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ArticlesPeer ReviewedFull Text
Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model
Author / Creator:Kuepfer, L ; Niederalt, C ; Wendl, T ; Schlender, J‐F ; Willmann, S ; Lippert, J ; Block, M ; Eissing, T ; Teutonico, D
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2016-10, Vol.5 (10), p.516-531
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Predicting Drug–Drug Interactions between Rifampicin and Ritonavir-Boosted Atazanavir Using PBPK Modelling
Author / Creator:Montanha, Maiara Camotti ; Fabrega, Francesc ; Howarth, Alice ; Cottura, Nicolas ; Kinvig, Hannah ; Bunglawala, Fazila ; Lloyd, Andrew ; Denti, Paolo ; Waitt, Catriona ; Siccardi, Marco
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2022-03, Vol.61 (3), p.375-386
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Applications, Challenges, and Outlook for PBPK Modeling and Simulation: A Regulatory, Industrial and Academic Perspective
Author / Creator:Lin, Wen ; Chen, Yuan ; Unadkat, Jashvant D. ; Zhang, Xinyuan ; Wu, Di ; Heimbach, Tycho
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2022-08, Vol.39 (8), p.1701-1731
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Quality Assurance of PBPK Modeling Platforms and Guidance on Building, Evaluating, Verifying and Applying PBPK Models Prudently under the Umbrella of Qualification: Why, When, What, How and By Whom?
Author / Creator:Frechen, Sebastian ; Rostami-Hodjegan, Amin
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2022-08, Vol.39 (8), p.1733-1748
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Application of Physiologically Based Pharmacokinetic (PBPK) Modeling to Support Dose Selection: Report of an FDA Public Workshop on PBPK
Author / Creator:Wagner, C ; Zhao, P ; Pan, Y ; Hsu, V ; Grillo, J ; Huang, SM ; Sinha, V
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2015-04, Vol.4 (4), p.226-230
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Making PBPK models more reproducible in practice
Author / Creator:Domínguez-Romero, Elena ; Mazurenko, Stanislav ; Scheringer, Martin ; Martins dos Santos, Vítor A P ; Evelo, Chris T ; Anton, Mihail ; Hancock, John M ; Županič, Anže ; Suarez-Diez, Maria
Publisher:England: Oxford University Press
Journal title:Briefings in bioinformatics, 2024-09, Vol.25 (6)
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PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates
Author / Creator:Reddy, Micaela B. ; Bolger, Michael B. ; Fraczkiewicz, Grace ; Del Frari, Laurence ; Luo, Laibin ; Lukacova, Viera ; Mitra, Amitava ; Macwan, Joyce S. ; Mullin, Jim M. ; Parrott, Neil ; Heikkinen, Aki T.
Publisher:Basel: MDPI AG
Journal title:Pharmaceutics, 2021-08, Vol.13 (9), p.1325
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Predicting the Effect of CYP3A Inducers on the Pharmacokinetics of Substrate Drugs Using Physiologically Based Pharmacokinetic (PBPK) Modeling: An Analysis of PBPK Submissions to the US FDA
Author / Creator:Wagner, Christian ; Pan, Yuzhuo ; Hsu, Vicky ; Sinha, Vikram ; Zhao, Ping
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2016-04, Vol.55 (4), p.475-483
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Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK...
Author / Creator:Verner, Marc-André ; Loccisano, Anne E ; Morken, Nils-Halvdan ; Yoon, Miyoung ; Wu, Huali ; McDougall, Robin ; Maisonet, Mildred ; Marcus, Michele ; Kishi, Reiko ; Miyashita, Chihiro ; Chen, Mei-Huei ; Hsieh, Wu-Shiun ; Andersen, Melvin E ; Clewell, 3rd, Harvey J ; Longnecker, Matthew P
Publisher:United States: National Institute of Environmental Health Sciences
Journal title:Environmental health perspectives, 2015-12, Vol.123 (12), p.1317-1324
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The Role of "Physiologically Based Pharmacokinetic Model (PBPK)" New Approach Methodology (NAM) in Pharmaceuticals and Environmental Chemical Risk Assessment
Author / Creator:Deepika, Deepika ; Kumar, Vikas
Publisher:Switzerland: MDPI AG
Journal title:International journal of environmental research and public health, 2023-02, Vol.20 (4), p.3473
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Predicting Food-Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling
Author / Creator:Lin, Feifei ; Hu, Yingchun ; Zhang, Yifan ; Zhao, Lijuan ; Zhong, Dafang ; Liu, Jia
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2024-10, Vol.25 (20), p.10955
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Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective
Author / Creator:Riedmaier, Arian Emami ; DeMent, Kevin ; Huckle, James ; Bransford, Phil ; Stillhart, Cordula ; Lloyd, Richard ; Alluri, Ravindra ; Basu, Sumit ; Chen, Yuan ; Dhamankar, Varsha ; Dodd, Stephanie ; Kulkarni, Priyanka ; Olivares-Morales, Andrés ; Peng, Chi-Chi ; Pepin, Xavier ; Ren, Xiaojun ; Tran, Thuy ; Tistaert, Christophe ; Heimbach, Tycho ; Kesisoglou, Filippos ; Wagner, Christian ; Parrott, Neil
Publisher:Cham: Springer International Publishing
Journal title:The AAPS journal, 2020-09, Vol.22 (6), p.123, Article 123
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PBPK Models for CYP3A4 and P‐gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin
Author / Creator:Hanke, Nina ; Frechen, Sebastian ; Moj, Daniel ; Britz, Hannah ; Eissing, Thomas ; Wendl, Thomas ; Lehr, Thorsten
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2018-10, Vol.7 (10), p.647-659
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Determination of the Number of Tissue Groups of Kinetically Distinct Transit Time in Whole-Body Physiologically Based Pharmacokinetic (PBPK) Models I: Theoretical Consideration of Bottom-Up Approach o...
Author / Creator:Jeong, Yoo-Seong ; Kim, Min-Soo ; Chung, Suk-Jae
Publisher:Cham: Springer International Publishing
Journal title:The AAPS journal, 2022-08, Vol.24 (5), p.90-90, Article 90
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Dose adjustment of venetoclax when co-administered with posaconazole: clinical drug–drug interaction predictions using a PBPK approach
Author / Creator:Bhatnagar, Sumit ; Mukherjee, Dwaipayan ; Salem, Ahmed Hamed ; Miles, Dale ; Menon, Rajeev M. ; Gibbs, John P.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer chemotherapy and pharmacology, 2021-04, Vol.87 (4), p.465-474
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6 PBPK model-informed dosing guidelines in pediatric clinical care – initiation and drug prioritization
Author / Creator:Freriksen, Jolien ; de Hoop-Sommen, Marika ; van der Heijden, Joyce ; Greupink, Rick ; de Wildt, Saskia
Publisher:London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
Journal title:Archives of disease in childhood, 2023-06, Vol.108 (6), p.A2-A2
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Prediction of oral hepatotoxic dose of natural products derived from traditional Chinese medicines based on SVM classifier and PBPK modeling
Author / Creator:Li, Size ; Yu, Yiqun ; Bian, Xiaolan ; Yao, Li ; Li, Min ; Lou, Yan-Ru ; Yuan, Jing ; Lin, Hai-shu ; Liu, Lucy ; Han, Bing ; Xiang, Xiaoqiang
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Archives of toxicology, 2021-05, Vol.95 (5), p.1683-1701
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Development and In Vitro Evaluation of Controlled Release Viagra® Containing Poloxamer-188 Using Gastroplus™ PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments
Author / Creator:Arafat, Mosab ; Sarfraz, Muhammad ; AbuRuz, Salahdein
Publisher:Basel: MDPI AG
Journal title:Pharmaceuticals (Basel, Switzerland), 2021-05, Vol.14 (5), p.479
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Elucidation of DPP‐4 involvement in systemic distribution and renal reabsorption of linagliptin by PBPK modeling with a cluster Gauss–Newton method
Author / Creator:Nakamura, Ryo ; Yoshikado, Takashi ; Aoki, Yasunori ; Sugiyama, Yuichi ; Chiba, Koji
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical and translational science, 2024-10, Vol.17 (10), p.e70047-n/a
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Clinical Ocular Exposure Extrapolation for Ophthalmic Solutions Using PBPK Modeling and Simulation
Author / Creator:Le Merdy, Maxime ; AlQaraghuli, Farah ; Tan, Ming-Liang ; Walenga, Ross ; Babiskin, Andrew ; Zhao, Liang ; Lukacova, Viera
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2023-02, Vol.40 (2), p.431-447
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Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model

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Predicting Drug–Drug Interactions between Rifampicin and Ritonavir-Boosted Atazanavir Using PBPK Modelling

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Applications, Challenges, and Outlook for PBPK Modeling and Simulation: A Regulatory, Industrial and Academic Perspective

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Quality Assurance of PBPK Modeling Platforms and Guidance on Building, Evaluating, Verifying and Applying PBPK Models Prudently under the Umbrella of Qualification: Why, When, What, How and By Whom?

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Application of Physiologically Based Pharmacokinetic (PBPK) Modeling to Support Dose Selection: Report of an FDA Public Workshop on PBPK

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Making PBPK models more reproducible in practice

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PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates

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Predicting the Effect of CYP3A Inducers on the Pharmacokinetics of Substrate Drugs Using Physiologically Based Pharmacokinetic (PBPK) Modeling: An Analysis of PBPK Submissions to the US FDA

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Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK...

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The Role of "Physiologically Based Pharmacokinetic Model (PBPK)" New Approach Methodology (NAM) in Pharmaceuticals and Environmental Chemical Risk Assessment

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Predicting Food-Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling

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Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective

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PBPK Models for CYP3A4 and P‐gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin

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Determination of the Number of Tissue Groups of Kinetically Distinct Transit Time in Whole-Body Physiologically Based Pharmacokinetic (PBPK) Models I: Theoretical Consideration of Bottom-Up Approach o...

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Dose adjustment of venetoclax when co-administered with posaconazole: clinical drug–drug interaction predictions using a PBPK approach

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6 PBPK model-informed dosing guidelines in pediatric clinical care – initiation and drug prioritization

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Prediction of oral hepatotoxic dose of natural products derived from traditional Chinese medicines based on SVM classifier and PBPK modeling

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Development and In Vitro Evaluation of Controlled Release Viagra® Containing Poloxamer-188 Using Gastroplus™ PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments

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Elucidation of DPP‐4 involvement in systemic distribution and renal reabsorption of linagliptin by PBPK modeling with a cluster Gauss–Newton method

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Clinical Ocular Exposure Extrapolation for Ophthalmic Solutions Using PBPK Modeling and Simulation

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