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ArticlesPeer ReviewedFull Text
PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland
Author / Creator:Joshi, Purna A. ; Waterhouse, Paul D. ; Kasaian, Katayoon ; Fang, Hui ; Gulyaeva, Olga ; Sul, Hei Sook ; Boutros, Paul C. ; Khokha, Rama
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-04, Vol.10 (1), p.1760-14, Article 1760
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Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer
Author / Creator:Schramek, Daniel ; Leibbrandt, Andreas ; Sigl, Verena ; Kenner, Lukas ; Pospisilik, John A. ; Lee, Heather J. ; Hanada, Reiko ; Joshi, Purna A. ; Aliprantis, Antonios ; Glimcher, Laurie ; Pasparakis, Manolis ; Khokha, Rama ; Ormandy, Christopher J. ; Widschwendter, Martin ; Schett, Georg ; Penninger, Josef M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2010-11, Vol.468 (7320), p.98-102
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ArticlesPeer ReviewedFull Text
Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state
Author / Creator:Shimoda, Masayuki ; Principe, Simona ; Jackson, Hartland W. ; Luga, Valbona ; Fang, Hui ; Molyneux, Sam D. ; Shao, Yang W. ; Aiken, Alison ; Waterhouse, Paul D. ; Karamboulas, Christina ; Hess, Franz M. ; Ohtsuka, Takashi ; Okada, Yasunori ; Ailles, Laurie ; Ludwig, Andreas ; Wrana, Jeffrey L. ; Kislinger, Thomas ; Khokha, Rama
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2014-09, Vol.16 (9), p.889-901
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Modification of BRCA1-associated breast cancer risk by HMMR overexpression
Author / Creator:Mateo, Francesca ; He, Zhengcheng ; Mei, Lin ; de Garibay, Gorka Ruiz ; Herranz, Carmen ; García, Nadia ; Lorentzian, Amanda ; Baiges, Alexandra ; Blommaert, Eline ; Gómez, Antonio ; Mirallas, Oriol ; Garrido-Utrilla, Anna ; Palomero, Luis ; Espín, Roderic ; Extremera, Ana I. ; Soler-Monsó, M. Teresa ; Petit, Anna ; Li, Rong ; Brunet, Joan ; Chen, Ke ; Tan, Susanna ; Eaves, Connie J. ; McCloskey, Curtis ; Hakem, Razq ; Khokha, Rama ; Lange, Philipp F. ; Lázaro, Conxi ; Maxwell, Christopher A. ; Pujana, Miquel Angel
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-04, Vol.13 (1), p.1895-16, Article 1895
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ArticlesPeer ReviewedFull Text
Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer
Author / Creator:Klein, Lukas ; Tu, Mengyu ; Krebs, Niklas ; Urbach, Laura ; Grimm, Daniela ; Latif, Muhammad Umair ; Penz, Frederike ; Blandau, Anna ; Wu, Xueyan ; Samuel, Rebecca Diya ; Küffer, Stefan ; Wegwitz, Florian ; Chan, Nathan ; Aliar, Kazeera ; Vyas, Foram ; Kishore, Uday ; Hessmann, Elisabeth ; Trumpp, Andreas ; Espinet, Elisa ; Papantonis, Argyris ; Khokha, Rama ; Ellenrieder, Volker ; Grünwald, Barbara T. ; Singh, Shiv K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-01, Vol.16 (1), p.335-19, Article 335
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ArticlesPeer ReviewedFull Text
Regulation of cancer cell migration and bone metastasis by RANKL
Author / Creator:Jones, D. Holstead ; Nakashima, Tomoki ; Sanchez, Otto H. ; Kozieradzki, Ivona ; Komarova, Svetlana V. ; Sarosi, Ildiko ; Morony, Sean ; Rubin, Evelyn ; Sarao, Renu ; Hojilla, Carlo V. ; Komnenovic, Vukoslav ; Kong, Young-Yun ; Schreiber, Martin ; Dixon, S. Jeffrey ; Sims, Stephen M. ; Khokha, Rama ; Wada, Teiji ; Penninger, Josef M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature, 2006-03, Vol.440 (7084), p.692-696
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ArticlesPeer ReviewedFull Text
Proliferative heterogeneity of murine epithelial cells in the adult mammary gland
Author / Creator:Shehata, Mona ; Waterhouse, Paul D. ; Casey, Alison E. ; Fang, Hui ; Hazelwood, Lee ; Khokha, Rama
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2018-08, Vol.1 (1), p.111-111, Article 111
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ArticlesPeer ReviewedFull Text
Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay
Author / Creator:Fiorentino, Loredana ; Cavalera, Michele ; Menini, Stefano ; Marchetti, Valentina ; Mavilio, Maria ; Fabrizi, Marta ; Conserva, Francesca ; Casagrande, Viviana ; Menghini, Rossella ; Pontrelli, Paola ; Arisi, Ivan ; D'Onofrio, Mara ; Lauro, Davide ; Khokha, Rama ; Accili, Domenico ; Pugliese, Giuseppe ; Gesualdo, Loreto ; Lauro, Renato ; Federici, Massimo
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2013-03, Vol.5 (3), p.441-455
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ArticlesPeer ReviewedFull Text
Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice
Author / Creator:Murthy, Aditya ; Defamie, Virginie ; Smookler, David S. ; Di Grappa, Marco A. ; Horiuchi, Keisuke ; Federici, Massimo ; Sibilia, Maria ; Blobel, Carl P. ; Khokha, Rama
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2010-08, Vol.120 (8), p.2731-2744
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ArticlesPeer ReviewedFull Text
Timp3 Deficient Mice Show Resistance to Developing Breast Cancer
Author / Creator:Jackson, Hartland W. ; Hojilla, Carlo V. ; Weiss, Ashley ; Sanchez, Otto H. ; Wood, Geoffrey A. ; Khokha, Rama
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-03, Vol.10 (3), p.e0120107-e0120107
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ArticlesPeer ReviewedFull Text
Proteolysis during Tumor Cell Extravasation In Vitro: Metalloproteinase Involvement across Tumor Cell Types
Author / Creator:Voura, Evelyn B. ; English, Jane L. ; Yu, Hoi-Ying E. ; Ho, Andrew T. ; Subarsky, Patrick ; Hill, Richard P. ; Hojilla, Carlo V. ; Khokha, Rama
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-10, Vol.8 (10), p.e78413-e78413
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ArticlesPeer ReviewedFull Text
Abnormal TNF activity in Timp3−/− mice leads to chronic hepatic inflammation and failure of liver regeneration
Author / Creator:Mohammed, Fazilat F ; Smookler, David S ; Taylor, Suzanne E M ; Fingleton, Barbara ; Kassiri, Zamaneh ; Sanchez, Otto H ; English, Jane L ; Matrisian, Lynn M ; Au, Billie ; Yeh, Wen-Chen ; Khokha, Rama
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2004-09, Vol.36 (9), p.969-977
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ArticlesPeer ReviewedFull Text
TIMP3 Regulates Mammary Epithelial Apoptosis with Immune Cell Recruitment Through Differential TNF Dependence
Author / Creator:Hojilla, Carlo V. ; Jackson, Hartland W. ; Khokha, Rama
Publisher:United States: Public Library of Science
Journal title:PloS one, 2011-10, Vol.6 (10), p.e26718-e26718
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Newspaper ArticlesFull Text
Local research finds vital clue to breast cancer
Author / Creator:Ogilvie, Megan
Publisher:Toronto, Ont: Torstar Syndication Services, a Division of Toronto Star Newspapers Limited
Journal title:Toronto star, 2010-05-06
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ArticlesPeer ReviewedFull Text
Suppression of tumor growth and metastasis in Mgat5-deficient mice
Author / Creator:Granovsky, Maria ; Fata, Jimmie ; Pawling, Judy ; Muller, William J. ; Khokha, Rama ; Dennis, James W.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2000-03, Vol.6 (3), p.306-312
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Identifying the murine mammary cell target of metformin exposure
Author / Creator:Shehata, Mona ; Kim, Hyeyeon ; Vellanki, Ravi ; Waterhouse, Paul D. ; Mahendralingam, Mathepan ; Casey, Alison E. ; Koritzinsky, Marianne ; Khokha, Rama
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2019-05, Vol.2 (1), p.192-192, Article 192
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Involvement of Mammalian Mus81 in Genome Integrity and Tumor Suppression
Author / Creator:McPherson, John Peter ; Lemmers, Bénédicte ; Chahwan, Richard ; Pamidi, Ashwin ; Migon, Eva ; Matysiak-Zablocki, Elzbieta ; Moynahan, Mary Ellen ; Essers, Jeroen ; Hanada, Katsuhiro ; Poonepalli, Anuradha ; Sanchez-Sweatman, Otto ; Khokha, Rama ; Kanaar, Roland ; Jasin, Maria ; Hande, M. Prakash ; Hakem, Razqallah
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2004-06, Vol.304 (5678), p.1822-1826
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ArticlesPeer ReviewedFull Text
Metalloproteinases and their natural inhibitors in inflammation and immunity
Author / Creator:Khokha, Rama ; Murthy, Aditya ; Weiss, Ashley
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Immunology, 2013-09, Vol.13 (9), p.649-665
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Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinoma
Author / Creator:Moorehead, Roger A ; Sanchez, Otto H ; Baldwin, R Mitchell ; Khokha, Rama
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2003-02, Vol.22 (6), p.853-857
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ArticlesPeer ReviewedFull Text
TIMPs: versatile extracellular regulators in cancer
Author / Creator:Jackson, Hartland W. ; Defamie, Virginie ; Waterhouse, Paul ; Khokha, Rama
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Cancer, 2017-01, Vol.17 (1), p.38-53
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Showing 1 to 20 of 68 results

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PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland

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Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

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Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

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Modification of BRCA1-associated breast cancer risk by HMMR overexpression

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Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer

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Regulation of cancer cell migration and bone metastasis by RANKL

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Proliferative heterogeneity of murine epithelial cells in the adult mammary gland

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Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay

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Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice

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Timp3 Deficient Mice Show Resistance to Developing Breast Cancer

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Proteolysis during Tumor Cell Extravasation In Vitro: Metalloproteinase Involvement across Tumor Cell Types

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Abnormal TNF activity in Timp3−/− mice leads to chronic hepatic inflammation and failure of liver regeneration

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TIMP3 Regulates Mammary Epithelial Apoptosis with Immune Cell Recruitment Through Differential TNF Dependence

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Local research finds vital clue to breast cancer

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Suppression of tumor growth and metastasis in Mgat5-deficient mice

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Identifying the murine mammary cell target of metformin exposure

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Involvement of Mammalian Mus81 in Genome Integrity and Tumor Suppression

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Metalloproteinases and their natural inhibitors in inflammation and immunity

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Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinoma

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TIMPs: versatile extracellular regulators in cancer

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