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ArticlesPeer ReviewedFull Text
Gene therapy for lysosomal storage diseases and peroxisomal diseases
Author / Creator:Ohashi, Toya
Publisher:England: Springer Science and Business Media LLC
Journal title:Journal of Human Genetics, 2019-02, Vol.64 (2), p.139-143
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A novel preclinical model of mucopolysaccharidosis type II for developing human hematopoietic stem cell gene therapy
Author / Creator:Shimada, Yohta ; Ishii, Natsumi ; Higuchi, Takashi ; Goto, Motohito ; Ohashi, Toya ; Kobayashi, Hiroshi
Publisher:London: Nature Publishing Group UK
Journal title:Gene therapy, 2023-04, Vol.30 (3-4), p.288-296
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ArticlesPeer ReviewedFull Text
Mutation spectrum of α-Galactosidase gene in Japanese patients with Fabry disease
Author / Creator:Kobayashi, Masahisa ; Ohashi, Toya ; Kaneshiro, Eiko ; Higuchi, Takashi ; Ida, Hiroyuki
Publisher:England: Nature Publishing Group
Journal title:Journal of human genetics, 2019-07, Vol.64 (7), p.695-699
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Suppression of lysosomal acid alpha‐glucosidase impacts the modulation of transcription factor EB translocation in pancreatic cancer
Author / Creator:Hamura, Ryoga ; Shirai, Yoshihiro ; Shimada, Yohta ; Saito, Nobuhiro ; Taniai, Tomohiko ; Horiuchi, Takashi ; Takada, Naoki ; Kanegae, Yumi ; Ikegami, Toru ; Ohashi, Toya ; Yanaga, Katsuhiko
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2021-06, Vol.112 (6), p.2335-2348
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ArticlesPeer ReviewedFull Text
Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells
Author / Creator:Taniai, Tomohiko ; Shirai, Yoshihiro ; Shimada, Yohta ; Hamura, Ryoga ; Yanagaki, Mitsuru ; Takada, Naoki ; Horiuchi, Takashi ; Haruki, Koichiro ; Furukawa, Kenei ; Uwagawa, Tadashi ; Tsuboi, Kazuhito ; Okamoto, Yasuo ; Shimada, Shu ; Tanaka, Shinji ; Ohashi, Toya ; Ikegami, Toru
Publisher:Tokyo: John Wiley & Sons, Inc
Journal title:Cancer science, 2021-11, Vol.112 (11), p.4570-4579
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ArticlesPeer ReviewedFull Text
Cochlear Implantation for Isoleucyl-tRNA Synthetase Mutation-Associated Mitochondrial Disease: A Case Report
Author / Creator:Motegi, Masaomi ; Sakurai, Yuika ; Mio, Yasushi ; Ohashi, Toya
Publisher:United States: Springer Nature B.V
Journal title:Curēus (Palo Alto, CA), 2024-08, Vol.16 (8), p.e67760
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ArticlesPeer ReviewedFull Text
The production of human glucocerebrosidase in glyco‐engineered Nicotiana benthamiana plants
Author / Creator:Limkul, Juthamard ; Iizuka, Sayoko ; Sato, Yohei ; Misaki, Ryo ; Ohashi, Takao ; Ohashi, Toya ; Fujiyama, Kazuhito
Publisher:England: John Wiley & Sons, Inc
Journal title:Plant biotechnology journal, 2016-08, Vol.14 (8), p.1682-1694
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ArticlesPeer ReviewedFull Text
Efficacy and safety of migalastat in a Japanese population: a subgroup analysis of the ATTRACT study
Author / Creator:Narita Ichiei ; Ohashi Toya ; Sakai Norio ; Hamazaki Takashi ; Skuban Nina ; Castelli, Jeffrey P ; Lagast Hjalmar ; Barth, Jay A
Publisher:Tokyo: Springer Nature B.V
Journal title:Clinical and experimental nephrology, 2020-02, Vol.24 (2), p.157-166
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Nafamostat mesilate, a nuclear factor kappa B inhibitor, enhances the antitumor action of radiotherapy on gallbladder cancer cells
Author / Creator:Takada, Naoki ; Sugano, Hiroshi ; Shirai, Yoshihiro ; Saito, Nobuhiro ; Hamura, Ryoga ; Taniai, Tomohiko ; Uwagawa, Tadashi ; Yanaga, Katsuhiko ; Ikegami, Toru ; Ohashi, Toya ; Eto, Ken
Publisher:San Francisco: Public Library of Science
Journal title:PloS one, 2021-09, Vol.16 (9), p.e0257019
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ArticlesPeer ReviewedFull Text
Rapid Immunochromatographic Detection of Serum Anti-α-Galactosidase A Antibodies in Fabry Patients after Enzyme Replacement Therapy
Author / Creator:Nakano, Sachie ; Tsukimura, Takahiro ; Togawa, Tadayasu ; Ohashi, Toya ; Kobayashi, Masahisa ; Takayama, Katsuyoshi ; Kobayashi, Yukuharu ; Abiko, Hiroshi ; Satou, Masatsugu ; Nakahata, Tohru ; Warnock, David G. ; Sakuraba, Hitoshi ; Shibasaki, Futoshi
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-06, Vol.10 (6), p.e0128351
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ArticlesPeer ReviewedFull Text
Nafamostat Mesilate Enhances the Radiosensitivity and Reduces the Radiation-Induced Invasive Ability of Colorectal Cancer Cells
Author / Creator:Sugano, Hiroshi ; Shirai, Yoshihiro ; Horiuchi, Takashi ; Saito, Nobuhiro ; Shimada, Yohta ; Eto, Ken ; Uwagawa, Tadashi ; Ohashi, Toya ; Yanaga, Katsuhiko
Publisher:Switzerland: MDPI AG
Journal title:Cancers, 2018-10, Vol.10 (10), p.386
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ArticlesPeer ReviewedFull Text
TFEB overexpression promotes glycogen clearance of Pompe disease iPSC-derived skeletal muscle
Author / Creator:Sato, Yohei ; Kobayashi, Hiroshi ; Higuchi, Takashi ; Shimada, Yohta ; Ida, Hiroyuki ; Ohashi, Toya
Publisher:United States: Elsevier Limited
Journal title:Molecular therapy. Methods & clinical development, 2016-01, Vol.3 (C), p.16054, Article 16054
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ArticlesPeer ReviewedFull Text
Human Mesenchymal Stem Cells in Rodent Whole-Embryo Culture Are Reprogrammed to Contribute to Kidney Tissues
Author / Creator:Yokoo, Takashi ; Ohashi, Toya ; Shen, Jin Song ; Sakurai, Ken ; Miyazaki, Yoichi ; Utsunomiya, Yasunori ; Takahashi, Masanori ; Terada, Yoshio ; Eto, Yoshikatsu ; Kawamura, Tetsuya ; Osumi, Noriko ; Hosoya, Tatsuo ; Ruoslahti, Erkki
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2005-03, Vol.102 (9), p.3296-3300
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ArticlesPeer ReviewedFull Text
Induced pluripotent stem cells derived from mouse models of lysosomal storage disorders
Author / Creator:Meng, Xing-Li ; Shen, Jin-Song ; Kawagoe, Shiho ; Ohashi, Toya ; Brady, Roscoe O ; Eto, Yoshikatsu
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-04, Vol.107 (17), p.7886-7891
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ArticlesPeer ReviewedFull Text
375. Direct Reprogramming of Fibroblast Allows Live-Cell Imaging of Autophagic Buildup in Pompe Disease Skeletal Myoblast
Author / Creator:Sato, Yohei ; Kobayashi, Hiroshi ; Shimada, Yohta ; Ida, Hiroyuki ; Eto, Yoshikatsu ; Ohashi, Toya
Publisher:Elsevier Inc
Journal title:Molecular Therapy, 2015-05, Vol.23, p.S149-S149
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ArticlesPeer ReviewedFull Text
Disease modeling and lentiviral gene transfer in patient-specific induced pluripotent stem cells from late-onset Pompe disease patient
Author / Creator:Sato, Yohei ; Kobayashi, Hiroshi ; Higuchi, Takashi ; Shimada, Yohta ; Era, Takumi ; Kimura, Shigemi ; Eto, Yoshikatsu ; Ida, Hiroyuki ; Ohashi, Toya
Publisher:United States: Elsevier Limited
Journal title:Molecular therapy. Methods & clinical development, 2015-01, Vol.2, p.15023-15023, Article 15023
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ArticlesPeer ReviewedFull Text
Correction: Hiroshi Sugano et al. Nafamostat Mesilate Enhances the Radiosensitivity and Reduces the Radiation-Induced Invasive Ability of Colorectal Cancer Cells. Cancers 2018, 10, 386
Author / Creator:Sugano, Hiroshi ; Shirai, Yoshihiro ; Horiuchi, Takashi ; Saito, Nobuhiro ; Shimada, Yohta ; Eto, Ken ; Uwagawa, Tadashi ; Ohashi, Toya ; Yanaga, Katsuhiko
Publisher:Switzerland: MDPI AG
Journal title:Cancers, 2019-03, Vol.11 (3), p.335
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Effect of donor chimerism to reduce the level of glycosaminoglycans following bone marrow transplantation in a murine model of mucopolysaccharidosis type II
Author / Creator:Yokoi, Kentaro ; Akiyama, Kazumasa ; Kaneshiro, Eiko ; Higuchi, Takashi ; Shimada, Yohta ; Kobayashi, Hiroshi ; Akiyama, Masaharu ; Otsu, Makoto ; Nakauchi, Hiromitsu ; Ohashi, Toya ; Ida, Hiroyuki
Publisher:Dordrecht: Springer Netherlands
Journal title:Journal of inherited metabolic disease, 2015-03, Vol.38 (2), p.333-340
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Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography
Author / Creator:Nemoto, Masami ; Nishimura, Rimei ; Sasaki, Takashi ; Hiki, Yoshito ; Miyashita, Yumi ; Nishioka, Makiko ; Fujimoto, Kei ; Sakuma, Toru ; Ohashi, Toya ; Fukuda, Kunihiko ; Eto, Yoshikatsu ; Tajima, Naoko
Publisher:England: BioMed Central Ltd
Journal title:Cardiovascular diabetology, 2007-09, Vol.6 (1), p.23-23
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Glycogen synthase kinase‐3β activity plays a key role in the antitumor effect of nafamostat mesilate in pancreatic cancer cells
Author / Creator:Haruki, Koichiro ; Shiba, Hiroaki ; Shimada, Yohta ; Shirai, Yoshihiro ; Iwase, Ryota ; Fujiwara, Yuki ; Uwagawa, Tadashi ; Ohashi, Toya ; Yanaga, Katsuhiko
Publisher:Japan: John Wiley & Sons, Inc
Journal title:Annals of gastroenterological surgery, 2018-01, Vol.2 (1), p.65-71
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Showing 1 to 20 of 56 results

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Gene therapy for lysosomal storage diseases and peroxisomal diseases

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A novel preclinical model of mucopolysaccharidosis type II for developing human hematopoietic stem cell gene therapy

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Mutation spectrum of α-Galactosidase gene in Japanese patients with Fabry disease

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Suppression of lysosomal acid alpha‐glucosidase impacts the modulation of transcription factor EB translocation in pancreatic cancer

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Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells

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Cochlear Implantation for Isoleucyl-tRNA Synthetase Mutation-Associated Mitochondrial Disease: A Case Report

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The production of human glucocerebrosidase in glyco‐engineered Nicotiana benthamiana plants

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Efficacy and safety of migalastat in a Japanese population: a subgroup analysis of the ATTRACT study

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Nafamostat mesilate, a nuclear factor kappa B inhibitor, enhances the antitumor action of radiotherapy on gallbladder cancer cells

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Rapid Immunochromatographic Detection of Serum Anti-α-Galactosidase A Antibodies in Fabry Patients after Enzyme Replacement Therapy

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Nafamostat Mesilate Enhances the Radiosensitivity and Reduces the Radiation-Induced Invasive Ability of Colorectal Cancer Cells

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TFEB overexpression promotes glycogen clearance of Pompe disease iPSC-derived skeletal muscle

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Human Mesenchymal Stem Cells in Rodent Whole-Embryo Culture Are Reprogrammed to Contribute to Kidney Tissues

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Induced pluripotent stem cells derived from mouse models of lysosomal storage disorders

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375. Direct Reprogramming of Fibroblast Allows Live-Cell Imaging of Autophagic Buildup in Pompe Disease Skeletal Myoblast

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Disease modeling and lentiviral gene transfer in patient-specific induced pluripotent stem cells from late-onset Pompe disease patient

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Correction: Hiroshi Sugano et al. Nafamostat Mesilate Enhances the Radiosensitivity and Reduces the Radiation-Induced Invasive Ability of Colorectal Cancer Cells. Cancers 2018, 10, 386

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Effect of donor chimerism to reduce the level of glycosaminoglycans following bone marrow transplantation in a murine model of mucopolysaccharidosis type II

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Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography

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Glycogen synthase kinase‐3β activity plays a key role in the antitumor effect of nafamostat mesilate in pancreatic cancer cells

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