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Series 01: Allen & Unwin further records, being editorial files, ca. 1983-2008: Boxes 44-87

Natto, known for its high vitamin K content, has been demonstrated to suppress atherosclerosis in large-scale clinical trials through a yet-unknown mechanism. In this study, we used a previously reported mouse model, transplanting the bone marrow of mice expressing infra-red fluorescent protein (iRFP) into LDLR-deficient mice, allowing unique and non-invasive observation of foam cells expressing iRFP in atherosclerotic lesions. Using 3 natto strains, we meticulously examined the effects of varying vitamin K levels on atherosclerosis in these mice. Notably, high vitamin K natto significantly reduced aortic staining and iRFP fluorescence, indicative of decreased atherosclerosis. Furthermore, mice administered natto showed changes in gut microbiota, including an increase in natto bacteria within the cecum, and a significant reduction in serum CCL2 expression. In experiments with LPS-stimulated macrophages, adding natto decreased CCL2 expression and increased anti-inflammatory cytokine IL-10 expression. This suggests that natto inhibits atherosclerosis through suppression of intestinal inflammation and reduced CCL2 expression in macrophages.

Scientific reports, 2023-12, Vol.13 (1), p.22469-22469, Article 22469

Natto consumption suppresses atherosclerotic plaque progression in LDL receptor-deficient mice transplanted with iRFP-expressing hematopoietic cells

Non-alcoholic fatty liver disease (NAFLD) constitutes a metabolic disorder with high worldwide prevalence and increasing incidence. The inflammatory progressive state, non-alcoholic steatohepatitis (NASH), leads to liver fibrosis and carcinogenesis. Here, we evaluated whether tyrosinase mutation underlies NASH pathophysiology. Tyrosinase point-mutated B6 (Cg)-
Tyr
c-2J
/J mice (B6 albino) and C57BL/6J black mice (B6 black) were fed with high cholesterol diet (HCD) for 10 weeks. Normal diet-fed mice served as controls. HCD-fed B6 albino exhibited high NASH susceptibility compared to B6 black, a phenotype not previously reported. Liver injury occurred in approximately 50% of B6 albino from one post HCD feeding, with elevated serum alanine aminotransferase and aspartate aminotransferase levels. NASH was induced following 2 weeks in severe-phenotypic B6 albino (sB6), but B6 black exhibited no symptoms, even after 10 weeks. HCD-fed sB6 albino showed significantly higher mortality rate. Histological analysis of the liver revealed significant inflammatory cell and lipid infiltration and severe fibrosis. Serum lipoprotein analysis revealed significantly higher chylomicron and very low-density lipoprotein levels in sB6 albino. Moreover, significantly higher small intestinal lipid absorption and lower fecal lipid excretion occurred together with elevated intestinal NPC1L1 expression. As the tyrosinase point mutation represents the only genetic difference between B6 albino and B6 black, our work will facilitate the identification of susceptible genetic factors for NASH development and expand the understanding of NASH pathophysiology.

Scientific reports, 2021-11, Vol.11 (1), p.21827-21827, Article 21827

Albino mice with the point mutation at the tyrosinase locus show high cholesterol diet-induced NASH susceptibility

Best known as Detective Tim Bayliss of the Baltimore NBC drama, Homicide: Life on the Street, [Kyle Secor] is breaking ground this season in his role with Geena Davis as President Mackenzie Allen. In the pilot episode, Secor and Academy-Award-winner Davis adeptly established what has become the show's leitmotif: the underlying tensions that swirl between a husband and wife when the balance of power suddenly shifts. In one scene, President Allen tells her husband and long-time political partner that he will not be her chief of staff - despite his expectations. The look of surprise, hurt and anger that crosses Secor's face as the news registers captures the emotional complexity of the moment as no words could. One production that Secor, who is married to actress Kari Coleman, feels good about is the 2003 ABC-Disney miniseries, A Wrinkle in Time. Based on the celebrated children's book series, it tells the tale of a brother and sister searching the universe for their missing father. "I liked doing A Wrinkle in Time, and it's something I can show my daughter."

The Sun (Baltimore, Md. : 1837), 2005-12-04

Televisionland's first first gentleman ; Kyle Secor plays the first female president's husband on `Commander in Chief': FINAL Edition

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Series 01: Allen & Unwin further records, being editorial files, ca. 1983-2008: Boxes 44-87

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Natto consumption suppresses atherosclerotic plaque progression in LDL receptor-deficient mice transplanted with iRFP-expressing hematopoietic cells

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Albino mice with the point mutation at the tyrosinase locus show high cholesterol diet-induced NASH susceptibility

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Televisionland's first first gentleman ; Kyle Secor plays the first female president's husband on `Commander in Chief': FINAL Edition

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