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138 results for Liver+X+Receptors+-+genetics

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ArticlesPeer ReviewedFull Text
Liver X receptors in lipid signalling and membrane homeostasis
Author / Creator:Wang, Bo ; Tontonoz, Peter
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Endocrinology, 2018-08, Vol.14 (8), p.452-463
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Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA
Author / Creator:Sallam, Tamer ; Jones, Marius ; Thomas, Brandon J ; Wu, Xiaohui ; Gilliland, Thomas ; Qian, Kevin ; Eskin, Ascia ; Casero, David ; Zhang, Zhengyi ; Sandhu, Jaspreet ; Salisbury, David ; Rajbhandari, Prashant ; Civelek, Mete ; Hong, Cynthia ; Ito, Ayaka ; Liu, Xin ; Daniel, Bence ; Lusis, Aldons J ; Whitelegge, Julian ; Nagy, Laszlo ; Castrillo, Antonio ; Smale, Stephen ; Tontonoz, Peter
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2018-03, Vol.24 (3), p.304-312
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Quercetin protects against atherosclerosis by regulating the expression of PCSK9, CD36, PPARγ, LXRα and ABCA1
Author / Creator:Jia, Qingling ; Cao, Hui ; Shen, Dingzhu ; Li, Shanshan ; Yan, Li ; Chen, Chuan ; Xing, Sanli ; Dou, Fangfang
Publisher:Athens: D.A. Spandidos
Journal title:International journal of molecular medicine, 2019-09, Vol.44 (3), p.893-902
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Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs)
Author / Creator:Slominski, Andrzej T. ; Kim, Tae-Kang ; Qayyum, Shariq ; Song, Yuwei ; Janjetovic, Zorica ; Oak, Allen S. W. ; Slominski, Radomir M. ; Raman, Chander ; Stefan, Joanna ; Mier-Aguilar, Carlos A. ; Atigadda, Venkatram ; Crossman, David K. ; Golub, Andriy ; Bilokin, Yaroslav ; Tang, Edith K. Y. ; Chen, Jake Y. ; Tuckey, Robert C. ; Jetten, Anton M. ; Song, Yuhua
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-04, Vol.11 (1), p.8002-23, Article 8002
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LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes
Author / Creator:Ding, Jingzhong ; Nguyen, Anh Tram ; Lohman, Kurt ; Hensley, Michael T. ; Parker, Daniel ; Hou, Li ; Taylor, Jackson ; Voora, Deepak ; Sawyer, Janet K. ; Boudyguina, Elena ; Bancks, Michael P. ; Bertoni, Alain ; Pankow, James S. ; Rotter, Jerome I. ; Goodarzi, Mark O. ; Tracy, Russell P. ; Murdoch, David M. ; Duprez, Daniel ; Rich, Stephen S. ; Psaty, Bruce M. ; Siscovick, David ; Newgard, Christopher B. ; Herrington, David ; Hoeschele, Ina ; Shea, Steven ; Stein, James H. ; Patel, Manesh ; Post, Wendy ; Jacobs, David ; Parks, John S. ; Liu, Yongmei
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2024-08, Vol.134 (16)
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LXR-dependent enhancer activation regulates the temporal organization of the liver’s response to refeeding leading to lipogenic gene overshoot
Author / Creator:Korenfeld, Noga ; Gorbonos, Tali ; Romero Florian, Maria C. ; Rotaro, Dan ; Goldberg, Dana ; Radushkevitz-Frishman, Talia ; Charni-Natan, Meital ; Bar-Shimon, Meirav ; Cummins, Carolyn L. ; Goldstein, Ido
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2024-09, Vol.22 (9), p.e3002735
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Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction
Author / Creator:Hammer, Sandra S ; Vieira, Cristiano P ; McFarland Delaney ; Sandler, Maximilian ; Levitsky, Yan ; Dorweiler, Tim F ; Lydic, Todd A ; Asare-Bediako Bright ; Adu-Agyeiwaah Yvonne ; Sielski, Micheli S ; Dupont, Mariana ; Longhini Ana Leda ; Li Calzi Sergio ; Chakraborty Dibyendu ; Seigel, Gail M ; Proshlyakov, Denis A ; Grant, Maria B ; Busik, Julia V
Publisher:Heidelberg: Springer Nature B.V
Journal title:Diabetologia, 2021-07, Vol.64 (7), p.1674-1689
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Loss of liver X receptor β in astrocytes leads to anxiety-like behaviors via regulating synaptic transmission in the medial prefrontal cortex in mice
Author / Creator:Li, Xin ; Zhong, Hongyu ; Wang, Zhongke ; Xiao, Rui ; Antonson, Per ; Liu, Tianyao ; Wu, Chuan ; Zou, Jiao ; Wang, Lian ; Nalvarte, Ivan ; Xu, Haiwei ; Warner, Margaret ; Gustafsson, Jan-Ake ; Fan, Xiaotang
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2021-11, Vol.26 (11), p.6380-6393
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Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver
Author / Creator:Bideyan, Lara ; Fan, Wenxin ; Kaczor-Urbanowicz, Karolina Elżbieta ; Priest, Christina ; Casero, David ; Tontonoz, Peter
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2022-02, Vol.119 (7), p.1-11
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ArticlesPeer ReviewedFull Text
LXRα Regulates oxLDL-Induced Trained Immunity in Macrophages
Author / Creator:Findeisen, Hannes M. ; Voges, Vivienne C. ; Braun, Laura C. ; Sonnenberg, Jannik ; Schwarz, Dennis ; Körner, Helena ; Reinecke, Holger ; Sohrabi, Yahya
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2022-05, Vol.23 (11), p.6166
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The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis
Author / Creator:Xu, Pengfei ; Zhai, Yonggong ; Wang, Jing
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2018-04, Vol.19 (4), p.1260
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Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals
Author / Creator:Kimura, Tetsuya ; Nada, Shigeyuki ; Takegahara, Noriko ; Okuno, Tatsusada ; Nojima, Satoshi ; Kang, Sujin ; Ito, Daisuke ; Morimoto, Keiko ; Hosokawa, Takashi ; Hayama, Yoshitomo ; Mitsui, Yuichi ; Sakurai, Natsuki ; Sarashina-Kida, Hana ; Nishide, Masayuki ; Maeda, Yohei ; Takamatsu, Hyota ; Okuzaki, Daisuke ; Yamada, Masaki ; Okada, Masato ; Kumanogoh, Atsushi
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-10, Vol.7 (1), p.13130-17, Article 13130
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25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome
Author / Creator:Jang, Jiho ; Park, Sangjun ; Jin Hur, Hye ; Cho, Hyun-Ju ; Hwang, Inhwa ; Pyo Kang, Yun ; Im, Isak ; Lee, Hyunji ; Lee, Eunju ; Yang, Wonsuk ; Kang, Hoon-Chul ; Won Kwon, Sung ; Yu, Je-Wook ; Kim, Dong-Wook
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-10, Vol.7 (1), p.13129-11, Article 13129
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Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution
Author / Creator:Körner, Andreas ; Zhou, Enchen ; Müller, Christoph ; Mohammed, Yassene ; Herceg, Sandra ; Bracher, Franz ; Rensen, Patrick C. N. ; Wang, Yanan ; Mirakaj, Valbona ; Giera, Martin
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (41), p.20623-20634
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Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation
Author / Creator:Gage, M. C. ; Bécares, N. ; Louie, R. ; Waddington, K. E. ; Zhang, Y. ; Tittanegro, T. H. ; Rodríguez-Lorenzo, S. ; Jathanna, A. ; Pourcet, B. ; Pello, O. M. ; De la Rosa, J. V. ; Castrillo, A. ; Pineda-Torra, I.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-07, Vol.115 (28), p.E6556-E6565
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A mutation in LXRα uncovers a role for cholesterol sensing in limiting metabolic dysfunction-associated steatohepatitis
Author / Creator:Clark, Alexis T. ; Russo-Savage, Lillian ; Ashton, Luke A. ; Haghshenas, Niki ; Amselle, Nicolas A. ; Schulman, Ira G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-01, Vol.16 (1), p.1102-19, Article 1102
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The type of diet consumed during prepuberty modulates plasma cholesterol, hepatic LXRα expression, and DNA methylation and hydroxymethylation during adulthood in male rats
Author / Creator:Aguilar-Lozano, Ana ; Palacios-González, Berenice ; Guevara-Cruz, Martha ; Tovar, Armando R. ; Palma-Guzman, Alam ; Noriega, Lilia G.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2025-01, Vol.20 (1), p.e0315197
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LXR directly regulates glycosphingolipid synthesis and affects human CD4+ T cell function
Author / Creator:Waddington, Kirsty E. ; Robinson, George A. ; Rubio-Cuesta, Beatriz ; Chrifi-Alaoui, Eden ; Andreone, Sara ; Poon, Kok-Siong ; Ivanova, Iveta ; Martin-Gutierrez, Lucia ; Owen, Dylan M. ; Jury, Elizabeth C. ; Pineda-Torra, Inés
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-05, Vol.118 (21), p.1-12
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ER phospholipid composition modulates lipogenesis during feeding and in obesity
Author / Creator:Rong, Xin ; Wang, Bo ; Palladino, Elisa N.D. ; de Aguiar Vallim, Thomas Q. ; Ford, David A. ; Tontonoz, Peter
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2017-10, Vol.127 (10), p.3640-3651
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Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis
Author / Creator:El Kasmi, Karim C ; Vue, Padade M ; Anderson, Aimee L ; Devereaux, Michael W ; Ghosh, Swati ; Natarajan Balasubramaniyan ; Fillon, Sophie A ; Dahrenmoeller, Carola ; Allawzi, Ayed ; Woods, Crystal ; McKenna, Sarah ; Wright, Clyde J ; Johnson, Linda ; Angelo D’Alessandro ; Reisz, Julie A ; Nozik-Grayck, Eva ; Suchy, Frederick J ; Sokol, Ronald J
Publisher:London: Nature Publishing Group
Journal title:Nature communications, 2018-04, Vol.9, p.1-14
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Showing 1 to 20 of 138 results

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Liver X receptors in lipid signalling and membrane homeostasis

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Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA

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Quercetin protects against atherosclerosis by regulating the expression of PCSK9, CD36, PPARγ, LXRα and ABCA1

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Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs)

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LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes

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LXR-dependent enhancer activation regulates the temporal organization of the liver’s response to refeeding leading to lipogenic gene overshoot

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Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction

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Loss of liver X receptor β in astrocytes leads to anxiety-like behaviors via regulating synaptic transmission in the medial prefrontal cortex in mice

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Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver

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LXRα Regulates oxLDL-Induced Trained Immunity in Macrophages

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The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis

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Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals

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25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome

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Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution

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Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation

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A mutation in LXRα uncovers a role for cholesterol sensing in limiting metabolic dysfunction-associated steatohepatitis

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The type of diet consumed during prepuberty modulates plasma cholesterol, hepatic LXRα expression, and DNA methylation and hydroxymethylation during adulthood in male rats

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LXR directly regulates glycosphingolipid synthesis and affects human CD4+ T cell function

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ER phospholipid composition modulates lipogenesis during feeding and in obesity

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Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis

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