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Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diag...

Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diag...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2d76c4e060a14eb1ad32c85894d62d96

Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diagnostic tumor biopsies

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Adoptive cell therapy with tumor-infiltrating lymphocytes (TIL) can mediate tumor regression, including complete and durable responses, in a range of solid cancers, most notably in melanoma. However, its wider application and efficacy has been restricted by the limited accessibility, proliferative capacity and effector function of tumor-specific TI...

Alternative Titles

Full title

Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diagnostic tumor biopsies

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_2d76c4e060a14eb1ad32c85894d62d96

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2d76c4e060a14eb1ad32c85894d62d96

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-024-55420-6

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