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ArticlesPeer ReviewedFull Text
Small-molecule targeting of brachyury transcription factor addiction in chordoma
Author / Creator:Sharifnia, Tanaz ; Wawer, Mathias J. ; Chen, Ting ; Huang, Qing-Yuan ; Weir, Barbara A. ; Sizemore, Ann ; Lawlor, Matthew A. ; Goodale, Amy ; Cowley, Glenn S. ; Vazquez, Francisca ; Ott, Christopher J. ; Francis, Joshua M. ; Sassi, Slim ; Cogswell, Patricia ; Sheppard, Hadley E. ; Zhang, Tinghu ; Gray, Nathanael S. ; Clarke, Paul A. ; Blagg, Julian ; Workman, Paul ; Sommer, Josh ; Hornicek, Francis ; Root, David E. ; Hahn, William C. ; Bradner, James E. ; Wong, Kwok K. ; Clemons, Paul A. ; Lin, Charles Y. ; Kotz, Joanne D. ; Schreiber, Stuart L.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2019-02, Vol.25 (2), p.292-300
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brachyury
Publisher:Oxford University Press
Journal title:A Dictionary of Biomedicine, 2019
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Randomized, Double‐Blind, Placebo‐Controlled Phase II Study of Yeast‐Brachyury Vaccine (GI‐6301) in Combination with Standard‐of‐Care Radiotherapy in Locally Advanced, Unresectable Chordoma
Author / Creator:DeMaria, Peter Joseph ; Bilusic, Marijo ; Park, Deric M. ; Heery, Christopher R. ; Donahue, Renee N. ; Madan, Ravi A. ; Bagheri, Mohammad Hadi ; Strauss, Julius ; Shen, Victoria ; Marté, Jennifer L. ; Steinberg, Seth M. ; Schlom, Jeffrey ; Gilbert, Mark R. ; Gulley, James L.
Publisher:Hoboken, USA: John Wiley & Sons, Inc
Journal title:The oncologist (Dayton, Ohio), 2021-05, Vol.26 (5), p.e847-e858
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Conserved enhancers control notochord expression of vertebrate Brachyury
Author / Creator:Kemmler, Cassie L. ; Smolikova, Jana ; Moran, Hannah R. ; Mannion, Brandon J. ; Knapp, Dunja ; Lim, Fabian ; Czarkwiani, Anna ; Hermosilla Aguayo, Viviana ; Rapp, Vincent ; Fitch, Olivia E. ; Bötschi, Seraina ; Selleri, Licia ; Farley, Emma ; Braasch, Ingo ; Yun, Maximina ; Visel, Axel ; Osterwalder, Marco ; Mosimann, Christian ; Kozmik, Zbynek ; Burger, Alexa
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-10, Vol.14 (1), p.6594-6594, Article 6594
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Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state
Author / Creator:Tosic, Jelena ; Kim, Gwang-Jin ; Pavlovic, Mihael ; Schröder, Chiara M. ; Mersiowsky, Sophie-Luise ; Barg, Margareta ; Hofherr, Alexis ; Probst, Simone ; Köttgen, Michael ; Hein, Lutz ; Arnold, Sebastian J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2019-12, Vol.21 (12), p.1518-1531
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Brachyury cooperates with Wnt/β-catenin signalling to elicit primitive-streak-like behaviour in differentiating mouse embryonic stem cells
Author / Creator:Turner, David A ; Rué, Pau ; Mackenzie, Jonathan P ; Davies, Eleanor ; Martinez Arias, Alfonso
Publisher:England: BioMed Central
Journal title:BMC biology, 2014-08, Vol.12 (1), p.63-63, Article 63
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Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy
Author / Creator:Newman, Joseph A. ; Gavard, Angeline E. ; Imprachim, Nergis ; Aitkenhead, Hazel ; Sheppard, Hadley E. ; te Poele, Robert ; Clarke, Paul A. ; Hossain, Mohammad Anwar ; Temme, Louisa ; Oh, Hans J. ; Wells, Carrow I. ; Davis-Gilbert, Zachary W. ; Workman, Paul ; Gileadi, Opher ; Drewry, David H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-02, Vol.16 (1), p.1596-14
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Charting Brachyury-mediated developmental pathways during early mouse embryogenesis
Author / Creator:Lolas, Macarena ; Valenzuela, Pablo D. T. ; Tjian, Robert ; Liu, Zhe
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (12), p.4478-4483
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Brachyury, Foxa2 and the cis-Regulatory Origins of the Notochord
Author / Creator:José-Edwards, Diana S. ; Oda-Ishii, Izumi ; Kugler, Jamie E. ; Passamaneck, Yale J. ; Katikala, Lavanya ; Nibu, Yutaka ; Di Gregorio, Anna
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2015-12, Vol.11 (12), p.e1005730-e1005730
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Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT
Author / Creator:Zhu, Jianjian ; Kwan, Kin Ming ; Mackem, Susan
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-04, Vol.113 (14), p.3820-3825
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Maturation of human induced pluripotent stem cell-derived cardiomyocytes promoted by Brachyury priming
Author / Creator:Kargaran, Parisa K. ; Garmany, Armin ; Garmany, Ramin ; Stutzman, Marissa J. ; Sadeghian, Maryam ; Ackerman, Michael J. ; Perez-Terzic, Carmen M. ; Terzic, Andre ; Behfar, Atta
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-04, Vol.15 (1), p.14399-13, Article 14399
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Brachyury Is Associated with Glioma Differentiation and Response to Temozolomide
Author / Creator:Pinto, Filipe ; Costa, Ângela M. ; Andrade, Raquel P. ; Reis, Rui Manuel
Publisher:Cham: Springer International Publishing
Journal title:Neurotherapeutics, 2020-10, Vol.17 (4), p.2015-2027
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Cucurbitacin B Exhibits Antitumor Effects on Chordoma Cells via Disruption of Brachyury
Author / Creator:Seeling, Carolin ; Neumahr, Johannes ; Häberle, Fabian ; Lechel, André ; Möller, Peter ; Gaisa, Nadine T. ; Barth, Thomas F. E. ; Mellert, Kevin
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2025-04, Vol.26 (8), p.3864
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Brachyury-targeted immunotherapy combined with gemcitabine against head and neck cancer
Author / Creator:Yamaki, Hidekiyo ; Kono, Michihisa ; Wakisaka, Risa ; Komatsuda, Hiroki ; Kumai, Takumi ; Hayashi, Ryusuke ; Sato, Ryosuke ; Nagato, Toshihiro ; Ohkuri, Takayuki ; Kosaka, Akemi ; Ohara, Kenzo ; Kishibe, Kan ; Takahara, Miki ; Hayashi, Tatsuya ; Kobayashi, Hiroya ; Katada, Akihiro
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer Immunology, Immunotherapy, 2023-08, Vol.72 (8), p.2799-2812
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Brachyury engineers cardiac repair competent stem cells
Author / Creator:Li, Mark ; Yamada, Satsuki ; Shi, Ao ; Singh, Raman Deep ; Rolland, Tyler J. ; Jeon, Ryounghoon ; Lopez, Natalia ; Shelerud, Lukas ; Terzic, Andre ; Behfar, Atta
Publisher:Hoboken, USA: John Wiley & Sons, Inc
Journal title:Stem cells translational medicine, 2021-03, Vol.10 (3), p.385-397
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Genomic Targets of Brachyury (T) in Differentiating Mouse Embryonic Stem Cells
Author / Creator:Evans, Amanda L. ; Faial, Tiago ; Gilchrist, Michael J. ; Down, Thomas ; Vallier, Ludovic ; Pedersen, Roger A. ; Wardle, Fiona C. ; Smith, James C.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-03, Vol.7 (3), p.e33346-e33346
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The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells
Author / Creator:Fernando, Romaine I. ; Litzinger, Mary ; Trono, Paola ; Hamilton, Duane H. ; Schlom, Jeffrey ; Palena, Claudia
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2010-02, Vol.120 (2), p.533-544
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Snail Transcriptionally Represses Brachyury to Promote the Mesenchymal-Epithelial Transition in Ascidian Notochord Cells
Author / Creator:Wu, Bingtong ; Ouyang, Xiuke ; Yang, Xiuxia ; Dong, Bo
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2024-03, Vol.25 (6), p.3413
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T (brachyury) gene duplication confers major susceptibility to familial chordoma
Author / Creator:Yang, Xiaohong R ; Ng, David ; Alcorta, David A ; Liebsch, Norbert J ; Sheridan, Eamonn ; Li, Sufeng ; Goldstein, Alisa M ; Parry, Dilys M ; Kelley, Michael J
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2009-11, Vol.41 (11), p.1176-1178
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The evolutionary history of Brachyury genes in Hydrozoa involves duplications, divergence, and neofunctionalization
Author / Creator:Vetrova, Alexandra A. ; Kupaeva, Daria M. ; Kizenko, Alena ; Lebedeva, Tatiana S. ; Walentek, Peter ; Tsikolia, Nikoloz ; Kremnyov, Stanislav V.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2023-06, Vol.13 (1), p.9382-9382, Article 9382
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Small-molecule targeting of brachyury transcription factor addiction in chordoma

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brachyury

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Randomized, Double‐Blind, Placebo‐Controlled Phase II Study of Yeast‐Brachyury Vaccine (GI‐6301) in Combination with Standard‐of‐Care Radiotherapy in Locally Advanced, Unresectable Chordoma

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Conserved enhancers control notochord expression of vertebrate Brachyury

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Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state

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Brachyury cooperates with Wnt/β-catenin signalling to elicit primitive-streak-like behaviour in differentiating mouse embryonic stem cells

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Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy

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Charting Brachyury-mediated developmental pathways during early mouse embryogenesis

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Brachyury, Foxa2 and the cis-Regulatory Origins of the Notochord

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Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT

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Maturation of human induced pluripotent stem cell-derived cardiomyocytes promoted by Brachyury priming

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Brachyury Is Associated with Glioma Differentiation and Response to Temozolomide

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Cucurbitacin B Exhibits Antitumor Effects on Chordoma Cells via Disruption of Brachyury

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Brachyury-targeted immunotherapy combined with gemcitabine against head and neck cancer

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Brachyury engineers cardiac repair competent stem cells

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Genomic Targets of Brachyury (T) in Differentiating Mouse Embryonic Stem Cells

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The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells

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Snail Transcriptionally Represses Brachyury to Promote the Mesenchymal-Epithelial Transition in Ascidian Notochord Cells

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T (brachyury) gene duplication confers major susceptibility to familial chordoma

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The evolutionary history of Brachyury genes in Hydrozoa involves duplications, divergence, and neofunctionalization

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