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Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
Author / Creator:Flach, Johanna ; Bakker, Sietske T. ; Mohrin, Mary ; Conroy, Pauline C. ; Pietras, Eric M. ; Reynaud, Damien ; Alvarez, Silvia ; Diolaiti, Morgan E. ; Ugarte, Fernando ; Forsberg, E. Camilla ; Le Beau, Michelle M. ; Stohr, Bradley A. ; Méndez, Juan ; Morrison, Ciaran G. ; Passegué, Emmanuelle
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2014-08, Vol.512 (7513), p.198-202
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The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice
Author / Creator:Yesbolatova, Aisha ; Saito, Yuichiro ; Kitamoto, Naomi ; Makino-Itou, Hatsune ; Ajima, Rieko ; Nakano, Risako ; Nakaoka, Hirofumi ; Fukui, Kosuke ; Gamo, Kanae ; Tominari, Yusuke ; Takeuchi, Haruki ; Saga, Yumiko ; Hayashi, Ken-ichiro ; Kanemaki, Masato T.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-11, Vol.11 (1), p.5701-5701, Article 5701
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Exome sequencing reveals MCM8 mutation underlies ovarian failure and chromosomal instability
Author / Creator:AlAsiri, Saleh ; Basit, Sulman ; Wood-Trageser, Michelle A ; Yatsenko, Svetlana A ; Jeffries, Elizabeth P ; Surti, Urvashi ; Ketterer, Deborah M ; Afzal, Sibtain ; Ramzan, Khushnooda ; Faiyaz-Ul Haque, Muhammad ; Jiang, Huaiyang ; Trakselis, Michael A ; Rajkovic, Aleksandar
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2015-01, Vol.125 (1), p.258-262
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MCM8 and MCM9 Nucleotide Variants in Women with Primary Ovarian Insufficiency
Author / Creator:Desai, Swapna ; Wood-Trageser, Michelle ; Matic, Jelena ; Chipkin, Jaqueline ; Jiang, Huaiyang ; Bachelot, Anne ; Dulon, Jerome ; Sala, Cinzia ; Barbieri, Caterina ; Cocca, Massimiliano ; Toniolo, Daniela ; Philippe, Touraine ; Witchel, Selma ; Rajkovic, Aleksandar
Publisher:Washington, DC: Endocrine Society
Journal title:The journal of clinical endocrinology and metabolism, 2017-02, Vol.102 (2), p.576-582
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Exome Sequencing of a Primary Ovarian Insufficiency Cohort Reveals Common Molecular Etiologies for a Spectrum of Disease
Author / Creator:Jolly, Angad ; Bayram, Yavuz ; Turan, Serap ; Aycan, Zehra ; Tos, Tulay ; Abali, Zehra Yavas ; Hacihamdioglu, Bulent ; Coban Akdemir, Zeynep Hande ; Hijazi, Hadia ; Bas, Serpil ; Atay, Zeynep ; Guran, Tulay ; Abali, Saygin ; Bas, Firdevs ; Darendeliler, Feyza ; Colombo, Roberto ; Barakat, Tahsin Stefan ; Rinne, Tuula ; White, Janson J ; Yesil, Gozde ; Gezdirici, Alper ; Gulec, Elif Yilmaz ; Karaca, Ender ; Pehlivan, Davut ; Jhangiani, Shalini N ; Muzny, Donna M ; Poyrazoglu, Sukran ; Bereket, Abdullah ; Gibbs, Richard A ; Posey, Jennifer E ; Lupski, James R
Publisher:Washington, DC: Endocrine Society
Journal title:The journal of clinical endocrinology and metabolism, 2019-08, Vol.104 (8), p.3049-3067
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MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression
Author / Creator:Liu, Zhikun ; Li, Jie ; Chen, Jun ; Shan, Qiaonan ; Dai, Haojiang ; Xie, Haiyang ; Zhou, Lin ; Xu, Xiao ; Zheng, Shusen
Publisher:England: BioMed Central Ltd
Journal title:BMC cancer, 2018-02, Vol.18 (1), p.200-200, Article 200
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BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage
Author / Creator:Kang, Zhihua ; Fu, Pan ; Alcivar, Allen L. ; Fu, Haiqing ; Redon, Christophe ; Foo, Tzeh Keong ; Zuo, Yamei ; Ye, Caiyong ; Baxley, Ryan ; Madireddy, Advaitha ; Buisson, Remi ; Bielinsky, Anja-Katrin ; Zou, Lee ; Shen, Zhiyuan ; Aladjem, Mirit I. ; Xia, Bing
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-10, Vol.12 (1), p.5966-5966, Article 5966
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ArticlesPeer ReviewedFull Text
Human NK cell deficiency as a result of biallelic mutations in MCM10
Author / Creator:Mace, Emily M ; Paust, Silke ; Conte, Matilde I ; Baxley, Ryan M ; Schmit, Megan M ; Patil, Sagar L ; Guilz, Nicole C ; Mukherjee, Malini ; Pezzi, Ashley E ; Chmielowiec, Jolanta ; Tatineni, Swetha ; Chinn, Ivan K ; Akdemir, Zeynep Coban ; Jhangiani, Shalini N ; Muzny, Donna M ; Stray-Pedersen, Asbjørg ; Bradley, Rachel E ; Moody, Mo ; Connor, Philip P ; Heaps, Adrian G ; Steward, Colin ; Banerjee, Pinaki P ; Gibbs, Richard A ; Borowiak, Malgorzata ; Lupski, James R ; Jolles, Stephen ; Bielinsky, Anja K ; Orange, Jordan S
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2020-10, Vol.130 (10), p.5272-5286
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A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress
Author / Creator:Griffin, Wezley C. ; McKinzey, David R. ; Klinzing, Kathleen N. ; Baratam, Rithvik ; Eliyapura, Achini ; Trakselis, Michael A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-08, Vol.13 (1), p.5090-5090, Article 5090
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Reconstitution of translesion synthesis reveals a mechanism of eukaryotic DNA replication restart
Author / Creator:Guilliam, Thomas A. ; Yeeles, Joseph T. P.
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2020-05, Vol.27 (5), p.450-460
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Chromosomal Mcm2-7 distribution and the genome replication program in species from yeast to humans
Author / Creator:Foss, Eric J ; Sripathy, Smitha ; Gatbonton-Schwager, Tonibelle ; Kwak, Hyunchang ; Thiesen, Adam H ; Lao, Uyen ; Bedalov, Antonio
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2021-09, Vol.17 (9), p.e1009714-e1009714
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Mechanism of DNA unwinding by MCM8-9 in complex with HROB
Author / Creator:Acharya, Ananya ; Bret, Hélène ; Huang, Jen-Wei ; Mütze, Martin ; Göse, Martin ; Kissling, Vera Maria ; Seidel, Ralf ; Ciccia, Alberto ; Guérois, Raphaël ; Cejka, Petr
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-04, Vol.15 (1), p.3584-3584, Article 3584
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Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening
Author / Creator:Baxley, Ryan M. ; Leung, Wendy ; Schmit, Megan M. ; Matson, Jacob Peter ; Yin, Lulu ; Oram, Marissa K. ; Wang, Liangjun ; Taylor, John ; Hedberg, Jack ; Rogers, Colette B. ; Harvey, Adam J. ; Basu, Debashree ; Taylor, Jenny C. ; Pagnamenta, Alistair T. ; Dreau, Helene ; Craft, Jude ; Ormondroyd, Elizabeth ; Watkins, Hugh ; Hendrickson, Eric A. ; Mace, Emily M. ; Orange, Jordan S. ; Aihara, Hideki ; Stewart, Grant S. ; Blair, Edward ; Cook, Jeanette Gowen ; Bielinsky, Anja-Katrin
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-03, Vol.12 (1), p.1626-1626, Article 1626
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ArticlesPeer ReviewedFull Text
The CMG helicase and cancer: a tumor “engine” and weakness with missing mutations
Author / Creator:Xiang, Shengyan ; Reed, Damon R. ; Alexandrow, Mark G.
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2023-02, Vol.42 (7), p.473-490
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MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing
Author / Creator:Reuter, L. Maximilian ; Khadayate, Sanjay P. ; Mossler, Audrey ; Liebl, Korbinian ; Faull, Sarah V. ; Karimi, Mohammad M. ; Speck, Christian
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-08, Vol.15 (1), p.7306-16, Article 7306
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MCM10: An effective treatment target and a prognostic biomarker in patients with uterine corpus endometrial carcinoma
Author / Creator:Chen, Junyu ; Wu, Shan ; Wang, Junwei ; Han, Chunying ; Zhao, Lijing ; He, Kang ; Jia, Yan ; Cui, Manhua
Publisher:England: John Wiley and Sons Inc
Journal title:Journal of cellular and molecular medicine, 2023-06, Vol.27 (12), p.1708-1724
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The capacity of origins to load MCM establishes replication timing patterns
Author / Creator:Dukaj, Livio ; Rhind, Nicholas
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2021-03, Vol.17 (3), p.e1009467
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DNA replication origins retain mobile licensing proteins
Author / Creator:Sánchez, Humberto ; McCluskey, Kaley ; van Laar, Theo ; van Veen, Edo ; Asscher, Filip M. ; Solano, Belén ; Diffley, John F. X. ; Dekker, Nynke H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-03, Vol.12 (1), p.1908-1908, Article 1908
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A Novel Phenotype Combining Primary Ovarian Insufficiency Growth Retardation and Pilomatricomas With MCM8 Mutation
Author / Creator:Heddar, Abdelkader ; Beckers, Dominique ; Fouquet, Baptiste ; Roland, Dominique ; Misrahi, Micheline
Publisher:US: Oxford University Press
Journal title:The journal of clinical endocrinology and metabolism, 2020-06, Vol.105 (6), p.1973-1982
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ArticlesPeer ReviewedFull Text
MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
Author / Creator:Huang, Jen-Wei ; Acharya, Ananya ; Taglialatela, Angelo ; Nambiar, Tarun S. ; Cuella-Martin, Raquel ; Leuzzi, Giuseppe ; Hayward, Samuel B. ; Joseph, Sarah A. ; Brunette, Gregory J. ; Anand, Roopesh ; Soni, Rajesh K. ; Clark, Nathan L. ; Bernstein, Kara A. ; Cejka, Petr ; Ciccia, Alberto
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-06, Vol.11 (1), p.2948-2948, Article 2948
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Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

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The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice

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Exome sequencing reveals MCM8 mutation underlies ovarian failure and chromosomal instability

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MCM8 and MCM9 Nucleotide Variants in Women with Primary Ovarian Insufficiency

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Exome Sequencing of a Primary Ovarian Insufficiency Cohort Reveals Common Molecular Etiologies for a Spectrum of Disease

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MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression

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BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage

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Human NK cell deficiency as a result of biallelic mutations in MCM10

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A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress

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Reconstitution of translesion synthesis reveals a mechanism of eukaryotic DNA replication restart

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Chromosomal Mcm2-7 distribution and the genome replication program in species from yeast to humans

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Mechanism of DNA unwinding by MCM8-9 in complex with HROB

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Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening

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The CMG helicase and cancer: a tumor “engine” and weakness with missing mutations

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MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing

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MCM10: An effective treatment target and a prognostic biomarker in patients with uterine corpus endometrial carcinoma

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The capacity of origins to load MCM establishes replication timing patterns

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DNA replication origins retain mobile licensing proteins

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A Novel Phenotype Combining Primary Ovarian Insufficiency Growth Retardation and Pilomatricomas With MCM8 Mutation

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MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage

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