Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironmen...
Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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A low response rate, acquired resistance and severe side effects have limited the clinical outcomes of immune checkpoint therapy. Here, we show that combining cancer nanovaccines with an anti-PD-1 antibody (αPD-1) for immunosuppression blockade and an anti-OX40 antibody (αOX40) for effector T-cell stimulation, expansion and survival can potentiate...
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Full title
Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators
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TN_cdi_proquest_miscellaneous_2268939192
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2268939192
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ISSN
1748-3387
E-ISSN
1748-3395
DOI
10.1038/s41565-019-0512-0
