Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation–π...
Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation–π interactions
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Author / Creator
Wilkinson, Oliver J , Latypov, Vitaly , Tubbs, Julie L , Millington, Christopher L , Morita, Rihito , Blackburn, Hannah , Marriott, Andrew , McGown, Gail , Thorncroft, Mary , Watson, Amanda J , Connolly, Bernard A , Grasby, Jane A , Masui, Ryoji , Hunter, Christopher A , Tainer, John A , Margison, Geoffrey P and Williams, David M
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Alkyltransferase-like (ATL) proteins in Schizosaccharomyces pombe (Atl1) and Thermus thermophilus (TTHA1564) protect against the adverse effects of DNA alkylation damage by flagging O ⁶-alkylguanine lesions for nucleotide excision repair (NER). We show that both ATL proteins bind with high affinity to oligodeoxyribonucleotides containing O ⁶-alkylg...
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Full title
Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation–π interactions
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Record Identifier
TN_cdi_pubmed_primary_23112169
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_23112169
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1209451109
