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62 results for Diarylquinolines+-+pharmacology

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ArticlesPeer ReviewedFull Text
Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline
Author / Creator:Diacon, Andreas H ; Pym, Alexander ; Grobusch, Martin P ; de los Rios, Jorge M ; Gotuzzo, Eduardo ; Vasilyeva, Irina ; Leimane, Vaira ; Andries, Koen ; Bakare, Nyasha ; De Marez, Tine ; Haxaire-Theeuwes, Myriam ; Lounis, Nacer ; Meyvisch, Paul ; De Paepe, Els ; van Heeswijk, Rolf P.G ; Dannemann, Brian
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2014-08, Vol.371 (8), p.723-732
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Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline
Author / Creator:Guo, Hui ; Courbon, Gautier M. ; Bueler, Stephanie A. ; Mai, Juntao ; Liu, Jun ; Rubinstein, John L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-01, Vol.589 (7840), p.143-147
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Acquired Resistance of Mycobacterium tuberculosis to Bedaquiline
Author / Creator:Andries, Koen ; Villellas, Cristina ; Coeck, Nele ; Thys, Kim ; Gevers, Tom ; Vranckx, Luc ; Lounis, Nacer ; de Jong, Bouke C. ; Koul, Anil
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-07, Vol.9 (7), p.e102135
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Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection
Author / Creator:Kalia, Nitin P. ; Hasenoehrl, Erik J. ; Rahman, Nurlilah B. Ab ; Koh, Vanessa H. ; Ang, Michelle L. T. ; Sajorda, Dannah R. ; Hards, Kiel ; Grüber, Gerhard ; Alonso, Sylvie ; Cook, Gregory M. ; Berney, Michael ; Pethe, Kevin
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-07, Vol.114 (28), p.7426-7431
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Delamanid and Bedaquiline Resistance in Mycobacterium tuberculosis Ancestral Beijing Genotype Causing Extensively Drug-Resistant Tuberculosis in a Tibetan Refugee
Author / Creator:Hoffmann, Harald ; Kohl, Thomas A. ; Hofmann-Thiel, Sabine ; Merker, Matthias ; Beckert, Patrick ; Jaton, Katia ; Nedialkova, Lubov ; Sahalchyk, Evgeni ; Rothe, Thomas ; Keller, Peter M. ; Niemann, Stefan
Publisher:United States: American Thoracic Society
Journal title:American journal of respiratory and critical care medicine, 2016-02, Vol.193 (3), p.337-340
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Ionophoric effects of the antitubercular drug bedaquiline
Author / Creator:Hards, Kiel ; McMillan, Duncan G. G. ; Schurig-Briccio, Lici A. ; Gennis, Robert B. ; Lilld, Holger ; Bald, Dirk ; Cook, Gregory M.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-07, Vol.115 (28), p.7326-7331
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Genetic diversity of candidate loci linked to Mycobacterium tuberculosis resistance to bedaquiline, delamanid and pretomanid
Author / Creator:Gómez-González, Paula J. ; Perdigao, Joao ; Gomes, Pedro ; Puyen, Zully M. ; Santos-Lazaro, David ; Napier, Gary ; Hibberd, Martin L. ; Viveiros, Miguel ; Portugal, Isabel ; Campino, Susana ; Phelan, Jody E. ; Clark, Taane G.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-09, Vol.11 (1), p.19431-19431, Article 19431
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Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism
Author / Creator:Koul, Anil ; Vranckx, Luc ; Dhar, Neeraj ; Göhlmann, Hinrich W.H. ; Özdemir, Emre ; Neefs, Jean-Marc ; Schulz, Melanie ; Lu, Ping ; Mørtz, Ejvind ; McKinney, John D. ; Andries, Koen ; Bald, Dirk
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2014-02, Vol.5 (1), p.3369, Article 3369
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Turning the respiratory flexibility of Mycobacterium tuberculosis against itself
Author / Creator:Lamprecht, Dirk A. ; Finin, Peter M. ; Rahman, Md. Aejazur ; Cumming, Bridgette M. ; Russell, Shannon L. ; Jonnala, Surendranadha R. ; Adamson, John H. ; Steyn, Adrie J. C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-08, Vol.7 (1), p.12393-14, Article 12393
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Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide
Author / Creator:Santucci, Pierre ; Greenwood, Daniel J. ; Fearns, Antony ; Chen, Kai ; Jiang, Haibo ; Gutierrez, Maximiliano G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-06, Vol.12 (1), p.3816-3816, Article 3816
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Outcomes of Bedaquiline Treatment in Patients with Multidrug-Resistant Tuberculosis
Author / Creator:Mbuagbaw, Lawrence ; Guglielmetti, Lorenzo ; Hewison, Catherine ; Bakare, Nyasha ; Bastard, Mathieu ; Caumes, Eric ; Fréchet-Jachym, Mathilde ; Robert, Jérôme ; Veziris, Nicolas ; Khachatryan, Naira ; Kotrikadze, Tinatin ; Hayrapetyan, Armen ; Avaliani, Zaza ; Schünemann, Holger J. ; Lienhardt, Christian
Publisher:United States: U.S. National Center for Infectious Diseases
Journal title:Emerging infectious diseases, 2019-05, Vol.25 (5), p.936-943
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Empirical ways to identify novel Bedaquiline resistance mutations in AtpE
Author / Creator:Karmakar, Malancha ; Rodrigues, Carlos H. M. ; Holt, Kathryn E. ; Dunstan, Sarah J. ; Denholm, Justin ; Ascher, David B.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2019-05, Vol.14 (5), p.e0217169
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Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase
Author / Creator:Fiorillo, Marco ; Scatena, Cristian ; Naccarato, Antonio Giuseppe ; Sotgia, Federica ; Lisanti, Michael P.
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2021-09, Vol.28 (9), p.2797-2817
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Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline
Author / Creator:Wang, Zhe ; Soni, Vijay ; Marriner, Gwendolyn ; Kaneko, Takushi ; Boshoff, Helena I. M. ; Barry, Clifton E. ; Rhee, Kyu Y.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-09, Vol.116 (39), p.19646-19651
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Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis
Author / Creator:Mackenzie, Jared S. ; Lamprecht, Dirk A. ; Asmal, Rukaya ; Adamson, John H. ; Borah, Khushboo ; Beste, Dany J. V. ; Lee, Bei Shi ; Pethe, Kevin ; Rousseau, Simon ; Krieger, Inna ; Sacchettini, James C. ; Glasgow, Joel N. ; Steyn, Adrie J. C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-11, Vol.11 (1), p.6092-6092, Article 6092
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The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection
Author / Creator:Giraud-Gatineau, Alexandre ; Coya, Juan Manuel ; Maure, Alexandra ; Biton, Anne ; Thomson, Michael ; Bernard, Elliott M ; Marrec, Jade ; Gutierrez, Maximiliano G ; Larrouy-Maumus, Gérald ; Brosch, Roland ; Gicquel, Brigitte ; Tailleux, Ludovic
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2020-05, Vol.9
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Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex
Author / Creator:Merker, Matthias ; Kohl, Thomas A. ; Barilar, Ivan ; Andres, Sönke ; Fowler, Philip W. ; Chryssanthou, Erja ; Ängeby, Kristian ; Jureen, Pontus ; Moradigaravand, Danesh ; Parkhill, Julian ; Peacock, Sharon J. ; Schön, Thomas ; Maurer, Florian P. ; Walker, Timothy ; Köser, Claudio ; Niemann, Stefan
Publisher:England: BioMed Central Ltd
Journal title:Genome medicine, 2020-03, Vol.12 (1), p.27-8, Article 27
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Ligand and structure-based Virtual Screening Applied to the SARS-CoV-2 Main Protease: an In Silico Repurposing Study
Author / Creator:Ferraz, Witor Ribeiro ; Gomes, Renan Augusto ; S Novaes, Andre Luis ; Goulart Trossini, Gustavo Henrique
Publisher:England: Newlands Press
Journal title:Future medicinal chemistry, 2020-10, Vol.12 (20), p.1815-1828
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Therapeutic Failure and Acquired Bedaquiline and Delamanid Resistance in Treatment of Drug-Resistant TB
Author / Creator:Millard, James ; Rimmer, Stephanie ; Nimmo, Camus ; O’Donnell, Max
Publisher:United States: U.S. National Center for Infectious Diseases
Journal title:Emerging infectious diseases, 2023-05, Vol.29 (5), p.1081-1084
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High Prevalence of atpE Mutations in Bedaquiline-Resistant Mycobacterium tuberculosis Isolates, Russia
Author / Creator:Zimenkov, Danila ; Ushtanit, Anastasia ; Gordeeva, Elizaveta ; Guselnikova, Elena ; Schwartz, Yakov ; Stavitskaya, Natalia
Publisher:United States: Centers for Disease Control and Prevention
Journal title:Emerging infectious diseases, 2025-03, Vol.31 (3), p.525-535
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Showing 1 to 20 of 62 results

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Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline

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Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline

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Acquired Resistance of Mycobacterium tuberculosis to Bedaquiline

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Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection

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Delamanid and Bedaquiline Resistance in Mycobacterium tuberculosis Ancestral Beijing Genotype Causing Extensively Drug-Resistant Tuberculosis in a Tibetan Refugee

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Ionophoric effects of the antitubercular drug bedaquiline

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Genetic diversity of candidate loci linked to Mycobacterium tuberculosis resistance to bedaquiline, delamanid and pretomanid

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Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism

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Turning the respiratory flexibility of Mycobacterium tuberculosis against itself

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Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide

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Outcomes of Bedaquiline Treatment in Patients with Multidrug-Resistant Tuberculosis

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Empirical ways to identify novel Bedaquiline resistance mutations in AtpE

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Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase

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Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline

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Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis

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The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection

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Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex

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Ligand and structure-based Virtual Screening Applied to the SARS-CoV-2 Main Protease: an In Silico Repurposing Study

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Therapeutic Failure and Acquired Bedaquiline and Delamanid Resistance in Treatment of Drug-Resistant TB

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High Prevalence of atpE Mutations in Bedaquiline-Resistant Mycobacterium tuberculosis Isolates, Russia

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