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Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice
Author / Creator:Novais, Emanuel J. ; Tran, Victoria A. ; Johnston, Shira N. ; Darris, Kayla R. ; Roupas, Alex J. ; Sessions, Garrett A. ; Shapiro, Irving M. ; Diekman, Brian O. ; Risbud, Makarand V.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-09, Vol.12 (1), p.5213-17, Article 5213
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MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology
Author / Creator:Cazzanelli, Petra ; Wuertz-Kozak, Karin
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2020-05, Vol.21 (10), p.3601
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Mesenchymal stem cells‐derived exosomes ameliorate intervertebral disc degeneration through inhibiting pyroptosis
Author / Creator:Zhang, Jingwei ; Zhang, Jieyuan ; Zhang, Yunlong ; Liu, Wenjun ; Ni, Weifeng ; Huang, Xiaoyan ; Yuan, Junjie ; Zhao, Bizeng ; Xiao, Haijun ; Xue, Feng
Publisher:England: John Wiley & Sons, Inc
Journal title:Journal of cellular and molecular medicine, 2020-10, Vol.24 (20), p.11742-11754
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Acid‐sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration
Author / Creator:Zhao, Kangcheng ; An, Ran ; Xiang, Qian ; Li, Gaocai ; Wang, Kun ; Song, Yu ; Liao, Zhiwei ; Li, Shuai ; Hua, Wenbin ; Feng, Xiaobo ; Wu, Xinghuo ; Zhang, Yukun ; Das, Abhirup ; Yang, Cao
Publisher:England: John Wiley & Sons, Inc
Journal title:Cell proliferation, 2021-01, Vol.54 (1), p.e12941-n/a
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Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration
Author / Creator:Wang, Bingjin ; Ke, Wencan ; Wang, Kun ; Li, Gaocai ; Ma, Liang ; Lu, Saideng ; Xiang, Qian ; Liao, Zhiwei ; Luo, Rongjin ; Song, Yu ; Hua, Wenbin ; Wu, Xinghuo ; Zhang, Yukun ; Zeng, Xianlin ; Yang, Cao
Publisher:United States: Hindawi
Journal title:Oxidative medicine and cellular longevity, 2021, Vol.2021 (1), p.8884922-8884922
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Human umbilical cord mesenchymal stem cells deliver exogenous miR-26a-5p via exosomes to inhibit nucleus pulposus cell pyroptosis through METTL14/NLRP3
Author / Creator:Yuan, Xiaoqiu ; Li, Tiefeng ; Shi, Lei ; Miao, Jinhao ; Guo, Yongfei ; Chen, Yu
Publisher:England: BioMed Central
Journal title:Molecular medicine (Cambridge, Mass.), 2021-08, Vol.27 (1), p.91-91, Article 91
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Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo
Author / Creator:Lu, Saideng ; Song, Yu ; Luo, Rongjin ; Li, Shuai ; Li, Gaocai ; Wang, Kun ; Liao, Zhiwei ; Wang, Bingjin ; Ke, Wencan ; Xiang, Qian ; Chen, Chao ; Wu, Xinghuo ; Zhang, Yukun ; Ling, Li ; Yang, Cao
Publisher:United States: Hindawi
Journal title:Oxidative medicine and cellular longevity, 2021, Vol.2021 (1), p.6670497
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Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo
Author / Creator:Chen, Deheng ; Xia, Dongdong ; Pan, Zongyou ; Xu, Daoliang ; Zhou, Yifei ; Wu, Yaosen ; Cai, Ningyu ; Tang, Qian ; Wang, Chenggui ; Yan, Meijun ; Zhang, Jing Jie ; Zhou, Kailiang ; Wang, Quan ; Feng, Yongzeng ; Wang, Xiangyang ; Xu, Huazi ; Zhang, Xiaolei ; Tian, Naifeng
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2016-10, Vol.7 (10), p.e2441-e2441
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Mitochondrial quality control in intervertebral disc degeneration
Author / Creator:Song, Yu ; Lu, Saideng ; Geng, Wen ; Feng, Xiaobo ; Luo, Rongjin ; Li, Gaocai ; Yang, Cao
Publisher:London: Nature Publishing Group UK
Journal title:Experimental and Molecular Medicine, 2021, 53(0), , pp.1-10
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IL-1β induces apoptosis and autophagy via mitochondria pathway in human degenerative nucleus pulposus cells
Author / Creator:Shen, Jieliang ; Xu, Shengxi ; Zhou, Hao ; Liu, Huzhe ; Jiang, Wei ; Hao, Jie ; Hu, Zhenming
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-01, Vol.7 (1), p.41067-41067, Article 41067
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Exosomal MATN3 of Urine-Derived Stem Cells Ameliorates Intervertebral Disc Degeneration by Antisenescence Effects and Promotes NPC Proliferation and ECM Synthesis by Activating TGF-β
Author / Creator:Guo, Zhu ; Su, WeiLiang ; Zhou, RongYao ; Zhang, GuoQing ; Yang, Shuai ; Wu, XiaoLin ; Qiu, ChenSheng ; Cong, WenBin ; Shen, Nana ; Guo, JianWei ; Liu, Chang ; Yang, Shang-You ; Xing, DongMing ; Wang, Yan ; Chen, BoHua ; Xiang, HongFei
Publisher:United States: Hindawi
Journal title:Oxidative medicine and cellular longevity, 2021, Vol.2021 (1), p.5542241-5542241
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Intervertebral Disc Nucleus Repair: Hype or Hope?
Author / Creator:Tendulkar, Gauri ; Chen, Tao ; Ehnert, Sabrina ; Kaps, Hans-Peter ; Nüssler, Andreas K
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2019-07, Vol.20 (15), p.3622
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Resveratrol attenuates high glucose-induced nucleus pulposus cell apoptosis and senescence through activating the ROS-mediated PI3K/Akt pathway
Author / Creator:Wang, Wenping ; Li, Pei ; Xu, Jiagang ; Wu, Xiangkun ; Guo, Zhiliang ; Fan, Lijing ; Song, Ruipeng ; Wang, Jianli ; Wei, Li ; Teng, Haijun
Publisher:England: Portland Press Ltd
Journal title:Bioscience reports, 2018-04, Vol.38 (2)
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Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane
Author / Creator:Xu, Xiaolong ; Wang, Di ; Zheng, Chao ; Gao, Bo ; Fan, Jing ; Cheng, Pengzhen ; Liu, Baohua ; Yang, Liu ; Luo, Zhuojing
Publisher:Australia: Ivyspring International Publisher
Journal title:Theranostics, 2019-01, Vol.9 (8), p.2252-2267
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lncRNA/circRNA‑miRNA‑mRNA ceRNA network in lumbar intervertebral disc degeneration
Author / Creator:Zhu, Jinwen ; Zhang, Xinliang ; Gao, Wenjie ; Hu, Huimin ; Wang, Xiaodong ; Hao, Dingjun
Publisher:Greece: Spandidos Publications
Journal title:Molecular medicine reports, 2019-10, Vol.20 (4), p.3160-3174
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Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition
Author / Creator:Chen, Yu ; Wu, Yanqing ; Shi, Hongxue ; Wang, Jianle ; Zheng, Zengming ; Chen, Jian ; Chen, Xibang ; Zhang, Zengjie ; Xu, Daoliang ; Wang, Xiangyang ; Xiao, Jian
Publisher:England: John Wiley & Sons, Inc
Journal title:Journal of cellular and molecular medicine, 2019-03, Vol.23 (3), p.2136-2148
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Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target
Author / Creator:Gilbert, Hamish T. J. ; Hodson, Nathan ; Baird, Pauline ; Richardson, Stephen M. ; Hoyland, Judith A.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-11, Vol.6 (1), p.37360-37360, Article 37360
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Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus
Author / Creator:Shan, Liang ; Xu, Ximing ; Zhang, Jing ; Cai, Peng ; Gao, Han ; Lu, Yingjie ; Shi, Jiangang ; Guo, Yinlong ; Su, Yue
Publisher:England: BioMed Central
Journal title:Molecular medicine (Cambridge, Mass.), 2021-09, Vol.27 (1), p.103-103, Article 103
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Bulk RNA-seq conjoined with ScRNA-seq analysis reveals the molecular characteristics of nucleus pulposus cell ferroptosis in rat aging intervertebral discs
Author / Creator:Chen, Shipeng ; Fu, Jiawei ; Long, Jiang ; Liu, Chang ; Ai, Xuezheng ; Long, Dan ; Leng, Xue ; Zhang, Yang ; Liao, Zhengao ; Li, Changqing ; Zhou, Yue ; Dong, Shiwu ; Huang, Bo ; Feng, Chencheng
Publisher:England: BioMed Central Ltd
Journal title:Arthritis research & therapy, 2025-04, Vol.27 (1), p.90-20, Article 90
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Silencing ATF3 Might Delay TBHP-Induced Intervertebral Disc Degeneration by Repressing NPC Ferroptosis, Apoptosis, and ECM Degradation
Author / Creator:Li, Yongjin ; Pan, Dayu ; Wang, Xuke ; Huo, Zhenxin ; Wu, Xiaojing ; Li, Jianhua ; Cao, Jiasong ; Xu, Haiwei ; Du, Lilong ; Xu, Baoshan
Publisher:United States: Hindawi
Journal title:Oxidative medicine and cellular longevity, 2022, Vol.2022, p.1-17
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Showing 1 to 20 of 191 results

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Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

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MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology

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Mesenchymal stem cells‐derived exosomes ameliorate intervertebral disc degeneration through inhibiting pyroptosis

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Acid‐sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration

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Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration

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Human umbilical cord mesenchymal stem cells deliver exogenous miR-26a-5p via exosomes to inhibit nucleus pulposus cell pyroptosis through METTL14/NLRP3

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Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo

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Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

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Mitochondrial quality control in intervertebral disc degeneration

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IL-1β induces apoptosis and autophagy via mitochondria pathway in human degenerative nucleus pulposus cells

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Exosomal MATN3 of Urine-Derived Stem Cells Ameliorates Intervertebral Disc Degeneration by Antisenescence Effects and Promotes NPC Proliferation and ECM Synthesis by Activating TGF-β

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Intervertebral Disc Nucleus Repair: Hype or Hope?

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Resveratrol attenuates high glucose-induced nucleus pulposus cell apoptosis and senescence through activating the ROS-mediated PI3K/Akt pathway

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Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane

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lncRNA/circRNA‑miRNA‑mRNA ceRNA network in lumbar intervertebral disc degeneration

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Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition

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Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target

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Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus

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Bulk RNA-seq conjoined with ScRNA-seq analysis reveals the molecular characteristics of nucleus pulposus cell ferroptosis in rat aging intervertebral discs

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Silencing ATF3 Might Delay TBHP-Induced Intervertebral Disc Degeneration by Repressing NPC Ferroptosis, Apoptosis, and ECM Degradation

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