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Lingo [videorecording] : language needs of non-english speaking background second phase language learners in schools / produced by the Educational Media Unit for the Participation and Equity Programme.

Multiculturalism in art museums today / edited by Joni Boyd Acuff and Laura Evans.

The presence of CD8
+
T cells in the cytoplasm of biliary epithelial cells (BEC) has been correlated with biliary damage associated with primary biliary cholangitis (PBC). Here, we characterise the mechanism of CD8
+
T cell invasion into BEC. CD8
+
T cells observed within BEC were large, eccentric, and expressed E-cadherin, CD103 and CD69. They were also not contained within secondary vesicles. Internalisation required cytoskeletal rearrangements which facilitated contact with BEC. Internalised CD8
+
T cells were observed in both non-cirrhotic and cirrhotic diseased liver tissues but enriched in PBC patients, both during active disease and at the time of transplantation. E-cadherin expression by CD8
+
T cells correlated with frequency of internalisation of these cells into BEC. E-cadherin
+
CD8
+
T cells formed β-catenin-associated interactions with BEC, were larger than E-cadherin
-
CD8
+
T cells and invaded into BEC more frequently. Overall, we unveil a distinct cell-in-cell structure process in the liver detailing the invasion of E-cadherin
+
CD103
+
CD69
+
CD8
+
T cells into BEC.
The presence of CD8
+
T cells in the cytoplasm of biliary epithelial cells (BEC) has been associated with primary biliary cholangitis. Here, the authors demonstrate that CD8
+
T cells invade BEC using a mechanism that is dependent on cytoskeletal rearrangements and E-cadherin:β-catenin interactions.

Nature communications, 2024-01, Vol.15 (1), p.853-22, Article 853

Expression of E-cadherin by CD8+ T cells promotes their invasion into biliary epithelial cells

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Lingo [videorecording] : language needs of non-english speaking background second phase language learners in schools / produced by the Educational Media Unit for the Participation and Equity Programme...

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Multiculturalism in art museums today / edited by Joni Boyd Acuff and Laura Evans.

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Expression of E-cadherin by CD8+ T cells promotes their invasion into biliary epithelial cells

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