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ArticlesPeer ReviewedFull Text
Engineering an allosteric transcription factor to respond to new ligands
Author / Creator:Taylor, Noah D ; Garruss, Alexander S ; Moretti, Rocco ; Chan, Sum ; Arbing, Mark A ; Cascio, Duilio ; Rogers, Jameson K ; Isaacs, Farren J ; Kosuri, Sriram ; Baker, David ; Fields, Stanley ; Church, George M ; Raman, Srivatsan
Publisher:New York: Nature Publishing Group US
Journal title:Nature methods, 2016-02, Vol.13 (2), p.177-183
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Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids
Author / Creator:Amiram, Miriam ; Haimovich, Adrian D ; Fan, Chenguang ; Wang, Yane-Shih ; Aerni, Hans-Rudolf ; Ntai, Ioanna ; Moonan, Daniel W ; Ma, Natalie J ; Rovner, Alexis J ; Hong, Seok Hoon ; Kelleher, Neil L ; Goodman, Andrew L ; Jewett, Michael C ; Söll, Dieter ; Rinehart, Jesse ; Isaacs, Farren J
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2015-12, Vol.33 (12), p.1272-1279
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ArticlesPeer ReviewedFull Text
Genomically Recoded Organisms Expand Biological Functions
Author / Creator:Lajoie, Marc J. ; Rovner, Alexis J. ; Goodman, Daniel B. ; Aerni, Hans-Rudolf ; Haimovich, Adrian D. ; Kuznetsov, Gleb ; Mercer, Jaron A. ; Wang, Harris H. ; Carr, Peter A. ; Mosberg, Joshua A. ; Rohland, Nadin ; Schultz, Peter G. ; Jacobson, Joseph M. ; Rinehart, Jesse ; Church, George M. ; Isaacs, Farren J.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2013-10, Vol.342 (6156), p.357-360
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Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids
Author / Creator:Martin, Rey W. ; Des Soye, Benjamin J. ; Kwon, Yong-Chan ; Kay, Jennifer ; Davis, Roderick G. ; Thomas, Paul M. ; Majewska, Natalia I. ; Chen, Cindy X. ; Marcum, Ryan D. ; Weiss, Mary Grace ; Stoddart, Ashleigh E. ; Amiram, Miriam ; Ranji Charna, Arnaz K. ; Patel, Jaymin R. ; Isaacs, Farren J. ; Kelleher, Neil L. ; Hong, Seok Hoon ; Jewett, Michael C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-03, Vol.9 (1), p.1203-9, Article 1203
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Enhanced eMAGE applied to identify genetic factors of nuclear hormone receptor dysfunction via combinatorial gene editing
Author / Creator:Ciaccia, Peter N. ; Liang, Zhuobin ; Schweitzer, Anabel Y. ; Metzner, Eli ; Isaacs, Farren J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-06, Vol.15 (1), p.5218-11, Article 5218
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ArticlesPeer ReviewedFull Text
Targeted editing and evolution of engineered ribosomes in vivo by filtered editing
Author / Creator:Radford, Felix ; Elliott, Shane D. ; Schepartz, Alanna ; Isaacs, Farren J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-01, Vol.13 (1), p.180-13, Article 180
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ArticlesPeer ReviewedFull Text
The Genome Project–Write
Author / Creator:Boeke, Jef D. ; Church, George ; Hessel, Andrew ; Kelley, Nancy J. ; Arkin, Adam ; Cai, Yizhi ; Carlson, Rob ; Chakravarti, Aravinda ; Cornish, Virginia W. ; Holt, Liam ; Isaacs, Farren J. ; Kuiken, Todd ; Lajoie, Marc ; Lessor, Tracy ; Lunshof, Jeantine ; Maurano, Matthew T. ; Mitchell, Leslie A. ; Rine, Jasper ; Rosser, Susan ; Sanjana, Neville E. ; Silver, Pamela A. ; Valle, David ; Wang, Harris ; Way, Jeffrey C. ; Yang, Luhan
Publisher:Washington: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2016-07, Vol.353 (6295), p.126-127
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Rapid editing and evolution of bacterial genomes using libraries of synthetic DNA
Author / Creator:Gallagher, Ryan R ; Li, Zhe ; Lewis, Aaron O ; Isaacs, Farren J
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2014-10, Vol.9 (10), p.2301-2316
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Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement
Author / Creator:Isaacs, Farren J. ; Carr, Peter A. ; Wang, Harris H. ; Lajoie, Marc J. ; Sterling, Bram ; Kraal, Laurens ; Tolonen, Andrew C. ; Gianoulis, Tara A. ; Goodman, Daniel B. ; Reppas, Nikos B. ; Emig, Christopher J. ; Bang, Duhee ; Hwang, Samuel J. ; Jewett, Michael C. ; Jacobson, Joseph M. ; Church, George M.
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2011-07, Vol.333 (6040), p.348-353
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ArticlesPeer ReviewedFull Text
Protein nanowires with tunable functionality and programmable self-assembly using sequence-controlled synthesis
Author / Creator:Shapiro, Daniel Mark ; Mandava, Gunasheil ; Yalcin, Sibel Ebru ; Arranz-Gibert, Pol ; Dahl, Peter J. ; Shipps, Catharine ; Gu, Yangqi ; Srikanth, Vishok ; Salazar-Morales, Aldo I. ; O’Brien, J. Patrick ; Vanderschuren, Koen ; Vu, Dennis ; Batista, Victor S. ; Malvankar, Nikhil S. ; Isaacs, Farren J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-02, Vol.13 (1), p.829-829, Article 829
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ArticlesPeer ReviewedFull Text
A flexible codon in genomically recoded Escherichia coli permits programmable protein phosphorylation
Author / Creator:Pirman, Natasha L. ; Barber, Karl W. ; Aerni, Hans R. ; Ma, Natalie J. ; Haimovich, Adrian D. ; Rogulina, Svetlana ; Isaacs, Farren J. ; Rinehart, Jesse
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-09, Vol.6 (1), p.8130-8130, Article 8130
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ArticlesPeer ReviewedFull Text
Precise manipulation of bacterial chromosomes by conjugative assembly genome engineering
Author / Creator:Ma, Natalie J ; Moonan, Daniel W ; Isaacs, Farren J
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2014-10, Vol.9 (10), p.2285-2300
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ArticlesPeer ReviewedFull Text
Encoding human serine phosphopeptides in bacteria for proteome-wide identification of phosphorylation-dependent interactions
Author / Creator:Barber, Karl W ; Muir, Paul ; Szeligowski, Richard V ; Rogulina, Svetlana ; Gerstein, Mark ; Sampson, Jeffrey R ; Isaacs, Farren J ; Rinehart, Jesse
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2018-08, Vol.36 (7), p.638-644
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ArticlesPeer ReviewedFull Text
Tracking, tuning, and terminating microbial physiology using synthetic riboregulators
Author / Creator:Callura, Jarred M. ; Dwyer, Daniel J. ; Isaacs, Farren J. ; Cantor, Charles R. ; Collins, James J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (36), p.15898-15903
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ArticlesPeer ReviewedFull Text
Organisms with alternative genetic codes resolve unassigned codons via mistranslation and ribosomal rescue
Author / Creator:Ma, Natalie Jing ; Hemez, Colin F ; Barber, Karl W ; Rinehart, Jesse ; Isaacs, Farren J
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2018-10, Vol.7
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ArticlesPeer ReviewedFull Text
The Role of Orthogonality in Genetic Code Expansion
Author / Creator:Arranz-Gibert, Pol ; Patel, Jaymin R ; Isaacs, Farren J
Publisher:Switzerland: MDPI AG
Journal title:Life (Basel, Switzerland), 2019-07, Vol.9 (3), p.58
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Prediction and Measurement of an Autoregulatory Genetic Module
Author / Creator:Isaacs, Farren J. ; Hasty, Jeff ; Cantor, Charles R. ; Collins, J. J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2003-06, Vol.100 (13), p.7714-7719
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Hydrogel-based biocontainment of bacteria for continuous sensing and computation
Author / Creator:Tang, Tzu-Chieh ; Tham, Eléonore ; Liu, Xinyue ; Yehl, Kevin ; Rovner, Alexis J. ; Yuk, Hyunwoo ; de la Fuente-Nunez, Cesar ; Isaacs, Farren J. ; Zhao, Xuanhe ; Lu, Timothy K.
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2021-06, Vol.17 (6), p.724-731
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ArticlesPeer ReviewedFull Text
Programming cells by multiplex genome engineering and accelerated evolution
Author / Creator:Wang, Harris H. ; Isaacs, Farren J. ; Carr, Peter A. ; Sun, Zachary Z. ; Xu, George ; Forest, Craig R. ; Church, George M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2009-08, Vol.460 (7257), p.894-898
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ArticlesPeer ReviewedFull Text
Recoded organisms engineered to depend on synthetic amino acids
Author / Creator:Rovner, Alexis J. ; Haimovich, Adrian D. ; Katz, Spencer R. ; Li, Zhe ; Grome, Michael W. ; Gassaway, Brandon M. ; Amiram, Miriam ; Patel, Jaymin R. ; Gallagher, Ryan R. ; Rinehart, Jesse ; Isaacs, Farren J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-02, Vol.518 (7537), p.89-93
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Engineering an allosteric transcription factor to respond to new ligands

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Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids

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Genomically Recoded Organisms Expand Biological Functions

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Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids

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Enhanced eMAGE applied to identify genetic factors of nuclear hormone receptor dysfunction via combinatorial gene editing

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Targeted editing and evolution of engineered ribosomes in vivo by filtered editing

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The Genome Project–Write

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Rapid editing and evolution of bacterial genomes using libraries of synthetic DNA

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Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement

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Protein nanowires with tunable functionality and programmable self-assembly using sequence-controlled synthesis

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A flexible codon in genomically recoded Escherichia coli permits programmable protein phosphorylation

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Precise manipulation of bacterial chromosomes by conjugative assembly genome engineering

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Encoding human serine phosphopeptides in bacteria for proteome-wide identification of phosphorylation-dependent interactions

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Tracking, tuning, and terminating microbial physiology using synthetic riboregulators

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Organisms with alternative genetic codes resolve unassigned codons via mistranslation and ribosomal rescue

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The Role of Orthogonality in Genetic Code Expansion

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Prediction and Measurement of an Autoregulatory Genetic Module

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Hydrogel-based biocontainment of bacteria for continuous sensing and computation

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Programming cells by multiplex genome engineering and accelerated evolution

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Recoded organisms engineered to depend on synthetic amino acids

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