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ArticlesPeer ReviewedFull Text
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
Author / Creator:Huo, Jiandong ; Le Bas, Audrey ; Ruza, Reinis R. ; Duyvesteyn, Helen M. E. ; Mikolajek, Halina ; Malinauskas, Tomas ; Tan, Tiong Kit ; Rijal, Pramila ; Dumoux, Maud ; Ward, Philip N. ; Ren, Jingshan ; Zhou, Daming ; Harrison, Peter J. ; Weckener, Miriam ; Clare, Daniel K. ; Vogirala, Vinod K. ; Radecke, Julika ; Moynié, Lucile ; Zhao, Yuguang ; Gilbert-Jaramillo, Javier ; Knight, Michael L. ; Tree, Julia A. ; Buttigieg, Karen R. ; Coombes, Naomi ; Elmore, Michael J. ; Carroll, Miles W. ; Carrique, Loic ; Shah, Pranav N. M. ; James, William ; Townsend, Alain R. ; Stuart, David I. ; Owens, Raymond J. ; Naismith, James H.
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2020-09, Vol.27 (9), p.846-854
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ArticlesPeer ReviewedFull Text
A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
Author / Creator:Huo, Jiandong ; Mikolajek, Halina ; Le Bas, Audrey ; Clark, Jordan J. ; Sharma, Parul ; Kipar, Anja ; Dormon, Joshua ; Norman, Chelsea ; Weckener, Miriam ; Clare, Daniel K. ; Harrison, Peter J. ; Tree, Julia A. ; Buttigieg, Karen R. ; Salguero, Francisco J. ; Watson, Robert ; Knott, Daniel ; Carnell, Oliver ; Ngabo, Didier ; Elmore, Michael J. ; Fotheringham, Susan ; Harding, Adam ; Moynié, Lucile ; Ward, Philip N. ; Dumoux, Maud ; Prince, Tessa ; Hall, Yper ; Hiscox, Julian A. ; Owen, Andrew ; James, William ; Carroll, Miles W. ; Stewart, James P. ; Naismith, James H. ; Owens, Raymond J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-09, Vol.12 (1), p.5469-5469, Article 5469
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ArticlesPeer ReviewedFull Text
In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease
Author / Creator:Miura, Takashi ; Malla, Tika R. ; Owen, C. David ; Tumber, Anthony ; Brewitz, Lennart ; McDonough, Michael A. ; Salah, Eidarus ; Terasaka, Naohiro ; Katoh, Takayuki ; Lukacik, Petra ; Strain-Damerell, Claire ; Mikolajek, Halina ; Walsh, Martin A. ; Kawamura, Akane ; Schofield, Christopher J. ; Suga, Hiroaki
Publisher:London: Nature Publishing Group UK
Journal title:Nature chemistry, 2023-07, Vol.15 (7), p.998-1005
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ArticlesPeer ReviewedFull Text
Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi
Author / Creator:Mikolajek, Halina ; Sanchez-Weatherby, Juan ; Sandy, James ; Gildea, Richard J. ; Campeotto, Ivan ; Cheruvara, Harish ; Clarke, John D. ; Foster, Toshana ; Fujii, Sotaro ; Paulsen, Ian T. ; Shah, Bhumika S. ; Hough, Michael A.
Publisher:England: International Union of Crystallography
Journal title:IUCrJ, 2023-07, Vol.10 (4), p.420-429
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ArticlesPeer ReviewedFull Text
Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2
Author / Creator:Cornish, Katy ; Huo, Jiandong ; Jones, Luke ; Sharma, Parul ; Thrush, Joseph W. ; Abdelkarim, Sahar ; Kipar, Anja ; Ramadurai, Siva ; Weckener, Miriam ; Mikolajek, Halina ; Liu, Sai ; Buckle, Imogen ; Bentley, Eleanor ; Kirby, Adam ; Han, Ximeng ; Laidlaw, Stephen M. ; Hill, Michelle ; Eyssen, Lauren ; Norman, Chelsea ; Le Bas, Audrey ; Clarke, John ; James, William ; Stewart, James P. ; Carroll, Miles ; Naismith, James H. ; Owens, Raymond J.
Publisher:England: The Royal Society Publishing
Journal title:Open biology, 2024-06, Vol.14 (6), p.230252-17
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ArticlesPeer ReviewedFull Text
Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
Author / Creator:Huo, Jiandong ; Bas, Audrey Le ; Ruza, Reinis R. ; Duyvesteyn, Helen M. E. ; Mikolajek, Halina ; Malinauskas, Tomas ; Tan, Tiong Kit ; Rijal, Pramila ; Dumoux, Maud ; Ward, Philip N. ; Ren, Jingshan ; Zhou, Daming ; Harrison, Peter J. ; Weckener, Miriam ; Clare, Daniel K. ; Vogirala, Vinod K. ; Radecke, Julika ; Moynié, Lucile ; Zhao, Yuguang ; Gilbert-Jaramillo, Javier ; Knight, Michael L. ; Tree, Julia A. ; Buttigieg, Karen R. ; Coombes, Naomi ; Elmore, Michael J. ; Carroll, Miles W. ; Carrique, Loic ; Shah, Pranav N. M. ; James, William ; Townsend, Alain R. ; Stuart, David I. ; Owens, Raymond J. ; Naismith, James H.
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2021-03, Vol.28 (3), p.326-326
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ArticlesPeer ReviewedFull Text
Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
Author / Creator:Huo, Jiangdong ; Le Bas, Audrey ; Ruza, Reinis R. ; Duyvesteyn, Helen M. E. ; Mikolajek, Halina ; Malinauskas, Tomas ; Tan, Tiong Kit ; Rijal, Pramila ; Dumoux, Maud ; Ward, Philip N. ; Ren, Jingshan ; Zhou, Daming ; Harrison, Peter J. ; Weckener, Miriam ; Clare, Daniel K. ; Vogirala, Vinod K. ; Radecke, Julika ; Moynié, Lucile ; Zhao, Yuguang ; Gilbert-Jaramillo, Javier ; Knight, Michael L. ; Tree, Julia A. ; Buttigieg, Karen R. ; Coombes, Naomi ; Elmore, Michael J. ; Carroll, Miles W. ; Carrique, Loic ; Shah, Pranav N. M. ; James, William ; Townsend, Alain R. ; Stuart, David I. ; Owens, Raymond J. ; Naismith, James H.
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2020-11, Vol.27 (11), p.1094-1094
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ArticlesPeer ReviewedFull Text
Marine picocyanobacterial PhnD1 shows specificity for various phosphorus sources but likely represents a constitutive inorganic phosphate transporter
Author / Creator:Shah, Bhumika S. ; Ford, Benjamin A. ; Varkey, Deepa ; Mikolajek, Halina ; Orr, Christian ; Mykhaylyk, Vitaliy ; Owens, Raymond J. ; Paulsen, Ian T.
Publisher:London: Nature Publishing Group UK
Journal title:The ISME Journal, 2023-07, Vol.17 (7), p.1040-1051
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ArticlesPeer ReviewedFull Text
In vitro selection of macrocyclic peptide inhibitors containing cyclic γ 2,4 -amino acids targeting the SARS-CoV-2 main protease
Author / Creator:Miura, Takashi ; Malla, Tika R ; Owen, C David ; Tumber, Anthony ; Brewitz, Lennart ; McDonough, Michael A ; Salah, Eidarus ; Terasaka, Naohiro ; Katoh, Takayuki ; Lukacik, Petra ; Strain-Damerell, Claire ; Mikolajek, Halina ; Walsh, Martin A ; Kawamura, Akane ; Schofield, Christopher J ; Suga, Hiroaki
Publisher:England
Journal title:Nature chemistry, 2023-07, Vol.15 (7), p.998
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Text ResourcesFull Text
Structural characterisation of a nanobody derived from a naïve library that neutralises SARS-CoV-2
Author / Creator:Huo, Jiangdong ; Audrey Le Bas ; Ruza, Reinis R ; Helen M.E. Duyvesteyn ; Mikolajek, Halina ; Malinauskas, Tomas ; Tan, Tiong Kit ; Rijal, Pramila ; Dumoux, Maud ; Ward, Philip N ; Ren, Jingshan ; Zhou, Daming ; Harrison, Peter J ; Radeke, Julika ; Zhao, Yuguang ; Gilbert-Jaramillo, Javier ; Knight, Michael ; Carrique, Loic ; Pranav N.M. Shah ; James, William ; Townsend, Alain ; Stuart, David I ; Owens, Raymond J ; Naismith, James H
Publisher:Durham: Research Square
Journal title:Nature Portfolio, 2020
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Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

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A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

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In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease

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Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi

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Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2

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Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

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Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

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Marine picocyanobacterial PhnD1 shows specificity for various phosphorus sources but likely represents a constitutive inorganic phosphate transporter

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In vitro selection of macrocyclic peptide inhibitors containing cyclic γ 2,4 -amino acids targeting the SARS-CoV-2 main protease

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Structural characterisation of a nanobody derived from a naïve library that neutralises SARS-CoV-2

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