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63 results for Genetic+Vectors+-+toxicity

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ArticlesPeer ReviewedFull Text
Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits Metachromatic Leukodystrophy
Author / Creator:Biffi, Alessandra ; Montini, Eugenio ; Lorioli, Laura ; Cesani, Martina ; Fumagalli, Francesca ; Plati, Tiziana ; Baldoli, Cristina ; Martino, Sabata ; Calabria, Andrea ; Canale, Sabrina ; Benedicenti, Fabrizio ; Vallanti, Giuliana ; Biasco, Luca ; Leo, Simone ; Kabbara, Nabil ; Zanetti, Gianluigi ; Rizzo, William B. ; Mehta, Nalini A. L. ; Cicalese, Maria Pia ; Casiraghi, Miriam ; Boelens, Jaap J. ; Del Carro, Ubaldo ; Dow, David J. ; Schmidt, Manfred ; Assanelli, Andrea ; Neduva, Victor ; Di Serio, Clelia ; Stupka, Elia ; Gardner, Jason ; von Kalle, Christof ; Bordignon, Claudio ; Ciceri, Fabio ; Rovelli, Attilio ; Roncarolo, Maria Grazia ; Aiuti, Alessandro ; Sessa, Maria ; Naldini, Luigi
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2013-08, Vol.341 (6148), p.864-864
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Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5–based Constructs
Author / Creator:Alonso-Padilla, Julio ; Papp, Tibor ; Kaján, Győző L ; Benkő, Mária ; Havenga, Menzo ; Lemckert, Angelique ; Harrach, Balázs ; Baker, Andrew H
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2016-01, Vol.24 (1), p.6-16
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ArticlesPeer ReviewedFull Text
Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons
Author / Creator:Lundblad, Martin ; Decressac, Mickael ; Mattsson, Bengt ; Björklund, Anders
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (9), p.3213-3219
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ArticlesPeer ReviewedFull Text
Physiological Promoters Reduce the Genotoxic Risk of Integrating Gene Vectors
Author / Creator:Zychlinski, Daniela ; Schambach, Axel ; Modlich, Ute ; Maetzig, Tobias ; Meyer, Johann ; Grassman, Elke ; Mishra, Anjali ; Baum, Christopher
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2008-04, Vol.16 (4), p.718-725
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ArticlesPeer ReviewedFull Text
Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model
Author / Creator:Loyola, Lorenz ; Achuthan, Vasudevan ; Gilroy, Kathryn ; Borland, Gillian ; Kilbey, Anna ; Mackay, Nancy ; Bell, Margaret ; Hay, Jodie ; Aiyer, Sriram ; Fingerman, Dylan ; Villanueva, Rodrigo A. ; Cameron, Ewan ; Kozak, Christine A. ; Engelman, Alan N. ; Neil, James ; Roth, Monica J.
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2019-12, Vol.15 (12), p.e1008154
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Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice
Author / Creator:Ceballos-Diaz, Carolina ; Rosario, Awilda M. ; Park, Hyo-Jin ; Chakrabarty, Paramita ; Sacino, Amanda ; Cruz, Pedro E. ; Siemienski, Zoe ; Lara, Nicolas ; Moran, Corey ; Ravelo, Natalia ; Golde, Todd E. ; McFarland, Nikolaus R.
Publisher:England: BioMed Central Ltd
Journal title:Molecular neurodegeneration, 2015-07, Vol.10 (1), p.25-25, Article 25
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ArticlesPeer ReviewedFull Text
Efficient, Long-term Hepatic Gene Transfer Using Clinically Relevant HDAd Doses by Balloon Occlusion Catheter Delivery in Nonhuman Primates
Author / Creator:Brunetti-Pierri, Nicola ; Stapleton, Gary E ; Law, Mark ; Breinholt, John ; Palmer, Donna J ; Zuo, Yu ; Grove, Nathan C ; Finegold, Milton J ; Rice, Karen ; Beaudet, Arthur L ; Mullins, Charles E ; Ng, Philip
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2009-02, Vol.17 (2), p.327-333
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Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity
Author / Creator:Wu, Chuanfeng ; E. Dunbar, Cynthia
Publisher:Heidelberg: Higher Education Press
Journal title:Frontiers of medicine, 2011-12, Vol.5 (4), p.356-371
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ArticlesPeer ReviewedFull Text
Lifelong Elimination of Hyperbilirubinemia in the Gunn Rat with a Single Injection of Helper-Dependent Adenoviral Vector
Author / Creator:Toietta, Gabriele ; Mane, Viraj P. ; Norona, Wilma S. ; Finegold, Milton J. ; Ng, Philip ; McDonagh, Antony F. ; Beaudet, Arthur L. ; Lee, Brendan ; Schmid, Rudi
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2005-03, Vol.102 (11), p.3930-3935
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ArticlesPeer ReviewedFull Text
In Vivo Gene Knockdown in Rat Dorsal Root Ganglia Mediated by Self-Complementary Adeno-Associated Virus Serotype 5 Following Intrathecal Delivery
Author / Creator:Xu, Qinghao ; Chou, Beverly ; Fitzsimmons, Bethany ; Miyanohara, Atsushi ; Shubayev, Veronica ; Santucci, Camila ; Hefferan, Michael ; Marsala, Martin ; Hua, Xiao-Ying
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-03, Vol.7 (3), p.e32581
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ArticlesPeer ReviewedFull Text
Systemic Delivery of a Novel Liver-Detargeted Oncolytic Adenovirus Causes Reduced Liver Toxicity but Maintains the Antitumor Response in a Breast Cancer Bone Metastasis Model
Author / Creator:Zhang, Zhenwei ; Krimmel, Jeffrey ; Zhang, Zhiling ; Hu, Zebin ; Seth, Prem
Publisher:Larchmont, NY: Liebert
Journal title:Human gene therapy, 2011-09, Vol.22 (9), p.1137-1142
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ArticlesPeer ReviewedFull Text
CpG-Depleted Plasmid DNA Vectors with Enhanced Safety and Long-Term Gene Expression in Vivo
Author / Creator:Yew, Nelson S. ; Zhao, Hongmei ; Przybylska, Malgorzata ; Wu, I-Huan ; Tousignant, Jennifer D. ; Scheule, Ronald K. ; Cheng, Seng H.
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2002-06, Vol.5 (6), p.731-738
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ArticlesPeer ReviewedFull Text
Carbosilane Dendrimers to Transfect Human Astrocytes with Small Interfering RNA Targeting Human Immunodeficiency Virus
Author / Creator:Jiménez, Jose Luis ; Clemente, María Isabel ; Weber, Nick D. ; Sanchez, Javier ; Ortega, Paula ; de la Mata, F. Javier ; Gómez, Rafael ; García, Dolores ; López-Fernández, Luis A. ; Muñoz-Fernández, María Ángeles
Publisher:Cham: Springer International Publishing
Journal title:BioDrugs : clinical immunotherapeutics, biopharmaceuticals, and gene therapy, 2010-10, Vol.24 (5), p.331-343
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ArticlesPeer ReviewedFull Text
Pre-existing Immunity and Passive Immunity to Adenovirus 5 Prevents Toxicity Caused by an Oncolytic Adenovirus Vector in the Syrian Hamster Model
Author / Creator:Dhar, Debanjan ; Spencer, Jacqueline F ; Toth, Karoly ; Wold, William SM
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2009-10, Vol.17 (10), p.1724-1732
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ArticlesPeer ReviewedFull Text
CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors
Author / Creator:Alemany, R ; Curiel, DT
Publisher:Basingstoke: Nature Publishing Group
Journal title:Gene therapy, 2001-09, Vol.8 (17), p.1347-1353
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ArticlesPeer ReviewedFull Text
Augmenting the Antitumor Effect of TRAIL by SOCS3 with Double-Regulated Replicating Oncolytic Adenovirus in Hepatocellular Carcinoma
Author / Creator:Wei, Rui-Cheng ; Cao, Xin ; Gui, Jing-Hua ; Zhou, Xiu-Mei ; Zhong, Dan ; Yan, Qiao-Lin ; Huang, Wei-Dan ; Qian, Qi-Jun ; Zhao, Feng-Li ; Liu, Xin-Yuan
Publisher:Larchmont, NY: Liebert
Journal title:Human gene therapy, 2011-09, Vol.22 (9), p.1109-1119
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Second-Generation Replication-Competent Oncolytic Adenovirus Armed with Improved Suicide Genes and ADP Gene Demonstrates Greater Efficacy without Increased Toxicity
Author / Creator:Barton, Kenneth N. ; Paielli, Dell ; Zhang, Yingshu ; Koul, Sweaty ; Brown, Stephen L. ; Lu, Mei ; Seely, John ; Ho Kim, Jae ; Freytag, Svend O.
Publisher:United States: Elsevier Limited
Journal title:Molecular therapy, 2006-02, Vol.13 (2), p.347-356
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ArticlesPeer ReviewedFull Text
PEGylated helper-dependent adenoviral vectors: highly efficient vectors with an enhanced safety profile
Author / Creator:Croyle, M A ; Le, H T ; Linse, K D ; Cerullo, V ; Toietta, G ; Beaudet, A ; Pastore, L
Publisher:London: Nature Publishing Group UK
Journal title:Gene therapy, 2005-04, Vol.12 (7), p.579-587
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ArticlesPeer ReviewedFull Text
AAV-mediated gene transfer of human pigment epithelium-derived factor inhibits Lewis lung carcinoma growth in mice
Author / Creator:HE, SHA-SHA ; SHI, HUA-SHAN ; YIN, TAO ; LI, YONG-XIA ; LUO, SHUN-TAO ; WU, QIN-JIE ; LU, LIAN ; WEI, YU-QUAN ; YANG, LI
Publisher:Greece: D.A. Spandidos
Journal title:Oncology reports, 2012-04, Vol.27 (4), p.1142-1148
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ArticlesPeer ReviewedFull Text
Evaluation of toxicity from high-dose systemic administration of recombinant adenovirus vector in vector-naïve and pre-immunized mice
Author / Creator:Varnavski, A N ; Calcedo, R ; Bove, M ; Gao, G ; Wilson, J M
Publisher:London: Nature Publishing Group UK
Journal title:Gene therapy, 2005-03, Vol.12 (5), p.427-436
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Showing 1 to 20 of 63 results

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Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits Metachromatic Leukodystrophy

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Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5–based Constructs

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Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons

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Physiological Promoters Reduce the Genotoxic Risk of Integrating Gene Vectors

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Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model

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Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice

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Efficient, Long-term Hepatic Gene Transfer Using Clinically Relevant HDAd Doses by Balloon Occlusion Catheter Delivery in Nonhuman Primates

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Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

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Lifelong Elimination of Hyperbilirubinemia in the Gunn Rat with a Single Injection of Helper-Dependent Adenoviral Vector

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In Vivo Gene Knockdown in Rat Dorsal Root Ganglia Mediated by Self-Complementary Adeno-Associated Virus Serotype 5 Following Intrathecal Delivery

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Systemic Delivery of a Novel Liver-Detargeted Oncolytic Adenovirus Causes Reduced Liver Toxicity but Maintains the Antitumor Response in a Breast Cancer Bone Metastasis Model

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CpG-Depleted Plasmid DNA Vectors with Enhanced Safety and Long-Term Gene Expression in Vivo

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Carbosilane Dendrimers to Transfect Human Astrocytes with Small Interfering RNA Targeting Human Immunodeficiency Virus

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Pre-existing Immunity and Passive Immunity to Adenovirus 5 Prevents Toxicity Caused by an Oncolytic Adenovirus Vector in the Syrian Hamster Model

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CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors

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Augmenting the Antitumor Effect of TRAIL by SOCS3 with Double-Regulated Replicating Oncolytic Adenovirus in Hepatocellular Carcinoma

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Second-Generation Replication-Competent Oncolytic Adenovirus Armed with Improved Suicide Genes and ADP Gene Demonstrates Greater Efficacy without Increased Toxicity

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PEGylated helper-dependent adenoviral vectors: highly efficient vectors with an enhanced safety profile

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AAV-mediated gene transfer of human pigment epithelium-derived factor inhibits Lewis lung carcinoma growth in mice

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Evaluation of toxicity from high-dose systemic administration of recombinant adenovirus vector in vector-naïve and pre-immunized mice

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