Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
About this item
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Author / Creator
Huo, Jiandong , Le Bas, Audrey , Ruza, Reinis R. , Duyvesteyn, Helen M. E. , Mikolajek, Halina , Malinauskas, Tomas , Tan, Tiong Kit , Rijal, Pramila , Dumoux, Maud , Ward, Philip N. , Ren, Jingshan , Zhou, Daming , Harrison, Peter J. , Weckener, Miriam , Clare, Daniel K. , Vogirala, Vinod K. , Radecke, Julika , Moynié, Lucile , Zhao, Yuguang , Gilbert-Jaramillo, Javier , Knight, Michael L. , Tree, Julia A. , Buttigieg, Karen R. , Coombes, Naomi , Elmore, Michael J. , Carroll, Miles W. , Carrique, Loic , Shah, Pranav N. M. , James, William , Townsend, Alain R. , Stuart, David I. , Owens, Raymond J. and Naismith, James H.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
The SARS-CoV-2 virus is more transmissible than previous coronaviruses and causes a more serious illness than influenza. The SARS-CoV-2 receptor binding domain (RBD) of the spike protein binds to the human angiotensin-converting enzyme 2 (ACE2) receptor as a prelude to viral entry into the cell. Using a naive llama single-domain antibody library an...
Alternative Titles
Full title
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
Authors, Artists and Contributors
Author / Creator
Le Bas, Audrey
Ruza, Reinis R.
Duyvesteyn, Helen M. E.
Mikolajek, Halina
Malinauskas, Tomas
Tan, Tiong Kit
Rijal, Pramila
Dumoux, Maud
Ward, Philip N.
Ren, Jingshan
Zhou, Daming
Harrison, Peter J.
Weckener, Miriam
Clare, Daniel K.
Vogirala, Vinod K.
Radecke, Julika
Moynié, Lucile
Zhao, Yuguang
Gilbert-Jaramillo, Javier
Knight, Michael L.
Tree, Julia A.
Buttigieg, Karen R.
Coombes, Naomi
Elmore, Michael J.
Carroll, Miles W.
Carrique, Loic
Shah, Pranav N. M.
James, William
Townsend, Alain R.
Stuart, David I.
Owens, Raymond J.
Naismith, James H.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2423800396
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2423800396
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-020-0469-6
