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183 results for Peptide+Synthases+-+chemistry

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ArticlesPeer ReviewedFull Text
De novo design and engineering of non-ribosomal peptide synthetases
Author / Creator:Bozhüyük, Kenan A J ; Fleischhacker, Florian ; Linck, Annabell ; Wesche, Frank ; Tietze, Andreas ; Niesert, Claus-peter ; Bode, Helge B
Publisher:London: Nature Publishing Group
Journal title:Nature chemistry, 2018-03, Vol.10 (3), p.275
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Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains
Author / Creator:Bozhüyük Kenan A J ; Linck Annabell ; Tietze, Andreas ; Kranz Janik ; Wesche, Frank ; Nowak, Sarah ; Fleischhacker Florian ; Yan-Ni, Shi ; Grün, Peter ; Bode, Helge B
Publisher:London: Nature Publishing Group
Journal title:Nature chemistry, 2019-07, Vol.11 (7), p.653-661
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Structures of two distinct conformations of holo-non-ribosomal peptide synthetases
Author / Creator:Drake, Eric J. ; Miller, Bradley R. ; Shi, Ce ; Tarrasch, Jeffrey T. ; Sundlov, Jesse A. ; Leigh Allen, C. ; Skiniotis, Georgios ; Aldrich, Courtney C. ; Gulick, Andrew M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2016-01, Vol.529 (7585), p.235-238
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A lanthipeptide library used to identify a protein–protein interaction inhibitor
Author / Creator:Yang, Xiao ; Lennard, Katherine R ; Chang, He ; Walker, Mark C ; Ball, Andrew T ; Doigneaux, Cyrielle ; Tavassoli, Ali ; Wilfred A van der Donk
Publisher:Cambridge: Nature Publishing Group
Journal title:Nature chemical biology, 2018-04, Vol.14 (4), p.375-380
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Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis
Author / Creator:Nguyen, Giang K T ; Wang, Shujing ; Qiu, Yibo ; Hemu, Xinya ; Lian, Yilong ; Tam, James P
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2014-09, Vol.10 (9), p.732-738
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High-throughput reprogramming of an NRPS condensation domain
Author / Creator:Folger, Ines B. ; Frota, Natália F. ; Pistofidis, Angelos ; Niquille, David L. ; Hansen, Douglas A. ; Schmeing, T. Martin ; Hilvert, Donald
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2024-06, Vol.20 (6), p.761-769
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Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity
Author / Creator:Izoré, Thierry ; Candace Ho, Y. T. ; Kaczmarski, Joe A. ; Gavriilidou, Athina ; Chow, Ka Ho ; Steer, David L. ; Goode, Robert J. A. ; Schittenhelm, Ralf B. ; Tailhades, Julien ; Tosin, Manuela ; Challis, Gregory L. ; Krenske, Elizabeth H. ; Ziemert, Nadine ; Jackson, Colin J. ; Cryle, Max J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-05, Vol.12 (1), p.2511-2511, Article 2511
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The structural biology of biosynthetic megaenzymes
Author / Creator:Weissman, Kira J
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2015-09, Vol.11 (9), p.660-670
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X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis
Author / Creator:Haslinger, Kristina ; Peschke, Madeleine ; Brieke, Clara ; Maximowitsch, Egle ; Cryle, Max J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-05, Vol.521 (7550), p.105-109
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Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research
Author / Creator:Zhang, Chen ; Idelbayev, Yerlan ; Roberts, Nicholas ; Tao, Yiwen ; Nannapaneni, Yashwanth ; Duggan, Brendan M. ; Min, Jie ; Lin, Eugene C. ; Gerwick, Erik C. ; Cottrell, Garrison W. ; Gerwick, William H.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-10, Vol.7 (1), p.14243-17, Article 14243
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Gene editing enables rapid engineering of complex antibiotic assembly lines
Author / Creator:Thong, Wei Li ; Zhang, Yingxin ; Zhuo, Ying ; Robins, Katherine J. ; Fyans, Joanna K. ; Herbert, Abigail J. ; Law, Brian J. C. ; Micklefield, Jason
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-11, Vol.12 (1), p.6872-6872, Article 6872
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Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain
Author / Creator:Wang, Jialiang ; Li, Dandan ; Chen, Lu ; Cao, Wei ; Kong, Liangliang ; Zhang, Wei ; Croll, Tristan ; Deng, Zixin ; Liang, Jingdan ; Wang, Zhijun
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-02, Vol.13 (1), p.592-592, Article 592
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Synthetic cycle of the initiation module of a formylating nonribosomal peptide synthetase
Author / Creator:Reimer, Janice M. ; Aloise, Martin N. ; Harrison, Paul M. ; Martin Schmeing, T.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2016-01, Vol.529 (7585), p.239-242
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Docking domain-mediated subunit interactions in natural product megasynth(et)ases
Author / Creator:Smith, Helen G ; Beech, Matthew J ; Lewandowski, Józef R ; Challis, Gregory L ; Jenner, Matthew
Publisher:Germany: Oxford University Press
Journal title:Journal of industrial microbiology & biotechnology, 2021-06, Vol.48 (3-4)
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Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS–PKS hybrid enzyme
Author / Creator:Yun, Choong-Soo ; Motoyama, Takayuki ; Osada, Hiroyuki
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-10, Vol.6 (1), p.8758-8758, Article 8758
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Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes
Author / Creator:Mahalingan, Kishore K. ; Keith Keenan, E. ; Strickland, Madeleine ; Li, Yan ; Liu, Yanjie ; Ball, Haydn L. ; Tanner, Martin E. ; Tjandra, Nico ; Roll-Mecak, Antonina
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2020-09, Vol.27 (9), p.802-813
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Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis
Author / Creator:Cogan, Dillon P. ; Hudson, Graham A. ; Zhang, Zhengan ; Pogorelov, Taras V. ; van der Donk, Wilfred A. ; Mitchell, Douglas A. ; Nair, Satish K.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-12, Vol.114 (49), p.12928-12933
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Genome mining of cyclodipeptide synthases unravels unusual tRNA-dependent diketopiperazine-terpene biosynthetic machinery
Author / Creator:Yao, Tingting ; Liu, Jing ; Liu, Zengzhi ; Li, Tong ; Li, Huayue ; Qian Che ; Zhu, Tianjiao ; Li, Dehai ; Gu, Qianqun ; Li, Wenli
Publisher:London: Nature Publishing Group
Journal title:Nature communications, 2018-10, Vol.9, p.1-12
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Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS
Author / Creator:Hacker, Carolin ; Cai, Xiaofeng ; Kegler, Carsten ; Zhao, Lei ; Weickhmann, A Katharina ; Wurm, Jan Philip ; Bode, Helge B ; Wöhnert, Jens
Publisher:London: Nature Publishing Group
Journal title:Nature communications, 2018-10, Vol.9, p.1-11
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Structural basis for backbone N-methylation by an interrupted adenylation domain
Author / Creator:Mori, Shogo ; Pang, Allan H ; Lundy, Taylor A ; Garzan, Atefeh ; Tsodikov, Oleg V ; Garneau-Tsodikova, Sylvie
Publisher:Cambridge: Nature Publishing Group
Journal title:Nature chemical biology, 2018-05, Vol.14 (5), p.428-430
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Showing 1 to 20 of 183 results

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De novo design and engineering of non-ribosomal peptide synthetases

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Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains

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Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

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A lanthipeptide library used to identify a protein–protein interaction inhibitor

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Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis

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High-throughput reprogramming of an NRPS condensation domain

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Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity

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The structural biology of biosynthetic megaenzymes

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X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis

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Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research

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Gene editing enables rapid engineering of complex antibiotic assembly lines

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Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain

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Synthetic cycle of the initiation module of a formylating nonribosomal peptide synthetase

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Docking domain-mediated subunit interactions in natural product megasynth(et)ases

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Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS–PKS hybrid enzyme

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Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes

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Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis

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Genome mining of cyclodipeptide synthases unravels unusual tRNA-dependent diketopiperazine-terpene biosynthetic machinery

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Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS

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Structural basis for backbone N-methylation by an interrupted adenylation domain

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