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ArticlesPeer ReviewedFull Text
Development and Application of a Slot-Blot Assay Using the Damage Sensing Protein Atl1 to Detect and Quantify O6-Alkylated Guanine Bases in DNA
Author / Creator:Yaakub, Hanum ; Howell, Anthony ; Margison, Geoffrey P. ; Povey, Andrew C.
Publisher:Basel: MDPI AG
Journal title:Toxics (Basel), 2024-09, Vol.12 (9), p.649
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QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency
Author / Creator:Sun, Guohui ; Bai, Peiying ; Fan, Tengjiao ; Zhao, Lijiao ; Zhong, Rugang ; McElhinney, R. ; McMurry, T. ; Donnelly, Dorothy ; McCormick, Joan ; Kelly, Jane ; Margison, Geoffrey
Publisher:Basel: MDPI AG
Journal title:Pharmaceutics, 2023-08, Vol.15 (8), p.2170
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ArticlesPeer ReviewedFull Text
O⁶-methylguanine–induced transcriptional mutagenesis reduces p53 tumor-suppressor function
Author / Creator:Ezerskyte, Monika ; Paredes, João A. ; Malvezzi, Stefano ; Burns, John A. ; Margison, Geoffrey P. ; Olsson, Magnus ; Scicchitano, David A. ; Dreij, Kristian
Publisher:National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (18), p.4731-4736
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ArticlesPeer ReviewedFull Text
The DNA Alkyltransferase Family of DNA Repair Proteins: Common Mechanisms, Diverse Functions
Author / Creator:Tessmer, Ingrid ; Margison, Geoffrey P
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2023-12, Vol.25 (1), p.463
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Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation–π interactions
Author / Creator:Wilkinson, Oliver J ; Latypov, Vitaly ; Tubbs, Julie L ; Millington, Christopher L ; Morita, Rihito ; Blackburn, Hannah ; Marriott, Andrew ; McGown, Gail ; Thorncroft, Mary ; Watson, Amanda J ; Connolly, Bernard A ; Grasby, Jane A ; Masui, Ryoji ; Hunter, Christopher A ; Tainer, John A ; Margison, Geoffrey P ; Williams, David M
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-11, Vol.109 (46), p.18755-18760
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Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients
Author / Creator:Agnihotri, Sameer ; Gajadhar, Aaron S ; Ternamian, Christian ; Gorlia, Thierry ; Diefes, Kristin L ; Mischel, Paul S ; Kelly, Joanna ; McGown, Gail ; Thorncroft, Mary ; Carlson, Brett L ; Sarkaria, Jann N ; Margison, Geoffrey P ; Aldape, Kenneth ; Hawkins, Cynthia ; Hegi, Monika ; Guha, Abhijit
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2012-01, Vol.122 (1), p.253-266
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ArticlesPeer ReviewedFull Text
O 6 -methylguanine-induced transcriptional mutagenesis reduces p53 tumor-suppressor function
Author / Creator:Ezerskyte, Monika ; Paredes, João A ; Malvezzi, Stefano ; Burns, John A ; Margison, Geoffrey P ; Olsson, Magnus ; Scicchitano, David A ; Dreij, Kristian
Publisher:United States
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (18), p.4731-4736
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ArticlesPeer ReviewedFull Text
Flipping of alkylated DNA damage bridges base and nucleotide excision repair
Author / Creator:Tubbs, Julie L. ; Latypov, Vitaly ; Kanugula, Sreenivas ; Butt, Amna ; Melikishvili, Manana ; Kraehenbuehl, Rolf ; Fleck, Oliver ; Marriott, Andrew ; Watson, Amanda J. ; Verbeek, Barbara ; McGown, Gail ; Thorncroft, Mary ; Santibanez-Koref, Mauro F. ; Millington, Christopher ; Arvai, Andrew S. ; Kroeger, Matthew D. ; Peterson, Lisa A. ; Williams, David M. ; Fried, Michael G. ; Margison, Geoffrey P. ; Pegg, Anthony E. ; Tainer, John A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2009-06, Vol.459 (7248), p.808-813
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ArticlesPeer ReviewedFull Text
Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells
Author / Creator:Arozarena, Imanol ; Goicoechea, Ibai ; Erice, Oihane ; Ferguson, Jennnifer ; Margison, Geoffrey P ; Wellbrock, Claudia
Publisher:England: BioMed Central Ltd
Journal title:Molecular cancer, 2014-06, Vol.13 (1), p.154-154
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ArticlesPeer ReviewedFull Text
Targeting O6-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy
Author / Creator:Kaina, Bernd ; Margison, Geoffrey P. ; Christmann, Markus
Publisher:Basel: SP Birkhäuser Verlag Basel
Journal title:Cellular and molecular life sciences : CMLS, 2010-11, Vol.67 (21), p.3663-3681
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ArticlesPeer ReviewedFull Text
Targeting O ⁶-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy
Author / Creator:Kaina, Bernd ; Margison, Geoffrey P ; Christmann, Markus
Publisher:Basel: Basel : SP Birkhäuser Verlag Basel
Journal title:Cellular and molecular life sciences : CMLS, 2010-11, Vol.67 (21), p.3663-3681
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ArticlesPeer ReviewedFull Text
Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway
Author / Creator:Middleton, Mark R ; Margison, Geoffrey P
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2003, Vol.4 (1), p.37-44
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Heterogeneity of O6-Alkylguanine-DNA Alkyltransferase Activity in Colorectal Cancer: Implications for Treatment
Author / Creator:Lees, Nicholas P. ; Harrison, Kathryn L. ; Hill, Elizabeth ; Hall, C. Nicholas ; Povey, Andrew C. ; Margison, Geoffrey P.
Publisher:Basel, Switzerland: S. Karger AG
Journal title:Oncology, 2002-01, Vol.63 (4), p.393-397
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ArticlesPeer ReviewedFull Text
Msh2 Status Modulates Both Apoptosis and Mutation Frequency in the Murine Small Intestine
Author / Creator:Toft, Neil J. ; Winton, Douglas J. ; Kelly, Jane ; Howard, Louise A. ; Dekker, Marleen ; Riele, Hein te ; Arends, Mark J. ; Wyllie, Andrew H. ; Margison, Geoffrey P. ; Clarke, Alan R.
Publisher:United States: National Academy of Sciences of the United States of America
Journal title:Proceedings of the National Academy of Sciences - PNAS, 1999-03, Vol.96 (7), p.3911-3915
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ArticlesPeer ReviewedFull Text
Thermostable Archaeal O6-alkylguanine-DNA Alkyltransferases
Author / Creator:Skorvaga, Milan ; Neil D. H. Raven ; Margison, Geoffrey P.
Publisher:United States: National Academy of Sciences of the United States of America
Journal title:Proceedings of the National Academy of Sciences - PNAS, 1998-06, Vol.95 (12), p.6711-6715
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Dual agent chemoprotection by retroviral co-expression of either MDR1 or MRP1 with the P140K mutant of O6-methylguanine-DNA-methyl transferase
Author / Creator:Southgate, Thomas D. ; Garside, Elloise ; Margison, Geoffrey P. ; Fairbairn, Leslie J.
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The journal of gene medicine, 2006-08, Vol.8 (8), p.972-979
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Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells
Author / Creator:Schambach, Axel ; Bohne, Jens ; Chandra, Saurabh ; Will, Elke ; Margison, Geoffrey P ; Williams, David A ; Baum, Christopher
Publisher:United States: Elsevier Limited
Journal title:Molecular therapy, 2006-02, Vol.13 (2), p.391-400
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Erratum to “Enhanced in Vivo Selection of Bone Marrow Cells by Retroviral-Mediated Coexpression of Mutant O6-Methylguanine-DNA-methyltransferase and HOXB4”
Author / Creator:Milsom, Michael D. ; Woolford, Lorna B. ; Margison, Geoffrey P. ; Humphries, R. Keith ; Fairbairn, Leslie J.
Publisher:Milwaukee: Elsevier Limited
Journal title:Molecular therapy, 2005-10, Vol.12 (4), p.772-773
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ArticlesPeer ReviewedFull Text
Development and Application of a Slot-Blot Assay Using the Damage Sensing Protein Atl1 to Detect and Quantify O 6 -Alkylated Guanine Bases in DNA
Author / Creator:Yaakub, Hanum ; Howell, Anthony ; Margison, Geoffrey P ; Povey, Andrew C
Publisher:Switzerland
Journal title:Toxics (Basel), 2024-09, Vol.12 (9)
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ArticlesPeer ReviewedFull Text
Development and Application of a Slot-Blot Assay Using the Damage Sensing Protein Atl1 to Detect and Quantify O[sup.6]-Alkylated Guanine Bases in DNA
Author / Creator:Yaakub, Hanum ; Howell, Anthony ; Margison, Geoffrey P ; Povey, Andrew C
Publisher:MDPI AG
Journal title:Toxics (Basel), 2024-09, Vol.12 (9)
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Development and Application of a Slot-Blot Assay Using the Damage Sensing Protein Atl1 to Detect and Quantify O6-Alkylated Guanine Bases in DNA

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QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency

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O⁶-methylguanine–induced transcriptional mutagenesis reduces p53 tumor-suppressor function

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The DNA Alkyltransferase Family of DNA Repair Proteins: Common Mechanisms, Diverse Functions

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Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation–π interactions

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Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients

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O 6 -methylguanine-induced transcriptional mutagenesis reduces p53 tumor-suppressor function

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Flipping of alkylated DNA damage bridges base and nucleotide excision repair

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Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells

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Targeting O6-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy

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Targeting O ⁶-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy

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Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway

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Heterogeneity of O6-Alkylguanine-DNA Alkyltransferase Activity in Colorectal Cancer: Implications for Treatment

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Msh2 Status Modulates Both Apoptosis and Mutation Frequency in the Murine Small Intestine

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Thermostable Archaeal O6-alkylguanine-DNA Alkyltransferases

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Dual agent chemoprotection by retroviral co-expression of either MDR1 or MRP1 with the P140K mutant of O6-methylguanine-DNA-methyl transferase

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Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells

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Erratum to “Enhanced in Vivo Selection of Bone Marrow Cells by Retroviral-Mediated Coexpression of Mutant O6-Methylguanine-DNA-methyltransferase and HOXB4”

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Development and Application of a Slot-Blot Assay Using the Damage Sensing Protein Atl1 to Detect and Quantify O 6 -Alkylated Guanine Bases in DNA

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Development and Application of a Slot-Blot Assay Using the Damage Sensing Protein Atl1 to Detect and Quantify O[sup.6]-Alkylated Guanine Bases in DNA

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