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ArticlesPeer ReviewedFull Text
A Comprehensive Review on Current Advances in Peptide Drug Development and Design
Author / Creator:Lee, Andy Chi-Lung ; Harris, Janelle Louise ; Khanna, Kum Kum ; Hong, Ji-Hong
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2019-05, Vol.20 (10), p.2383
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Serendipity, luck and hard work
Author / Creator:Khanna, Kum Kum
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2018-09, Vol.20 (9), p.1004-1004
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The Integrator complex controls the termination of transcription at diverse classes of gene targets
Author / Creator:Skaar, Jeffrey R ; Ferris, Andrea L ; Wu, Xiaolin ; Saraf, Anita ; Khanna, Kum Kum ; Florens, Laurence ; Washburn, Michael P ; Hughes, Stephen H ; Pagano, Michele
Publisher:London: Nature Publishing Group UK
Journal title:Cell research, 2015-03, Vol.25 (3), p.288-305
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Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis
Author / Creator:Rashidieh, Behnam ; Shohayeb, Belal ; Bain, Amanda Louise ; Fortuna, Patrick R. J ; Sinha, Debottam ; Burgess, Andrew ; Mills, Richard ; Adams, Rachael C ; Lopez, J. Alejandro ; Blumbergs, Peter ; Finnie, John ; Kalimutho, Murugan ; Piper, Michael ; Hudson, James Edward ; Ng, Dominic C. H ; Khanna, Kum Kum
Publisher:San Francisco: Public Library of Science
Journal title:PLoS genetics, 2021-10, Vol.17 (10), p.e1009334
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Chromosome arm aneuploidies shape tumour evolution and drug response
Author / Creator:Shukla, Ankit ; Nguyen, Thu H. M. ; Moka, Sarat B. ; Ellis, Jonathan J. ; Grady, John P. ; Oey, Harald ; Cristino, Alexandre S. ; Khanna, Kum Kum ; Kroese, Dirk P. ; Krause, Lutz ; Dray, Eloise ; Fink, J. Lynn ; Duijf, Pascal H. G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-01, Vol.11 (1), p.449-14, Article 449
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ArticlesPeer ReviewedFull Text
Optimizing poly (ADP‐ribose) polymerase inhibition through combined epigenetic and immunotherapy
Author / Creator:Prasanna, Thiru ; Wu, Fan ; Khanna, Kum Kum ; Yip, Desmond ; Malik, Laeeq ; Dahlstrom, Jane E. ; Rao, Sudha
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2018-11, Vol.109 (11), p.3383-3392
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Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice
Author / Creator:Tomimatsu, Nozomi ; Mukherjee, Bipasha ; Catherine Hardebeck, Molly ; Ilcheva, Mariya ; Vanessa Camacho, Cristel ; Louise Harris, Janelle ; Porteus, Matthew ; Llorente, Bertrand ; Khanna, Kum Kum ; Burma, Sandeep
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2014-04, Vol.5 (1), p.3561-3561, Article 3561
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CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer
Author / Creator:Sanij, Elaine ; Hannan, Katherine M. ; Xuan, Jiachen ; Yan, Shunfei ; Ahern, Jessica E. ; Trigos, Anna S. ; Brajanovski, Natalie ; Son, Jinbae ; Chan, Keefe T. ; Kondrashova, Olga ; Lieschke, Elizabeth ; Wakefield, Matthew J. ; Frank, Daniel ; Ellis, Sarah ; Cullinane, Carleen ; Kang, Jian ; Poortinga, Gretchen ; Nag, Purba ; Deans, Andrew J. ; Khanna, Kum Kum ; Mileshkin, Linda ; McArthur, Grant A. ; Soong, John ; Berns, Els M. J. J. ; Hannan, Ross D. ; Scott, Clare L. ; Sheppard, Karen E. ; Pearson, Richard B.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-05, Vol.11 (1), p.2641-18, Article 2641
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Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition
Author / Creator:Raninga, Prahlad V ; Lee, Andy ; Sinha, Debottam ; Dong, Lan-Feng ; Datta, Keshava K ; Lu, Xue ; Kalita-de Croft, Priyakshi ; Dutt, Mriga ; Hill, Michelle ; Pouliot, Normand ; Gowda, Harsha ; Kalimutho, Murugan ; Neuzil, Jiri ; Khanna, Kum Kum
Publisher:Australia: Ivyspring International Publisher Pty Ltd
Journal title:Theranostics, 2020-01, Vol.10 (12), p.5259-5275
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CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer
Author / Creator:Kalimutho, Murugan ; Sinha, Debottam ; Jeffery, Jessie ; Nones, Katia ; Srihari, Sriganesh ; Fernando, Winnie C ; Duijf, Pascal HG ; Vennin, Claire ; Raninga, Prahlad ; Nanayakkara, Devathri ; Mittal, Deepak ; Saunus, Jodi M ; Lakhani, Sunil R ; López, J Alejandro ; Spring, Kevin J ; Timpson, Paul ; Gabrielli, Brian ; Waddell, Nicola ; Khanna, Kum Kum
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2018-09, Vol.10 (9), p.1-n/a
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Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans
Author / Creator:Schoenmakers, Erik ; Agostini, Maura ; Mitchell, Catherine ; Schoenmakers, Nadia ; Papp, Laura ; Rajanayagam, Odelia ; Padidela, Raja ; Ceron-Gutierrez, Lourdes ; Doffinger, Rainer ; Prevosto, Claudia ; Luan, Jian'an ; Montano, Sergio ; Lu, Jun ; Castanet, Mireille ; Clemons, Nick ; Groeneveld, Matthijs ; Castets, Perrine ; Karbaschi, Mahsa ; Aitken, Sri ; Dixon, Adrian ; Williams, Jane ; Campi, Irene ; Blount, Margaret ; Burton, Hannah ; Muntoni, Francesco ; O'Donovan, Dominic ; Dean, Andrew ; Warren, Anne ; Brierley, Charlotte ; Baguley, David ; Guicheney, Pascale ; Fitzgerald, Rebecca ; Coles, Alasdair ; Gaston, Hill ; Todd, Pamela ; Holmgren, Arne ; Khanna, Kum Kum ; Cooke, Marcus ; Semple, Robert ; Halsall, David ; Wareham, Nicholas ; Schwabe, John ; Grasso, Lucia ; Beck-Peccoz, Paolo ; Ogunko, Arthur ; Dattani, Mehul ; Gurnell, Mark ; Chatterjee, Krishna
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2010-12, Vol.120 (12), p.4220-4235
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ArticlesPeer ReviewedFull Text
RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC
Author / Creator:Kim, Seong-Jin ; Ju, Jin-Sung ; Kang, Myoung-Hee ; Eun, Ji Won ; Kim, Young Ha ; Raninga, Prahlad V ; Khanna, Kum Kum ; Győrffy, Balázs ; Pack, Chan-Gi ; Han, Hee-Dong ; Lee, Hee Jin ; Gong, Gyungyub ; Shin, Yong ; Mills, Gordon B ; Eyun, Seong-Il ; Park, Yun-Yong
Publisher:Australia: Ivyspring International Publisher Pty Ltd
Journal title:Theranostics, 2020-01, Vol.10 (18), p.7974-7992
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Differential Regulation of Lacto-/Neolacto- Glycosphingolipid Biosynthesis Pathway Reveals Transcription Factors as Potential Candidates in Triple-Negative Breast Cancer
Author / Creator:Zeng, Ruichao ; Mohamed, Ahmed ; Khanna, Kum Kum ; Hill, Michelle M.
Publisher:Basel: MDPI AG
Journal title:Cancers, 2021-07, Vol.13 (13), p.3330
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CBL0137 impairs homologous recombination repair and sensitizes high-grade serous ovarian carcinoma to PARP inhibitors
Author / Creator:Lu, Xue ; He, Yaowu ; Johnston, Rebecca L ; Nanayakarra, Devathri ; Sankarasubramanian, Sivanandhini ; Lopez, J Alejandro ; Friedlander, Michael ; Kalimutho, Murugan ; Hooper, John D ; Raninga, Prahlad V ; Khanna, Kum Kum
Publisher:England: BioMed Central Ltd
Journal title:Journal of experimental & clinical cancer research, 2022-12, Vol.41 (1), p.355-355, Article 355
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Targeting BRF2 in Cancer Using Repurposed Drugs
Author / Creator:Rashidieh, Behnam ; Molakarimi, Maryam ; Mohseni, Ammar ; Tria, Simon Manuel ; Truong, Hein ; Srihari, Sriganesh ; Adams, Rachael C. ; Jones, Mathew ; Duijf, Pascal H. G. ; Kalimutho, Murugan ; Khanna, Kum Kum
Publisher:Basel: MDPI AG
Journal title:Cancers, 2021-07, Vol.13 (15), p.3778
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GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival
Author / Creator:Cabrera, Elisa ; Raninga, Prahlad ; Khanna, Kum Kum ; Freire, Raimundo
Publisher:Switzerland: MDPI AG
Journal title:Cancers, 2019-07, Vol.11 (8), p.1073
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The metastasis suppressor RARRES3 as an endogenous inhibitor of the immunoproteasome expression in breast cancer cells
Author / Creator:Anderson, Alison M. ; Kalimutho, Murugan ; Harten, Sarah ; Nanayakkara, Devathri M. ; Khanna, Kum Kum ; Ragan, Mark A.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-01, Vol.7 (1), p.39873-39873, Article 39873
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A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure
Author / Creator:Luijsterburg, Martijn S ; Acs, Klara ; Ackermann, Leena ; Wiegant, Wouter W ; Bekker-Jensen, Simon ; Larsen, Dorthe H ; Khanna, Kum Kum ; van Attikum, Haico ; Mailand, Niels ; Dantuma, Nico P
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2012-05, Vol.31 (11), p.2511-2527
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COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis
Author / Creator:Hancock, Janelle L ; Kalimutho, Murugan ; Straube, Jasmin ; Lim, Malcolm ; Gresshoff, Irma ; Saunus, Jodi M ; Lee, Jason S ; Lakhani, Sunil R ; Simpson, Kaylene J ; Bush, Ashley I ; Anderson, Robin L ; Khanna, Kum Kum
Publisher:England: BioMed Central Ltd
Journal title:Journal of experimental & clinical cancer research, 2023-04, Vol.42 (1), p.90-90, Article 90
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hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage
Author / Creator:Boucher, Didier ; Kariawasam, Ruvini ; Burgess, Joshua ; Gimenez, Adrian ; Ocampo, Tristan E. ; Ferguson, Blake ; Naqi, Ali ; Walker, Graeme J. ; Bolderson, Emma ; Gamsjaeger, Roland ; O’Byrne, Kenneth J. ; Cubeddu, Liza ; Khanna, Kum Kum ; Richard, Derek J.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-10, Vol.11 (1), p.20256-12, Article 20256
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Showing 1 to 20 of 110 results

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A Comprehensive Review on Current Advances in Peptide Drug Development and Design

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Serendipity, luck and hard work

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The Integrator complex controls the termination of transcription at diverse classes of gene targets

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Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis

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Chromosome arm aneuploidies shape tumour evolution and drug response

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Optimizing poly (ADP‐ribose) polymerase inhibition through combined epigenetic and immunotherapy

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Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

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CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

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Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition

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CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer

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Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

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RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC

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Differential Regulation of Lacto-/Neolacto- Glycosphingolipid Biosynthesis Pathway Reveals Transcription Factors as Potential Candidates in Triple-Negative Breast Cancer

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CBL0137 impairs homologous recombination repair and sensitizes high-grade serous ovarian carcinoma to PARP inhibitors

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Targeting BRF2 in Cancer Using Repurposed Drugs

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GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival

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The metastasis suppressor RARRES3 as an endogenous inhibitor of the immunoproteasome expression in breast cancer cells

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A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure

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COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis

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hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage

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