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Yi Hyo-sŏk Munhaksang susang chakp'umjip 2016 / Cho Hae-jin, Yi Chi-hun, Kwŏn Yŏ-sŏn, Kim Sa-gwa, Kim Sum, Kim Yu-jin, Pak Hyŏng-sŏ, Yi Chang-uk, Chŏng Mi-gyŏng, Chŏn Sŏng-t'ae chiŭm.

이 효석 문학상 수상 작품집 2016 / 조 해진, 이 지훈, 권 여선, 김 사과, 김 숨, 김 유진, 박 형서, 이 장욱, 정 미경, 전 성태 지음.

P'unggyŏng sori oe 5-p'yŏn : 2017-Yŏndo che 41-hoe Yi Sang Munhaksang chakp'umjip.

풍경 소리 외 5편 : 2017년도 제 41회 이상 문학상 작품집.

Spt5 is a well-conserved factor that manipulates multiple stages of transcription from promoter-proximal pausing (PPP) to termination. Recent studies have revealed an unexpected increase of antisense transcripts near promoters in cells expressing mutant Spt5. Here, we identify Spt5p-restricted intragenic antisense transcripts and their close relationship with sense transcription in yeast. We confirm that Spt5 CTR phosphorylation is also important to retain Spt5’s facility to regulate antisense transcription. The genes whose antisense transcription is strongly suppressed by Spt5p share strong endogenous sense transcription and weak antisense transcription, and this pattern is conserved in humans. Mechanistically, we found that Spt5p depletion increased histone acetylation to initiate intragenic antisense transcription by altering chromatin structure. We additionally identified termination factors that appear to be involved in the ability of Spt5p to restrict antisense transcription. By unveiling a new role of Spt5 in finely balancing the bidirectionality of transcription, we demonstrate that Spt5-mediated suppression of DSIF complex regulated-unstable transcripts (DUTs) is essential to sustain the accurate transcription by RNA polymerase II.
A study suggests that Spt5 regulates intragenic antisense transcription by preserving chromatin structure. This conserved role of Spt5 indicates that balancing bidirectional transcription is crucial to sustain accurate gene expression.

Communications biology, 2024-10, Vol.7 (1), p.1370-14, Article 1370

Spt5 orchestrates cryptic transcript suppression and transcriptional directionality

Mitochondria are pivotal for energy regulation and are linked to cancer. Mitochondrial sirtuins, (Sirtuin) SIRT3, SIRT4, and SIRT5, play crucial roles in cancer metabolism. This review explores their impact on cellular processes, with a focus on the NAD+ interplay and the modulation of their enzymatic activities. The varied roles of SIRT3, SIRT4, and SIRT5 in metabolic adaptation and cancer are outlined, emphasizing their tumor suppressor or oncogenic nature. We propose new insights into sirtuin biology, and cancer therapeutics, suggesting an integrated proteomics and metabolomics approach for a comprehensive understanding of mitochondrial sirtuins in cancer.

Molecules and cells, 2024, Vol.47 (2), p.100029.1-100029.11

Mitochondrial sirtuins: Energy dynamics and cancer metabolism

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Yi Hyo-sŏk Munhaksang susang chakp'umjip 2016 / Cho Hae-jin, Yi Chi-hun, Kwŏn Yŏ-sŏn, Kim Sa-gwa, Kim Sum, Kim Yu-jin, Pak Hyŏng-sŏ, Yi Chang-uk, Chŏng Mi-gyŏng, Chŏn Sŏng-t'ae chiŭm.

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P'unggyŏng sori oe 5-p'yŏn : 2017-Yŏndo che 41-hoe Yi Sang Munhaksang chakp'umjip.

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Spt5 orchestrates cryptic transcript suppression and transcriptional directionality

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Mitochondrial sirtuins: Energy dynamics and cancer metabolism

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