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72 results for Lapatinib+-+pharmacology

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ArticlesPeer ReviewedFull Text
HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway
Author / Creator:Smith, Alison E. ; Ferraro, Emanuela ; Safonov, Anton ; Morales, Cristina Bernado ; Lahuerta, Enrique J. Arenas ; Li, Qing ; Kulick, Amanda ; Ross, Dara ; Solit, David B. ; de Stanchina, Elisa ; Reis-Filho, Jorge ; Rosen, Neal ; Arribas, Joaquín ; Razavi, Pedram ; Chandarlapaty, Sarat
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-11, Vol.12 (1), p.6667-10, Article 6667
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Phenotypic changes of HER2-positive breast cancer during and after dual HER2 blockade
Author / Creator:Brasó-Maristany, Fara ; Griguolo, Gaia ; Pascual, Tomás ; Paré, Laia ; Nuciforo, Paolo ; Llombart-Cussac, Antonio ; Bermejo, Begoña ; Oliveira, Mafalda ; Morales, Serafín ; Martínez, Noelia ; Vidal, Maria ; Adamo, Barbara ; Martínez, Olga ; Pernas, Sonia ; López, Rafael ; Muñoz, Montserrat ; Chic, Núria ; Galván, Patricia ; Garau, Isabel ; Manso, Luis ; Alarcón, Jesús ; Martínez, Eduardo ; Gregorio, Sara ; Gomis, Roger R. ; Villagrasa, Patricia ; Cortés, Javier ; Ciruelos, Eva ; Prat, Aleix
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-01, Vol.11 (1), p.385-385, Article 385
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Comparative analysis of drug response and gene profiling of HER2-targeted tyrosine kinase inhibitors
Author / Creator:Conlon, Neil T. ; Kooijman, Jeffrey J. ; van Gerwen, Suzanne J. C. ; Mulder, Winfried R. ; Zaman, Guido J. R. ; Diala, Irmina ; Eli, Lisa D. ; Lalani, Alshad S. ; Crown, John ; Collins, Denis M.
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2021-03, Vol.124 (7), p.1249-1259
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Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures
Author / Creator:Vander Velde, Robert ; Yoon, Nara ; Marusyk, Viktoriya ; Durmaz, Arda ; Dhawan, Andrew ; Miroshnychenko, Daria ; Lozano-Peral, Diego ; Desai, Bina ; Balynska, Olena ; Poleszhuk, Jan ; Kenian, Liu ; Teng, Mingxiang ; Abazeed, Mohamed ; Mian, Omar ; Tan, Aik Choon ; Haura, Eric ; Scott, Jacob ; Marusyk, Andriy
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-05, Vol.11 (1), p.2393-13, Article 2393
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Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells
Author / Creator:Fujimoto Yumi ; Morita, Tomoko Yamamori ; Ohashi Akihiro ; Haeno Hiroshi ; Hakozaki Yumi ; Fujii Masanori ; Kashima Yukie ; Kobayashi, Susumu S ; Mukohara Toru
Publisher:London: Nature Publishing Group
Journal title:Scientific reports, 2020-12, Vol.10 (1)
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Co-loaded lapatinib/PAB by ferritin nanoparticles eliminated ECM-detached cluster cells via modulating EGFR in triple-negative breast cancer
Author / Creator:Wu, Xinghan ; Sheng, Huan ; Zhao, Liping ; Jiang, Mingxia ; Lou, Han ; Miao, Yue ; Cheng, Ni ; Zhang, Weifen ; Ding, Dejun ; Li, Wentong
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2022-06, Vol.13 (6), p.557-13, Article 557
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The role of HER2 and HER3 in HER2-amplified cancers beyond breast cancers
Author / Creator:Majumder, Avisek ; Sandhu, Manbir ; Banerji, Debarko ; Steri, Veronica ; Olshen, Adam ; Moasser, Mark M.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-04, Vol.11 (1), p.9091-11, Article 9091
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Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer
Author / Creator:Zhang, Jinrui ; Li, Qiong ; Wu, Yueguang ; Wang, Duchuang ; Xu, Lu ; Zhang, Yang ; Wang, Shanshan ; Wang, Taishu ; Liu, Fang ; Zaky, Mohamed Y. ; Hou, Shuai ; Liu, Shuyan ; Zou, Kun ; Lei, Haixin ; Zou, Lijuan ; Zhang, Yingqiu ; Liu, Han
Publisher:England: BioMed Central Ltd
Journal title:Cell communication and signaling, 2019-02, Vol.17 (1), p.15-15, Article 15
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SLC35F2–SYVN1–TRIM59 axis critically regulates ferroptosis of pancreatic cancer cells by inhibiting endogenous p53
Author / Creator:Che, Ben ; Du, Yunyan ; Yuan, Rongfa ; Xiao, Han ; Zhang, Wenming ; Shao, Jun ; Lu, Hongcheng ; Yu, Yi ; Xiang, Mingfeng ; Hao, Liang ; Zhang, Shouhua ; Du, Xiaohong ; Liu, Xiuxia ; Zhou, Wei ; Wang, Kai ; Chen, Leifeng
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2023-10, Vol.42 (44), p.3260-3273
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Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer
Publisher:Basel: Springer Nature B.V
Journal title:Cellular and molecular life sciences : CMLS, 2023-04, Vol.80 (4), p.100
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Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers
Author / Creator:Sun, Bowen ; Mason, Seth ; Wilson, Robert C. ; Hazard, Starr E. ; Wang, Yubao ; Fang, Rong ; Wang, Qiwei ; Yeh, Elizabeth S. ; Yang, Meixiang ; Roberts, Thomas M. ; Zhao, Jean J. ; Wang, Qi
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2020-01, Vol.39 (1), p.50-63
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Transcriptional suppression of AMPKα1 promotes breast cancer metastasis upon oncogene activation
Author / Creator:Yi, Yong ; Chen, Deshi ; Ao, Juan ; Zhang, Wenhua ; Yi, Jianqiao ; Ren, Xiaokun ; Fei, Junjie ; Li, Fengtian ; Niu, Mengmeng ; Chen, Hu ; Luo, Yangkun ; Luo, Zhijun ; Xiao, Zhi-Xiong Jim
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-04, Vol.117 (14), p.8013-8021
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ArticlesPeer ReviewedFull Text
Lapatinib antitumor effect is associated with PI3K and MAPK pathway: An analysis in human and canine prostate cancer cells
Author / Creator:Fonseca-Alves, Carlos Eduardo ; Leis-Filho, Antonio Fernando ; Lacerda, Zara Alves ; de Faria Lainetti, Patricia ; Amorim, Renee Laufer ; Rogatto, Silvia Regina
Publisher:United States: Public Library of Science
Journal title:PloS one, 2024-04, Vol.19 (4), p.e0297043-e0297043
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Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects
Author / Creator:Saul, Sirle ; Karim, Marwah ; Ghita, Luca ; Huang, Pei-Tzu ; Chiu, Winston ; Durán, Verónica ; Lo, Chieh-Wen ; Kumar, Sathish ; Bhalla, Nishank ; Leyssen, Pieter ; Alem, Farhang ; Boghdeh, Niloufar A. ; Tran, Do H.N. ; Cohen, Courtney A. ; Brown, Jacquelyn A. ; Huie, Kathleen E. ; Tindle, Courtney ; Sibai, Mamdouh ; Ye, Chengjin ; Khalil, Ahmed Magdy ; Chiem, Kevin ; Martinez-Sobrido, Luis ; Dye, John M. ; Pinsky, Benjamin A. ; Ghosh, Pradipta ; Das, Soumita ; Solow-Cordero, David E. ; Jin, Jing ; Wikswo, John P. ; Jochmans, Dirk ; Neyts, Johan ; De Jonghe, Steven ; Narayanan, Aarthi ; Einav, Shirit
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2023-10, Vol.133 (19), p.1-17
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Assessment of modelling strategies for drug response prediction in cell lines and xenografts
Author / Creator:Kurilov Roman ; Haibe-Kains Benjamin ; Brors Benedikt
Publisher:London: Nature Publishing Group
Journal title:Scientific reports, 2020-02, Vol.10 (1)
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Lapatinib ameliorates skin fibrosis by inhibiting TGF-β1/Smad and non-Smad signaling pathway
Author / Creator:Wang, Yongping ; Zhang, Tiantian ; Song, Hao ; Yang, Cheng
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-03, Vol.15 (1), p.8444-17, Article 8444
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Effects of the fatty acid synthase inhibitors triclosan and lapatinib on dengue virus and Zika virus infection
Author / Creator:Sornprasert, Suthatta ; Jaratsittisin, Janejira ; Chumchanchira, Chanida ; Smith, Duncan R.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-03, Vol.15 (1), p.10731-16, Article 10731
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HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies
Author / Creator:Tracey, Natasha ; Creedon, Helen ; Kemp, Alain J. ; Culley, Jayne ; Muir, Morwenna ; Klinowska, Teresa ; Brunton, Valerie G.
Publisher:New York: Springer US
Journal title:Breast cancer research and treatment, 2020-02, Vol.179 (3), p.543-555
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Human induced pluripotent stem cell-derived platelets loaded with lapatinib effectively target HER2+ breast cancer metastasis to the brain
Author / Creator:Bhan, Arunoday ; Ansari, Khairul ; Chen, Mike Y ; Jandial, Rahul
Publisher:England: Nature Publishing Group UK
Journal title:Scientific reports, 2021-10, Vol.11 (1), p.16866
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Antioxidant functions of DHHC3 suppress anti-cancer drug activities
Publisher:Basel: Springer Nature B.V
Journal title:Cellular and molecular life sciences : CMLS, 2021-03, Vol.78 (5), p.2341-2353
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Showing 1 to 20 of 72 results

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HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway

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Phenotypic changes of HER2-positive breast cancer during and after dual HER2 blockade

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Comparative analysis of drug response and gene profiling of HER2-targeted tyrosine kinase inhibitors

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Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

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Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells

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Co-loaded lapatinib/PAB by ferritin nanoparticles eliminated ECM-detached cluster cells via modulating EGFR in triple-negative breast cancer

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The role of HER2 and HER3 in HER2-amplified cancers beyond breast cancers

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Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer

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SLC35F2–SYVN1–TRIM59 axis critically regulates ferroptosis of pancreatic cancer cells by inhibiting endogenous p53

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Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer

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Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers

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Transcriptional suppression of AMPKα1 promotes breast cancer metastasis upon oncogene activation

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Lapatinib antitumor effect is associated with PI3K and MAPK pathway: An analysis in human and canine prostate cancer cells

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Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects

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Assessment of modelling strategies for drug response prediction in cell lines and xenografts

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Lapatinib ameliorates skin fibrosis by inhibiting TGF-β1/Smad and non-Smad signaling pathway

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Effects of the fatty acid synthase inhibitors triclosan and lapatinib on dengue virus and Zika virus infection

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HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies

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Human induced pluripotent stem cell-derived platelets loaded with lapatinib effectively target HER2+ breast cancer metastasis to the brain

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Antioxidant functions of DHHC3 suppress anti-cancer drug activities

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