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A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer
Author / Creator:Polak, Paz ; Kim, Jaegil ; Braunstein, Lior Z ; Karlic, Rosa ; Haradhavala, Nicholas J ; Tiao, Grace ; Rosebrock, Daniel ; Livitz, Dimitri ; Kübler, Kirsten ; Mouw, Kent W ; Kamburov, Atanas ; Maruvka, Yosef E ; Leshchiner, Ignaty ; Lander, Eric S ; Golub, Todd R ; Zick, Aviad ; Orthwein, Alexandre ; Lawrence, Michael S ; Batra, Rajbir N ; Caldas, Carlos ; Haber, Daniel A ; Laird, Peter W ; Shen, Hui ; Ellisen, Leif W ; D'Andrea, Alan D ; Chanock, Stephen J ; Foulkes, William D ; Getz, Gad
Publisher:New York: Springer New York
Journal title:Nature genetics, 2017-10, Vol.49 (10), p.1476-1486
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A plant-specific module for homologous recombination repair
Author / Creator:Wang, Xuanpeng ; Wang, Lili ; Huang, Yongchi ; Deng, Zhiping ; Li, Cunliang ; Zhang, Jian ; Zheng, Mingxi ; Yan, Shunping
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2022-04, Vol.119 (16), p.1-12
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RAD18 transmits DNA damage signalling to elicit homologous recombination repair
Author / Creator:Huang, Jun ; Huen, Michael S. Y. ; Kim, Hongtae ; Leung, Charles Chung Yun ; Glover, J N Mark ; Yu, Xiaochun ; Chen, Junjie
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2009-05, Vol.11 (5), p.592-603
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Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer
Author / Creator:Abkevich, V ; Timms, K M ; Hennessy, B T ; Potter, J ; Carey, M S ; Meyer, L A ; Smith-McCune, K ; Broaddus, R ; Lu, K H ; Chen, J ; Tran, T V ; Williams, D ; Iliev, D ; Jammulapati, S ; FitzGerald, L M ; Krivak, T ; DeLoia, J A ; Gutin, A ; Mills, G B ; Lanchbury, J S
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2012-11, Vol.107 (10), p.1776-1782
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The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors
Author / Creator:Peng, Yihan ; Liao, Qingchao ; Tan, Wei ; Peng, Changmin ; Hu, Zhaohua ; Chen, Yali ; Li, Zhuqing ; Li, Jing ; Zhen, Bei ; Zhu, Wenge ; Li, Xiangpan ; Yao, Yi ; Song, Qibin ; Liu, Chengsheng ; Qi, Xiangdong ; He, Fuchu ; Pei, Huadong
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-03, Vol.10 (1), p.1224-15, Article 1224
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Leveraging homologous recombination repair deficiency in sarcoma
Author / Creator:Slade, Dea ; Loizou, Joanna I
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2023-04, Vol.15 (4), p.e17453-n/a
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Homologous Recombination Repair Deficiency and Implications for Tumor Immunogenicity
Author / Creator:van Wilpe, Sandra ; Tolmeijer, Sofie H. ; Koornstra, Rutger H. T. ; de Vries, I. Jolanda M. ; Gerritsen, Winald R. ; Ligtenberg, Marjolijn ; Mehra, Niven
Publisher:Basel: MDPI AG
Journal title:Cancers, 2021-05, Vol.13 (9), p.2249
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Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair
Author / Creator:Sanchez-Bailon, Maria Pilar ; Choi, Soo-Youn ; Dufficy, Elizabeth R. ; Sharma, Karan ; McNee, Gavin S. ; Gunnell, Emma ; Chiang, Kelly ; Sahay, Debashish ; Maslen, Sarah ; Stewart, Grant S. ; Skehel, J. Mark ; Dreveny, Ingrid ; Davies, Clare C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-11, Vol.12 (1), p.6313-6313, Article 6313
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Targeting autophagy reverses de novo resistance in homologous recombination repair proficient breast cancers to PARP inhibition
Author / Creator:Pai Bellare, Ganesh ; Saha, Bhaskar ; Patro, Birija Sankar
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2021-03, Vol.124 (7), p.1260-1274
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Alterations in homologous recombination repair genes in prostate cancer brain metastases
Author / Creator:Rodriguez-Calero, Antonio ; Gallon, John ; Akhoundova, Dilara ; Maletti, Sina ; Ferguson, Alison ; Cyrta, Joanna ; Amstutz, Ursula ; Garofoli, Andrea ; Paradiso, Viola ; Tomlins, Scott A. ; Hewer, Ekkehard ; Genitsch, Vera ; Fleischmann, Achim ; Vassella, Erik ; Rushing, Elisabeth J. ; Grobholz, Rainer ; Fischer, Ingeborg ; Jochum, Wolfram ; Cathomas, Gieri ; Osunkoya, Adeboye O. ; Bubendorf, Lukas ; Moch, Holger ; Thalmann, George ; Ng, Charlotte K. Y. ; Gillessen, Silke ; Piscuoglio, Salvatore ; Rubin, Mark A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-05, Vol.13 (1), p.2400-10, Article 2400
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Examining the prevalence of homologous recombination repair defects in ER+ breast cancers
Author / Creator:Moore, Grace M. ; Powell, Simon N. ; Higginson, Daniel S. ; Khan, Atif J.
Publisher:New York: Springer US
Journal title:Breast cancer research and treatment, 2022-04, Vol.192 (3), p.649-653
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Pan-cancer analysis of homologous recombination deficiency and homologous recombination repair–associated gene alterations in solid tumors from a large Asian cohort
Author / Creator:Ren, Lili ; Yao, Runsi ; Hou, Ting ; Liu, Chenglin ; Zhao, Fei ; Chen, Xiaojun ; Zhang, Zhou ; Huang, Yan
Publisher:England: BioMed Central Ltd
Journal title:BMC cancer, 2025-05, Vol.25 (1), p.946-15, Article 946
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PALB2 is an integral component of the BRCA complex required for homologous recombination repair
Author / Creator:Sy, Shirley M.H ; Huen, Michael S.Y ; Chen, Junjie
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-04, Vol.106 (17), p.7155-7160
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SART3 promotes homologous recombination repair by stimulating DNA-RNA hybrids removal and DNA end resection
Author / Creator:Fu, Hui ; Huang, Min ; Wu, Honglin ; Zheng, Hui ; Gong, Yifei ; Xing, Lingyu ; Gong, Juanjuan ; An, Ruiyuan ; Li, Qian ; Jie, Xinyu ; Ma, Xiaolu ; Tang, Tie-Shan ; Guo, Caixia
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-03, Vol.16 (1), p.2244-18, Article 2244
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MiR-7-5p-mediated downregulation of PARP1 impacts DNA homologous recombination repair and resistance to doxorubicin in small cell lung cancer
Author / Creator:Lai, Jinzhi ; Yang, Hainan ; Zhu, Yanyang ; Ruan, Mei ; Huang, Yayu ; Zhang, Qiuyu
Publisher:England: BioMed Central Ltd
Journal title:BMC cancer, 2019-06, Vol.19 (1), p.602-602, Article 602
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Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks
Author / Creator:Whelan, Donna R. ; Lee, Wei Ting C. ; Yin, Yandong ; Ofri, Dylan M. ; Bermudez-Hernandez, Keria ; Keegan, Sarah ; Fenyo, David ; Rothenberg, Eli
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-09, Vol.9 (1), p.3882-15, Article 3882
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Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors
Author / Creator:Pacaud, Romain ; Thomas, Scott ; Chaudhuri, Sibapriya ; Lazar, Ann ; Timmerman, Luika A. ; Munster, Pamela N.
Publisher:England: BioMed Central Ltd
Journal title:Breast cancer research : BCR, 2025-01, Vol.27 (1), p.8-15, Article 8
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FIGNL1-containing protein complex is required for efficient homologous recombination repair
Author / Creator:Yuan, Jingsong ; Chen, Junjie
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (26), p.10640-10645
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Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance
Author / Creator:Wang, Li‐Min ; Wang, Pingyuan ; Chen, Xiao‐Min ; Yang, Hui ; Song, Shan‐Shan ; Song, Zilan ; Jia, Li ; Chen, Hua‐Dong ; Bao, Xu‐Bin ; Guo, Ne ; Huan, Xia‐Juan ; Xi, Yong ; Shen, Yan‐Yan ; Yang, Xin‐Ying ; Su, Yi ; Sun, Yi‐Ming ; Gao, Ying‐Lei ; Chen, Yi ; Ding, Jian ; Lang, Jing‐Yu ; Miao, Ze‐Hong ; Zhang, Ao ; He, Jin‐Xue
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2023-03, Vol.15 (3), p.e16235-n/a
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METTL3 promotes homologous recombination repair and modulates chemotherapeutic response in breast cancer by regulating the EGF/RAD51 axis
Author / Creator:Li, Enjie ; Xia, Mingyue ; Du, Yu ; Long, Kaili ; Ji, Feng ; Pan, Feiyan ; He, Lingfeng ; Hu, Zhigang ; Guo, Zhigang
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2022-05, Vol.11
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Showing 1 to 20 of 1,469 results

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A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

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A plant-specific module for homologous recombination repair

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RAD18 transmits DNA damage signalling to elicit homologous recombination repair

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Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer

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The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors

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Leveraging homologous recombination repair deficiency in sarcoma

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Homologous Recombination Repair Deficiency and Implications for Tumor Immunogenicity

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Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair

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Targeting autophagy reverses de novo resistance in homologous recombination repair proficient breast cancers to PARP inhibition

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Alterations in homologous recombination repair genes in prostate cancer brain metastases

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Examining the prevalence of homologous recombination repair defects in ER+ breast cancers

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Pan-cancer analysis of homologous recombination deficiency and homologous recombination repair–associated gene alterations in solid tumors from a large Asian cohort

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PALB2 is an integral component of the BRCA complex required for homologous recombination repair

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SART3 promotes homologous recombination repair by stimulating DNA-RNA hybrids removal and DNA end resection

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MiR-7-5p-mediated downregulation of PARP1 impacts DNA homologous recombination repair and resistance to doxorubicin in small cell lung cancer

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Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks

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Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors

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FIGNL1-containing protein complex is required for efficient homologous recombination repair

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Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance

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METTL3 promotes homologous recombination repair and modulates chemotherapeutic response in breast cancer by regulating the EGF/RAD51 axis

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