Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
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Author / Creator
Filbin, Mariella G. , Tirosh, Itay , Hovestadt, Volker , Shaw, McKenzie L. , Escalante, Leah E. , Mathewson, Nathan D. , Neftel, Cyril , Frank, Nelli , Pelton, Kristine , Hebert, Christine M. , Haberler, Christine , Yizhak, Keren , Gojo, Johannes , Egervari, Kristof , Mount, Christopher , van Galen, Peter , Bonal, Dennis M. , Nguyen, Quang-De , Beck, Alexander , Sinai, Claire , Czech, Thomas , Dorfer, Christian , Goumnerova, Liliana , Lavarino, Cinzia , Carcaboso, Angel M. , Mora, Jaume , Mylvaganam, Ravindra , Luo, Christina C. , Peyrl, Andreas , Popović, Mara , Azizi, Amedeo , Batchelor, Tracy T. , Frosch, Matthew P. , Martinez-Lage, Maria , Kieran, Mark W. , Bandopadhayay, Pratiti , Beroukhim, Rameen , Fritsch, Gerhard , Getz, Gad , Rozenblatt-Rosen, Orit , Wucherpfennig, Kai W. , Louis, David N. , Monje, Michelle , Slavc, Irene , Ligon, Keith L. , Golub, Todd R. , Regev, Aviv , Bernstein, Bradley E. and Suvà, Mario L.
Publisher
United States: The American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: The American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Diffuse midline gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) are an aggressive type of childhood cancer with few options for treatment. Filbin
et al.
used a single-cell sequencing approach to study the oncogenic programs, genetics, and cellular hierarchies of H3K27M-glioma. Tumors were mainly composed of cells rese...
Alternative Titles
Full title
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
Authors, Artists and Contributors
Author / Creator
Tirosh, Itay
Hovestadt, Volker
Shaw, McKenzie L.
Escalante, Leah E.
Mathewson, Nathan D.
Neftel, Cyril
Frank, Nelli
Pelton, Kristine
Hebert, Christine M.
Haberler, Christine
Yizhak, Keren
Gojo, Johannes
Egervari, Kristof
Mount, Christopher
van Galen, Peter
Bonal, Dennis M.
Nguyen, Quang-De
Beck, Alexander
Sinai, Claire
Czech, Thomas
Dorfer, Christian
Goumnerova, Liliana
Lavarino, Cinzia
Carcaboso, Angel M.
Mora, Jaume
Mylvaganam, Ravindra
Luo, Christina C.
Peyrl, Andreas
Popović, Mara
Azizi, Amedeo
Batchelor, Tracy T.
Frosch, Matthew P.
Martinez-Lage, Maria
Kieran, Mark W.
Bandopadhayay, Pratiti
Beroukhim, Rameen
Fritsch, Gerhard
Getz, Gad
Rozenblatt-Rosen, Orit
Wucherpfennig, Kai W.
Louis, David N.
Monje, Michelle
Slavc, Irene
Ligon, Keith L.
Golub, Todd R.
Regev, Aviv
Bernstein, Bradley E.
Suvà, Mario L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5949869
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5949869
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aao4750
