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Sub-series 2: Angus & Robertson book reviews, loose, 1957-1972

Sub-series 1: Angus & Robertson book reviews in bound volumes, 1894-1970

Recovery plans made or adopted under the Environment Protection and Biodiversity Conservation Act 1999 [electronic resource].

395 - SP/M5/400 - Manly Balgowlah Estate - Main Sydney Rd, Hill St, Griffiths St, Austin St, La Perouse St, 1902

600 - SP/M5/632 - 39 Allotments, Bassett Darley Estate Manly - The Corso, The Steyne, Reddal St, Addison Rd, Osborne Rd, The Esplanade, Wentworth St, Victoria Pde, Ashburner St, Darley Rd

SP/M5/440 - 2nd Subdivision -  West St, Balgowlah Rd, Boyle St, Main Sydney Rd, Woodlands St, Lombard St

[Manly subdivision plans] [cartographic material]

This analysis is part of an investigation designed for the elucidation of the correlation between mutagenesis and carcinogenesis. Diepoxybutane was found to be a strong mutagen when injected into the haemocoel of adult Drosophila males, producing lethal, semi-lethal and ‘visible’ mutations. One of the ‘visible’ mutations produced resulted in the appearance of neoplastic melanotic ‘tumours’ in the offspring of the treated flies. This is most significant in relation to the mutation theory of cancer causation. The successive stages of the male germ line manifest a varied susceptibility to mutagenic action, there being a certain stage among the earlier germ cells which is the most sensitive. The proportion of major structural rearrangements among the sex-linked recessive lethals produced by chemical agents (diepoxybutane and mustard gas) is far lower than that produced by mutagenically equivalent doses of X-rays. Small deficiencies, on the other hand, are twice as frequent among diepoxybutane lethals as among the same type of mutation induced by mustard gas or X -rays. The quality of the bands involved in the deficiencies is also different, diepoxybutane affecting the darker bands of the salivary gland X-chromosome preferentially, mustard gas the lighter ones. This might indicate that diepoxybutane has a preferential action on the gene loci with a higher charge of nucleic acid. A ‘coarse’ specificity for chromosome segments, however, does not seem to occur. The distributions of recessive lethals and loci of damage, induced by the diepoxide and mustard gas in the successive segments of the X-chromosome, are not significantly different. Mosaics for visible mutations and chromosomal changes occur more frequently after treatment with chemical mutagens than after X-radiation. This mosaicism has been explained on the basis of the multiple-strand structure of the mitotic chromosome and partial damage to some of its subunits.

Proceedings of the Royal Society of London. Series B, Biological sciences, 1953-01, Vol.140 (901), p.556-578

Cytogenetic Analysis of the Action of Carcinogens and Tumour Inhibitors in Drosophila melanogaster. I. 1:2, 3:4-Diepoxybutane

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Sub-series 2: Angus & Robertson book reviews, loose, 1957-1972

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Sub-series 1: Angus & Robertson book reviews in bound volumes, 1894-1970

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Recovery plans made or adopted under the Environment Protection and Biodiversity Conservation Act 1999 [electronic resource].

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[Manly subdivision plans] [cartographic material]

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Cytogenetic Analysis of the Action of Carcinogens and Tumour Inhibitors in Drosophila melanogaster. I. 1:2, 3:4-Diepoxybutane

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