ; Schwartz, Sharon B. ; Komáromy, András M. ; Hauswirth, William W. ; Aguirre, Gustavo D.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (6), p.1984-1984
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ArticlesPeer ReviewedFull Text
GTPBP2 in-frame deletion in canine model with non-syndromic progressive retinal atrophy
Author / Creator:Murgiano, Leonardo ; Niggel, Jessica K ; Akyürek, Eylem Emek ; Sacchetto, Roberta ; Aguirre, Gustavo D.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-02, Vol.15 (1), p.6079-15, Article 6079
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ArticlesPeer ReviewedFull Text
Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations
Author / Creator:Beltran, William A ; Cideciyan, Artur V ; Guziewicz, Karina E ; Iwabe, Simone ; Swider, Malgorzata ; Scott, Erin M ; Savina, Svetlana V ; Ruthel, Gordon ; Stefano, Frank ; Zhang, Lingli ; Zorger, Richard ; Sumaroka, Alexander ; Jacobson, Samuel G ; Aguirre, Gustavo D
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-03, Vol.9 (3), p.e90390-e90390
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ArticlesPeer ReviewedFull Text
Formal commentary
Author / Creator:Aguirre, Gustavo D ; Lohi, Hannes ; Kaukonen, Maria ; Murgiano, Leonardo
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2020-11, Vol.16 (11), p.e1009059-e1009059
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ArticlesPeer ReviewedFull Text
Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa
Author / Creator:Beltran, William A. ; Cideciyan, Artur V. ; Lewin, Alfred S. ; Iwabe, Simone ; Khanna, Hemant ; Sumaroka, Alexander ; Chiodo, Vince A. ; Fajardo, Diego S. ; Román, Alejandro J. ; Deng, Wen-Tao ; Swider, Malgorzata ; Alemán, Tomas S. ; Boye, Sanford L. ; Genini, Sem ; Swaroop, Anand ; Hauswirth, William W. ; Jacobson, Samuel G. ; Aguirre, Gustavo D.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (6), p.2132-2137
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ArticlesPeer ReviewedFull Text
Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells
Author / Creator:Gaub, Benjamin M. ; Berry, Michael H. ; Holt, Amy E. ; Reiner, Andreas ; Kienzler, Michael A. ; Dolgova, Natalia ; Nikonov, Sergei ; Aguirre, Gustavo D. ; Beltran, William A. ; Flannery, John G. ; Isacoff, Ehud Y.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (51), p.18111-18111
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Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease
Author / Creator:Beltran, William A. ; Cideciyan, Artur V. ; Iwabe, Simone ; Swider, Malgorzata ; Kosyk, Mychajlo S. ; McDaid, Kendra ; Martynyuk, Inna ; Ying, Gui-Shuang ; Shaffer, James ; Deng, Wen-Tao ; Boye, Sanford L. ; Lewin, Alfred S. ; Hauswirth, William W. ; Jacobson, Samuel G. ; Aguirre, Gustavo D.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-10, Vol.112 (43), p.E5844-E5853
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ArticlesPeer ReviewedFull Text
Molecular characterization of MAP9 in the photoreceptor sensory cilia as a modifier in canine RPGRIP1 -associated cone-rod dystrophy
Author / Creator:Takahashi, Kei ; Kwok, Jennifer C ; Sato, Yu ; Aguirre, Gustavo D ; Miyadera, Keiko
Publisher:Switzerland: Frontiers Research Foundation
Journal title:Frontiers in cellular neuroscience, 2023-08, Vol.17, p.1226603
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ArticlesPeer ReviewedFull Text
Retinal prolactin isoform PRLΔE1 sustains rod disease in inherited retinal degenerations
Author / Creator:Sudharsan, Raghavi ; Kwok, Jennifer ; Swider, Malgorzata ; Sumaroka, Alexander ; Aguirre, Gustavo D. ; Cideciyan, Artur V. ; Beltran, William A.
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2024-09, Vol.15 (9), p.682-10, Article 682
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ArticlesPeer ReviewedFull Text
Genetic and phenotypic variations of inherited retinal diseases in dogs: the power of within- and across-breed studies
Author / Creator:Miyadera, Keiko ; Acland, Gregory M ; Aguirre, Gustavo D
Publisher:New York: Springer-Verlag
Journal title:Mammalian genome, 2012-02, Vol.23 (1-2), p.40-61
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ArticlesPeer ReviewedFull Text
Up-regulation of tumor necrosis factor superfamily genes in early phases of photoreceptor degeneration
Author / Creator:Genini, Sem ; Beltran, William A ; Aguirre, Gustavo D
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-12, Vol.8 (12), p.e85408-e85408
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ArticlesPeer ReviewedFull Text
Short prolactin isoforms are expressed in photoreceptors of canine retinas undergoing retinal degeneration
Author / Creator:Sudharsan, Raghavi ; Murgiano, Leonardo ; Tang, Hsin-Yao ; Olsen, Timothy W. ; Chavali, Venkata R. M. ; Aguirre, Gustavo D. ; Beltran, William A.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-01, Vol.11 (1), p.460-460, Article 460
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ArticlesPeer ReviewedFull Text
A Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night Blindness
Author / Creator:Kondo, Mineo ; Das, Gautami ; Imai, Ryoetsu ; Santana, Evelyn ; Nakashita, Tomio ; Imawaka, Miho ; Ueda, Kosuke ; Ohtsuka, Hirohiko ; Sakai, Kazuhiko ; Aihara, Takehiro ; Kato, Kumiko ; Sugimoto, Masahiko ; Ueno, Shinji ; Nishizawa, Yuji ; Aguirre, Gustavo D ; Miyadera, Keiko
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-09, Vol.10 (9), p.e0137072-e0137072
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ArticlesPeer ReviewedFull Text
Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects
Author / Creator:Guziewicz, Karina E ; Zangerl, Barbara ; Komáromy, András M ; Iwabe, Simone ; Chiodo, Vincent A ; Boye, Sanford L ; Hauswirth, William W ; Beltran, William A ; Aguirre, Gustavo D
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-10, Vol.8 (10), p.e75666-e75666
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ArticlesPeer ReviewedFull Text
A digital atlas of the dog brain
Author / Creator:Datta, Ritobrato ; Lee, Jongho ; Duda, Jeffrey ; Avants, Brian B ; Vite, Charles H ; Tseng, Ben ; Gee, James C ; Aguirre, Gustavo D ; Aguirre, Geoffrey K
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-12, Vol.7 (12), p.e52140-e52140
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ArticlesPeer ReviewedFull Text
Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa
Author / Creator:Marsili, Stefania ; Genini, Sem ; Sudharsan, Raghavi ; Gingrich, Jeremy ; Aguirre, Gustavo D ; Beltran, William A
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-02, Vol.10 (2), p.e0115723
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Photochemical Restoration of Light Sensitivity in the Degenerated Canine Retina
Author / Creator:Nikonov, Sergei ; Dolgova, Natalia ; Sudharsan, Raghavi ; Tochitsky, Ivan ; Iwabe, Simone ; Guzman, Jose-Manuel ; Van Gelder, Russell N ; Kramer, Richard H ; Aguirre, Gustavo D ; Beltran, William A
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceutics, 2022-12, Vol.14 (12), p.2711
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ArticlesPeer ReviewedFull Text
Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness
Author / Creator:Acland, Gregory M ; Aguirre, Gustavo D ; Bennett, Jean ; Aleman, Tomas S ; Cideciyan, Artur V ; Bennicelli, Jeannette ; Dejneka, Nadine S ; Pearce-Kelling, Susan E ; Maguire, Albert M ; Palczewski, Krzysztof ; Hauswirth, William W ; Jacobson, Samuel G
Publisher:United States: Elsevier Limited
Journal title:Molecular therapy, 2005-12, Vol.12 (6), p.1072-1082
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Transient Photoreceptor Deconstruction by CNTF Enhances rAAV-Mediated Cone Functional Rescue in Late Stage CNGB3-Achromatopsia
Author / Creator:Komáromy, András M ; Rowlan, Jessica S ; Corr, Amanda T Parton ; Reinstein, Shelby L ; Boye, Sanford L ; Cooper, Ann E ; Gonzalez, Amaliris ; Levy, Britt ; Wen, Rong ; Hauswirth, William W ; Beltran, William A ; Aguirre, Gustavo D
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2013-06, Vol.21 (6), p.1131-1141
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Showing 1 to 20 of 75 results

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Strong upregulation of inflammatory genes accompanies photoreceptor demise in canine models of retinal degeneration

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Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement

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GTPBP2 in-frame deletion in canine model with non-syndromic progressive retinal atrophy

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Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations

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Formal commentary

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Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa

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Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells

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Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease

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Molecular characterization of MAP9 in the photoreceptor sensory cilia as a modifier in canine RPGRIP1 -associated cone-rod dystrophy

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Retinal prolactin isoform PRLΔE1 sustains rod disease in inherited retinal degenerations

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Genetic and phenotypic variations of inherited retinal diseases in dogs: the power of within- and across-breed studies

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Up-regulation of tumor necrosis factor superfamily genes in early phases of photoreceptor degeneration

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Short prolactin isoforms are expressed in photoreceptors of canine retinas undergoing retinal degeneration

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A Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night Blindness

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Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects

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A digital atlas of the dog brain

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Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa

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Photochemical Restoration of Light Sensitivity in the Degenerated Canine Retina

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Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness

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Transient Photoreceptor Deconstruction by CNTF Enhances rAAV-Mediated Cone Functional Rescue in Late Stage CNGB3-Achromatopsia

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