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ArticlesPeer ReviewedFull Text
Challenges in developing personalized neoantigen cancer vaccines
Author / Creator:Katsikis, Peter D. ; Ishii, Ken J. ; Schliehe, Christopher
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Immunology, 2024-03, Vol.24 (3), p.213-227
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Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination
Author / Creator:Desmet, Christophe J. ; Ishii, Ken J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Immunology, 2012-07, Vol.12 (7), p.479-491
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Virological characteristics of the SARS-CoV-2 JN.1 variant
Author / Creator:Kaku, Yu ; Okumura, Kaho ; Padilla-Blanco, Miguel ; Kosugi, Yusuke ; Uriu, Keiya ; Hinay, Alfredo A ; Chen, Luo ; Plianchaisuk, Arnon ; Kobiyama, Kouji ; Ishii, Ken J ; Zahradnik, Jiri ; Ito, Jumpei ; Sato, Kei
Publisher:United States: Elsevier Limited
Journal title:The Lancet infectious diseases, 2024-02, Vol.24 (2), p.e82-e82
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ArticlesPeer ReviewedFull Text
Tissue-specific immunopathology during malaria infection
Author / Creator:Coban, Cevayir ; Lee, Michelle Sue Jann ; Ishii, Ken J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Immunology, 2018-04, Vol.18 (4), p.266-278
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ArticlesPeer ReviewedFull Text
DNA released from dying host cells mediates aluminum adjuvant activity
Author / Creator:Marichal, Thomas ; Ohata, Keiichi ; Bedoret, Denis ; Mesnil, Claire ; Sabatel, Catherine ; Kobiyama, Kouji ; Lekeux, Pierre ; Coban, Cevayir ; Akira, Shizuo ; Ishii, Ken J ; Bureau, Fabrice ; Desmet, Christophe J
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2011-08, Vol.17 (8), p.996-1002
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ArticlesPeer ReviewedFull Text
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking
Author / Creator:Kondo, Takeshi ; Kobayashi, Junya ; Saitoh, Tatsuya ; Maruyama, Kenta ; Ishii, Ken J. ; Barber, Glen N. ; Komatsu, Kenshi ; Akira, Shizuo ; Kawai, Taro
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (8), p.2969-2974
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Contribution of IL-33–activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice
Author / Creator:Yasuda, Koubun ; Muto, Taichiro ; Kawagoe, Tatsukata ; Matsumoto, Makoto ; Sasaki, Yuki ; Matsushita, Kazufumi ; Taki, Yuko ; Futatsugi-Yumikura, Shizue ; Tsutsui, Hiroko ; Ishii, Ken J ; Yoshimoto, Tomohiro ; Akira, Shizuo ; Nakanishi, Kenji
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (9), p.3451-3456
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ArticlesPeer ReviewedFull Text
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Author / Creator:Kawai, Taro ; Takahashi, Ken ; Sato, Shintaro ; Coban, Cevayir ; Kumar, Himanshu ; Kato, Hiroki ; Ishii, Ken J ; Takeuchi, Osamu ; Akira, Shizuo
Publisher:New York: Nature Publishing Group US
Journal title:Nature Immunology, 2005-10, Vol.6 (10), p.981-988
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Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5
Author / Creator:Uematsu, Satoshi ; Fujimoto, Kosuke ; Jang, Myoung Ho ; Yang, Bo-Gie ; Jung, Yun-Jae ; Nishiyama, Mika ; Sato, Shintaro ; Tsujimura, Tohru ; Yamamoto, Masafumi ; Yokota, Yoshifumi ; Kiyono, Hiroshi ; Miyasaka, Masayuki ; Ishii, Ken J ; Akira, Shizuo
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2008-07, Vol.9 (7), p.769-776
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ArticlesPeer ReviewedFull Text
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
Author / Creator:Ishii, Ken J. ; Kawagoe, Tatsukata ; Koyama, Shohei ; Matsui, Kosuke ; Kumar, Himanshu ; Kawai, Taro ; Uematsu, Satoshi ; Takeuchi, Osamu ; Takeshita, Fumihiko ; Coban, Cevayir ; Akira, Shizuo
Publisher:London: Nature Publishing Group UK
Journal title:Nature, 2008-02, Vol.451 (7179), p.725-729
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Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis
Author / Creator:Ohta, Tomokazu ; Sugiyama, Masanaka ; Hemmi, Hiroaki ; Yamazaki, Chihiro ; Okura, Soichiro ; Sasaki, Izumi ; Fukuda, Yuri ; Orimo, Takashi ; Ishii, Ken J. ; Hoshino, Katsuaki ; Ginhoux, Florent ; Kaisho, Tsuneyasu
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-03, Vol.6 (1), p.23505-23505, Article 23505
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ArticlesPeer ReviewedFull Text
Atg5-Atg12 conjugate associates with innate antiviral immune responses
Author / Creator:Jounai, Nao ; Takeshita, Fumihiko ; Kobiyama, Kouji ; Sawano, Asako ; Miyawaki, Atsushi ; Xin, Ke-Qin ; Ishii, Ken J ; Kawai, Taro ; Akira, Shizuo ; Suzuki, Koichi ; Okuda, Kenji
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2007-08, Vol.104 (35), p.14050-14055
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ArticlesPeer ReviewedFull Text
Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist
Author / Creator:Kobiyama, Kouji ; Aoshi, Taiki ; Narita, Hirotaka ; Kuroda, Etsushi ; Hayashi, Masayuki ; Tetsutani, Kohhei ; Koyama, Shohei ; Mochizuki, Shinichi ; Sakurai, Kazuo ; Katakai, Yuko ; Yasutomi, Yasuhiro ; Saijo, Shinobu ; Iwakura, Yoichiro ; Akira, Shizuo ; Coban, Cevayir ; Ishii, Ken J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-02, Vol.111 (8), p.3086-3091
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ArticlesPeer ReviewedFull Text
CpG ODN (K3)—toll-like receptor 9 agonist—induces Th1-type immune response and enhances cytotoxic activity in advanced lung cancer patients: a phase I study
Author / Creator:Otsuka, Tomoyuki ; Nishida, Sumiyuki ; Shibahara, Takayuki ; Temizoz, Burcu ; Hamaguchi, Masanari ; Shiroyama, Takayuki ; Kimura, Keiko ; Miyake, Kotaro ; Hirata, Haruhiko ; Mizuno, Yumiko ; Yagita, Mayu ; Manabe, Yusuke ; Kuroda, Etsushi ; Takeda, Yoshito ; Kida, Hiroshi ; Ishii, Ken J. ; Kumanogoh, Atsushi
Publisher:London: BioMed Central Ltd
Journal title:BMC cancer, 2022-07, Vol.22 (1), p.1-744, Article 744
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ArticlesPeer ReviewedFull Text
Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome
Author / Creator:Takemura, Naoki ; Kawasaki, Takumi ; Kunisawa, Jun ; Sato, Shintaro ; Lamichhane, Aayam ; Kobiyama, Kouji ; Aoshi, Taiki ; Ito, Junichi ; Mizuguchi, Kenji ; Karuppuchamy, Thangaraj ; Matsunaga, Kouta ; Miyatake, Shoichiro ; Mori, Nobuko ; Tsujimura, Tohru ; Satoh, Takashi ; Kumagai, Yutaro ; Kawai, Taro ; Standley, Daron M. ; Ishii, Ken J. ; Kiyono, Hiroshi ; Akira, Shizuo ; Uematsu, Satoshi
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2014-03, Vol.5 (1), p.3492, Article 3492
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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Author / Creator:Kato, Hiroki ; Takeuchi, Osamu ; Sato, Shintaro ; Yoneyama, Mitsutoshi ; Yamamoto, Masahiro ; Matsui, Kosuke ; Uematsu, Satoshi ; Jung, Andreas ; Kawai, Taro ; Ishii, Ken J. ; Yamaguchi, Osamu ; Otsu, Kinya ; Tsujimura, Tohru ; Koh, Chang-Sung ; Reis e Sousa, Caetano ; Matsuura, Yoshiharu ; Fujita, Takashi ; Akira, Shizuo
Publisher:London: Nature Publishing Group UK
Journal title:Nature, 2006-05, Vol.441 (7089), p.101-105
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Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
Author / Creator:Adachi, Yu ; Tonouchi, Keisuke ; Nithichanon, Arnone ; Kuraoka, Masayuki ; Watanabe, Akiko ; Shinnakasu, Ryo ; Asanuma, Hideki ; Ainai, Akira ; Ohmi, Yusuke ; Yamamoto, Takuya ; Ishii, Ken J. ; Hasegawa, Hideki ; Takeyama, Haruko ; Lertmemongkolchai, Ganjana ; Kurosaki, Tomohiro ; Ato, Manabu ; Kelsoe, Garnett ; Takahashi, Yoshimasa
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-08, Vol.10 (1), p.3883-13, Article 3883
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Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity
Author / Creator:Shibata, Naoko ; Kunisawa, Jun ; Hosomi, Koji ; Fujimoto, Yukari ; Mizote, Keisuke ; Kitayama, Naohiro ; Shimoyama, Atsushi ; Mimuro, Hitomi ; Sato, Shintaro ; Kishishita, Natsuko ; Ishii, Ken J ; Fukase, Koichi ; Kiyono, Hiroshi
Publisher:New York: Nature Publishing Group US
Journal title:Mucosal immunology, 2018-05, Vol.11 (3), p.693-702
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Modeling for influenza vaccines and adjuvants profile for safety prediction system using gene expression profiling and statistical tools
Author / Creator:Sasaki, Eita ; Momose, Haruka ; Hiradate, Yuki ; Furuhata, Keiko ; Takai, Mamiko ; Asanuma, Hideki ; Ishii, Ken J. ; Mizukami, Takuo ; Hamaguchi, Isao
Publisher:United States: Public Library of Science
Journal title:PloS one, 2018-02, Vol.13 (2), p.e0191896
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Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen
Author / Creator:Washizaki, Ayaka ; Murayama, Asako ; Murata, Megumi ; Kiyohara, Tomoko ; Yato, Keigo ; Yamada, Norie ; Aly, Hussein Hassan ; Tanaka, Tomohisa ; Moriishi, Kohji ; Nishitsuji, Hironori ; Shimotohno, Kunitada ; Goh, Yasumasa ; Ishii, Ken J. ; Yotsuyanagi, Hiroshi ; Muramatsu, Masamichi ; Ishii, Koji ; Takahashi, Yoshimasa ; Suzuki, Ryosuke ; Akari, Hirofumi ; Kato, Takanobu
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-09, Vol.13 (1), p.5207-5207, Article 5207
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Challenges in developing personalized neoantigen cancer vaccines

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Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination

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Virological characteristics of the SARS-CoV-2 JN.1 variant

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Tissue-specific immunopathology during malaria infection

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DNA released from dying host cells mediates aluminum adjuvant activity

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DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

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Contribution of IL-33–activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

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TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

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Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis

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Atg5-Atg12 conjugate associates with innate antiviral immune responses

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Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist

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CpG ODN (K3)—toll-like receptor 9 agonist—induces Th1-type immune response and enhances cytotoxic activity in advanced lung cancer patients: a phase I study

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Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

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Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies

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Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity

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Modeling for influenza vaccines and adjuvants profile for safety prediction system using gene expression profiling and statistical tools

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Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen

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