Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage...
Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53
About this item
Full title
Author / Creator
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publication information
Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Scope and Contents
Contents
Miscoordination of growth and proliferation with the cellular stress response can lead to tumorigenesis. Mammalian target of rapamycin (mTOR), a central cell growth controller, is highly activated in some malignant neoplasms, and its clinical implications are under extensive investigation. We show that constitutive mTOR activity amplifies p53 activ...
Alternative Titles
Full title
Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2099465
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2099465
Other Identifiers
ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/sj.emboj.7601900
