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A low response rate, acquired resistance and severe side effects have limited the clinical outcomes of immune checkpoint therapy. Here, we show that combining cancer nanovaccines with an anti-PD-1 antibody (αPD-1) for immunosuppression blockade and an anti-OX40 antibody (αOX40) for effector T-cell stimulation, expansion and survival can potentiate the efficacy of melanoma therapy. Prophylactic and therapeutic combination regimens of dendritic cell-targeted mannosylated nanovaccines with αPD-1/αOX40 demonstrate a synergism that stimulates T-cell infiltration into tumours at early treatment stages. However, this treatment at the therapeutic regimen does not result in an enhanced inhibition of tumour growth compared to αPD-1/αOX40 alone and is accompanied by an increased infiltration of myeloid-derived suppressor cells in tumours. Combining the double therapy with ibrutinib, a myeloid-derived suppressor cell inhibitor, leads to a remarkable tumour remission and prolonged survival in melanoma-bearing mice. The synergy between the mannosylated nanovaccines, ibrutinib and αPD-1/αOX40 provides essential insights to devise alternative regimens to improve the efficacy of immune checkpoint modulators in solid tumours by regulating the endogenous immune response.
Combination of dendritic-cell-targeted nanovaccines with a myeloid-derived suppressor cell inhibitor and immune checkpoint modulators expands the host antitumour immune cells, restricts tumour growth and prolongs survival in orthotopic melanoma models.

Nature nanotechnology, 2019-09, Vol.14 (9), p.891-901

Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators

The deployment of structures that enable localized release of bioactive molecules can result in more efficacious treatment of disease and better integration of implantable bionic devices. The strategic design of a biopolymeric coating can be used to engineer the optimal release profile depending on the task at hand. As illustrative examples, here advances in delivery of drugs from bone, brain, ocular, and cardiovascular implants are reviewed. These areas are focused to highlight that both hard and soft tissue implants can benefit from controlled localized delivery. The composition of biopolymers used to achieve appropriate delivery to the selected tissue types, and their corresponding outcomes are brought to the fore. To conclude, key factors in designing drug‐loaded biopolymeric coatings for biomedical implants are highlighted.
Strategic design of a biopolymeric coating can be used to engineer the optimal release profile of the therapeutics depending on the task at hand. Here advances in delivery of therapeutics from bone, brain, ocular, and cardiovascular implants are reviewed.

Advanced science, 2023-04, Vol.10 (12), p.e2207603-n/a

Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants

Thanks to the great efforts of our reviewers, Biosensors was able to maintain its standards for the high quality of its published papers. Thanks to the contribution of our reviewers, in 2021, the median time to first decision was 15 days and the median time to publication was 37 days. The editors would like to extend their gratitude and recognition to the following reviewers for their precious time and dedication, regardless of whether the papers they reviewed were finally published: Abate, Giulia Liou, Gunn‐Guang Abbas, Naseem Liu, Chaoxing Abreu, Carlos Liu, Cheng-Hsien Adeloju, Samuel Liu, Chung-Chiun Adhikari, Bal Ram Liu, Fang Adhikari, Kishor Kumar Liu, Jia Ahire, Jayesh J. Liu, Luo Aich, Satyabrata Liu, Yifan Akhtar, Jawaid Liu, Yu Aleksandrova, Mariya Liu, Zhifu Alfinito, Eleonora Livaniou, Evangelia Alpar, Donat Lobato-Morales, Humberto Al-Sayah, Mohammad Lobo-Castañón, María Jesús Altini, Marco Lohr, Dieter Álvarez, María S. Londergan, Casey Alvarez-Malmagro, Julia Loo, Jacky F. C. Amorim, Cleber A. Lopes, Paula Amouroux, Marine Lopez Martinez, Maria José Anahtar, Melis N. López, Miguel Ángel Anastassiu, Hristos López-Martínez, Alberto Andrianova, Mariia Lorenzo, Encarnación Anni, Marco Lorenzo, Julia Antunes, Rui Loyez, Médéric Aoki, Kazuhiro Lu, Dingqiang Apetrei, Constantin Lucío, María Isabel Araújo, Alberto N. Luna Moreno, Donato Arsenin, Aleksey V. Luo, Haiming Asif, Muhammad Lupu, Stelian Ayankojo, Akinrinade George Lutz, David Aydemir, Nihan Lyu, Jian Badea Doni, Mihaela Ma, Guangzhong Badea, Mihaela Ma, Lan Bae, Hyung D. Ma, Lina Bai, Shi Ma, Xing Bajic, Dragana Macagnano, Antonella Balvedi, Renata Alves Macchia, Eleonora Bañuelos, Jorge Maesako, Masato Barek, Jiří Maglio, Ornella Baron, Julianne L. Magna, Gabriele Barrio, Melisa Del Malecka, Kamila Bastos-Arrieta, Julio Manderville, Richard A. Batrinou, Anthimia Marcin Szymon, Filipiak Baumann, Bernd Marconcini, Paolo Bayram, Abdullah Marietta, Fodor Beach, Christopher Marpu, Sreekar Babu BelBruno, Joseph Marques, Carlos Alberto Ferreira Bene, László Marrazza, Giovanna Bercu, Mioara Martella, Daniele Beretta-Piccoli, Matteo Martin, Maria Alba Berlina, Anna N. Martínez López, José Israel Bernasconi, Roberto Martínez-Lillo, José Berto, Marcello Martínez-Periñán, Emiliano Bhalla, Nikhil Maruccio, Giuseppe Biagi, Lyvia Maruthamuthu, Murali Bibikova, Olga Maruthamuthu, Muralikannan Bilatto, Stanley Marzullo, Vincenzo Manuel Bing, Tao Mascini, Marcello Bizzarri, Anna Rita Maskeliūnas, Rytis Bonyár, Attila Mastrangeli, Massimo Borges, Keyller Bastos Mathew, Bobby Borowik, Piotr Matos, Luís Carlos Bortolotti, Carlo A. Matzeu, Giusy Bossi, Alessandra Maria Mauriz, Elba Bourguignon, Natalia Meder, Roger Bourillot, Eric Mejía-Salazar, Jorge Ricardo Bratashov, Daniil N. 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Concellón, Alberto Osterman, Natan Conniot, João Ostrovidov, Serge Cordeiro, Cristiano Oza, Goldie Cornelis, Jan Paczkowski, Jon Coros, Maria Palestri, Pierpaolo Cortés, Araceli González Palma, Alberto Covington, James Paluch, Emil Crnkovic, Ana Pan, Houwen Cruz, Andrea Pan, Matthew Cubillana-Aguilera, Laura Pankratov, Dmitrii Cui, Feiyun Pannico, Marianna Cui, Kang Paolo, Bollella Cumbo, Cosimo Papazova, Nina Cusso, Fernando Paredes-Madrid, Leonel D’Acunto, Mario Paria, Debadrita D’Andrea, Cristiano Park, Chan Ho D’Angelo, Pasquale Park, Chulhwan D’Aurelio, Roberta Park, Hae-Min Da Silva Barros Allil, Regina Célia Park, Jaeho Dabaghi, Mohammadhossein Park, Je-Kyun Dalamitros, Athanasios Park, Jongmin Das, Anupam Park, Ki Soo Das, Pradip Park, Min David, Gabriela Iulia Patel, Brijeshkumar De Geest, Bart Patiño, Yolanda De Oliveira Junior, Marcos Pavel, Ileana Alexandra De Souza Gil, Eric Pedone, Deborah De Stefano, Luca Peixoto De Almeida, Miguel Debela, Ahmed M. Pellitero, Miguel A. 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Firtat, Bogdan Ray, Sujay Fisher, Aron B. Raymundo-Pereira, Paulo A. Florescu, Monica Razumiene, Julija Foguel, Marcos Vinicius Reale, Riccardo Fologea, Daniel Reddy, Mogalahalli V. Fortunati, Ilaria Rengarajan, Venkatakrishnan Fraleoni-Morgera, Alessandro Richtera, Lukáš Francés-Soriano, Laura Righetti, Laura Franco, Diego Leoni Rizal, Conrad Franco, Domenico Rizzo, Carmen Frank, Ludmila A. Robinson, Mathew Frense, Dieter Rocchitta, Gaia Fu, Gengtao Rodrigues-de-Souza, Daiana Priscila Furlan De Oliveira, Rafael Rodriguez-Lorenzo, Laura Gaft, Michael Roka-Moiia, Yana Galan-Vidal, Carlos Andres Romero-Sánchez, Francisco Galian, Raquel E. Rothkrantz, Leon Gallelli, Luca Roy, Dhruvajyoti Gamarra, Lionel Fernel Rubin, Robert L. Gao, Shiqiang Rutyna, Iwona García-Meza, Jessica Viridiana Ryazantsev, Mikhail Garoli, Denis Sadabadi, Hamid Gartia, Manas Ranjan Sadok, Ilona Gąsior-Głogowska, Marlena Saftics, Andras Gasiūnas, Giedrius Saharan, Lalita Gauden, Piotr Sahu, Rakesh Ge, Guangbo Sahu, Rama Shanker Gerislioglu, Burak Saito, Noriko Gheorghiu, Eugen Sakthivel, Kogularasu Ghiami, Amir Sallabi, Farag M. Ghibaudo, Gérard Samiei, Ehsan Ghita, Adrian Sang, Mei Gillanders, Ross N. Santana, Ted Giménez, David Santilli, Manlio Gioulekas, Fotios Santos, Adriano Gnyba, Marcin Santos, Jaime Batista Dos Godinho, Maria Helena Santos, João H. P. M. Gómez-Graña, Sergio Saratale, Ganesh Gong, Shu Sarolic, Antonio Gong, Zhenfeng Sasaki, Akira González-Cortés, Araceli Sawan, Mohamad González-González, Mirna Sbrollini, Agnese Göpfert, Beat Scaramuzza, Matteo Gopu, Sriram Gopu Schulze-Tanzil, Gundula Gesine Gorodkiewicz, Ewa Schwenker, Friedhelm Grabowska, Iwona Sedgwick, Adam C. Grossi, Marco Sed

Biosensors (Basel), 2022-01, Vol.12 (2), p.80

Acknowledgment to Reviewers of Biosensors in 2021

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Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators

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Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants

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Acknowledgment to Reviewers of Biosensors in 2021

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Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators

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Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants

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Acknowledgment to Reviewers of Biosensors in 2021

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