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ArticlesPeer ReviewedFull Text
Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant
Author / Creator:Spoerke, Jill M. ; Gendreau, Steven ; Walter, Kimberly ; Qiu, Jiaheng ; Wilson, Timothy R. ; Savage, Heidi ; Aimi, Junko ; Derynck, Mika K. ; Chen, Meng ; Chan, Iris T. ; Amler, Lukas C. ; Hampton, Garret M. ; Johnston, Stephen ; Krop, Ian ; Schmid, Peter ; Lackner, Mark R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-05, Vol.7 (1), p.11579-11579, Article 11579
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Molecular biomarker analyses using circulating tumor cells
Author / Creator:Punnoose, Elizabeth A ; Atwal, Siminder K ; Spoerke, Jill M ; Savage, Heidi ; Pandita, Ajay ; Yeh, Ru-Fang ; Pirzkall, Andrea ; Fine, Bernard M ; Amler, Lukas C ; Chen, Daniel S ; Lackner, Mark R
Publisher:United States: Public Library of Science
Journal title:PloS one, 2010-09, Vol.5 (9), p.e12517-e12517
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Biomarker analysis of the NeoSphere study: pertuzumab, trastuzumab, and docetaxel versus trastuzumab plus docetaxel, pertuzumab plus trastuzumab, or pertuzumab plus docetaxel for the neoadjuvant treat...
Author / Creator:Bianchini, Giampaolo ; Kiermaier, Astrid ; Bianchi, Giulia Valeria ; Im, Young-Hyuck ; Pienkowski, Tadeusz ; Liu, Mei-Ching ; Tseng, Ling-Ming ; Dowsett, Mitch ; Zabaglo, Lila ; Kirk, Sarah ; Szado, Tania ; Eng-Wong, Jennifer ; Amler, Lukas C ; Valagussa, Pinuccia ; Gianni, Luca
Publisher:England: BioMed Central
Journal title:Breast cancer research : BCR, 2017-02, Vol.19 (1), p.16-16, Article 16
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Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer
Author / Creator:Theelen, Willemijn S M E ; Kuilman, Thomas ; Schulze, Katja ; Zou, Wei ; Krijgsman, Oscar ; Peters, Dennis D G C ; Cornelissen, Sten ; Monkhorst, Kim ; Sarma, Pranamee ; Sumiyoshi, Teiko ; Amler, Lukas C ; Willems, Stefan M ; Blaauwgeers, Johannes L G ; van Noesel, Carel J M ; Peeper, Daniel S ; van den Heuvel, Michel M ; Kowanetz, Marcin
Publisher:United States: Public Library of Science
Journal title:PloS one, 2019-05, Vol.14 (5), p.e0216864-e0216864
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A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types
Author / Creator:Wagle, Marie-Claire ; Kirouac, Daniel ; Klijn, Christiaan ; Liu, Bonnie ; Mahajan, Shilpi ; Junttila, Melissa ; Moffat, John ; Merchant, Mark ; Huw, Ling ; Wongchenko, Matthew ; Okrah, Kwame ; Srinivasan, Shrividhya ; Mounir, Zineb ; Sumiyoshi, Teiko ; Haverty, Peter M. ; Yauch, Robert L. ; Yan, Yibing ; Kabbarah, Omar ; Hampton, Garret ; Amler, Lukas ; Ramanujan, Saroja ; Lackner, Mark R. ; Huang, Shih-Min A.
Publisher:London: Nature Publishing Group UK
Journal title:NPJ precision oncology, 2018-03, Vol.2 (1), p.7-7, Article 7
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High heregulin expression is associated with activated HER3 and may define an actionable biomarker in patients with squamous cell carcinomas of the head and neck
Author / Creator:Shames, David S ; Carbon, Juliet ; Walter, Kim ; Jubb, Adrian M ; Kozlowski, Cleopatra ; Januario, Tom ; Do, An ; AnDo ; Fu, Ling ; Xiao, Yuanyuan ; Raja, Rajiv ; Jiang, Brittany ; Malekafzali, Ashi ; Stern, Howard ; Settleman, Jeff ; Wilson, Timothy R ; Hampton, Garret M ; Yauch, Robert L ; Pirzkall, Andrea ; Amler, Lukas C
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-02, Vol.8 (2), p.e56765-e56765
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Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
Author / Creator:Wagner, Klaus W ; Punnoose, Elizabeth A ; Januario, Thomas ; Lawrence, David A ; Pitti, Robert M ; Lancaster, Kate ; Lee, Dori ; von Goetz, Melissa ; Yee, Sharon Fong ; Totpal, Klara ; Huw, Ling ; Katta, Viswanatham ; Cavet, Guy ; Hymowitz, Sarah G ; Amler, Lukas ; Ashkenazi, Avi
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2007-09, Vol.13 (9), p.1070-1077
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Relationship between HER2 expression and efficacy with first-line trastuzumab emtansine compared with trastuzumab plus docetaxel in TDM4450g: a randomized phase II study of patients with previously un...
Author / Creator:Perez, Edith A ; Hurvitz, Sara A ; Amler, Lukas C ; Mundt, Kirsten E ; Ng, Vivian ; Guardino, Ellie ; Gianni, Luca
Publisher:England: BioMed Central Ltd
Journal title:Breast cancer research : BCR, 2014-05, Vol.16 (3), p.R50-R50, Article R50
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Development and Application of a Microfluidics-Based Panel in the Basal/Luminal Transcriptional Characterization of Archival Bladder Cancers
Author / Creator:Kim, Doris ; Choi, YounJeong ; Ireland, James ; Foreman, Oded ; Tam, Rachel N ; Patel, Rajesh ; Schleifman, Erica B ; Motlhabi, Maipelo ; French, Dorothy ; Wong, Cheryl V ; Peters, Eric ; Molinero, Luciana ; Raja, Rajiv ; Amler, Lukas C ; Hampton, Garret M ; Lackner, Mark R ; Kabbarah, Omar
Publisher:United States: Public Library of Science
Journal title:PloS one, 2016-11, Vol.11 (11), p.e0165856-e0165856
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Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts
Author / Creator:Pawitan, Yudi ; Bjöhle, Judith ; Amler, Lukas ; Borg, Anna-Lena ; Egyhazi, Suzanne ; Hall, Per ; Han, Xia ; Holmberg, Lars ; Huang, Fei ; Klaar, Sigrid ; Liu, Edison T ; Miller, Lance ; Nordgren, Hans ; Ploner, Alexander ; Sandelin, Kerstin ; Shaw, Peter M ; Smeds, Johanna ; Skoog, Lambert ; Wedrén, Sara ; Bergh, Jonas
Publisher:England: BioMed Central Ltd
Journal title:Breast cancer research : BCR, 2005-01, Vol.7 (6), p.R953-R964, Article R953
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ArticlesPeer ReviewedFull Text
whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis
Author / Creator:Dompe, Nicholas ; Rivers, Celina Sanchez ; Li, Li ; Cordes, Shaun ; Schwickart, Martin ; Punnoose, Elizabeth A ; Amler, Lukas ; Seshagiri, Somasekar ; Tang, Jerry ; Modrusan, Zora ; Davis, David P
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-10, Vol.108 (43), p.E943-E951
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Correction: High Heregulin Expression Is Associated with Activated HER3 and May Define an Actionable Biomarker in Patients with Squamous Cell Carcinomas of the Head and Neck
Author / Creator:Shames, David S. ; Carbon, Juliet ; Walter, Kim ; Jubb, Adrian M. ; Kozlowski, Cleopatra ; Januario, Tom ; Do, An ; Fu, Ling ; Xiao, Yuanyuan ; Raja, Rajiv ; Jiang, Brittany ; Malekafzali, Ashi ; Stern, Howard ; Settleman, Jeff ; Wilson, Timothy R. ; Hampton, Garret M. ; Yauch, Robert L. ; Pirzkall, Andrea ; Amler, Lukas C.
Publisher:San Francisco: Public Library of Science
Journal title:PloS one, 2013-06, Vol.8 (6)
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Discovery and development of DNA methylation-based biomarkers for lung cancer
Author / Creator:Walter, Kimberly ; Holcomb, Thomas ; Januario, Tom ; Yauch, Robert L ; Du, Pan ; Bourgon, Richard ; Seshagiri, Somasekar ; Amler, Lukas C ; Hampton, Garret M ; S Shames, David
Publisher:England: Future Medicine Ltd
Journal title:Epigenomics, 2014-02, Vol.6 (1), p.59-72
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Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab
Author / Creator:Gandara, David R. ; Paul, Sarah M. ; Kowanetz, Marcin ; Schleifman, Erica ; Zou, Wei ; Li, Yan ; Rittmeyer, Achim ; Fehrenbacher, Louis ; Otto, Geoff ; Malboeuf, Christine ; Lieber, Daniel S. ; Lipson, Doron ; Silterra, Jacob ; Amler, Lukas ; Riehl, Todd ; Cummings, Craig A. ; Hegde, Priti S. ; Sandler, Alan ; Ballinger, Marcus ; Fabrizio, David ; Mok, Tony ; Shames, David S.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2018-09, Vol.24 (9), p.1441-1448
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Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti–PD-L1)
Author / Creator:Kowanetz, Marcin ; Zou, Wei ; Gettinger, Scott N. ; Koeppen, Hartmut ; Kockx, Mark ; Schmid, Peter ; Kadel, Edward E. ; Wistuba, Ignacio ; Chaft, Jamie ; Rizvi, Naiyer A. ; Spigel, David R. ; Spira, Alexander ; Hirsch, Fred R. ; Cohen, Victor ; Smith, Dustin ; Boyd, Zach ; Miley, Natasha ; Flynn, Susan ; Leveque, Vincent ; Shames, David S. ; Ballinger, Marcus ; Mocci, Simonetta ; Shankar, Geetha ; Funke, Roel ; Hampton, Garret ; Sandler, Alan ; Amler, Lukas ; Mellman, Ira ; Chen, Daniel S. ; Hegde, Priti S.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-10, Vol.115 (43), p.E10119-E10126
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PTEN loss in circulating tumour cells correlates with PTEN loss in fresh tumour tissue from castration-resistant prostate cancer patients
Author / Creator:Punnoose, Elizabeth A ; Ferraldeschi, Roberta ; Szafer-Glusman, Edith ; Tucker, Eric K ; Mohan, Sankar ; Flohr, Penelope ; Riisnaes, Ruth ; Miranda, Susana ; Figueiredo, Ines ; Rodrigues, Daniel Nava ; Omlin, Aurelius ; Pezaro, Carmel ; Zhu, Jin ; Amler, Lukas ; Patel, Premal ; Yan, Yibing ; Bales, Natalee ; Werner, Shannon L ; Louw, Jessica ; Pandita, Ajay ; Marrinucci, Dena ; Attard, Gerhardt ; de Bono, Johann
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2015-10, Vol.113 (8), p.1225-1233
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MYCN is Retained in Single Copy at Chromosome 2 Band p23-24 During Amplification in Human Neuroblastoma Cells
Author / Creator:Corvi, Raffaella ; Amler, Lukas C. ; Savelyeva, Larissa ; Gehring, Manuela ; Schwab, Manfred
Publisher:United States: National Academy of Sciences of the United States of America
Journal title:Proceedings of the National Academy of Sciences - PNAS, 1994-06, Vol.91 (12), p.5523-5527
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Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFN[gamma] signaling in non-small cell lung cancer
Author / Creator:Theelen, Willemijn S. M. E ; Kuilman, Thomas ; Schulze, Katja ; Zou, Wei ; Krijgsman, Oscar ; Peters, Dennis D. G. C ; Cornelissen, Sten ; Monkhorst, Kim ; Sarma, Pranamee ; Sumiyoshi, Teiko ; Amler, Lukas C ; Willems, Stefan M ; Blaauwgeers, Johannes L. G ; van Noesel, Carel J. M ; Peeper, Daniel S ; van den Heuvel, Michel M ; Kowanetz, Marcin
Publisher:Public Library of Science
Journal title:PloS one, 2019-05, Vol.14 (5), p.e0216864
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ArticlesPeer ReviewedFull Text
A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis
Author / Creator:Dompe, Nicholas ; Rivers, Celina Sanchez ; Li Li ; Cordes, Shaun ; Schwickart, Martin ; Punnoose, Elizabeth A. ; Amler, Lukas ; Seshagiri, Somasekar ; Tang, Jerry ; Modrusan, Zora ; Davis, David P.
Publisher:National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-10, Vol.108 (43), p.17591-17592
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Functional dissection of transcriptional profiles in androgen-dependent and -independent prostate cancer
Author / Creator:Amler, Lukas ; Agus, David ; Dracopoli, Nicholas ; Scher, Howard ; Hampton, Garret
Publisher:New York: Nature Publishing Group
Journal title:Nature genetics, 2001-04, Vol.27 (S4), p.39-39
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Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant

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Molecular biomarker analyses using circulating tumor cells

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Biomarker analysis of the NeoSphere study: pertuzumab, trastuzumab, and docetaxel versus trastuzumab plus docetaxel, pertuzumab plus trastuzumab, or pertuzumab plus docetaxel for the neoadjuvant treat...

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Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer

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A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types

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High heregulin expression is associated with activated HER3 and may define an actionable biomarker in patients with squamous cell carcinomas of the head and neck

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Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL

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Relationship between HER2 expression and efficacy with first-line trastuzumab emtansine compared with trastuzumab plus docetaxel in TDM4450g: a randomized phase II study of patients with previously un...

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Development and Application of a Microfluidics-Based Panel in the Basal/Luminal Transcriptional Characterization of Archival Bladder Cancers

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Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts

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whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis

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Correction: High Heregulin Expression Is Associated with Activated HER3 and May Define an Actionable Biomarker in Patients with Squamous Cell Carcinomas of the Head and Neck

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Discovery and development of DNA methylation-based biomarkers for lung cancer

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Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab

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Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti–PD-L1)

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PTEN loss in circulating tumour cells correlates with PTEN loss in fresh tumour tissue from castration-resistant prostate cancer patients

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MYCN is Retained in Single Copy at Chromosome 2 Band p23-24 During Amplification in Human Neuroblastoma Cells

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Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFN[gamma] signaling in non-small cell lung cancer

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A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis

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Functional dissection of transcriptional profiles in androgen-dependent and -independent prostate cancer

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