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Inoki, Ken
Journal title:American Men & Women of Science : A Biographical Directory of Today’s Leaders in Physical, Biological and Related Sciences: ING-KNI, 2022, p.5356-5356
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Inoki, Ken
Journal title:American Men & Women of Science : A Biographical Directory of Today’s Leaders in Physical, Biological and Related Sciences: ING-KNI, 2021, p.5335-5335
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ArticlesPeer ReviewedFull Text
LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
Author / Creator:Hong, Sungki ; Freeberg, Mallory A ; Han, Ting ; Kamath, Avani ; Yao, Yao ; Fukuda, Tomoko ; Suzuki, Tsukasa ; Kim, John K ; Inoki, Ken
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2017-06, Vol.6
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PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity
Author / Creator:Hasegawa, Junya ; Tokuda, Emi ; Yao, Yao ; Sasaki, Takehiko ; Inoki, Ken ; Weisman, Lois S
Publisher:United States: The American Society for Cell Biology
Journal title:Molecular biology of the cell, 2022-03, Vol.33 (3), p.ar26-ar26
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SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes
Author / Creator:Schaub, Jennifer A ; AlAkwaa, Fadhl M ; McCown, Phillip J ; Naik, Abhijit S ; Nair, Viji ; Eddy, Sean ; Menon, Rajasree ; Otto, Edgar A ; Demeke, Dawit ; Hartman, John ; Fermin, Damian ; O'Connor, Christopher L ; Subramanian, Lalita ; Bitzer, Markus ; Harned, Roger ; Ladd, Patricia ; Pyle, Laura ; Pennathur, Subramaniam ; Inoki, Ken ; Hodgin, Jeffrey B ; Brosius, 3rd, Frank C ; Nelson, Robert G ; Kretzler, Matthias ; Bjornstad, Petter
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2023-03, Vol.133 (5)
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Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR
Author / Creator:Zhang, Xiaoli ; Chen, Wei ; Gao, Qiong ; Yang, Junsheng ; Yan, Xueni ; Zhao, Han ; Su, Lin ; Yang, Meimei ; Gao, Chenlang ; Yao, Yao ; Inoki, Ken ; Li, Dan ; Shao, Rong ; Wang, Shiyi ; Sahoo, Nirakar ; Kudo, Fumitaka ; Eguchi, Tadashi ; Ruan, Benfang ; Xu, Haoxing
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2019-05, Vol.17 (5), p.e3000252-e3000252
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ArticlesPeer ReviewedFull Text
mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice
Author / Creator:Inoki, Ken ; Mori, Hiroyuki ; Wang, Junying ; Suzuki, Tsukasa ; Hong, SungKi ; Yoshida, Sei ; Blattner, Simone M ; Ikenoue, Tsuneo ; Rüegg, Markus A ; Hall, Michael N ; Kwiatkowski, David J ; Rastaldi, Maria P ; Huber, Tobias B ; Kretzler, Matthias ; Holzman, Lawrence B ; Wiggins, Roger C ; Guan, Kun-Liang
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2011-06, Vol.121 (6), p.2181-2196
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Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes
Author / Creator:Narita, Masako ; Young, Andrew R. J. ; Arakawa, Satoko ; Samarajiwa, Shamith A. ; Nakashima, Takayuki ; Yoshida, Sei ; Hong, Sungki ; Berry, Lorraine S. ; Reichelt, Stefanie ; Ferreira, Manuela ; Tavaré, Simon ; Inoki, Ken ; Shimizu, Shigeomi ; Narita, Masashi
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2011-05, Vol.332 (6032), p.966-970
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ArticlesPeer ReviewedFull Text
mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism
Author / Creator:Tang, Huibin ; Inoki, Ken ; Brooks, Susan V. ; Okazawa, Hideki ; Lee, Myung ; Wang, Junying ; Kim, Michael ; Kennedy, Catherine L. ; Macpherson, Peter C. D. ; Ji, Xuhuai ; Van Roekel, Sabrina ; Fraga, Danielle A. ; Wang, Kun ; Zhu, Jinguo ; Wang, Yoyo ; Sharp, Zelton D. ; Miller, Richard A. ; Rando, Thomas A. ; Goldman, Daniel ; Guan, Kun‐Liang ; Shrager, Joseph B.
Publisher:England: John Wiley & Sons, Inc
Journal title:Aging cell, 2019-06, Vol.18 (3), p.e12943-n/a
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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
Author / Creator:Alexander, Angela ; Cai, Sheng-Li ; Kim, Jinhee ; Nanez, Adrian ; Sahin, Mustafa ; MacLean, Kirsteen H ; Inoki, Ken ; Guan, Kun-Liang ; Shen, Jianjun ; Person, Maria D ; Kusewitt, Donna ; Mills, Gordon B ; Kastan, Michael B ; Walker, Cheryl Lyn
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-03, Vol.107 (9), p.4153-4158
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ArticlesPeer ReviewedFull Text
Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells
Author / Creator:Yao, Yao ; Jones, Edith ; Inoki, Ken
Publisher:Switzerland: MDPI AG
Journal title:Biomolecules (Basel, Switzerland), 2017-07, Vol.7 (3), p.51
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ArticlesPeer ReviewedFull Text
Role of mTOR in podocyte function and diabetic nephropathy in humans and mice
Author / Creator:Gödel, Markus ; Hartleben, Björn ; Herbach, Nadja ; Liu, Shuya ; Zschiedrich, Stefan ; Lu, Shun ; Debreczeni-Mór, Andrea ; Lindenmeyer, Maja T ; Rastaldi, Maria-Pia ; Hartleben, Götz ; Wiech, Thorsten ; Fornoni, Alessia ; Nelson, Robert G ; Kretzler, Matthias ; Wanke, Rüdiger ; Pavenstädt, Hermann ; Kerjaschki, Dontscho ; Cohen, Clemens D ; Hall, Michael N ; Rüegg, Markus A ; Inoki, Ken ; Walz, Gerd ; Huber, Tobias B
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2011-06, Vol.121 (6), p.2197-2209
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Dysregulation of the TSC-mTOR pathway in human disease
Author / Creator:Inoki, Ken ; Corradetti, Michael N ; Guan, Kun-Liang
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2005-01, Vol.37 (1), p.19-24
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Ume6 transcription factor is part of a signaling cascade that regulates autophagy
Author / Creator:Bartholomew, Clinton R ; Suzuki, Tsukasa ; Du, Zhou ; Backues, Steven K ; Jin, Meiyan ; Lynch-Day, Melinda A ; Umekawa, Midori ; Kamath, Avani ; Zhao, Mantong ; Xie, Zhiping ; Inoki, Ken ; Klionsky, Daniel J
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (28), p.11206-11210
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Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53
Author / Creator:Lee, Chung-Han ; Inoki, Ken ; Karbowniczek, Magdalena ; Petroulakis, Emmanuel ; Sonenberg, Nahum ; Henske, Elizabeth Petri ; Guan, Kun-Liang
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2007-11, Vol.26 (23), p.4812-4823
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The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures
Author / Creator:Mori, Hiroyuki ; Dugan, Colleen E ; Nishii, Akira ; Benchamana, Ameena ; Li, Ziru ; Cadenhead, 4th, Thomas S ; Das, Arun K ; Evans, Charles R ; Overmyer, Katherine A ; Romanelli, Steven M ; Peterson, Sydney K ; Bagchi, Devika P ; Corsa, Callie A ; Hardij, Julie ; Learman, Brian S ; El Azzouny, Mahmoud ; Coon, Joshua J ; Inoki, Ken ; MacDougald, Ormond A
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2021-05, Vol.19 (5), p.e3000988-e3000988
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Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy
Author / Creator:Zhou, Xiaoming ; Ikenoue, Tsuneo ; Chen, Xiaowei ; Li, Li ; Inoki, Ken ; Guan, Kun-Liang
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-06, Vol.106 (22), p.8923-8928
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TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity
Author / Creator:Yang, Q ; Inoki, K ; Kim, E ; Guan, K.L
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (18), p.6811-6816
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Rag GTPases regulate cellular amino acid homeostasis
Author / Creator:Inoki, Ken ; Guan, Kun-Liang
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2022-02, Vol.119 (8), p.1-3
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Macropinocytosis, mTORC1 and cellular growth control
Author / Creator:Yoshida, Sei ; Pacitto, Regina ; Inoki, Ken ; Swanson, Joel
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2018-04, Vol.75 (7), p.1227-1239
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Inoki, Ken

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Inoki, Ken

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LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

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PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity

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SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes

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Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

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mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

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Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

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mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism

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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

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Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells

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Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

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Dysregulation of the TSC-mTOR pathway in human disease

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Ume6 transcription factor is part of a signaling cascade that regulates autophagy

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Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53

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The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures

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Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy

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TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

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Rag GTPases regulate cellular amino acid homeostasis

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Macropinocytosis, mTORC1 and cellular growth control

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