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ArticlesPeer ReviewedFull Text
Evaluation of the Efficacy and Safety of Rivaroxaban Using a Computer Model for Blood Coagulation
Author / Creator:Burghaus, Rolf ; Coboeken, Katrin ; Gaub, Thomas ; Kuepfer, Lars ; Sensse, Anke ; Siegmund, Hans-Ulrich ; Weiss, Wolfgang ; Mueck, Wolfgang ; Lippert, Joerg
Publisher:United States: Public Library of Science
Journal title:PloS one, 2011-04, Vol.6 (4), p.e17626
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Translational learning from clinical studies predicts drug pharmacokinetics across patient populations
Author / Creator:Krauss, Markus ; Hofmann, Ute ; Schafmayer, Clemens ; Igel, Svitlana ; Schlender, Jan ; Mueller, Christian ; Brosch, Mario ; von Schoenfels, Witigo ; Erhart, Wiebke ; Schuppert, Andreas ; Block, Michael ; Schaeffeler, Elke ; Boehmer, Gabriele ; Goerlitz, Linus ; Hoecker, Jan ; Lippert, Joerg ; Kerb, Reinhold ; Hampe, Jochen ; Kuepfer, Lars ; Schwab, Matthias
Publisher:London: Nature Publishing Group UK
Journal title:NPJ systems biology and applications, 2017-03, Vol.3 (1), p.11-11, Article 11
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Finerenone Dose–Exposure–Serum Potassium Response Analysis of FIDELIO-DKD Phase III: The Role of Dosing, Titration, and Inclusion Criteria
Author / Creator:Goulooze, Sebastiaan Camiel ; Snelder, Nelleke ; Seelmann, Andreas ; Horvat-Broecker, Andrea ; Brinker, Meike ; Joseph, Amer ; Garmann, Dirk ; Lippert, Joerg ; Eissing, Thomas
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2022-03, Vol.61 (3), p.451-462
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Finerenone Dose-Exposure-Response for the Primary Kidney Outcome in FIDELIO-DKD Phase III: Population Pharmacokinetic and Time-to-Event Analysis
Author / Creator:van den Berg, Paul ; Ruppert, Martijn ; Mesic, Emir ; Snelder, Nelleke ; Seelmann, Andreas ; Heinig, Roland ; Joseph, Amer ; Garmann, Dirk ; Lippert, Joerg ; Eissing, Thomas
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2022-03, Vol.61 (3), p.439-450
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Population Pharmacokinetic and Exposure–Response Analysis of Finerenone: Insights Based on Phase IIb Data and Simulations to Support Dose Selection for Pivotal Trials in Type 2 Diabetes with Chronic K...
Author / Creator:Snelder, Nelleke ; Heinig, Roland ; Drenth, Henk-Jan ; Joseph, Amer ; Kolkhof, Peter ; Lippert, Jörg ; Garmann, Dirk ; Ploeger, Bart ; Eissing, Thomas
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2020-03, Vol.59 (3), p.359-370
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Dose–Exposure–Response Analysis of the Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone on UACR and eGFR: An Analysis from FIDELIO-DKD
Author / Creator:Goulooze, Sebastiaan Camiel ; Heerspink, Hiddo J. L. ; van Noort, Martijn ; Snelder, Nelleke ; Brinker, Meike ; Lippert, Joerg ; Eissing, Thomas
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2022-07, Vol.61 (7), p.1013-1025
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A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim
Author / Creator:Niederalt, Christoph ; Kuepfer, Lars ; Solodenko, Juri ; Eissing, Thomas ; Siegmund, Hans-Ulrich ; Block, Michael ; Willmann, Stefan ; Lippert, Jörg
Publisher:New York: Springer US
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2018-04, Vol.45 (2), p.235-257
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Integrating Cellular Metabolism into a Multiscale Whole-Body Model
Author / Creator:Krauss, Markus ; Schaller, Stephan ; Borchers, Steffen ; Findeisen, Rolf ; Lippert, Jörg ; Kuepfer, Lars
Publisher:United States: Public Library of Science
Journal title:PLoS computational biology, 2012-10, Vol.8 (10), p.e1002750
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ArticlesPeer ReviewedFull Text
Development of a Paediatric Population-Based Model of the Pharmacokinetics of Rivaroxaban
Author / Creator:Willmann, Stefan ; Becker, Corina ; Burghaus, Rolf ; Coboeken, Katrin ; Edginton, Andrea ; Lippert, Jörg ; Siegmund, Hans-Ulrich ; Thelen, Kirstin ; Mück, Wolfgang
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2014-01, Vol.53 (1), p.89-102
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Open Systems Pharmacology Community—An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences
Author / Creator:Lippert, Jörg ; Burghaus, Rolf ; Edginton, Andrea ; Frechen, Sebastian ; Karlsson, Mats ; Kovar, Andreas ; Lehr, Thorsten ; Milligan, Peter ; Nock, Valerie ; Ramusovic, Sergej ; Riggs, Matthew ; Schaller, Stephan ; Schlender, Jan ; Schmidt, Stephan ; Sevestre, Michaël ; Sjögren, Erik ; Solodenko, Juri ; Staab, Alexander ; Teutonico, Donato
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2019-12, Vol.8 (12), p.878-882
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Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach
Author / Creator:Kalra, Priyata ; Brandl, Julian ; Gaub, Thomas ; Niederalt, Christoph ; Lippert, Jörg ; Sahle, Sven ; Küpfer, Lars ; Kummer, Ursula
Publisher:United States: Public Library of Science
Journal title:PloS one, 2019-02, Vol.14 (2), p.e0209587-e0209587
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Pharmacokinetics of rivaroxaban in children using physiologically based and population pharmacokinetic modelling: an EINSTEIN-Jr phase I study
Author / Creator:Willmann, Stefan ; Thelen, Kirstin ; Kubitza, Dagmar ; Lensing, Anthonie W. A. ; Frede, Matthias ; Coboeken, Katrin ; Stampfuss, Jan ; Burghaus, Rolf ; Mück, Wolfgang ; Lippert, Jörg
Publisher:England: BioMed Central Ltd
Journal title:Thrombosis journal, 2018-12, Vol.16 (1), p.32-12, Article 32
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Physiologically based pharmacokinetic modelling of high- and low-dose etoposide: from adults to children
Author / Creator:Kersting, Gisela ; Willmann, Stefan ; Würthwein, Gudrun ; Lippert, Jörg ; Boos, Joachim ; Hempel, Georg
Publisher:Berlin/Heidelberg: Springer-Verlag
Journal title:Cancer chemotherapy and pharmacology, 2012-02, Vol.69 (2), p.397-405
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Algorithmic surveillance of I CU patients with acute respiratory distress syndrome (ASIC): protocol for a multicentre stepped-wedge cluster randomised quality improvement strategy
Author / Creator:Marx, Gernot ; Bickenbach, Johannes ; Fritsch, Sebastian Johannes ; Kunze, Julian Benedict ; Maassen, Oliver ; Deffge, Saskia ; Kistermann, Jennifer ; Haferkamp, Silke ; Lutz, Irina ; Voellm, Nora Kristiana ; Lowitsch, Volker ; Polzin, Richard ; Sharafutdinov, Konstantin ; Mayer, Hannah ; Kuepfer, Lars ; Burghaus, Rolf ; Schmitt, Walter ; Lippert, Joerg ; Riedel, Morris ; Barakat, Chadi ; Stollenwerk, André ; Fonck, Simon ; Putensen, Christian ; Zenker, Sven ; Erdfelder, Felix ; Grigutsch, Daniel ; Kram, Rainer ; Beyer, Susanne ; Kampe, Knut ; Gewehr, Jan Erik ; Salman, Friederike ; Juers, Patrick ; Kluge, Stefan ; Tiller, Daniel ; Wisotzki, Emilia ; Gross, Sebastian ; Homeister, Lorenz ; Bloos, Frank ; Scherag, André ; Ammon, Danny ; Mueller, Susanne ; Palm, Julia ; Simon, Philipp ; Jahn, Nora ; Loeffler, Markus ; Wendt, Thomas ; Schuerholz, Tobias ; Groeber, Petra ; Schuppert, Andreas
Journal title:BMJ open, 2021-04, Vol.11 (4), p.e045589
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CKD subpopulations defined by risk‐factors: A longitudinal analysis of electronic health records
Author / Creator:Ramaswamy, Rajagopalan ; Wee, Soon Nan ; George, Kavya ; Ghosh, Abhijit ; Sarkar, Joydeep ; Burghaus, Rolf ; Lippert, Jörg
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2021-11, Vol.10 (11), p.1343-1356
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Data‐driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment
Author / Creator:Fendt, Rebekka ; Hofmann, Ute ; Schneider, Annika R. P. ; Schaeffeler, Elke ; Burghaus, Rolf ; Yilmaz, Ali ; Blank, Lars Mathias ; Kerb, Reinhold ; Lippert, Jörg ; Schlender, Jan‐Frederik ; Schwab, Matthias ; Kuepfer, Lars
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2021-07, Vol.10 (7), p.782-793
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Model‐informed bridging of rivaroxaban doses for thromboprophylaxis in pediatric patients aged 9 years and older with congenital heart disease
Author / Creator:Willmann, Stefan ; Ince, Ibrahim ; Ahsman, Maurice ; Coboeken, Katrin ; Zhang, Yang ; Thelen, Kirstin ; Kubitza, Dagmar ; Zannikos, Peter ; Zhou, Wangda ; Pina, Liza Miriam ; Post, Teun ; Lippert, Jörg
Publisher:Hoboken: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2022-08, Vol.11 (8), p.1111-1121
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ArticlesPeer ReviewedFull Text
Population pharmacokinetic analysis of rivaroxaban in children and comparison to prospective physiologically‐based pharmacokinetic predictions
Author / Creator:Willmann, Stefan ; Coboeken, Katrin ; Zhang, Yang ; Mayer, Hannah ; Ince, Ibrahim ; Mesic, Emir ; Thelen, Kirstin ; Kubitza, Dagmar ; Lensing, Anthonie W. A. ; Yang, Haitao ; Zhu, Peijuan ; Mück, Wolfgang ; Drenth, Henk‐Jan ; Lippert, Jörg
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2021-10, Vol.10 (10), p.1195-1207
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ArticlesPeer ReviewedFull Text
Development of a Physiology-Based Whole-Body Population Model for Assessing the Influence of Individual Variability on the Pharmacokinetics of Drugs
Author / Creator:Willmann, Stefan ; Höhn, Karsten ; Edginton, Andrea ; Sevestre, Michael ; Solodenko, Juri ; Weiss, Wolfgang ; Lippert, Jörg ; Schmitt, Walter
Publisher:United States: Springer Nature B.V
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2007-06, Vol.34 (3), p.401-431
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Pharmacogenomics of Codeine, Morphine, and Morphine-6-Glucuronide: Model-Based Analysis of the Influence of CYP2D6 Activity, UGT2B7 Activity, Renal Impairment, and CYP3A4 Inhibition
Author / Creator:Eissing, Thomas ; Lippert, Jörg ; Willmann, Stefan
Publisher:Cham: Springer International Publishing
Journal title:Molecular diagnosis & therapy, 2012-02, Vol.16 (1), p.43-53
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Showing 1 to 20 of 20 results

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Evaluation of the Efficacy and Safety of Rivaroxaban Using a Computer Model for Blood Coagulation

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Translational learning from clinical studies predicts drug pharmacokinetics across patient populations

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Finerenone Dose–Exposure–Serum Potassium Response Analysis of FIDELIO-DKD Phase III: The Role of Dosing, Titration, and Inclusion Criteria

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Finerenone Dose-Exposure-Response for the Primary Kidney Outcome in FIDELIO-DKD Phase III: Population Pharmacokinetic and Time-to-Event Analysis

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Population Pharmacokinetic and Exposure–Response Analysis of Finerenone: Insights Based on Phase IIb Data and Simulations to Support Dose Selection for Pivotal Trials in Type 2 Diabetes with Chronic K...

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Dose–Exposure–Response Analysis of the Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone on UACR and eGFR: An Analysis from FIDELIO-DKD

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A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim

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Integrating Cellular Metabolism into a Multiscale Whole-Body Model

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Development of a Paediatric Population-Based Model of the Pharmacokinetics of Rivaroxaban

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Open Systems Pharmacology Community—An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

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Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach

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Pharmacokinetics of rivaroxaban in children using physiologically based and population pharmacokinetic modelling: an EINSTEIN-Jr phase I study

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Physiologically based pharmacokinetic modelling of high- and low-dose etoposide: from adults to children

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Algorithmic surveillance of I CU patients with acute respiratory distress syndrome (ASIC): protocol for a multicentre stepped-wedge cluster randomised quality improvement strategy

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CKD subpopulations defined by risk‐factors: A longitudinal analysis of electronic health records

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Data‐driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment

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Model‐informed bridging of rivaroxaban doses for thromboprophylaxis in pediatric patients aged 9 years and older with congenital heart disease

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Population pharmacokinetic analysis of rivaroxaban in children and comparison to prospective physiologically‐based pharmacokinetic predictions

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Development of a Physiology-Based Whole-Body Population Model for Assessing the Influence of Individual Variability on the Pharmacokinetics of Drugs

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Pharmacogenomics of Codeine, Morphine, and Morphine-6-Glucuronide: Model-Based Analysis of the Influence of CYP2D6 Activity, UGT2B7 Activity, Renal Impairment, and CYP3A4 Inhibition

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