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The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern
Author / Creator:Abdelnabi, Rana ; Foo, Caroline S. ; Jochmans, Dirk ; Vangeel, Laura ; De Jonghe, Steven ; Augustijns, Patrick ; Mols, Raf ; Weynand, Birgit ; Wattanakul, Thanaporn ; Hoglund, Richard M. ; Tarning, Joel ; Mowbray, Charles E. ; Sjö, Peter ; Escudié, Fanny ; Scandale, Ivan ; Chatelain, Eric ; Neyts, Johan
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-02, Vol.13 (1), p.719-719, Article 719
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Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects
Author / Creator:Bekerman, Elena ; Neveu, Gregory ; Shulla, Ana ; Brannan, Jennifer ; Pu, Szu-Yuan ; Wang, Stanley ; Xiao, Fei ; Barouch-Bentov, Rina ; Bakken, Russell R. ; Mateo, Roberto ; Govero, Jennifer ; Nagamine, Claude M. ; Diamond, Michael S. ; De Jonghe, Steven ; Herdewijn, Piet ; Dye, John M. ; Randall, Glenn ; Einav, Shirit
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2017-04, Vol.127 (4), p.1338-1352
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Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket – targeting P-pocket by fragment screening
Author / Creator:Singh, Abhimanyu K. ; Martinez, Sergio E. ; Gu, Weijie ; Nguyen, Hoai ; Schols, Dominique ; Herdewijn, Piet ; De Jonghe, Steven ; Das, Kalyan
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-12, Vol.12 (1), p.7127-10, Article 7127
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Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication
Author / Creator:Bardiot, Dorothée ; Vangeel, Laura ; Koukni, Mohamed ; Arzel, Philippe ; Zwaagstra, Marleen ; Lyoo, Heyrhyoung ; Wanningen, Patrick ; Ahmad, Shamshad ; Zhang, Linlin ; Sun, Xinyuanyuan ; Delpal, Adrien ; Eydoux, Cecilia ; Guillemot, Jean-Claude ; Lescrinier, Eveline ; Klaassen, Hugo ; Leyssen, Pieter ; Jochmans, Dirk ; Castermans, Karolien ; Hilgenfeld, Rolf ; Robinson, Colin ; Decroly, Etienne ; Canard, Bruno ; Snijder, Eric J. ; van Hemert, Martijn J. ; van Kuppeveld, Frank ; Chaltin, Patrick ; Neyts, Johan ; De Jonghe, Steven ; Marchand, Arnaud
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2022-02, Vol.27 (3), p.1052
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Exploring 4,7-Disubstituted Pyrimido[4,5-d]pyrimidines as Antiviral and Anticancer Agents
Author / Creator:Georgiou, Eleftheria A. ; Paraskevas, Konstantinos ; Koutra, Christina ; Persoons, Leentje ; Schols, Dominique ; De Jonghe, Steven ; Kostakis, Ioannis K.
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2024-12, Vol.29 (23), p.5549
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Synthesis of a 3,7-Disubstituted Isothiazolo[4,3-b]pyridine as a Potential Inhibitor of Cyclin G-Associated Kinase
Author / Creator:Grisez, Tom ; Ravi, Nitha Panikkassery ; Froeyen, Mathy ; Schols, Dominique ; Van Meervelt, Luc ; De Jonghe, Steven ; Dehaen, Wim
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2024-02, Vol.29 (5), p.954
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Anti-SARS-CoV-2 Activity and Cytotoxicity of Amaryllidaceae Alkaloids from Hymenocallis littoralis
Author / Creator:Le, Ngoc-Thao-Hien ; De Jonghe, Steven ; Erven, Kristien ; Vermeyen, Tom ; Baldé, Aliou M. ; Herrebout, Wouter A. ; Neyts, Johan ; Pannecouque, Christophe ; Pieters, Luc ; Tuenter, Emmy
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-04, Vol.28 (7), p.3222
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Exploration of Pyrido[3,4-d]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2
Author / Creator:Van Hoof, Max ; Claes, Sandra ; Boon, Katrijn ; Van Loy, Tom ; Schols, Dominique ; Dehaen, Wim ; De Jonghe, Steven
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-02, Vol.28 (5), p.2099
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Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3H)-Ones with Antiproliferative Activities
Author / Creator:Karelou, Maria ; Kampasis, Dionysis ; Kalampaliki, Amalia D. ; Persoons, Leentje ; Krämer, Andreas ; Schols, Dominique ; Knapp, Stefan ; De Jonghe, Steven ; Kostakis, Ioannis K.
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-12, Vol.28 (23), p.7912
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3-nitropyridine analogues as novel microtubule-targeting agents
Author / Creator:Herman, Jean ; Vanstreels, Els ; Bardiot, Dorothée ; Prota, Andrea E. ; Gaillard, Natacha ; Gao, Ling-Jie ; Vercruysse, Thomas ; Persoons, Leentje ; Daems, Tinne ; Waer, Mark ; Herdewijn, Piet ; Louat, Thierry ; Steinmetz, Michel O. ; De Jonghe, Steven ; Sprangers, Ben ; Daelemans, Dirk
Publisher:United States: Public Library of Science
Journal title:PloS one, 2024-11, Vol.19 (11), p.e0307153
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Synthesis and Anti-HIV Activity of a Novel Series of Isoquinoline-Based CXCR4 Antagonists
Author / Creator:Shad, Mastaneh ; Claes, Sandra ; Goffin, Eline ; Van Loy, Tom ; Schols, Dominique ; De Jonghe, Steven ; Dehaen, Wim
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2021-10, Vol.26 (20), p.6297
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Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors
Author / Creator:Gao, Shenghua ; Song, Letian ; Xu, Hongtao ; Fikatas, Antonios ; Oeyen, Merel ; De Jonghe, Steven ; Zhao, Fabao ; Jing, Lanlan ; Jochmans, Dirk ; Vangeel, Laura ; Cheng, Yusen ; Kang, Dongwei ; Neyts, Johan ; Herdewijn, Piet ; Schols, Dominique ; Zhan, Peng ; Liu, Xinyong
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2022-12, Vol.28 (1), p.160
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Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort
Author / Creator:Zaliani, Andrea ; Vangeel, Laura ; Reinshagen, Jeanette ; Iaconis, Daniela ; Kuzikov, Maria ; Keminer, Oliver ; Wolf, Markus ; Ellinger, Bernhard ; Esposito, Francesca ; Corona, Angela ; Tramontano, Enzo ; Manelfi, Candida ; Herzog, Katja ; Jochmans, Dirk ; De Jonghe, Steven ; Chiu, Winston ; Francken, Thibault ; Schepers, Joost ; Collard, Caroline ; Abbasi, Kayvan ; Claussen, Carsten ; Summa, Vincenzo ; Beccari, Andrea R. ; Neyts, Johan ; Gribbon, Philip ; Leyssen, Pieter
Publisher:London: Nature Publishing Group UK
Journal title:Scientific data, 2022-07, Vol.9 (1), p.405-11, Article 405
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Ivermectin Does Not Protect against SARS-CoV-2 Infection in the Syrian Hamster Model
Author / Creator:Foo, Caroline S. ; Abdelnabi, Rana ; Vangeel, Laura ; De Jonghe, Steven ; Jochmans, Dirk ; Weynand, Birgit ; Neyts, Johan
Publisher:Switzerland: MDPI AG
Journal title:Microorganisms (Basel), 2022-03, Vol.10 (3), p.633
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Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models
Author / Creator:Al Hamwi, Ghazl ; Alnouri, Mohamad Wessam ; Verdonck, Sven ; Leonczak, Piotr ; Chaki, Shaswati ; Frischbutter, Stefan ; Kolkhir, Pavel ; Matthey, Michaela ; Kopp, Constantin ; Bednarski, Marek ; Riedel, Yvonne K. ; Marx, Daniel ; Clemens, Sophie ; Namasivayam, Vigneshwaran ; Gattner, Susanne ; Thimm, Dominik ; Sylvester, Katharina ; Wolf, Katharina ; Kremer, Andreas E. ; De Jonghe, Steven ; Wenzel, Daniela ; Kotańska, Magdalena ; Ali, Hydar ; Herdewijn, Piet ; Müller, Christa E.
Publisher:London: Nature Publishing Group UK
Journal title:Signal transduction and targeted therapy, 2025-04, Vol.10 (1), p.128-17, Article 128
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Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2
Author / Creator:Doijen, Jordi ; Temmerman, Koen ; Van den Eynde, Christel ; Diels, Annick ; Van den Broeck, Nick ; Van Gool, Michiel ; Heo, Inha ; Jaensch, Steffen ; Zwaagstra, Marleen ; Diosa Toro, Mayra ; Chiu, Winston ; De Jonghe, Steven ; Leyssen, Pieter ; Bojkova, Denisa ; Ciesek, Sandra ; Cinatl, Jindrich ; Verschueren, Lore ; Buyck, Christophe ; Van Kuppeveld, Frank ; Neyts, Johan ; Van Loock, Marnix ; Van Damme, Ellen
Publisher:Basel: MDPI AG
Journal title:Microorganisms (Basel), 2023-03, Vol.11 (3), p.717
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Anti-inflammatory Activity of a Pteridine Derivative (4AZA2096) Alleviates TNBS-Induced Colitis in Mice
Author / Creator:Shen, Chong ; Dillissen, Ellen ; Kasran, Ahmad ; Lin, Yuan ; Clydesdale, Gavin ; Sienaert, Ilse ; Jonghe, Steven De ; Gao, Ling-Jie ; Geboes, Karel ; Boon, Louis ; Rutgeerts, Paul ; Ceuppens, Jan L.
Publisher:United States: Mary Ann Liebert, Inc
Journal title:Journal of interferon & cytokine research, 2006-08, Vol.26 (8), p.575-582
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ArticlesPeer ReviewedFull Text
Exploring 4,7-Disubstituted Pyrimido4,5-dpyrimidines as Antiviral and Anticancer Agents
Author / Creator:Georgiou, Eleftheria A ; Paraskevas, Konstantinos ; Koutra, Christina ; Persoons, Leentje ; Schols, Dominique ; De Jonghe, Steven ; Kostakis, Ioannis K
Journal title:Molecules (Basel, Switzerland), 2024-11, Vol.29 (23)
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Development of a cellular model to study CCR8 signaling in tumor-infiltrating regulatory T cells
Author / Creator:Liu, Libao ; Rangan, Laurie ; Vanalken, Nathan ; Kong, Qianqian ; Schlenner, Susan ; De Jonghe, Steven ; Schols, Dominique ; Van Loy, Tom
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer Immunology, Immunotherapy, 2024-01, Vol.73 (1), p.11, Article 11
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Optimization of SARS-CoV-2 M[sup.pro] Inhibitors by a Structure-Based Multilevel Virtual Screening Method
Author / Creator:Jing, Lanlan ; Zhao, Fabao ; Zheng, Lin ; Meng, Bairu ; Gao, Shenghua ; Laporte, Manon ; Jochmans, Dirk ; De Jonghe, Steven ; Neyts, Johan ; Zhan, Peng ; Kang, Dongwei ; Liu, Xinyong
Publisher:MDPI AG
Journal title:International journal of molecular sciences, 2025-01, Vol.26 (2)
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Showing 1 to 20 of 45 results

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The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern

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Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

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Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket – targeting P-pocket by fragment screening

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Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication

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Exploring 4,7-Disubstituted Pyrimido[4,5-d]pyrimidines as Antiviral and Anticancer Agents

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Synthesis of a 3,7-Disubstituted Isothiazolo[4,3-b]pyridine as a Potential Inhibitor of Cyclin G-Associated Kinase

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Anti-SARS-CoV-2 Activity and Cytotoxicity of Amaryllidaceae Alkaloids from Hymenocallis littoralis

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Exploration of Pyrido[3,4-d]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2

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Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3H)-Ones with Antiproliferative Activities

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3-nitropyridine analogues as novel microtubule-targeting agents

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Synthesis and Anti-HIV Activity of a Novel Series of Isoquinoline-Based CXCR4 Antagonists

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Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors

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Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort

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Ivermectin Does Not Protect against SARS-CoV-2 Infection in the Syrian Hamster Model

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Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models

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Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2

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Anti-inflammatory Activity of a Pteridine Derivative (4AZA2096) Alleviates TNBS-Induced Colitis in Mice

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Exploring 4,7-Disubstituted Pyrimido4,5-dpyrimidines as Antiviral and Anticancer Agents

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Development of a cellular model to study CCR8 signaling in tumor-infiltrating regulatory T cells

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Optimization of SARS-CoV-2 M[sup.pro] Inhibitors by a Structure-Based Multilevel Virtual Screening Method

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