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ArticlesPeer ReviewedFull Text
Melanoma
Author / Creator:Schadendorf, Dirk ; van Akkooi, Alexander C J ; Berking, Carola ; Griewank, Klaus G ; Gutzmer, Ralf ; Hauschild, Axel ; Stang, Andreas ; Roesch, Alexander ; Ugurel, Selma
Publisher:England: Elsevier Ltd
Journal title:The Lancet (British edition), 2018-09, Vol.392 (10151), p.971-984
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Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
Author / Creator:Liu, David ; Schilling, Bastian ; Liu, Derek ; Sucker, Antje ; Livingstone, Elisabeth ; Jerby-Arnon, Livnat ; Zimmer, Lisa ; Gutzmer, Ralf ; Satzger, Imke ; Loquai, Carmen ; Grabbe, Stephan ; Vokes, Natalie ; Margolis, Claire A. ; Conway, Jake ; He, Meng Xiao ; Elmarakeby, Haitham ; Dietlein, Felix ; Miao, Diana ; Tracy, Adam ; Gogas, Helen ; Goldinger, Simone M. ; Utikal, Jochen ; Blank, Christian U. ; Rauschenberg, Ricarda ; von Bubnoff, Dagmar ; Krackhardt, Angela ; Weide, Benjamin ; Haferkamp, Sebastian ; Kiecker, Felix ; Izar, Ben ; Garraway, Levi ; Regev, Aviv ; Flaherty, Keith ; Paschen, Annette ; Van Allen, Eliezer M. ; Schadendorf, Dirk
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2019-12, Vol.25 (12), p.1916-1927
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Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
Author / Creator:Van Allen, Eliezer M. ; Miao, Diana ; Schilling, Bastian ; Shukla, Sachet A. ; Blank, Christian ; Zimmer, Lisa ; Sucker, Antje ; Hillen, Uwe ; Foppen, Marnix H. Geukes ; Goldinger, Simone M. ; Utikal, Jochen ; Hassel, Jessica C. ; Weide, Benjamin ; Kaehler, Katharina C. ; Loquai, Carmen ; Mohr, Peter ; Gutzmer, Ralf ; Dummer, Reinhard ; Gabriel, Stacey ; Wu, Catherine J. ; Schadendorf, Dirk ; Garraway, Levi A.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2015-10, Vol.350 (6257), p.207-211
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Hedgehog Pathway Inhibition for the Treatment of Basal Cell Carcinoma
Author / Creator:Gutzmer, Ralf ; Solomon, James A.
Publisher:Cham: Springer International Publishing
Journal title:Targeted oncology, 2019-06, Vol.14 (3), p.253-267
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Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial
Author / Creator:Weber, Jeffrey S, Dr ; D'Angelo, Sandra P, MD ; Minor, David, MD ; Hodi, F Stephen, MD ; Gutzmer, Ralf, MD ; Neyns, Bart, MD ; Hoeller, Christoph, MD ; Khushalani, Nikhil I, MD ; Miller, Wilson H, MD ; Lao, Christopher D, MD ; Linette, Gerald P, MD ; Thomas, Luc, MD ; Lorigan, Paul, FRCP ; Grossmann, Kenneth F, MD ; Hassel, Jessica C, MD ; Maio, Michele, MD ; Sznol, Mario, MD ; Ascierto, Paolo A, MD ; Mohr, Peter, MD ; Chmielowski, Bartosz, MD ; Bryce, Alan, MD ; Svane, Inge M, MD ; Grob, Jean-Jacques, MD ; Krackhardt, Angela M, MD ; Horak, Christine, PhD ; Lambert, Alexandre, PhD ; Yang, Arvin S, MD ; Larkin, James, FRCP
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2015-04, Vol.16 (4), p.375-384
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Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions
Author / Creator:Sucker, Antje ; Zhao, Fang ; Pieper, Natalia ; Heeke, Christina ; Maltaner, Raffaela ; Stadtler, Nadine ; Real, Birgit ; Bielefeld, Nicola ; Howe, Sebastian ; Weide, Benjamin ; Gutzmer, Ralf ; Utikal, Jochen ; Loquai, Carmen ; Gogas, Helen ; Klein-Hitpass, Ludger ; Zeschnigk, Michael ; Westendorf, Astrid M. ; Trilling, Mirko ; Horn, Susanne ; Schilling, Bastian ; Schadendorf, Dirk ; Griewank, Klaus G. ; Paschen, Annette
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-05, Vol.8 (1), p.15440-15440, Article 15440
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Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma: a randomised, double-blind, multicentre, phase 3 trial
Author / Creator:Ascierto, Paolo A, Dr ; Del Vecchio, Michele, MD ; Robert, Caroline, Prof ; Mackiewicz, Andrzej, Prof ; Chiarion-Sileni, Vanna, MD ; Arance, Ana, MD ; Lebbé, Céleste, Prof ; Bastholt, Lars, MD ; Hamid, Omid, MD ; Rutkowski, Piotr, Prof ; McNeil, Catriona, MD ; Garbe, Claus, Prof ; Loquai, Carmen, MD ; Dreno, Brigitte, Prof ; Thomas, Luc, Prof ; Grob, Jean-Jacques, Prof ; Liszkay, Gabriella, Prof ; Nyakas, Marta, MD ; Gutzmer, Ralf, Prof ; Pikiel, Joanna, MD ; Grange, Florent, MD ; Hoeller, Christoph, MD ; Ferraresi, Virginia, MD ; Smylie, Michael, MD ; Schadendorf, Dirk, Prof ; Mortier, Laurent, Prof ; Svane, Inge Marie, MD ; Hennicken, Delphine, MSc ; Qureshi, Anila, MD ; Maio, Michele, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2017-05, Vol.18 (5), p.611-622
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Binimetinib versus dacarbazine in patients with advanced NRAS-mutant melanoma (NEMO): a multicentre, open-label, randomised, phase 3 trial
Author / Creator:Dummer, Reinhard, Prof ; Schadendorf, Dirk, Prof ; Ascierto, Paolo A, MD ; Arance, Ana, MD ; Dutriaux, Caroline, MD ; Di Giacomo, Anna Maria, MD ; Rutkowski, Piotr, Prof ; Del Vecchio, Michele, MD ; Gutzmer, Ralf, Prof ; Mandala, Mario, MD ; Thomas, Luc, Prof ; Demidov, Lev, Prof ; Garbe, Claus, Prof ; Hogg, David, MD ; Liszkay, Gabriella, Prof ; Queirolo, Paola, MD ; Wasserman, Ernesto, MD ; Ford, James, MS ; Weill, Marine, MSc ; Sirulnik, L Andres, MD ; Jehl, Valentine, MSc ; Bozón, Viviana, MD ; Long, Georgina V, Prof ; Flaherty, Keith, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2017-04, Vol.18 (4), p.435-445
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Overall survival with first-line atezolizumab in combination with vemurafenib and cobimetinib in BRAFV600 mutation-positive advanced melanoma (IMspire150): second interim analysis of a multicentre, ra...
Author / Creator:Ascierto, Paolo A, Prof ; Stroyakovskiy, Daniil, MD ; Gogas, Helen, Prof ; Robert, Caroline, Prof ; Lewis, Karl, Prof ; Protsenko, Svetlana, MD ; Pereira, Rodrigo P, MD ; Eigentler, Thomas, MD ; Rutkowski, Piotr, MD ; Demidov, Lev, MD ; Zhukova, Natalia, PhD ; Schachter, Jacob, Prof ; Yan, Yibing, PhD ; Caro, Ivor, MD ; Hertig, Christian, DVM ; Xue, Cloris, MSc ; Kusters, Lieke, MSc ; McArthur, Grant A, Prof ; Gutzmer, Ralf, Prof
Publisher:Elsevier Ltd
Journal title:The lancet oncology, 2023-01, Vol.24 (1), p.33-44
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Dabrafenib in BRAF -mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
Author / Creator:Hauschild, Axel, Prof ; Grob, Jean-Jacques, Prof ; Demidov, Lev V, Prof ; Jouary, Thomas, MD ; Gutzmer, Ralf, MD ; Millward, Michael, MD ; Rutkowski, Piotr, PhD ; Blank, Christian U, PhD ; Miller, Wilson H, PhD ; Kaempgen, Eckhart, PhD ; Martín-Algarra, Salvador, PhD ; Karaszewska, Boguslawa, MD ; Mauch, Cornelia, Prof ; Chiarion-Sileni, Vanna, MD ; Martin, Anne-Marie, PhD ; Swann, Suzanne, PhD ; Haney, Patricia, BSN ; Mirakhur, Beloo, PhD ; Guckert, Mary E, MSN ; Goodman, Vicki, MD ; Chapman, Paul B, MD
Publisher:England: Elsevier Ltd
Journal title:The Lancet (British edition), 2012-07, Vol.380 (9839), p.358-365
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Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial
Author / Creator:Migden, Michael R, Dr ; Guminski, Alexander, PhD ; Gutzmer, Ralf, Prof ; Dirix, Luc, MD ; Lewis, Karl D, MD ; Combemale, Patrick, MD ; Herd, Robert M, MD ; Kudchadkar, Ragini, MD ; Trefzer, Uwe, Prof ; Gogov, Sven, MD ; Pallaud, Celine, PhD ; Yi, Tingting, PhD ; Mone, Manisha, PhD ; Kaatz, Martin, MD ; Loquai, Carmen, MD ; Stratigos, Alexander J, Prof ; Schulze, Hans-Joachim, MD ; Plummer, Ruth, Prof ; Chang, Anne Lynn S, MD ; Cornélis, Frank, MD ; Lear, John T, MD ; Sellami, Dalila, MD ; Dummer, Reinhard, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2015-06, Vol.16 (6), p.716-728
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Assessment of various efficacy outcomes using ERIVANCE-like criteria in patients with locally advanced basal cell carcinoma receiving sonidegib: results from a preplanned sensitivity analysis
Author / Creator:Gutzmer, Ralf ; Robert, Caroline ; Loquai, Carmen ; Schadendorf, Dirk ; Squittieri, Nicholas ; Arntz, Ramon ; Martelli, Serena ; Dummer, Reinhard
Publisher:England: BioMed Central Ltd
Journal title:BMC cancer, 2021-11, Vol.21 (1), p.1244-1244, Article 1244
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Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: a phase 2 double-blind randomised study
Author / Creator:Robert, Caroline, Dr ; Dummer, Reinhard, Prof ; Gutzmer, Ralf, Prof ; Lorigan, Paul, MB ; Kim, Kevin B, MD ; Nyakas, Marta, MD ; Arance, Ana, MD ; Liszkay, Gabriella, Prof ; Schadendorf, Dirk, Prof ; Cantarini, Mireille, MBChB ; Spencer, Stuart, MSc ; Middleton, Mark R, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2013-07, Vol.14 (8), p.733-740
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Phase 2 study of cemiplimab in patients with metastatic cutaneous squamous cell carcinoma: primary analysis of fixed-dosing, long-term outcome of weight-based dosing
Author / Creator:Rischin, Danny ; Migden, Michael R ; Lim, Annette M ; Schmults, Chrysalyne D ; Khushalani, Nikhil I ; Hughes, Brett G M ; Schadendorf, Dirk ; Dunn, Lara A ; Hernandez-Aya, Leonel ; Chang, Anne Lynn S ; Modi, Badri ; Hauschild, Axel ; Ulrich, Claas ; Eigentler, Thomas ; Stein, Brian ; Pavlick, Anna C ; Geiger, Jessica L ; Gutzmer, Ralf ; Alam, Murad ; Okoye, Emmanuel ; Mathias, Melissa ; Jankovic, Vladimir ; Stankevich, Elizabeth ; Booth, Jocelyn ; Li, Siyu ; Lowy, Israel ; Fury, Matthew G ; Guminski, Alexander
Publisher:England: BMJ Publishing Group Ltd
Journal title:Journal for immunotherapy of cancer, 2020-06, Vol.8 (1), p.e000775
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Talimogene laherparepvec upregulates immune-cell populations in non-injected lesions: findings from a phase II, multicenter, open-label study in patients with stage IIIB–IVM1c melanoma
Author / Creator:Malvehy, Josep ; Samoylenko, Igor ; Schadendorf, Dirk ; Gutzmer, Ralf ; Grob, Jean-Jacques ; Sacco, Joseph J ; Gorski, Kevin S ; Anderson, Abraham ; Pickett, Cheryl A ; Liu, Kate ; Gogas, Helen
Publisher:England: BMJ Publishing Group LTD
Journal title:Journal for immunotherapy of cancer, 2021-03, Vol.9 (3), p.e001621
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Interim analysis of the multinational, post-authorization safety study (NISSO) to assess the long-term safety of sonidegib in patients with locally advanced basal cell carcinoma
Author / Creator:Gutzmer, Ralf ; Leiter, Ulrike ; Mohr, Peter ; Kähler, Katharina C. ; Ascierto, Paolo Antonio ; Scalvenzi, Massimiliano ; Peris, Ketty ; Pérez-Pastor, Gemma María ; Fernández-de-Misa, Ricardo ; Botella-Estrada, Rafael ; Hunger, Robert E. ; Martelli, Serena ; Güneli, Nur ; Arntz, Ramon ; Hauschild, Axel
Publisher:England: BioMed Central Ltd
Journal title:BMC cancer, 2024-11, Vol.24 (1), p.1401-9, Article 1401
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Interleukin-4 and -13 Gene Expression Profiles in Immune-Related Bullous Pemphigoid Indicate Efficacy of IL-4/IL-13 Inhibitors
Author / Creator:Arnold, Lisa ; Morak, Monika ; Kramer, Nora ; Berking, Carola ; Schefzyk, Matthias ; Hassel, Jessica C ; Ziemer, Mirjana ; French, Lars E ; Gutzmer, Ralf ; Nashan, Dorothee ; Heinzerling, Lucie
Publisher:Switzerland: MDPI AG
Journal title:Cancers, 2025-05, Vol.17 (11), p.1845
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Combined immunotherapy with nivolumab and ipilimumab with and without local therapy in patients with melanoma brain metastasis: a DeCOG study in 380 patients
Author / Creator:Amaral, Teresa ; Kiecker, Felix ; Schaefer, Sarah ; Stege, Henner ; Kaehler, Katharina ; Terheyden, Patrick ; Gesierich, Anja ; Gutzmer, Ralf ; Haferkamp, Sebastian ; Uttikal, Jochen ; Berking, Carola ; Rafei-Shamsabadi, David ; Reinhardt, Lydia ; Meier, Friedegund ; Karoglan, Ante ; Posch, Christian ; Gambichler, Thilo ; Pfoehler, Claudia ; Thoms, Kai ; Tietze, Julia ; Debus, Dirk ; Herbst, Rudolf ; Emmert, Steffen ; Loquai, Carmen ; Hassel, Jessica C ; Meiss, Frank ; Tueting, Thomas ; Heinrich, Vanessa ; Eigentler, Thomas ; Garbe, Claus ; Zimmer, Lisa
Publisher:England: BMJ Publishing Group Ltd
Journal title:Journal for immunotherapy of cancer, 2020-03, Vol.8 (1), p.e000333
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Long-term real-world experience with ipilimumab and non-ipilimumab therapies in advanced melanoma: the IMAGE study
Author / Creator:Dalle, Stéphane ; Mortier, Laurent ; Corrie, Pippa ; Lotem, Michal ; Board, Ruth ; Arance, Ana María ; Meiss, Frank ; Terheyden, Patrick ; Gutzmer, Ralf ; Buysse, Brian ; Oh, Kelly ; Brokaw, Jane ; Le, T. Kim ; Mathias, Susan D. ; Scotto, Julie ; Lord-Bessen, Jennifer ; Moshyk, Andriy ; Kotapati, Srividya ; Middleton, Mark R.
Publisher:London: BioMed Central Ltd
Journal title:BMC cancer, 2021-05, Vol.21 (1), p.1-642, Article 642
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Bilateral In Vivo Confocal Microscopic Changes of the Corneal Subbasal Nerve Plexus in Patients with Acute Herpes Zoster Ophthalmicus
Author / Creator:Della Franca, Barbara ; Yaïci, Rémi ; Matuszewska-Iwanicka, Aleksandra ; Nandrean, Simona ; Gutzmer, Ralf ; Hettlich, Hans-Joachim
Publisher:Cheshire: Springer Healthcare
Journal title:Ophthalmology and therapy, 2025-05, Vol.14 (5), p.941-957
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Showing 1 to 20 of 115 results

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Melanoma

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Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

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Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

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Hedgehog Pathway Inhibition for the Treatment of Basal Cell Carcinoma

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Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial

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Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions

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Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma: a randomised, double-blind, multicentre, phase 3 trial

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Binimetinib versus dacarbazine in patients with advanced NRAS-mutant melanoma (NEMO): a multicentre, open-label, randomised, phase 3 trial

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Overall survival with first-line atezolizumab in combination with vemurafenib and cobimetinib in BRAFV600 mutation-positive advanced melanoma (IMspire150): second interim analysis of a multicentre, ra...

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Dabrafenib in BRAF -mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial

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Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial

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Assessment of various efficacy outcomes using ERIVANCE-like criteria in patients with locally advanced basal cell carcinoma receiving sonidegib: results from a preplanned sensitivity analysis

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Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: a phase 2 double-blind randomised study

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Phase 2 study of cemiplimab in patients with metastatic cutaneous squamous cell carcinoma: primary analysis of fixed-dosing, long-term outcome of weight-based dosing

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Talimogene laherparepvec upregulates immune-cell populations in non-injected lesions: findings from a phase II, multicenter, open-label study in patients with stage IIIB–IVM1c melanoma

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Interim analysis of the multinational, post-authorization safety study (NISSO) to assess the long-term safety of sonidegib in patients with locally advanced basal cell carcinoma

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Interleukin-4 and -13 Gene Expression Profiles in Immune-Related Bullous Pemphigoid Indicate Efficacy of IL-4/IL-13 Inhibitors

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Combined immunotherapy with nivolumab and ipilimumab with and without local therapy in patients with melanoma brain metastasis: a DeCOG study in 380 patients

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Long-term real-world experience with ipilimumab and non-ipilimumab therapies in advanced melanoma: the IMAGE study

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Bilateral In Vivo Confocal Microscopic Changes of the Corneal Subbasal Nerve Plexus in Patients with Acute Herpes Zoster Ophthalmicus

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