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ArticlesPeer ReviewedFull Text
Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice
Author / Creator:Kenjo, Eriya ; Hozumi, Hiroyuki ; Makita, Yukimasa ; Iwabuchi, Kumiko A. ; Fujimoto, Naoko ; Matsumoto, Satoru ; Kimura, Maya ; Amano, Yuichiro ; Ifuku, Masataka ; Naoe, Youichi ; Inukai, Naoto ; Hotta, Akitsu
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-12, Vol.12 (1), p.7101-13, Article 7101
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Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping
Author / Creator:Gee, Peter ; Lung, Mandy S. Y. ; Okuzaki, Yuya ; Sasakawa, Noriko ; Iguchi, Takahiro ; Makita, Yukimasa ; Hozumi, Hiroyuki ; Miura, Yasutomo ; Yang, Lucy F. ; Iwasaki, Mio ; Wang, Xiou H. ; Waller, Matthew A. ; Shirai, Nanako ; Abe, Yasuko O. ; Fujita, Yoko ; Watanabe, Kei ; Kagita, Akihiro ; Iwabuchi, Kumiko A. ; Yasuda, Masahiko ; Xu, Huaigeng ; Noda, Takeshi ; Komano, Jun ; Sakurai, Hidetoshi ; Inukai, Naoto ; Hotta, Akitsu
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-03, Vol.11 (1), p.1334-18, Article 1334
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CRISPR-Cas3 induces broad and unidirectional genome editing in human cells
Author / Creator:Morisaka, Hiroyuki ; Yoshimi, Kazuto ; Okuzaki, Yuya ; Gee, Peter ; Kunihiro, Yayoi ; Sonpho, Ekasit ; Xu, Huaigeng ; Sasakawa, Noriko ; Naito, Yuki ; Nakada, Shinichiro ; Yamamoto, Takashi ; Sano, Shigetoshi ; Hotta, Akitsu ; Takeda, Junji ; Mashimo, Tomoji
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-12, Vol.10 (1), p.5302-13, Article 5302
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Optimized simple culture protocol for inducing mature myotubes from MYOD1-overexpressed human iPS cells
Author / Creator:Wada, Eiji ; Susumu, Nao ; Okuzaki, Yuya ; Hotta, Akitsu ; Sakurai, Hidetoshi ; Hayashi, Yukiko K.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-11, Vol.14 (1), p.28783-12, Article 28783
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Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells
Author / Creator:Wang, Bo ; Iriguchi, Shoichi ; Waseda, Masazumi ; Ueda, Norihiro ; Ueda, Tatsuki ; Xu, Huaigeng ; Minagawa, Atsutaka ; Ishikawa, Akihiro ; Yano, Hisashi ; Ishi, Tomoko ; Ito, Ryoji ; Goto, Motohito ; Takahashi, Riichi ; Uemura, Yasushi ; Hotta, Akitsu ; Kaneko, Shin
Publisher:London: Nature Publishing Group UK
Journal title:Nature biomedical engineering, 2021-05, Vol.5 (5), p.429-440
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Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro
Author / Creator:Tanaka, Akihito ; Woltjen, Knut ; Miyake, Katsuya ; Hotta, Akitsu ; Ikeya, Makoto ; Yamamoto, Takuya ; Nishino, Tokiko ; Shoji, Emi ; Sehara-Fujisawa, Atsuko ; Manabe, Yasuko ; Fujii, Nobuharu ; Hanaoka, Kazunori ; Era, Takumi ; Yamashita, Satoshi ; Isobe, Ken-ichi ; Kimura, En ; Sakurai, Hidetoshi
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-04, Vol.8 (4), p.e61540-e61540
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Establishment of quantitative and consistent in vitro skeletal muscle pathological models of myotonic dystrophy type 1 using patient-derived iPSCs
Author / Creator:Kawada, Ryu ; Jonouchi, Tatsuya ; Kagita, Akihiro ; Sato, Masae ; Hotta, Akitsu ; Sakurai, Hidetoshi
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2023-01, Vol.13 (1), p.94-94, Article 94
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Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy
Author / Creator:Gee, Peter ; Hotta, Akitsu ; Xu, Huaigeng
Publisher:Cairo, Egypt: Hindawi Publishing Corporation
Journal title:Stem cells international, 2017-01, Vol.2017 (2017), p.1-11
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Constitutive heterochromatin reorganization during somatic cell reprogramming
Author / Creator:Fussner, Eden ; Djuric, Ugljesa ; Strauss, Mike ; Hotta, Akitsu ; Perez-Iratxeta, Carolina ; Lanner, Fredrik ; Dilworth, F Jeffrey ; Ellis, James ; Bazett-Jones, David P
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2011-05, Vol.30 (9), p.1778-1789
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iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva
Author / Creator:Gao, Pan ; Inada, Yoshiko ; Hotta, Akitsu ; Sakurai, Hidetoshi ; Ikeya, Makoto
Publisher:England: BioMed Central Ltd
Journal title:Stem cell research & therapy, 2024-03, Vol.15 (1), p.83-83, Article 83
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Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency
Author / Creator:Hotta, Akitsu ; Cheung, Aaron Y L ; Farra, Natalie ; Vijayaragavan, Kausalia ; Séguin, Cheryle A ; Draper, Jonathan S ; Pasceri, Peter ; Maksakova, Irina A ; Mager, Dixie L ; Rossant, Janet ; Bhatia, Mickie ; Ellis, James
Publisher:New York: Nature Publishing Group US
Journal title:Nature methods, 2009-05, Vol.6 (5), p.370-376
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Delivery of Full-Length Factor VIII Using a piggyBac Transposon Vector to Correct a Mouse Model of Hemophilia A
Author / Creator:Matsui, Hideto ; Fujimoto, Naoko ; Sasakawa, Noriko ; Ohinata, Yasuhide ; Shima, Midori ; Yamanaka, Shinya ; Sugimoto, Mitsuhiko ; Hotta, Akitsu
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-08, Vol.9 (8), p.e104957-e104957
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Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs
Author / Creator:Ikeda, Takashi ; Hikichi, Takafusa ; Miura, Hisashi ; Shibata, Hirofumi ; Mitsunaga, Kanae ; Yamada, Yosuke ; Woltjen, Knut ; Miyamoto, Kei ; Hiratani, Ichiro ; Yamada, Yasuhiro ; Hotta, Akitsu ; Yamamoto, Takuya ; Okita, Keisuke ; Masui, Shinji
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-04, Vol.9 (1), p.1387-15, Article 1387
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Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells
Author / Creator:Yamashita, Akihiro ; Liu, Shiying ; Woltjen, Knut ; Thomas, Bradley ; Meng, Guoliang ; Hotta, Akitsu ; Takahashi, Kazutoshi ; Ellis, James ; Yamanaka, Shinya ; Rancourt, Derrick E.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2013-06, Vol.3 (1), p.1978, Article 1978
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iPSC-derived type IV collagen α5-expressing kidney organoids model Alport syndrome
Author / Creator:Hirayama, Ryuichiro ; Toyohara, Kosuke ; Watanabe, Kei ; Otsuki, Takeya ; Araoka, Toshikazu ; Mae, Shin-Ichi ; Horinouchi, Tomoko ; Yamamura, Tomohiko ; Okita, Keisuke ; Hotta, Akitsu ; Iijima, Kazumoto ; Nozu, Kandai ; Osafune, Kenji
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2023-09, Vol.6 (1), p.854-854, Article 854
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571. Precise Control of CRISPR-Cas9 Mediated Gene Editing for Correcting Mutation of Duchenne Muscular Dystrophy in iPS Cells
Author / Creator:Li, Hongmei L. ; Sasakawa, Norko ; Ishida, Kentaro ; Gee, Peter ; Hotta, Akitsu
Publisher:Elsevier Inc
Journal title:Molecular therapy, 2015-05, Vol.23, p.S227-S227
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Contractile Activity of Myotubes Derived from Human Induced Pluripotent Stem Cells: A Model of Duchenne Muscular Dystrophy
Author / Creator:Yoshioka, Kantaro ; Ito, Akira ; Horie, Masanobu ; Ikeda, Kazushi ; Kataoka, Sho ; Sato, Keiichiro ; Yoshigai, Taichi ; Sakurai, Hidetoshi ; Hotta, Akitsu ; Kawabe, Yoshinori ; Kamihira, Masamichi
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2021-09, Vol.10 (10), p.2556
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565. Human Dystrophin Expression in Rag/Mdx Mice Muscles Following the Graft Off Genetically Corrected Dystrophic hiPSCs
Author / Creator:Gravel, William-Édouard ; Oulette, Dominique L. ; Maltais, Chantale ; Gérard, Catherine ; Li, Hongmei L. ; Hotta, Akitsu ; Tremblay, Jacques-P.
Publisher:Elsevier Inc
Journal title:Molecular therapy, 2016-05, Vol.24, p.S226-S226
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MECP2 Isoform-Specific Vectors with Regulated Expression for Rett Syndrome Gene Therapy
Author / Creator:Rastegar, Mojgan ; Hotta, Akitsu ; Pasceri, Peter ; Makarem, Maisam ; Cheung, Aaron Y. L. ; Elliott, Shauna ; Park, Katya J. ; Adachi, Megumi ; Jones, Frederick S. ; Clarke, Ian D. ; Dirks, Peter ; Ellis, James
Publisher:United States: Public Library of Science
Journal title:PloS one, 2009-08, Vol.4 (8), p.e6810-e6810
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CD151 expression marks atrial- and ventricular- differentiation from human induced pluripotent stem cells
Author / Creator:Nakanishi-Koakutsu, Misato ; Miki, Kenji ; Naka, Yuki ; Sasaki, Masako ; Wakimizu, Takayuki ; Napier, Stephanie C. ; Okubo, Chikako ; Narita, Megumi ; Nishikawa, Misato ; Hata, Reo ; Chonabayashi, Kazuhisa ; Hotta, Akitsu ; Imahashi, Kenichi ; Nishimoto, Tomoyuki ; Yoshida, Yoshinori
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2024-02, Vol.7 (1), p.231-14, Article 231
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Showing 1 to 20 of 37 results

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Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice

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Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping

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CRISPR-Cas3 induces broad and unidirectional genome editing in human cells

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Optimized simple culture protocol for inducing mature myotubes from MYOD1-overexpressed human iPS cells

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Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells

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Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro

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Establishment of quantitative and consistent in vitro skeletal muscle pathological models of myotonic dystrophy type 1 using patient-derived iPSCs

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Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy

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Constitutive heterochromatin reorganization during somatic cell reprogramming

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iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva

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Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency

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Delivery of Full-Length Factor VIII Using a piggyBac Transposon Vector to Correct a Mouse Model of Hemophilia A

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Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs

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Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells

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iPSC-derived type IV collagen α5-expressing kidney organoids model Alport syndrome

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571. Precise Control of CRISPR-Cas9 Mediated Gene Editing for Correcting Mutation of Duchenne Muscular Dystrophy in iPS Cells

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Contractile Activity of Myotubes Derived from Human Induced Pluripotent Stem Cells: A Model of Duchenne Muscular Dystrophy

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565. Human Dystrophin Expression in Rag/Mdx Mice Muscles Following the Graft Off Genetically Corrected Dystrophic hiPSCs

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MECP2 Isoform-Specific Vectors with Regulated Expression for Rett Syndrome Gene Therapy

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CD151 expression marks atrial- and ventricular- differentiation from human induced pluripotent stem cells

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