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125 results for Hyperinsulinism+-+pathology

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ArticlesPeer ReviewedFull Text
Inflammasome is a central player in the induction of obesity and insulin resistance
Author / Creator:Stienstra, Rinke ; van Diepen, Janna A ; Tack, Cees J ; Zaki, Md. Hasan ; van de Veerdonk, Frank L ; Perera, Deshani ; Neale, Geoffrey A ; Hooiveld, Guido J ; Hijmans, Anneke ; Vroegrijk, Irene ; van den Berg, Sjoerd ; Romijn, Johannes ; Rensen, Patrick C. N ; Joosten, Leo A. B ; Netea, Mihai G ; Kanneganti, Thirumala-Devi
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-09, Vol.108 (37), p.15324-15329
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Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity
Author / Creator:Ježek, Petr ; Jabůrek, Martin ; Holendová, Blanka ; Plecitá-Hlavatá, Lydie
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2018-06, Vol.23 (6), p.1483
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MAFA missense mutation causes familial insulinomatosis and diabetes mellitus
Author / Creator:Iacovazzo, Donato ; Flanagan, Sarah E. ; Walker, Emily ; Quezado, Rosana ; de Sousa Barros, Fernando Antonio ; Caswell, Richard ; Johnson, Matthew B. ; Wakeling, Matthew ; Brändle, Michael ; Guo, Min ; Dang, Mary N. ; Gabrovska, Plamena ; Niederle, Bruno ; Christ, Emanuel ; Jenni, Stefan ; Sipos, Bence ; Nieser, Maike ; Frilling, Andrea ; Dhatariya, Ketan ; Chanson, Philippe ; de Herder, Wouter W. ; Konukiewitz, Björn ; Klöppel, Günter ; Stein, Roland ; Korbonits, Márta ; Ellard, Sian
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-01, Vol.115 (5), p.1027-1032
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Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance
Author / Creator:Skovsø, Søs ; Panzhinskiy, Evgeniy ; Kolic, Jelena ; Cen, Haoning Howard ; Dionne, Derek A. ; Dai, Xiao-Qing ; Sharma, Rohit B. ; Elghazi, Lynda ; Ellis, Cara E. ; Faulkner, Katharine ; Marcil, Stephanie A. M. ; Overby, Peter ; Noursadeghi, Nilou ; Hutchinson, Daria ; Hu, Xiaoke ; Li, Hong ; Modi, Honey ; Wildi, Jennifer S. ; Botezelli, J. Diego ; Noh, Hye Lim ; Suk, Sujin ; Gablaski, Brian ; Bautista, Austin ; Kim, Ryekjang ; Cras-Méneur, Corentin ; Flibotte, Stephane ; Sinha, Sunita ; Luciani, Dan S. ; Nislow, Corey ; Rideout, Elizabeth J. ; Cytrynbaum, Eric N. ; Kim, Jason K. ; Bernal-Mizrachi, Ernesto ; Alonso, Laura C. ; MacDonald, Patrick E. ; Johnson, James D.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-02, Vol.13 (1), p.735-22, Article 735
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High-Fat Diet-Induced Adiposity, Adipose Inflammation, Hepatic Steatosis and Hyperinsulinemia in Outbred CD-1 Mice
Author / Creator:Gao, Mingming ; Ma, Yongjie ; Liu, Dexi
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-03, Vol.10 (3), p.e0119784-e0119784
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ArticlesPeer ReviewedFull Text
Postprandial Dyslipidemia, Hyperinsulinemia, and Impaired Gut Peptides/Bile Acids in Adolescents with Obesity
Author / Creator:Higgins, Victoria ; Asgari, Shervin ; Hamilton, Jill K ; Wolska, Anna ; Remaley, Alan T ; Hartmann, Bolette ; Holst, Jens J ; Adeli, Khosrow
Publisher:US: Oxford University Press
Journal title:The journal of clinical endocrinology and metabolism, 2020-04, Vol.105 (4), p.1228-1241
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Retinal Neurodegeneration in Euglycemic Hyperinsulinemia, Prediabetes, and Diabetes
Author / Creator:Ebrahimi, Moein ; Sivaprasad, Sobha ; Thompson, Paul ; Perry, George
Publisher:Basel, Switzerland: S. Karger AG
Journal title:Ophthalmic research, 2023-01, Vol.66 (1), p.385-397
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Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
Author / Creator:Rung, Johan ; Cauchi, Stéphane ; Albrechtsen, Anders ; Shen, Lishuang ; Rocheleau, Ghislain ; Cavalcanti-Proença, Christine ; Bacot, François ; Balkau, Beverley ; Belisle, Alexandre ; Borch-Johnsen, Knut ; Charpentier, Guillaume ; Dina, Christian ; Durand, Emmanuelle ; Elliott, Paul ; Hadjadj, Samy ; Järvelin, Marjo-Riitta ; Laitinen, Jaana ; Lauritzen, Torsten ; Marre, Michel ; Mazur, Alexander ; Meyre, David ; Montpetit, Alexandre ; Pisinger, Charlotta ; Posner, Barry ; Poulsen, Pernille ; Pouta, Anneli ; Prentki, Marc ; Ribel-Madsen, Rasmus ; Ruokonen, Aimo ; Sandbaek, Anelli ; Serre, David ; Tichet, Jean ; Vaxillaire, Martine ; Wojtaszewski, Jørgen F P ; Vaag, Allan ; Hansen, Torben ; Polychronakos, Constantin ; Pedersen, Oluf ; Froguel, Philippe ; Sladek, Robert
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2009-10, Vol.41 (10), p.1110-1115
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ArticlesPeer ReviewedFull Text
Clinical and Genetic Characterization of 153 Patients with Persistent or Transient Congenital Hyperinsulinism
Author / Creator:Männistö, Jonna M E ; Maria, Maleeha ; Raivo, Joose ; Kuulasmaa, Teemu ; Otonkoski, Timo ; Huopio, Hanna ; Laakso, Markku
Publisher:United States: Oxford University Press
Journal title:The journal of clinical endocrinology and metabolism, 2020-04, Vol.105 (4), p.e1686-e1694
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SUR1-mutant iPS cell-derived islets recapitulate the pathophysiology of congenital hyperinsulinism
Author / Creator:Lithovius, Väinö ; Saarimäki-Vire, Jonna ; Balboa, Diego ; Ibrahim, Hazem ; Montaser, Hossam ; Barsby, Tom ; Otonkoski, Timo
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2021-03, Vol.64 (3), p.630-640
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Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes
Author / Creator:Tornovsky-Babeay, Sharona ; Weinberg-Corem, Noa ; Ben-Haroush Schyr, Rachel ; Avrahami, Dana ; Lavi, Judith ; Feleke, Eseye ; Kaestner, Klaus H. ; Dor, Yuval ; Glaser, Benjamin
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2021-05, Vol.64 (5), p.1133-1143
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Metabolic Syndrome Is Associated with Increased Oxo-Nitrative Stress and Asthma-Like Changes in Lungs
Author / Creator:Singh, Vijay Pal ; Aggarwal, Rangoli ; Singh, Suchita ; Banik, Arpita ; Ahmad, Tanveer ; Patnaik, Bijay Ranjan ; Nappanveettil, Giridharan ; Singh, Kunal Pratap ; Aggarwal, Madan Lal ; Ghosh, Balaram ; Agrawal, Anurag
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-06, Vol.10 (6), p.e0129850-e0129850
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ArticlesPeer ReviewedFull Text
Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells
Author / Creator:Lee, Young ; Berglund, Eric D. ; Yu, Xinxin ; Wang, May-Yun ; Evans, Matthew R. ; Scherer, Philipp E. ; Holland, William L. ; Charron, Maureen J. ; Roth, Michael G. ; Unger, Roger H.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (36), p.13217-13222
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Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours
Author / Creator:Jiang, Xiuli ; Cao, Yanan ; Li, Feng ; Su, Yutong ; Li, Yanli ; Peng, Ying ; Cheng, Yulong ; Zhang, Changxian ; Wang, Weiqing ; Ning, Guang
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2014-12, Vol.5 (1), p.5809-5809, Article 5809
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Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR−/−.Leiden mice
Author / Creator:Morrison, M C ; Mulder, P ; Salic, K ; Verheij, J ; Liang, W ; van Duyvenvoorde, W ; Menke, A ; Kooistra, T ; Kleemann, R ; Wielinga, P Y
Publisher:London: Nature Publishing Group UK
Journal title:International Journal of Obesity, 2016-09, Vol.40 (9), p.1416-1423
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d-allulose Ameliorates Metabolic Dysfunction in C57BL/KsJ-db/db Mice
Author / Creator:Lee, Dayoun ; Han, Youngji ; Kwon, Eun-Young ; Choi, Myung-Sook
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2020-08, Vol.25 (16), p.3656
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Non-coding cis-regulatory variants in HK1 cause congenital hyperinsulinism with variable disease severity
Author / Creator:Bennett, Jasmin J. ; Saint-Martin, Cécile ; Neumann, Bianca ; Männistö, Jonna M. E. ; Houghton, Jayne A. L. ; Empting, Susann ; Johnson, Matthew B. ; Laver, Thomas W. ; Locke, Jonathan M. ; Spurrier, Benjamin ; Wakeling, Matthew N. ; Banerjee, Indraneel ; Dastamani, Antonia ; Demirbilek, Hüseyin ; Mitchell, John ; Stange, Markus ; Abi Warde, Marie-Thérèse ; Amrita, Mehta ; Aravena, Romy ; Arion, Alina ; Atapattu, Navoda ; Barić, Ivo ; Bertherat, Jérôme ; Bilici, Esra ; Bouchereau, Juliette ; Braun, Karine ; Campas-Lebecque, Marie-Neige ; Castanet, Mireille ; Cessans, Catie ; Conwell, Louise S. ; Dabadghao, Preeti ; Dayal Arya, Archana ; de Lonlay, Pascale ; de Vries, Liat ; Droumaguet, Céline ; Faure-Galon, Noémie ; Gilly, Olivier ; Goldenberg, Alice ; Guemann, Anne-Sophie ; Guerrot, Anne-Marie ; Harvengt, Julie ; Hassan, Samar S. ; Hui, Saw Shi ; Humayun, Khadija Nuzhat ; Ibrahim, M. ; Jain, Vandana ; Jeevarathnam, Dhivyalakshmi ; Loke, Kah Yin ; Khadilkar, Vaman ; Kochar, I. P. S. ; Kulkarni, Abhishek ; Kumbhojkar, Aniket ; Lamireau, Delphine ; Levy-Khademi, Floris ; Limbert, Catarina ; Lindner, Martin ; Lombard, Catherine ; Maillot, François ; Mention, Karine ; Mericq, Verónica ; Mohamed, Zainaba ; Mornet, Coline ; Murray, Philip ; Naccache, Alexandre ; Navasardyan, Lusine V. ; Neville, Kristen ; Nicolescu, Ramona ; Nicolino, Marc ; Nishimura-Meguro, Elisa ; Numsriskulrat, Nattakarn ; O’sullivan, Sinead ; Ouarezki, Yasmine ; Pambou, Armelle ; Petit, Florence ; Praveen, V. P. ; Priou-Guesdon, Mélanie ; Radka, Stoeva ; Rami-Merhar, Birgit ; Rao, Sudha ; Reznik, Yves ; Rulquin, Laurence ; Salomon Estebanez, Maria ; Souto, Isabelle ; Tabarin, Antoine ; Tangari, Ana ; Van Aken, Sara ; Verge, Charles ; Vinolas, Hélène ; Voinot, Christel ; Wagner, Robert ; Walker, Jan ; Wiltshire, Esko ; Mohnike, Klaus ; Arnoux, Jean-Baptiste ; Owens, Nick D. L. ; Zenker, Martin ; Bellanné-Chantelot, Christine ; Flanagan, Sarah E.
Publisher:England: BioMed Central Ltd
Journal title:Genome medicine, 2025-03, Vol.17 (1), p.17-11, Article 17
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Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human...
Author / Creator:Lefort, Natalie ; Glancy, Brian ; Bowen, Benjamin ; Willis, Wayne T. ; Bailowitz, Zachary ; De Filippis, Elena A. ; Brophy, Colleen ; Meyer, Christian ; Højlund, Kurt ; Yi, Zhengping ; Mandarino, Lawrence J.
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2010-10, Vol.59 (10), p.2444-2452
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Whey protein isolate inhibits hepatic FGF21 production, which precedes weight gain, hyperinsulinemia and hyperglycemia in mice fed a high-fat diet
Author / Creator:Nonogaki, Katsunori ; Kaji, Takao
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-09, Vol.10 (1), p.15784-15784, Article 15784
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Enhanced Islet Cell Nucleomegaly Defines Diffuse Congenital Hyperinsulinism in Infancy but Not Other Forms of the Disease
Author / Creator:Han, Bing ; Newbould, Melanie ; Batra, Gauri ; Cheesman, Edmund ; Craigie, Ross J. ; Mohamed, Zainab ; Rigby, Lindsey ; Padidela, Raja ; Skae, Mars ; Mironov, Aleksandr ; Starborg, Tobias ; Kadler, Karl E. ; Cosgrove, Karen E. ; Banerjee, Indraneel ; Dunne, Mark J.
Publisher:England: Oxford University Press
Journal title:American journal of clinical pathology, 2016-06, Vol.145 (6), p.757-768
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Inflammasome is a central player in the induction of obesity and insulin resistance

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Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity

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MAFA missense mutation causes familial insulinomatosis and diabetes mellitus

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Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

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High-Fat Diet-Induced Adiposity, Adipose Inflammation, Hepatic Steatosis and Hyperinsulinemia in Outbred CD-1 Mice

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Postprandial Dyslipidemia, Hyperinsulinemia, and Impaired Gut Peptides/Bile Acids in Adolescents with Obesity

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Retinal Neurodegeneration in Euglycemic Hyperinsulinemia, Prediabetes, and Diabetes

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Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

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Clinical and Genetic Characterization of 153 Patients with Persistent or Transient Congenital Hyperinsulinism

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SUR1-mutant iPS cell-derived islets recapitulate the pathophysiology of congenital hyperinsulinism

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Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes

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Metabolic Syndrome Is Associated with Increased Oxo-Nitrative Stress and Asthma-Like Changes in Lungs

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Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells

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Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours

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Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR−/−.Leiden mice

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d-allulose Ameliorates Metabolic Dysfunction in C57BL/KsJ-db/db Mice

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Non-coding cis-regulatory variants in HK1 cause congenital hyperinsulinism with variable disease severity

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Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human...

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Whey protein isolate inhibits hepatic FGF21 production, which precedes weight gain, hyperinsulinemia and hyperglycemia in mice fed a high-fat diet

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Enhanced Islet Cell Nucleomegaly Defines Diffuse Congenital Hyperinsulinism in Infancy but Not Other Forms of the Disease

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