Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
About this item
Full title
Author / Creator
van Esbroeck, Annelot C. M. , Janssen, Antonius P. A. , Cognetta, Armand B. , Ogasawara, Daisuke , Shpak, Guy , van der Kroeg, Mark , Kantae, Vasudev , Baggelaar, Marc P. , de Vrij, Femke M. S. , Deng, Hui , Allarà, Marco , Fezza, Filomena , Lin, Zhanmin , van der Wel, Tom , Soethoudt, Marjolein , Mock, Elliot D. , den Dulk, Hans , Baak, Ilse L. , Florea, Bogdan I. , Hendriks, Giel , De Petrocellis, Luciano , Overkleeft, Herman S. , Hankemeier, Thomas , De Zeeuw, Chris I. , Di Marzo, Vincenzo , Maccarrone, Mauro , Cravatt, Benjamin F. , Kushner, Steven A. and van der Stelt, Mario
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
A recent phase 1 trial of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474 led to the death of one volunteer and produced mild-to-severe neurological symptoms in four others. Although the cause of the clinical neurotoxicity is unknown, it has been postulated, given the clinical safety profile of other tested FAAH inhibitors, that off-tar...
Alternative Titles
Full title
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
Authors, Artists and Contributors
Author / Creator
Janssen, Antonius P. A.
Cognetta, Armand B.
Ogasawara, Daisuke
Shpak, Guy
van der Kroeg, Mark
Kantae, Vasudev
Baggelaar, Marc P.
de Vrij, Femke M. S.
Deng, Hui
Allarà, Marco
Fezza, Filomena
Lin, Zhanmin
van der Wel, Tom
Soethoudt, Marjolein
Mock, Elliot D.
den Dulk, Hans
Baak, Ilse L.
Florea, Bogdan I.
Hendriks, Giel
De Petrocellis, Luciano
Overkleeft, Herman S.
Hankemeier, Thomas
De Zeeuw, Chris I.
Di Marzo, Vincenzo
Maccarrone, Mauro
Cravatt, Benjamin F.
Kushner, Steven A.
van der Stelt, Mario
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5641481
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5641481
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaf7497
