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ArticlesPeer ReviewedFull Text
Trastuzumab emtansine: mechanisms of action and drug resistance
Author / Creator:Barok, Mark ; Joensuu, Heikki ; Isola, Jorma
Publisher:England: BioMed Central Ltd
Journal title:Breast cancer research : BCR, 2014-03, Vol.16 (2), p.209-R22, Article 209
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Deep learning identifies morphological features in breast cancer predictive of cancer ERBB2 status and trastuzumab treatment efficacy
Author / Creator:Bychkov, Dmitrii ; Linder, Nina ; Tiulpin, Aleksei ; Kücükel, Hakan ; Lundin, Mikael ; Nordling, Stig ; Sihto, Harri ; Isola, Jorma ; Lehtimäki, Tiina ; Kellokumpu-Lehtinen, Pirkko-Liisa ; von Smitten, Karl ; Joensuu, Heikki ; Lundin, Johan
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-02, Vol.11 (1), p.4037-4037, Article 4037
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Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation
Author / Creator:Barok, Mark ; Puhka, Maija ; Vereb, Gyorgy ; Szollosi, Janos ; Isola, Jorma ; Joensuu, Heikki
Publisher:England: BioMed Central Ltd
Journal title:BMC cancer, 2018-05, Vol.18 (1), p.504-504, Article 504
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UV-induced local immunosuppression in the tumour microenvironment of eccrine porocarcinoma and poroma
Author / Creator:Puttonen, Maya ; Isola, Jorma ; Ylinen, Onni ; Böhling, Tom ; Koljonen, Virve ; Sihto, Harri
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-04, Vol.12 (1), p.5529-5529, Article 5529
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Triple-negative and HER2-positive breast cancers found by mammography screening show excellent prognosis
Author / Creator:Alanko, Johanna ; Tanner, Minna ; Vanninen, Ritva ; Auvinen, Anssi ; Isola, Jorma
Publisher:New York: Springer US
Journal title:Breast cancer research and treatment, 2021-05, Vol.187 (1), p.267-274
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ImmunoRatio: a publicly available web application for quantitative image analysis of estrogen receptor (ER), progesterone receptor (PR), and Ki-67
Author / Creator:Tuominen, Vilppu J ; Ruotoistenmäki, Sanna ; Viitanen, Arttu ; Jumppanen, Mervi ; Isola, Jorma
Publisher:England: National Library of Medicine - MEDLINE Abstracts
Journal title:Breast cancer research : BCR, 2010-01, Vol.12 (4), p.R56-R56, Article R56
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A New Intraepithelial γδ T-Lymphocyte Marker for Celiac Disease Classification in Formalin-Fixed Paraffin-Embedded (FFPE) Duodenal Biopsies
Author / Creator:Popp, Alina ; Taavela, Juha ; Graziano, Paolo ; Parente, Paola ; Covelli, Claudia ; Lamacchia, Carmela ; Andriulli, Angelo ; Mäki, Markku ; Isola, Jorma
Publisher:New York: Springer US
Journal title:Digestive diseases and sciences, 2021-10, Vol.66 (10), p.3352-3358
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HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient data
Author / Creator:Leo, Angelo Di, Dr ; Desmedt, Christine, PhD ; Bartlett, John M S, Prof ; Piette, Fanny, PhD ; Ejlertsen, Bent, MD ; Pritchard, Kathleen I, Prof ; Larsimont, Denis, MD ; Poole, Christopher, Prof ; Isola, Jorma, Prof ; Earl, Helena, Prof ; Mouridsen, Henning, MD ; O'Malley, Frances P, MD ; Cardoso, Fatima, MD ; Tanner, Minna, MD ; Munro, Alison, PhD ; Twelves, Chris J, Prof ; Sotiriou, Christos, MD ; Shepherd, Lois, MD ; Cameron, David, Prof ; Piccart, Martine J, Prof ; Buyse, Marc, PhD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2011-11, Vol.12 (12), p.1134-1142
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Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators, NEDD4-1 and NRDP1, in primary breast cancer
Author / Creator:Luhtala, Satu ; Staff, Synnöve ; Kallioniemi, Anne ; Tanner, Minna ; Isola, Jorma
Publisher:England: BioMed Central Ltd
Journal title:BMC cancer, 2018-10, Vol.18 (1), p.1045-1045, Article 1045
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Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study
Author / Creator:Sihto, Harri ; Lundin, Johan ; Lundin, Mikael ; Lehtimäki, Tiina ; Ristimäki, Ari ; Holli, Kaija ; Sailas, Liisa ; Kataja, Vesa ; Turpeenniemi-Hujanen, Taina ; Isola, Jorma ; Heikkilä, Päivi ; Joensuu, Heikki
Publisher:England: BioMed Central Ltd
Journal title:Breast cancer research : BCR, 2011-09, Vol.13 (5), p.R87-R87, Article R87
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Correction to: A New Intraepithelial γδ T-Lymphocyte Marker for Celiac Disease Classification in Formalin-Fixed Paraffin-Embedded (FFPE) Duodenal Biopsies
Author / Creator:Popp, Alina ; Taavela, Juha ; Graziano, Paolo ; Parente, Paola ; Covelli, Claudia ; Lamacchia, Carmela ; Andriulli, Angelo ; Mäki, Markku ; Isola, Jorma
Publisher:New York: Springer US
Journal title:Digestive diseases and sciences, 2021-12, Vol.66 (12), p.4572-4572
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Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity
Author / Creator:Saal, Lao H ; Johansson, Peter ; Holm, Karolina ; Gruvberger-Saal, Sofia K ; She, Qing-Bai ; Maurer, Matthew ; Koujak, Susan ; Ferrando, Adolfo A ; Malmström, Per ; Memeo, Lorenzo ; Isola, Jorma ; Bendahl, Pär-Ola ; Rosen, Neal ; Hibshoosh, Hanina ; Ringnér, Markus ; Borg, Åke ; Parsons, Ramon
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2007-05, Vol.104 (18), p.7564-7569
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Preservation of nucleic acids and tissue morphology in paraffin-embedded clinical samples: comparison of five molecular fixatives
Author / Creator:Staff, Synnöve ; Kujala, Paula ; Karhu, Ritva ; Rökman, Annika ; Ilvesaro, Joanna ; Kares, Saara ; Isola, Jorma
Publisher:England: BMJ Publishing Group Ltd and Association of Clinical Pathologists
Journal title:Journal of clinical pathology, 2013-09, Vol.66 (9), p.807-810
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Histological, immunohistochemical and mRNA gene expression responses in coeliac disease patients challenged with gluten using PAXgene fixed paraffin-embedded duodenal biopsies
Author / Creator:Taavela, Juha ; Viiri, Keijo ; Popp, Alina ; Oittinen, Mikko ; Dotsenko, Valeriia ; Peräaho, Markku ; Staff, Synnöve ; Sarin, Jani ; Leon, Francisco ; Mäki, Markku ; Isola, Jorma
Publisher:England: BioMed Central Ltd
Journal title:BMC gastroenterology, 2019-11, Vol.19 (1), p.189-189, Article 189
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Cytokeratin 5/14-positive breast cancer: true basal phenotype confined to BRCA1 tumors
Author / Creator:Laakso, Mervi ; Loman, Niklas ; Borg, Åke ; Isola, Jorma
Publisher:New York: Elsevier Inc
Journal title:Modern pathology, 2005-10, Vol.18 (10), p.1321-1328
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Optimized JPEG 2000 Compression for Efficient Storage of Histopathological Whole-Slide Images
Author / Creator:Helin, Henrik ; Tolonen, Teemu ; Ylinen, Onni ; Tolonen, Petteri ; Napankangas, Juha ; Isola, Jorma
Publisher:United States: Elsevier Inc
Journal title:Journal of pathology informatics, 2018-01, Vol.9 (1), p.20-20, Article 20
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Inherited Susceptibility to Uterine Leiomyomas and Renal Cell Cancer
Author / Creator:Launonen, Virpi ; Vierimaa, Outi ; Kiuru, Maija ; Isola, Jorma ; Roth, Stina ; Pukkala, Eero ; Sistonen, Pertti ; Herva, Riitta ; Aaltonen, Lauri A.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2001-03, Vol.98 (6), p.3387-3392
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Quantification of Estrogen Receptor-Alpha Expression in Human Breast Carcinomas With a Miniaturized, Low-Cost Digital Microscope: A Comparison with a High-End Whole Slide-Scanner
Author / Creator:Holmström, Oscar ; Linder, Nina ; Lundin, Mikael ; Moilanen, Hannu ; Suutala, Antti ; Turkki, Riku ; Joensuu, Heikki ; Isola, Jorma ; Diwan, Vinod ; Lundin, Johan
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-12, Vol.10 (12), p.e0144688-e0144688
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Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma
Author / Creator:LASSUS, Heini ; SIHTO, Harri ; LEMINEN, Arto ; JOENSUU, Heikki ; ISOLA, Jorma ; NUPPONEN, Nina N ; BUTZOW, Ralf
Publisher:Berlin: Springer
Journal title:Journal of molecular medicine (Berlin, Germany), 2006-08, Vol.84 (8), p.671-681
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Overall and worst gleason scores are equally good predictors of prostate cancer progression
Author / Creator:Tolonen, Teemu T ; Kujala, Paula M ; Tammela, Teuvo L J ; Tuominen, Vilppu J ; Isola, Jorma J ; Visakorpi, Tapio
Publisher:England: BioMed Central Ltd
Journal title:BMC urology, 2011-10, Vol.11 (1), p.21-21, Article 21
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Trastuzumab emtansine: mechanisms of action and drug resistance

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Deep learning identifies morphological features in breast cancer predictive of cancer ERBB2 status and trastuzumab treatment efficacy

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Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation

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UV-induced local immunosuppression in the tumour microenvironment of eccrine porocarcinoma and poroma

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Triple-negative and HER2-positive breast cancers found by mammography screening show excellent prognosis

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ImmunoRatio: a publicly available web application for quantitative image analysis of estrogen receptor (ER), progesterone receptor (PR), and Ki-67

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A New Intraepithelial γδ T-Lymphocyte Marker for Celiac Disease Classification in Formalin-Fixed Paraffin-Embedded (FFPE) Duodenal Biopsies

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HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient data

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Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators, NEDD4-1 and NRDP1, in primary breast cancer

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Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study

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Correction to: A New Intraepithelial γδ T-Lymphocyte Marker for Celiac Disease Classification in Formalin-Fixed Paraffin-Embedded (FFPE) Duodenal Biopsies

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Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity

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Preservation of nucleic acids and tissue morphology in paraffin-embedded clinical samples: comparison of five molecular fixatives

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Histological, immunohistochemical and mRNA gene expression responses in coeliac disease patients challenged with gluten using PAXgene fixed paraffin-embedded duodenal biopsies

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Cytokeratin 5/14-positive breast cancer: true basal phenotype confined to BRCA1 tumors

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Optimized JPEG 2000 Compression for Efficient Storage of Histopathological Whole-Slide Images

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Inherited Susceptibility to Uterine Leiomyomas and Renal Cell Cancer

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Quantification of Estrogen Receptor-Alpha Expression in Human Breast Carcinomas With a Miniaturized, Low-Cost Digital Microscope: A Comparison with a High-End Whole Slide-Scanner

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Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma

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Overall and worst gleason scores are equally good predictors of prostate cancer progression

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