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ArticlesPeer ReviewedFull Text
Inducing and exploiting vulnerabilities for the treatment of liver cancer
Author / Creator:Wang, Cun ; Vegna, Serena ; Jin, Haojie ; Benedict, Bente ; Lieftink, Cor ; Ramirez, Christel ; de Oliveira, Rodrigo Leite ; Morris, Ben ; Gadiot, Jules ; Wang, Wei ; du Chatinier, Aimée ; Wang, Liqin ; Gao, Dongmei ; Evers, Bastiaan ; Jin, Guangzhi ; Xue, Zheng ; Schepers, Arnout ; Jochems, Fleur ; Sanchez, Antonio Mulero ; Mainardi, Sara ; te Riele, Hein ; Beijersbergen, Roderick L. ; Qin, Wenxin ; Akkari, Leila ; Bernards, René
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-10, Vol.574 (7777), p.268-272
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ArticlesPeer ReviewedFull Text
Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma
Author / Creator:Kroon, Paula ; Gadiot, Jules ; Peeters, Marlies ; Gasparini, Alessia ; Deken, Marcel A. ; Yagita, Hideo ; Verheij, Marcel ; Borst, Jannie ; Blank, Christian U. ; Verbrugge, Inge
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer Immunology, Immunotherapy, 2016-06, Vol.65 (6), p.753-763
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ArticlesPeer ReviewedFull Text
GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors
Author / Creator:Westerman, Bart A ; Blom, Marleen ; Tanger, Ellen ; van der Valk, Martin ; Song, Ji-Ying ; van Santen, Marije ; Gadiot, Jules ; Cornelissen-Steijger, Paulien ; Zevenhoven, John ; Prosser, Haydn M ; Uren, Anthony ; Aronica, Eleonora ; van Lohuizen, Maarten
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-05, Vol.7 (5), p.e35943-e35943
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ArticlesPeer ReviewedFull Text
Sunitinib pretreatment improves tumor-infiltrating lymphocyte expansion by reduction in intratumoral content of myeloid-derived suppressor cells in human renal cell carcinoma
Author / Creator:Guislain, Aurelie ; Gadiot, Jules ; Kaiser, Andrew ; Jordanova, Ekaterina S. ; Broeks, Annegien ; Sanders, Joyce ; van Boven, Hester ; de Gruijl, Tanja D. ; Haanen, John B. A. G. ; Bex, Axel ; Blank, Christian U.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer Immunology, Immunotherapy, 2015-10, Vol.64 (10), p.1241-1250
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ArticlesPeer ReviewedFull Text
Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis
Author / Creator:March, H Nikki ; Rust, Alistair G ; Wright, Nicholas A ; ten Hoeve, Jelle ; de Ridder, Jeroen ; Eldridge, Matthew ; van der Weyden, Louise ; Berns, Anton ; Gadiot, Jules ; Uren, Anthony ; Kemp, Richard ; Arends, Mark J ; Wessels, Lodewyk F A ; Winton, Douglas J ; Adams, David J
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2011-12, Vol.43 (12), p.1202-1209
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ArticlesPeer ReviewedFull Text
Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diagnostic tumor biopsies
Author / Creator:Kuilman, Thomas ; Schrikkema, Deborah S. ; Gadiot, Jules ; Gomez-Eerland, Raquel ; Bies, Laura ; Walker, Julia ; Spaapen, Robbert M. ; Kok, Hanna ; Houg, Demi ; Viyacheva, Milena ; Claassen, Yvonne B. ; Saornil, Manuel ; Krijgsman, Oscar ; Stringer, Bas ; Ding, Huiwen ; Geleijnse, Anou ; Meinema, Anne C. ; Weissbrich, Bianca ; Lancee, Melissa ; Engele, Carmen G. ; Sabatino, Marianna ; Chen, Pei-Ling ; Tsai, Kenneth Y. ; Mulé, James J. ; Sondak, Vernon K. ; van den Bulk, Jitske ; de Miranda, Noel F. ; Jedema, Inge ; Haanen, John G. ; van Heijst, Jeroen W. J. ; Schumacher, Ton N. ; Linnemann, Carsten ; Bendle, Gavin M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-01, Vol.16 (1), p.649-14, Article 649
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ArticlesPeer ReviewedFull Text
Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in Pten super(LoxP/LoxP); B raf super(CA/+) Mice
Author / Creator:Deken, Marcel A ; Song, Ji-Ying ; Gadiot, Jules ; Bins, Adriaan D ; Kroon, Paula ; Verbrugge, Inge ; Blank, Christian U
Journal title:International journal of molecular sciences, 2016-12, Vol.17 (12), p.2149-2149
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ArticlesPeer ReviewedFull Text
Mimicking homeostatic proliferation in vitro generates T cells with high anti-tumor function in non-lymphopenic hosts
Author / Creator:Kaiser, Andrew D. ; Gadiot, Jules ; Guislain, Aurelie ; Blank, Christian U.
Publisher:Berlin/Heidelberg: Springer-Verlag
Journal title:Cancer Immunology, Immunotherapy, 2013-03, Vol.62 (3), p.503-515
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ArticlesPeer ReviewedFull Text
Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in PtenLoxP/LoxP;BrafCA/+ Mice
Author / Creator:Deken, Marcel ; Song, Ji-Ying ; Gadiot, Jules ; Bins, Adriaan ; Kroon, Paula ; Verbrugge, Inge ; Blank, Christian
Publisher:Basel: MDPI AG
Journal title:International journal of molecular sciences, 2016-12, Vol.17 (12), p.2149
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ArticlesPeer ReviewedFull Text
Synchronous BRAF(V600E) and MEK inhibition leads to superior control of murine melanoma by limiting MEK inhibitor induced skin toxicity
Author / Creator:Gadiot, Jules ; Hooijkaas, Anna I ; Deken, Marcel A ; Blank, Christian U
Publisher:New Zealand
Journal title:OncoTargets and therapy, 2013, Vol.6, p.1649-1658
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ArticlesPeer ReviewedFull Text
High expression of GCLC is associated with malignant melanoma of low oxidative phenotype and predicts a better prognosis
Author / Creator:Mougiakakos, Dimitrios ; Okita, Riki ; Ando, Takashi ; Dürr, Christoph ; Gadiot, Jules ; Ichikawa, Jiro ; Zeiser, Robert ; Blank, Christian ; Johansson, C. Christian ; Kiessling, Rolf
Publisher:Berlin/Heidelberg: Springer-Verlag
Journal title:Journal of molecular medicine (Berlin, Germany), 2012-08, Vol.90 (8), p.935-944
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ArticlesPeer ReviewedFull Text
Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in Pten LoxP/LoxP ;Braf CA/+ Mice
Author / Creator:Deken, Marcel A ; Song, Ji-Ying ; Gadiot, Jules ; Bins, Adriaan D ; Kroon, Paula ; Verbrugge, Inge ; Blank, Christian U
Publisher:Switzerland
Journal title:International journal of molecular sciences, 2016-12, Vol.17 (12)
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ArticlesPeer ReviewedFull Text
Insertional mutagenesis identifies multiple networks of co-operating genes driving intestinal tumorigenesis
Author / Creator:March, H. Nikki ; Rust, Alistair G. ; Wright, Nicholas A. ; Hoeve, Jelle ten ; de Ridder, Jeroen ; Eldridge, Matthew ; van der Weyden, Louise ; Berns, Anton ; Gadiot, Jules ; Uren, Anthony ; Kemp, Richard ; Arends, Mark J. ; Wessels, Lodewyk F. A. ; Winton, Douglas J. ; Adams, David J.
Journal title:Nature genetics, 2011-11, Vol.43 (12), p.1202-1209
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ArticlesPeer ReviewedFull Text
Synchronous BRAFV600E and MEK inhibition leads to superior control of murine melanoma by limiting MEK inhibitor induced skin toxicity
Author / Creator:Blank, Christian ; Gadiot, Jules ; Hooijkaas, Anna I. ; Deken, Marcel A.
Publisher:Macclesfield: Taylor & Francis Ltd
Journal title:OncoTargets and therapy, 2013-11, Vol.6, p.1649-1658
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ArticlesPeer ReviewedFull Text
Nodal as a biomarker for melanoma progression and a new therapeutic target for clinical intervention
Author / Creator:Strizzi, Luigi ; Postovit, Lynne-Marie ; Margaryan, Naira V ; Lipavsky, Alina ; Gadiot, Jules ; Blank, Christian ; Seftor, Richard EB ; Seftor, Elisabeth A ; Hendrix, Mary JC
Publisher:England: Informa Healthcare
Journal title:Expert review of dermatology, 2009-02, Vol.4 (1), p.67-78
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ReportsFull Text
Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis
Author / Creator:March, H. Nikki ; Rust, Alistair G ; Wright, Nicholas A ; Hoeve, Jelle ten ; de Ridder, Jeroen ; Eldridge, Matthew ; van der Weyden, Louise ; Berns, Anton ; Gadiot, Jules ; Uren, Anthony ; Kemp, Richard ; Arends, Mark J ; Wessels, Lodewyk F.A ; Winton, Douglas J ; Adams, David J
Publisher:Nature Publishing Group
Journal title:Nature Genetics, 2011, Vol.43 (12), p.1202
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Inducing and exploiting vulnerabilities for the treatment of liver cancer

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Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma

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GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors

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Sunitinib pretreatment improves tumor-infiltrating lymphocyte expansion by reduction in intratumoral content of myeloid-derived suppressor cells in human renal cell carcinoma

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Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis

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Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diagnostic tumor biopsies

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Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in Pten super(LoxP/LoxP); B raf super(CA/+) Mice

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Mimicking homeostatic proliferation in vitro generates T cells with high anti-tumor function in non-lymphopenic hosts

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Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in PtenLoxP/LoxP;BrafCA/+ Mice

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Synchronous BRAF(V600E) and MEK inhibition leads to superior control of murine melanoma by limiting MEK inhibitor induced skin toxicity

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High expression of GCLC is associated with malignant melanoma of low oxidative phenotype and predicts a better prognosis

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Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in Pten LoxP/LoxP ;Braf CA/+ Mice

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Insertional mutagenesis identifies multiple networks of co-operating genes driving intestinal tumorigenesis

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Synchronous BRAFV600E and MEK inhibition leads to superior control of murine melanoma by limiting MEK inhibitor induced skin toxicity

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Nodal as a biomarker for melanoma progression and a new therapeutic target for clinical intervention

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Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis

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