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677 results for Microsomes,+Liver+-+enzymology

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ArticlesPeer ReviewedFull Text
Transfer learning enables prediction of CYP2D6 haplotype function
Author / Creator:McInnes, Gregory ; Dalton, Rachel ; Sangkuhl, Katrin ; Whirl-Carrillo, Michelle ; Lee, Seung-been ; Tsao, Philip S. ; Gaedigk, Andrea ; Altman, Russ B. ; Woodahl, Erica L.
Publisher:United States: Public Library of Science
Journal title:PLoS computational biology, 2020-11, Vol.16 (11), p.e1008399
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Measurement of cytochrome P450 and NADPH–cytochrome P450 reductase
Author / Creator:Guengerich, F Peter ; Martin, Martha V ; Sohl, Christal D ; Cheng, Qian
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2009-09, Vol.4 (9), p.1245-1251
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Large scale enzyme based xenobiotic identification for exposomics
Author / Creator:Liu, Ken H. ; Lee, Choon M. ; Singer, Grant ; Bais, Preeti ; Castellanos, Francisco ; Woodworth, Michael H. ; Ziegler, Thomas R. ; Kraft, Colleen S. ; Miller, Gary W. ; Li, Shuzhao ; Go, Young-Mi ; Morgan, Edward T. ; Jones, Dean P.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-09, Vol.12 (1), p.5418-9, Article 5418
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Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective
Author / Creator:Kaplan, Anna ; Gaschler, Michael M. ; Dunn, Denise E. ; Colligan, Ryan ; Brown, Lewis M. ; Palmer, Arthur G. ; Lo, Donald C. ; Stockwell, Brent R.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-04, Vol.112 (17), p.E2245-E2252
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Effects of mallotus furetianus extract on CYP3A activities in rats
Author / Creator:Huang, Wei ; Kim, Hyo In ; Cao, Feng ; Li, Shuang ; Park, Jinbong ; Li, Peiqiong
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-05, Vol.15 (1), p.18530-9, Article 18530
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Novel Inhibitors of Nicotinamide-N-Methyltransferase for the Treatment of Metabolic Disorders
Author / Creator:Kannt, Aimo ; Rajagopal, Sridharan ; Hallur, Mahanandeesha S. ; Swamy, Indu ; Kristam, Rajendra ; Dhakshinamoorthy, Saravanakumar ; Czech, Joerg ; Zech, Gernot ; Schreuder, Herman ; Ruf, Sven
Publisher:Switzerland: MDPI
Journal title:Molecules (Basel, Switzerland), 2021-02, Vol.26 (4), p.991
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In vitro UGT1A1 inhibition by tyrosine kinase inhibitors and association with drug-induced hyperbilirubinemia
Author / Creator:Qosa, Hisham ; Avaritt, Brittany R. ; Hartman, Neil R. ; Volpe, Donna A.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer chemotherapy and pharmacology, 2018-11, Vol.82 (5), p.795-802
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New insight into the mechanism of mitochondrial cytochrome c function
Author / Creator:Chertkova, Rita V. ; Brazhe, Nadezda A. ; Bryantseva, Tatiana V. ; Nekrasov, Alexey N. ; Dolgikh, Dmitry A. ; Yusipovich, Alexander I. ; Sosnovtseva, Olga ; Maksimov, Georgy V. ; Rubin, Andrei B. ; Kirpichnikov, Mikhail P.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-05, Vol.12 (5), p.e0178280-e0178280
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In vitro Phase I and Phase II metabolism of α-pyrrolidinovalerophenone (α-PVP), methylenedioxypyrovalerone (MDPV) and methedrone by human liver microsomes and human liver cytosol
Author / Creator:Negreira, Noelia ; Erratico, Claudio ; Kosjek, Tina ; van Nuijs, Alexander L. N ; Heath, Ester ; Neels, Hugo ; Covaci, Adrian
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Analytical and bioanalytical chemistry, 2015-07, Vol.407 (19), p.5803-5816
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Identifying the Dominant Contribution of Human Cytochrome P450 2J2 to the Metabolism of Rivaroxaban, an Oral Anticoagulant
Author / Creator:Zhao, Tingting ; Chen, Yanwei ; Wang, Dalong ; Wang, Liyan ; Dong, Peipei ; Zhao, Shan ; Wang, Changyuan ; Meng, Qiang ; Sun, Huijun ; Liu, Kexin ; Wu, Jingjing
Publisher:New York: Springer US
Journal title:Cardiovascular drugs and therapy, 2022-02, Vol.36 (1), p.121-129
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Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD
Author / Creator:York, Brian ; Li, Feng ; Lin, Fumin ; Marcelo, Kathrina L. ; Mao, Jianqiang ; Dean, Adam ; Gonzales, Naomi ; Gooden, David ; Maity, Suman ; Coarfa, Cristian ; Putluri, Nagireddy ; Means, Anthony R.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-09, Vol.7 (1), p.11793-14, Article 11793
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ArticlesPeer ReviewedFull Text
Inhibition of UGT2B7 Enzyme Activity in Human and Rat Liver Microsomes by Herbal Constituents
Author / Creator:Abdullah, Nurul Huda ; Ismail, Sabariah
Publisher:Switzerland: MDPI
Journal title:Molecules (Basel, Switzerland), 2018-10, Vol.23 (10), p.2696
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Identification and characterization of the structure–activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum
Author / Creator:Wang, Qi ; Wang, Yadan ; Li, Yong ; Wen, Binyu ; Dai, Zhong ; Ma, Shuangcheng ; Zhang, Yujie
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-12, Vol.7 (1), p.17952-9, Article 17952
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Inhibition of human drug-metabolising cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in vitro by uremic toxins
Author / Creator:Barnes, Kyra J. ; Rowland, Andrew ; Polasek, Thomas M. ; Miners, John O.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:European journal of clinical pharmacology, 2014-09, Vol.70 (9), p.1097-1106
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ArticlesPeer ReviewedFull Text
Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content
Author / Creator:Shirasaka, Y ; Chaudhry, A S ; McDonald, M ; Prasad, B ; Wong, T ; Calamia, J C ; Fohner, A ; Thornton, T A ; Isoherranen, N ; Unadkat, J D ; Rettie, A E ; Schuetz, E G ; Thummel, K E
Publisher:London: Nature Publishing Group UK
Journal title:The pharmacogenomics journal, 2016-08, Vol.16 (4), p.375-387
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Role of Human Liver Microsomes in In Vitro Metabolism of Drugs—A Review
Author / Creator:Asha, Sepuri ; Vidyavathi, Maravajhala
Publisher:New York: New York : Humana Press Inc
Journal title:Applied biochemistry and biotechnology, 2010-03, Vol.160 (6), p.1699-1722
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Mammalian epoxide hydrolases in xenobiotic metabolism and signalling
Author / Creator:Decker, Martina ; Arand, Michael ; Cronin, Annette
Publisher:Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
Journal title:Archives of toxicology, 2009-04, Vol.83 (4), p.297-318
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Significantly Decreased and More Variable Expression of Major CYPs and UGTs in Liver Microsomes Prepared from HBV-Positive Human Hepatocellular Carcinoma and Matched Pericarcinomatous Tissues Determin...
Author / Creator:Yan, Tongmeng ; Gao, Song ; Peng, Xiaojuan ; Shi, Jian ; Xie, Cong ; Li, Qiang ; Lu, Linlin ; Wang, Ying ; Zhou, Fuyuan ; Liu, Zhongqiu ; Hu, Ming
Publisher:Boston: Springer US
Journal title:Pharmaceutical research, 2015-03, Vol.32 (3), p.1141-1157
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In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics
Author / Creator:Jin, Yi ; Borell, Hubert ; Gardin, Anne ; Ufer, Mike ; Huth, Felix ; Camenisch, Gian
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:European journal of clinical pharmacology, 2018-04, Vol.74 (4), p.455-464
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Inhibition of Tacrolimus Metabolism by Cannabidiol and Its Metabolites In Vitro
Author / Creator:So, Gerald C. ; Lu, Jessica Bo Li ; Cheng, Ying‐Hua ; Gisch, Debora L. ; Koyama, Sachiko ; Melo Ferreira, Ricardo ; Beamon, Travis R. ; Desta, Zeruesenay ; Eadon, Michael T.
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical and translational science, 2025-02, Vol.18 (2), p.e70152-n/a
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Showing 1 to 20 of 677 results

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Transfer learning enables prediction of CYP2D6 haplotype function

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Measurement of cytochrome P450 and NADPH–cytochrome P450 reductase

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Large scale enzyme based xenobiotic identification for exposomics

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Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective

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Effects of mallotus furetianus extract on CYP3A activities in rats

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Novel Inhibitors of Nicotinamide-N-Methyltransferase for the Treatment of Metabolic Disorders

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In vitro UGT1A1 inhibition by tyrosine kinase inhibitors and association with drug-induced hyperbilirubinemia

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New insight into the mechanism of mitochondrial cytochrome c function

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In vitro Phase I and Phase II metabolism of α-pyrrolidinovalerophenone (α-PVP), methylenedioxypyrovalerone (MDPV) and methedrone by human liver microsomes and human liver cytosol

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Identifying the Dominant Contribution of Human Cytochrome P450 2J2 to the Metabolism of Rivaroxaban, an Oral Anticoagulant

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Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD

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Inhibition of UGT2B7 Enzyme Activity in Human and Rat Liver Microsomes by Herbal Constituents

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Identification and characterization of the structure–activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum

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Inhibition of human drug-metabolising cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in vitro by uremic toxins

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Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content

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Role of Human Liver Microsomes in In Vitro Metabolism of Drugs—A Review

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Mammalian epoxide hydrolases in xenobiotic metabolism and signalling

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Significantly Decreased and More Variable Expression of Major CYPs and UGTs in Liver Microsomes Prepared from HBV-Positive Human Hepatocellular Carcinoma and Matched Pericarcinomatous Tissues Determin...

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In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics

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Inhibition of Tacrolimus Metabolism by Cannabidiol and Its Metabolites In Vitro

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