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168 results for Antimalarials+-+metabolism

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ArticlesPeer ReviewedFull Text
Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development
Author / Creator:Paddon, Chris J. ; Keasling, Jay D.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Microbiology, 2014-05, Vol.12 (5), p.355-367
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Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages
Author / Creator:Okombo, John ; Mok, Sachel ; Qahash, Tarrick ; Yeo, Tomas ; Bath, Jade ; Orchard, Lindsey M. ; Owens, Edward ; Koo, Imhoi ; Albert, Istvan ; Llinás, Manuel ; Fidock, David A.
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2022-10, Vol.18 (10), p.e1010926
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Effects of Antimalarial Drugs on Neuroinflammation-Potential Use for Treatment of COVID-19-Related Neurologic Complications
Author / Creator:Ong, Wei-Yi ; Go, Mei-Lin ; Wang, De-Yun ; Cheah, Irwin Kee-Mun ; Halliwell, Barry
Publisher:New York: Springer US
Journal title:Molecular neurobiology, 2021-01, Vol.58 (1), p.106-117
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ArticlesPeer ReviewedFull Text
High-level semi-synthetic production of the potent antimalarial artemisinin
Author / Creator:Paddon, C. J. ; Westfall, P. J. ; Pitera, D. J. ; Benjamin, K. ; Fisher, K. ; McPhee, D. ; Leavell, M. D. ; Tai, A. ; Main, A. ; Eng, D. ; Polichuk, D. R. ; Teoh, K. H. ; Reed, D. W. ; Treynor, T. ; Lenihan, J. ; Jiang, H. ; Fleck, M. ; Bajad, S. ; Dang, G. ; Dengrove, D. ; Diola, D. ; Dorin, G. ; Ellens, K. W. ; Fickes, S. ; Galazzo, J. ; Gaucher, S. P. ; Geistlinger, T. ; Henry, R. ; Hepp, M. ; Horning, T. ; Iqbal, T. ; Kizer, L. ; Lieu, B. ; Melis, D. ; Moss, N. ; Regentin, R. ; Secrest, S. ; Tsuruta, H. ; Vazquez, R. ; Westblade, L. F. ; Xu, L. ; Yu, M. ; Zhang, Y. ; Zhao, L. ; Lievense, J. ; Covello, P. S. ; Keasling, J. D. ; Reiling, K. K. ; Renninger, N. S. ; Newman, J. D.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2013-04, Vol.496 (7446), p.528-532
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ArticlesPeer ReviewedFull Text
Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin
Author / Creator:Westfall, Patrick J ; Pitera, Douglas J ; Lenihan, Jacob R ; Eng, Diana ; Woolard, Frank X ; Regentin, Rika ; Horning, Tizita ; Tsuruta, Hiroko ; Melis, David J ; Owens, Andrew ; Fickes, Scott ; Diola, Don ; Benjamin, Kirsten R ; Keasling, Jay D ; Leavell, Michael D ; McPhee, Derek J ; Renninger, Neil S ; Newman, Jack D ; Paddon, Chris J
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-01, Vol.109 (3), p.E111-E118
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Microbial siderophores and their potential applications: a review
Author / Creator:Saha, Maumita ; Sarkar, Subhasis ; Sarkar, Biplab ; Sharma, Bipin Kumar ; Bhattacharjee, Surajit ; Tribedi, Prosun
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Environmental science and pollution research international, 2016-03, Vol.23 (5), p.3984-3999
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ArticlesPeer ReviewedFull Text
Key insights into secondary metabolites from various Chaetomium species
Author / Creator:Dwibedi, Vagish ; Rath, Santosh Kumar ; Jain, Sahil ; Martínez-Argueta, Nayeli ; Prakash, Ranjana ; Saxena, Sanjai ; Rios-Solis, Leonardo
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Applied microbiology and biotechnology, 2023-02, Vol.107 (4), p.1077-1093
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ArticlesPeer ReviewedFull Text
A new synthetic biology approach allows transfer of an entire metabolic pathway from a medicinal plant to a biomass crop
Author / Creator:Fuentes, Paulina ; Zhou, Fei ; Erban, Alexander ; Karcher, Daniel ; Kopka, Joachim ; Bock, Ralph
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2016-06, Vol.5
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ArticlesPeer ReviewedFull Text
Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1
Author / Creator:Capper, Michael J ; O'Neill, Paul M ; Fisher, Nicholas ; Strange, Richard W ; Moss, Darren ; Ward, Stephen A ; Berry, Neil G ; Lawrenson, Alexandre S ; Hasnain, S Samar ; Biagini, Giancarlo A ; Antonyuk, Svetlana V
Publisher:United States: National Acad Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (3), p.755-760
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ArticlesPeer ReviewedFull Text
Fighting malaria with engineered symbiotic bacteria from vector mosquitoes
Author / Creator:Wang, Sibao ; Ghosh, Anil K ; Bongio, Nicholas ; Stebbings, Kevin A ; Lampe, David J ; Jacobs-Lorena, Marcelo
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (31), p.12734-12739
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ArticlesPeer ReviewedFull Text
Artemisia annua mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism
Author / Creator:Czechowski, Tomasz ; Larson, Tony R. ; Catania, Theresa M. ; Harvey, David ; Brown, Geoffrey D. ; Graham, Ian A.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-12, Vol.113 (52), p.15150-15155
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ArticlesPeer ReviewedFull Text
The Antagonizing Role of Heme in the Antimalarial Function of Artemisinin: Elevating Intracellular Free Heme Negatively Impacts Artemisinin Activity in Plasmodium falciparum
Author / Creator:Zhu, Pan ; Zhou, Bing
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2022-03, Vol.27 (6), p.1755
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ArticlesPeer ReviewedFull Text
Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin
Author / Creator:Graham, Ian A ; Besser, Katrin ; Blumer, Susan ; Branigan, Caroline A ; Czechowski, Tomasz ; Elias, Luisa ; Guterman, Inna ; Harvey, David ; Isaac, Peter G ; Khan, Awais M ; Larson, Tony R ; Li, Yi ; Pawson, Tanya ; Penfield, Teresa ; Rae, Anne M ; Rathbone, Deborah A ; Reid, Sonja ; Ross, Joe ; Smallwood, Margaret F ; Segura, Vincent ; Townsend, Theresa ; Vyas, Darshna ; Winzer, Thilo ; Bowles, Dianna
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2010-01, Vol.327 (5963), p.328-331
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ArticlesPeer ReviewedFull Text
Engineering yeast for industrial-level production of the antimalarial drug artemisinin
Author / Creator:Smith, Ayoola B ; Chekan, Jonathan R
Publisher:England: Elsevier Ltd
Journal title:Trends in biotechnology (Regular ed.), 2023-03, Vol.41 (3), p.267-269
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ArticlesPeer ReviewedFull Text
Dihydroartemisinic acid dehydrogenase-mediated alternative route for artemisinin biosynthesis
Author / Creator:Guo, Zizheng ; Zhou, Ying ; Li, Jiangqi ; Liu, De ; Huang, Yuwen ; Zhang, Yu ; Yu, Rongmin ; Zhu, Jianhua
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-04, Vol.16 (1), p.3888-16, Article 3888
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ArticlesPeer ReviewedFull Text
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Author / Creator:Ro, D.K ; Paradise, E.M ; Ouellet, M ; Fisher, K.J ; Newman, K.L ; Ndungu, J.M ; Ho, K.A ; Eachus, R.A ; Ham, T.S ; Kirby, J
Publisher:London: Nature Publishing Group UK
Journal title:Nature, 2006-04, Vol.440 (7086), p.940-943
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ArticlesPeer ReviewedFull Text
Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites
Author / Creator:Russell, Timothy James ; De Silva, Erandi K. ; Crowley, Valerie M. ; Shaw-Saliba, Kathryn ; Dube, Namita ; Josling, Gabrielle ; Pasaje, Charisse Flerida A. ; Kouskoumvekaki, Irene ; Panagiotou, Gianni ; Niles, Jacquin C. ; Jacobs-Lorena, Marcelo ; Denise Okafor, C. ; Gamo, Francisco-Javier ; Llinás, Manuel
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2022-10, Vol.18 (10), p.e1010887
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ArticlesPeer ReviewedFull Text
The metabolism of primaquine to its active metabolite is dependent on CYP 2D6
Author / Creator:Pybus, Brandon S ; Marcsisin, Sean R ; Jin, Xiannu ; Deye, Gregory ; Sousa, Jason C ; Li, Qigui ; Caridha, Diana ; Zeng, Qiang ; Reichard, Gregory A ; Ockenhouse, Christian ; Bennett, Jason ; Walker, Larry A ; Ohrt, Colin ; Melendez, Victor
Publisher:England: BioMed Central Ltd
Journal title:Malaria journal, 2013-06, Vol.12 (1), p.212-212, Article 212
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ArticlesPeer ReviewedFull Text
Virtual screening as a tool to discover new β-haematin inhibitors with activity against malaria parasites
Author / Creator:de Sousa, Ana Carolina C. ; Combrinck, Jill M. ; Maepa, Keletso ; Egan, Timothy J.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-02, Vol.10 (1), p.3374-3374, Article 3374
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Molecular basis of the functional conflict between chloroquine and peptide transport in the Malaria parasite chloroquine resistance transporter PfCRT
Author / Creator:Tanner, John D. ; Richards, Sashika N. ; Corry, Ben
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-03, Vol.16 (1), p.2987-16, Article 2987
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Showing 1 to 20 of 168 results

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Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

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Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages

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Effects of Antimalarial Drugs on Neuroinflammation-Potential Use for Treatment of COVID-19-Related Neurologic Complications

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High-level semi-synthetic production of the potent antimalarial artemisinin

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Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

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Microbial siderophores and their potential applications: a review

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Key insights into secondary metabolites from various Chaetomium species

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A new synthetic biology approach allows transfer of an entire metabolic pathway from a medicinal plant to a biomass crop

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Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1

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Fighting malaria with engineered symbiotic bacteria from vector mosquitoes

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Artemisia annua mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism

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The Antagonizing Role of Heme in the Antimalarial Function of Artemisinin: Elevating Intracellular Free Heme Negatively Impacts Artemisinin Activity in Plasmodium falciparum

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Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin

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Engineering yeast for industrial-level production of the antimalarial drug artemisinin

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Dihydroartemisinic acid dehydrogenase-mediated alternative route for artemisinin biosynthesis

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Production of the antimalarial drug precursor artemisinic acid in engineered yeast

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Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites

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The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

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Virtual screening as a tool to discover new β-haematin inhibitors with activity against malaria parasites

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Molecular basis of the functional conflict between chloroquine and peptide transport in the Malaria parasite chloroquine resistance transporter PfCRT

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