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IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma
Author / Creator:Kofuji, Satoshi ; Hirayama, Akiyoshi ; Eberhardt, Alexander Otto ; Kawaguchi, Risa ; Sugiura, Yuki ; Sampetrean, Oltea ; Ikeda, Yoshiki ; Warren, Mikako ; Sakamoto, Naoya ; Kitahara, Shuji ; Yoshino, Hirofumi ; Yamashita, Daisuke ; Sumita, Kazutaka ; Wolfe, Kara ; Lange, Lisa ; Ikeda, Satsuki ; Shimada, Hiroko ; Minami, Noriaki ; Malhotra, Akshiv ; Morioka, Shin ; Ban, Yuki ; Asano, Maya ; Flanary, Victoria L. ; Ramkissoon, Annmarie ; Chow, Lionel M. L. ; Kiyokawa, Juri ; Mashimo, Tomoyuki ; Lucey, Greg ; Mareninov, Sergey ; Ozawa, Tatsuya ; Onishi, Nobuyuki ; Okumura, Koichi ; Terakawa, Jumpei ; Daikoku, Takiko ; Wise-Draper, Trisha ; Majd, Nazanin ; Kofuji, Kaori ; Sasaki, Mika ; Mori, Masaru ; Kanemura, Yonehiro ; Smith, Eric P. ; Anastasiou, Dimitrios ; Wakimoto, Hiroaki ; Holland, Eric C. ; Yong, William H. ; Horbinski, Craig ; Nakano, Ichiro ; DeBerardinis, Ralph J. ; Bachoo, Robert M. ; Mischel, Paul S. ; Yasui, Wataru ; Suematsu, Makoto ; Saya, Hideyuki ; Soga, Tomoyoshi ; Grummt, Ingrid ; Bierhoff, Holger ; Sasaki, Atsuo T.
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2019-08, Vol.21 (8), p.1003-1014
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IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways
Author / Creator:Duan, Shiyu ; Huang, Wenqing ; Liu, Xiaoting ; Liu, Xuming ; Chen, Nana ; Xu, Qiong ; Hu, Yukun ; Song, Wen ; Zhou, Jun
Publisher:England: BioMed Central Ltd
Journal title:Journal of experimental & clinical cancer research, 2018-12, Vol.37 (1), p.304-304, Article 304
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Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation
Author / Creator:Johnson, Matthew C ; Kollman, Justin M
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2020-01, Vol.9
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Molecular crowding facilitates bundling of IMPDH polymers and cytoophidium formation
Author / Creator:Chang, Chia-Chun ; Peng, Min ; Zhong, Jiale ; Zhang, Ziheng ; Keppeke, Gerson Dierley ; Sung, Li-Ying ; Liu, Ji-Long
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2022-08, Vol.79 (8), p.420-420, Article 420
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Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell
Author / Creator:Pawlowic, Mattie C. ; Somepalli, Mastanbabu ; Sateriale, Adam ; Herbert, Gillian T. ; Gibson, Alexis R. ; Cuny, Gregory D. ; Hedstrom, Lizbeth ; Striepen, Boris
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (42), p.21160-21165
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Bidirectional communication between oocytes and ovarian follicular somatic cells is required for meiotic arrest of mammalian oocytes
Author / Creator:Wigglesworth, Karen ; Lee, Kyung-Bon ; O’Brien, Marilyn J. ; Peng, Jia ; Matzuk, Martin M. ; Eppig, John J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (39), p.E3723-E3729
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Regulation of local GTP availability controls RAC1 activity and cell invasion
Author / Creator:Bianchi-Smiraglia, Anna ; Wolff, David W. ; Marston, Daniel J. ; Deng, Zhiyong ; Han, Zhannan ; Moparthy, Sudha ; Wombacher, Rebecca M. ; Mussell, Ashley L. ; Shen, Shichen ; Chen, Jialin ; Yun, Dong-Hyun ; O’Brien Cox, Anderson ; Furdui, Cristina M. ; Hurley, Edward ; Feltri, Maria Laura ; Qu, Jun ; Hollis, Thomas ; Kengne, Jules Berlin Nde ; Fongang, Bernard ; Sousa, Rui J. ; Kandel, Mikhail E. ; Kandel, Eugene S. ; Hahn, Klaus M. ; Nikiforov, Mikhail A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-10, Vol.12 (1), p.6091-6091, Article 6091
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Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia
Author / Creator:Tzoneva, Gannie ; Dieck, Chelsea L. ; Oshima, Koichi ; Ambesi-Impiombato, Alberto ; Sánchez-Martín, Marta ; Madubata, Chioma J. ; Khiabanian, Hossein ; Yu, Jiangyan ; Waanders, Esme ; Iacobucci, Ilaria ; Sulis, Maria Luisa ; Kato, Motohiro ; Koh, Katsuyoshi ; Paganin, Maddalena ; Basso, Giuseppe ; Gastier-Foster, Julie M. ; Loh, Mignon L. ; Kirschner-Schwabe, Renate ; Mullighan, Charles G. ; Rabadan, Raul ; Ferrando, Adolfo A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-01, Vol.553 (7689), p.511-514
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Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases
Author / Creator:Buey, Rubén M. ; Ledesma-Amaro, Rodrigo ; Velázquez-Campoy, Adrián ; Balsera, Mónica ; Chagoyen, Mónica ; de Pereda, José M. ; Revuelta, José L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-11, Vol.6 (1), p.8923-8923, Article 8923
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Deciphering the allosteric regulation of mycobacterial inosine-5′-monophosphate dehydrogenase
Author / Creator:Bulvas, Ondřej ; Knejzlík, Zdeněk ; Sýs, Jakub ; Filimoněnko, Anatolij ; Čížková, Monika ; Clarová, Kamila ; Rejman, Dominik ; Kouba, Tomáš ; Pichová, Iva
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-08, Vol.15 (1), p.6673-14, Article 6673
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Inosine monophosphate dehydrogenase 2 (IMPDH2) modulates response to therapy and chemo-resistance in triple negative breast cancer
Author / Creator:da Silva Fernandes, Tatiane ; Gillard, Bryan M. ; Dai, Tao ; Martin, Jeffrey C. ; Chaudhry, Kanita A. ; Dugas, Scott M. ; Fisher, Alyssa A. ; Sharma, Pia ; Wu, RongRong ; Attwood, Kristopher M. ; Dasgupta, Subhamoy ; Takabe, Kazuaki ; Rosario, Spencer R. ; Bianchi-Smiraglia, Anna
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-01, Vol.15 (1), p.1061-14, Article 1061
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Nuclear IMPDH2 controls the DNA damage response by modulating PARP1 activity
Author / Creator:Espinar, Lorena ; Garcia-Cao, Marta ; Schmidt, Alisa ; Kourtis, Savvas ; Gañez Zapater, Antoni ; Aranda-Vallejo, Carla ; Ghose, Ritobrata ; Garcia-Lopez, Laura ; Sheraj, Ilir ; Pardo-Lorente, Natalia ; Bantulà, Marina ; Pascual-Reguant, Laura ; Darai, Evangelia ; Guirola, Maria ; Montero, Joan ; Sdelci, Sara
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-11, Vol.15 (1), p.9515-20, Article 9515
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Induction of cytoplasmic rods and rings structures by inhibition of the CTP and GTP synthetic pathway in mammalian cells
Author / Creator:Carcamo, Wendy C ; Satoh, Minoru ; Kasahara, Hideko ; Terada, Naohiro ; Hamazaki, Takashi ; Chan, Jason Y F ; Yao, Bing ; Tamayo, Stephanie ; Covini, Giovanni ; von Mühlen, Carlos A ; Chan, Edward K L
Publisher:United States: Public Library of Science
Journal title:PloS one, 2011-12, Vol.6 (12), p.e29690-e29690
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Mycophenolate Mofetil, an Inhibitor of Inosine Monophosphate Dehydrogenase, and Tofacitinib, a Janus Kinase Inhibitor, Attenuate Airway Inflammation and Hyperresponsiveness in a Mouse Model of Allergi...
Author / Creator:Kravčenia, Bernard ; Maślanka, Tomasz
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2024-11, Vol.29 (22), p.5293
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Nuclear IMPDH Filaments in Human Gliomas
Author / Creator:Ahangari, Narges ; Munoz, David G ; Coulombe, Josee ; Gray, Douglas A ; Engle, Elizabeth C ; Cheng, Long ; Woulfe, John
Publisher:England: Oxford University Press
Journal title:Journal of neuropathology and experimental neurology, 2021-10, Vol.80 (10), p.944-954
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IMPDH Inhibition Decreases TERT Expression and Synergizes the Cytotoxic Effect of Chemotherapeutic Agents in Glioblastoma Cells
Author / Creator:Liu, Xiaoqin ; Wang, Junying ; Wu, Laura J ; Trinh, Britni ; Tsai, Robert Y L
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2024-06, Vol.25 (11), p.5992
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Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer
Author / Creator:Huang, Yuting ; Chan, Szehoi ; Chen, Shuna ; Liu, Xueqi ; Li, Miao ; Zheng, Liyuan ; Dong, Zhaoxia ; Yang, Ziyi ; Liu, Zixuan ; Zhou, Disheng ; Zhang, Xingding ; Zhang, Bo
Publisher:England: BioMed Central
Journal title:Journal of translational medicine, 2024-02, Vol.22 (1), p.133-18, Article 133
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MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells
Author / Creator:Zhao, Jun-Zhang ; Wang, Wei ; Liu, Tao ; Zhang, Lei ; Lin, De-Zheng ; Yao, Jia-Yin ; Peng, Xiang ; Jin, Gang ; Ma, Tian-Tian ; Gao, Jin-Bo ; Huang, Fang ; Nie, Jun ; Lv, Qing
Publisher:England: BioMed Central Ltd
Journal title:BMC cancer, 2022-12, Vol.22 (1), p.1290-1290, Article 1290
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A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases
Author / Creator:Buey, Rubén M. ; Fernández-Justel, David ; Marcos-Alcalde, Íñigo ; Winter, Graeme ; Gómez-Puertas, Paulino ; de Pereda, José María ; Luis Revuelta, José
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-06, Vol.7 (1), p.2648-12, Article 2648
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Glutamine deprivation initiates reversible assembly of mammalian rods and rings
Author / Creator:Calise, S. John ; Carcamo, Wendy C ; Krueger, Claire ; Yin, Joyce D ; Purich, Daniel L ; Chan, Edward K. L
Publisher:Basel: Springer-Verlag
Journal title:Cellular and molecular life sciences : CMLS, 2014-08, Vol.71 (15), p.2963-2973
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Showing 1 to 20 of 81 results

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IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

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IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways

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Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation

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Molecular crowding facilitates bundling of IMPDH polymers and cytoophidium formation

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Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell

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Bidirectional communication between oocytes and ovarian follicular somatic cells is required for meiotic arrest of mammalian oocytes

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Regulation of local GTP availability controls RAC1 activity and cell invasion

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Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia

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Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases

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Deciphering the allosteric regulation of mycobacterial inosine-5′-monophosphate dehydrogenase

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Inosine monophosphate dehydrogenase 2 (IMPDH2) modulates response to therapy and chemo-resistance in triple negative breast cancer

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Nuclear IMPDH2 controls the DNA damage response by modulating PARP1 activity

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Induction of cytoplasmic rods and rings structures by inhibition of the CTP and GTP synthetic pathway in mammalian cells

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Mycophenolate Mofetil, an Inhibitor of Inosine Monophosphate Dehydrogenase, and Tofacitinib, a Janus Kinase Inhibitor, Attenuate Airway Inflammation and Hyperresponsiveness in a Mouse Model of Allergi...

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Nuclear IMPDH Filaments in Human Gliomas

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IMPDH Inhibition Decreases TERT Expression and Synergizes the Cytotoxic Effect of Chemotherapeutic Agents in Glioblastoma Cells

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Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer

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MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells

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A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases

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Glutamine deprivation initiates reversible assembly of mammalian rods and rings

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