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ArticlesPeer ReviewedFull Text
CRISPR off-target analysis in genetically engineered rats and mice
Author / Creator:Anderson, Keith R. ; Haeussler, Maximilian ; Watanabe, Colin ; Janakiraman, Vasantharajan ; Lund, Jessica ; Modrusan, Zora ; Stinson, Jeremy ; Bei, Qixin ; Buechler, Andrew ; Yu, Charles ; Thamminana, Sobha R. ; Tam, Lucinda ; Sowick, Michael-Anne ; Alcantar, Tuija ; O’Neil, Natasha ; Li, Jinjie ; Ta, Linda ; Lima, Lisa ; Roose-Girma, Merone ; Rairdan, Xin ; Durinck, Steffen ; Warming, Søren
Publisher:New York: Nature Publishing Group US
Journal title:Nature methods, 2018-07, Vol.15 (7), p.512-514
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Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes
Author / Creator:Durinck, Steffen ; Stawiski, Eric W ; Pavía-Jiménez, Andrea ; Modrusan, Zora ; Kapur, Payal ; Jaiswal, Bijay S ; Zhang, Na ; Toffessi-Tcheuyap, Vanina ; Nguyen, Thong T ; Pahuja, Kanika Bajaj ; Chen, Ying-Jiun ; Saleem, Sadia ; Chaudhuri, Subhra ; Heldens, Sherry ; Jackson, Marlena ; Peña-Llopis, Samuel ; Guillory, Joseph ; Toy, Karen ; Ha, Connie ; Harris, Corissa J ; Holloman, Eboni ; Hill, Haley M ; Stinson, Jeremy ; Rivers, Celina Sanchez ; Janakiraman, Vasantharajan ; Wang, Weiru ; Kinch, Lisa N ; Grishin, Nick V ; Haverty, Peter M ; Chow, Bernard ; Gehring, Julian S ; Reeder, Jens ; Pau, Gregoire ; Wu, Thomas D ; Margulis, Vitaly ; Lotan, Yair ; Sagalowsky, Arthur ; Pedrosa, Ivan ; de Sauvage, Frederic J ; Brugarolas, James ; Seshagiri, Somasekar
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2015-01, Vol.47 (1), p.13-21
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Diverse somatic mutation patterns and pathway alterations in human cancers
Author / Creator:Kan, Zhengyan ; Jaiswal, Bijay S. ; Stinson, Jeremy ; Janakiraman, Vasantharajan ; Bhatt, Deepali ; Stern, Howard M. ; Yue, Peng ; Haverty, Peter M. ; Bourgon, Richard ; Zheng, Jianbiao ; Moorhead, Martin ; Chaudhuri, Subhra ; Tomsho, Lynn P. ; Peters, Brock A. ; Pujara, Kanan ; Cordes, Shaun ; Davis, David P. ; Carlton, Victoria E. H. ; Yuan, Wenlin ; Li, Li ; Wang, Weiru ; Eigenbrot, Charles ; Kaminker, Joshua S. ; Eberhard, David A. ; Waring, Paul ; Schuster, Stephan C. ; Modrusan, Zora ; Zhang, Zemin ; Stokoe, David ; de Sauvage, Frederic J. ; Faham, Malek ; Seshagiri, Somasekar
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2010-08, Vol.466 (7308), p.869-873
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ArticlesPeer ReviewedFull Text
Disruption of PH–kinase domain interactions leads to oncogenic activation of AKT in human cancers
Author / Creator:Parikh, Chaitali ; Janakiraman, Vasantharajan ; Wu, Wen-I ; Foo, Catherine K ; Kljavin, Noelyn M ; Chaudhuri, Subhra ; Stawiski, Eric ; Lee, Brian ; Lin, Jie ; Li, Hong ; Lorenzo, Maria N ; Yuan, Wenlin ; Guillory, Joseph ; Jackson, Marlena ; Rondon, Jesus ; Franke, Yvonne ; Bowman, Krista K ; Sagolla, Meredith ; Stinson, Jeremy ; Wu, Thomas D ; Wu, Jiansheng ; Stokoe, David ; Stern, Howard M ; Brandhuber, Barbara J ; Lin, Kui ; Skelton, Nicholas J ; Seshagiri, Somasekar
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-11, Vol.109 (47), p.19368-19373
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CRISPR whole-genome screening identifies new necroptosis regulators and RIPK1 alternative splicing
Author / Creator:Callow, Marinella G. ; Watanabe, Colin ; Wickliffe, Katherine E. ; Bainer, Russell ; Kummerfield, Sarah ; Weng, Julie ; Cuellar, Trinna ; Janakiraman, Vasantharajan ; Chen, Honglin ; Chih, Ben ; Liang, Yuxin ; Haley, Benjamin ; Newton, Kim ; Costa, Michael R.
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2018-02, Vol.9 (3), p.261-13, Article 261
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Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors
Author / Creator:Jaiswal, Bijay S ; Janakiraman, Vasantharajan ; Kljavin, Noelyn M ; Eastham-Anderson, Jeffrey ; Cupp, James E ; Liang, Yuxin ; Davis, David P ; Hoeflich, Klaus P ; Seshagiri, Somasekar
Publisher:United States: Public Library of Science
Journal title:PloS one, 2009-05, Vol.4 (5), p.e5717-e5717
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Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110α and are disrupted in oncogenic p85 mutants
Author / Creator:Wu, Haiyan ; Shekar, S. Chandra ; Flinn, Rory J ; El-Sibai, Mirvat ; Jaiswal, Bijay S ; Sen, K. Ilker ; Janakiraman, Vasantharajan ; Seshagiri, Somasekar ; Gerfen, Gary J ; Girvin, Mark E ; Backer, Jonathan M
Publisher:National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (48), p.20258-20263
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Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding
Author / Creator:Koenig, Patrick ; Lee, Chingwei V. ; Walters, Benjamin T. ; Janakiraman, Vasantharajan ; Stinson, Jeremy ; Patapoff, Thomas W. ; Fuh, Germaine
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (4), p.E486-E495
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Recurrent R-spondin fusions in colon cancer
Author / Creator:Seshagiri, Somasekar ; Stawiski, Eric W. ; Durinck, Steffen ; Modrusan, Zora ; Storm, Elaine E. ; Conboy, Caitlin B. ; Chaudhuri, Subhra ; Guan, Yinghui ; Janakiraman, Vasantharajan ; Jaiswal, Bijay S. ; Guillory, Joseph ; Ha, Connie ; Dijkgraaf, Gerrit J. P. ; Stinson, Jeremy ; Gnad, Florian ; Huntley, Melanie A. ; Degenhardt, Jeremiah D. ; Haverty, Peter M. ; Bourgon, Richard ; Wang, Weiru ; Koeppen, Hartmut ; Gentleman, Robert ; Starr, Timothy K. ; Zhang, Zemin ; Largaespada, David A. ; Wu, Thomas D. ; de Sauvage, Frederic J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2012-08, Vol.488 (7413), p.660-664
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ArticlesPeer ReviewedFull Text
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
Author / Creator:Rudin, Charles M ; Durinck, Steffen ; Stawiski, Eric W ; Poirier, John T ; Modrusan, Zora ; Shames, David S ; Bergbower, Emily A ; Guan, Yinghui ; Shin, James ; Guillory, Joseph ; Rivers, Celina Sanchez ; Foo, Catherine K ; Bhatt, Deepali ; Stinson, Jeremy ; Gnad, Florian ; Haverty, Peter M ; Gentleman, Robert ; Chaudhuri, Subhra ; Janakiraman, Vasantharajan ; Jaiswal, Bijay S ; Parikh, Chaitali ; Yuan, Wenlin ; Zhang, Zemin ; Koeppen, Hartmut ; Wu, Thomas D ; Stern, Howard M ; Yauch, Robert L ; Huffman, Kenneth E ; Paskulin, Diego D ; Illei, Peter B ; Varella-Garcia, Marileila ; Gazdar, Adi F ; de Sauvage, Frederic J ; Bourgon, Richard ; Minna, John D ; Brock, Malcolm V ; Seshagiri, Somasekar
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2012-10, Vol.44 (10), p.1111-1116
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ArticlesPeer ReviewedFull Text
Comprehensive analysis of single molecule sequencing-derived complete genome and whole transcriptome of Hyposidra talaca nuclear polyhedrosis virus
Author / Creator:Nguyen, Thong T. ; Suryamohan, Kushal ; Kuriakose, Boney ; Janakiraman, Vasantharajan ; Reichelt, Mike ; Chaudhuri, Subhra ; Guillory, Joseph ; Divakaran, Neethu ; Rabins, P. E. ; Goel, Ridhi ; Deka, Bhabesh ; Sarkar, Suman ; Ekka, Preety ; Tsai, Yu-Chih ; Vargas, Derek ; Santhosh, Sam ; Mohan, Sangeetha ; Chin, Chen-Shan ; Korlach, Jonas ; Thomas, George ; Babu, Azariah ; Seshagiri, Somasekar
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-06, Vol.8 (1), p.8924-11, Article 8924
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Author Correction: Comprehensive analysis of single molecule sequencing-derived complete genome and whole transcriptome of Hyposidra talaca nuclear polyhedrosis virus
Author / Creator:Nguyen, Thong T. ; Suryamohan, Kushal ; Kuriakose, Boney ; Janakiraman, Vasantharajan ; Reichelt, Mike ; Chaudhuri, Subhra ; Guillory, Joseph ; Divakaran, Neethu ; Rabins, P. E. ; Goel, Ridhi ; Deka, Bhabesh ; Sarkar, Suman ; Ekka, Preety ; Tsai, Yu-Chih ; Vargas, Derek ; Santhosh, Sam ; Mohan, Sangeetha ; Chin, Chen-Shan ; Korlach, Jonas ; Thomas, George ; Babu, Azariah ; Seshagiri, Somasekar
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-08, Vol.8 (1), p.13274-2, Article 13274
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ArticlesPeer ReviewedFull Text
Estimation of baculovirus titer based on viable cell size
Author / Creator:Janakiraman, Vasantharajan ; Forrest, William F ; Seshagiri, Somasekar
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2006-12, Vol.1 (5), p.2271-2276
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ArticlesPeer ReviewedFull Text
Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110[alpha] and are disrupted in oncogenic p85 mutants
Author / Creator:Wu, Haiyan ; Shekar, S Chandra ; Flinn, Rory J ; El-Sibai, Mirvat ; Jaiswal, Bijay S ; Sen, K Ilker ; Janakiraman, Vasantharajan ; Seshagiri, Somasekar ; Gerfen, Gary J ; Girvin, Mark E ; Backer, Jonathan M
Publisher:Washington: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (48), p.20258
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Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110Î± and are disrupted in oncogenic p85 mutants
Author / Creator:Wu, Haiyan ; Shekar, S. Chandra ; Flinn, Rory J ; El-Sibai, Mirvat ; Jaiswal, Bijay S ; Sen, K. Ilker ; Janakiraman, Vasantharajan ; Seshagiri, Somasekar ; Gerfen, Gary J ; Girvin, Mark E ; Backer, Jonathan M
Publisher:National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009, Vol.106 (48), p.20258-20263
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ArticlesPeer ReviewedFull Text
Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants
Author / Creator:Wu, Haiyan ; Shekar, S Chandra ; Flinn, Rory J ; El-Sibai, Mirvat ; Jaiswal, Bijay S ; Sen, K Ilker ; Janakiraman, Vasantharajan ; Seshagiri, Somasekar ; Gerfen, Gary J ; Girvin, Mark E ; Backer, Jonathan M
Publisher:United States
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (48), p.20258-20263
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ReportsFull Text
CRISPR off-target analysis in genetically engineered rats and mice
Author / Creator:Anderson, Keith R ; Haeussler, Maximilian ; Watanabe, Colin ; Janakiraman, Vasantharajan ; Lund, Jessica ; Modrusan, Zora ; Stinson, Jeremy
Publisher:Nature Publishing Group
Journal title:Nature Methods, 2018, Vol.15 (7), p.512
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ReportsFull Text
Recurrent R-spondin fusions in colon cancer
Author / Creator:Seshagiri, Somasekar ; Stawiski, Eric W ; Durinck, Steffen ; Modrusan, Zora ; Storm, Elaine E ; Conboy, Caitlin B ; Chaudhuri, Subhra ; Guan, Yinghui ; Janakiraman, Vasantharajan ; Jaiswal, Bijay S ; Guillory, Joseph ; Ha, Connie ; Dijkgraaf, Gerrit J.P ; Stinson, Jeremy ; Gnad, Florian ; Huntley, Melanie A ; Degenhardt, Jeremiah D ; Haverty, Peter M ; Bourgon, Richard ; Wang, Weiru ; Koeppen, Hartmut ; Gentleman, Robert ; Starr, Timothy K ; Zhang, Zemin ; Largaespada, David A ; Wu, Thomas D ; de Sauvage, Frederic J
Publisher:Nature Publishing Group
Journal title:Nature, 2012, Vol.488 (7413), p.660
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ReportsFull Text
Recurrent R-spondin fusions in colon cancer
Author / Creator:Seshagiri, Somasekar ; Stawiski, Eric W ; Durinck, Steffen ; Modrusan, Zora ; Storm, Elaine E ; Conboy, Caitlin B ; Chaudhuri, Subhra ; Guan, Yinghui ; Janakiraman, Vasantharajan ; Jaiswal, Bijay S ; Guillory, Joseph ; Ha, Connie ; Dijkgraaf, Gerrit J.P ; Stinson, Jeremy ; Gnad, Florian ; Huntley, Melanie A ; Degenhardt, Jeremiah D ; Haverty, Peter M ; Bourgon, Richard ; Wang, Weiru ; Koeppen, Hartmut ; Gentleman, Robert ; Starr, Timothy K ; Zhang, Zemin ; Largaespada, David A ; Wu, Thomas D ; de Sauvage, Frederic J
Publisher:Nature Publishing Group
Journal title:Nature, 2012, Vol.488 (7413), p.660
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CRISPR off-target analysis in genetically engineered rats and mice

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Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes

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Diverse somatic mutation patterns and pathway alterations in human cancers

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Disruption of PH–kinase domain interactions leads to oncogenic activation of AKT in human cancers

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CRISPR whole-genome screening identifies new necroptosis regulators and RIPK1 alternative splicing

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Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors

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Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110α and are disrupted in oncogenic p85 mutants

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Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding

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Recurrent R-spondin fusions in colon cancer

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Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

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Comprehensive analysis of single molecule sequencing-derived complete genome and whole transcriptome of Hyposidra talaca nuclear polyhedrosis virus

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Author Correction: Comprehensive analysis of single molecule sequencing-derived complete genome and whole transcriptome of Hyposidra talaca nuclear polyhedrosis virus

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Estimation of baculovirus titer based on viable cell size

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Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110[alpha] and are disrupted in oncogenic p85 mutants

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Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110Î± and are disrupted in oncogenic p85 mutants

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Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants

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CRISPR off-target analysis in genetically engineered rats and mice

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Recurrent R-spondin fusions in colon cancer

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Recurrent R-spondin fusions in colon cancer

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