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34 results for Phthalazines+-+pharmacokinetics

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Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
Author / Creator:Fong, Peter C ; Boss, David S ; Yap, Timothy A ; Tutt, Andrew ; Wu, Peijun ; Mergui-Roelvink, Marja ; Mortimer, Peter ; Swaisland, Helen ; Lau, Alan ; O'Connor, Mark J ; Ashworth, Alan ; Carmichael, James ; Kaye, Stan B ; Schellens, Jan H.M ; de Bono, Johann S
Publisher:Waltham, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2009-07, Vol.361 (2), p.123-134
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Pharmacokinetic drug–drug interaction between olaparib and apixaban: a case report
Author / Creator:Berge, M ; Giraud, J. S ; De Percin, S ; Puszkiel, A ; Thomas-Schoemann, A ; Blanchet, B
Publisher:Heidelberg: Springer Nature B.V
Journal title:Cancer chemotherapy and pharmacology, 2024-05, Vol.93 (5), p.519-521
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Pharmacokinetics and Safety of Olaparib in Patients with Advanced Solid Tumours and Renal Impairment
Author / Creator:Rolfo, Christian ; de Vos-Geelen, Judith ; Isambert, Nicolas ; Molife, L. Rhoda ; Schellens, Jan H. M. ; De Grève, Jacques ; Dirix, Luc ; Grundtvig-Sørensen, Peter ; Jerusalem, Guy ; Leunen, Karin ; Mau-Sørensen, Morten ; Plummer, Ruth ; Learoyd, Maria ; Bannister, Wendy ; Fielding, Anitra ; Ravaud, Alain
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2019-09, Vol.58 (9), p.1165-1174
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Evaluation of Anticancer Efficacy of D-α-Tocopheryl Polyethylene-Glycol Succinate and Soluplus® Mixed Micelles Loaded with Olaparib and Rapamycin Against Ovarian Cancer
Author / Creator:Shin, Yu ; Choi, Ju-Yeon ; Yoon, Moon ; Yoo, Myeong ; Shin, Dae Hwan ; Lee, Jeong-Won
Publisher:New Zealand: Dove
Journal title:International journal of nanomedicine, 2024-01, Vol.19, p.7871-7893
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Effect of Itraconazole and Rifampin on the Pharmacokinetics of Olaparib in Patients With Advanced Solid Tumors: Results of Two Phase I Open-label Studies
Author / Creator:Dirix, Luc, MD, PhD ; Swaisland, Helen ; Verheul, Henk M.W., MD, PhD ; Rottey, Sylvie, MD, PhD ; Leunen, Karin, MD ; Jerusalem, Guy, MD, PhD ; Rolfo, Christian, MD, PhD ; Nielsen, Dorte, MD, DMSc ; Molife, L. Rhoda, BMedSci, BM BS, MRCP, MD, MSc ; Kristeleit, Rebecca, BSc, MRCP, PhD ; Vos-Geelen, Judith de, MD, PhD ; Mau-Sørensen, Morten, MD, PhD ; Soetekouw, Patricia, MD ; van Herpen, Carla, MD, PhD ; Fielding, Anitra, MBChB ; So, Karen, MBBS, MRCS, MD ; Bannister, Wendy ; Plummer, Ruth, MD, D.Phil, FRCP
Publisher:United States: Elsevier Inc
Journal title:Clinical therapeutics, 2016-10, Vol.38 (10), p.2286-2299
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A phase 1, first-in-human study of AMG 900, an orally administered pan-Aurora kinase inhibitor, in adult patients with advanced solid tumors
Author / Creator:Carducci, Michael ; Shaheen, Montaser ; Markman, Ben ; Hurvitz, Sara ; Mahadevan, Daruka ; Kotasek, Dusan ; Goodman, Oscar B. ; Rasmussen, Erik ; Chow, Vincent ; Juan, Gloria ; Friberg, Gregory R. ; Gamelin, Erick ; Vogl, Florian D. ; Desai, Jayesh
Publisher:New York: Springer US
Journal title:Investigational new drugs, 2018-12, Vol.36 (6), p.1060-1071
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Quantitative determination of niraparib and olaparib tumor distribution by mass spectrometry imaging
Author / Creator:Morosi, Lavinia ; Matteo, Cristina ; Ceruti, Tommaso ; Giordano, Silvia ; Ponzo, Marianna ; Frapolli, Roberta ; Zucchetti, Massimo ; Davoli, Enrico ; D'Incalci, Maurizio ; Ubezio, Paolo
Publisher:Australia: Ivyspring International Publisher Pty Ltd
Journal title:International journal of biological sciences, 2020-01, Vol.16 (8), p.1363-1375
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Evaluation of Olaparib Tablet Safety and Pharmacokinetics in Healthy Chinese Male Subjects
Author / Creator:Dong, Ruihua ; Chen, Jingcheng ; Guo, Nini ; Yang, Yingying ; Wu, Jingxuan ; Wang, Xiaoru ; Song, Yuqin ; Zhang, Xueyuan
Publisher:New Zealand: Dove Medical Press Limited
Journal title:Drug design, development and therapy, 2024-01, Vol.18, p.5529-5539
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A phase I dose-finding, pharmacokinetics and genotyping study of olaparib and lurbinectedin in patients with advanced solid tumors
Author / Creator:Poveda, Andres ; Oaknin, Ana ; Romero, Ignacio ; Guerrero-Zotano, Angel ; Fariñas-Madrid, Lorena ; Rodriguez-Freixinos, Victor ; Mallol, Pedro ; Lopez-Reig, Raquel ; Lopez-Guerrero, Jose Antonio
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-02, Vol.11 (1), p.4433-11, Article 4433
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Phase I study to assess the safety and tolerability of olaparib in combination with bevacizumab in patients with advanced solid tumours
Author / Creator:Dean, E ; Middleton, M R ; Pwint, T ; Swaisland, H ; Carmichael, J ; Goodege-Kunwar, P ; Ranson, M
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2012-01, Vol.106 (3), p.468-474
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Safety, pharmacokinetics, and preliminary efficacy of the PARP inhibitor talazoparib in Japanese patients with advanced solid tumors: phase 1 study
Author / Creator:Naito, Yoichi ; Kuboki, Yasutoshi ; Ikeda, Masafumi ; Harano, Kenichi ; Matsubara, Nobuaki ; Toyoizumi, Shigeyuki ; Mori, Yuko ; Hori, Natsuki ; Nagasawa, Takashi ; Kogawa, Takahiro
Publisher:New York: Springer US
Journal title:Investigational new drugs, 2021-12, Vol.39 (6), p.1568-1576
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A Phase I, dose‐finding and pharmacokinetic study of olaparib (AZD2281) in Japanese patients with advanced solid tumors
Author / Creator:Yamamoto, Noboru ; Nokihara, Hiroshi ; Yamada, Yasuhide ; Goto, Yasushi ; Tanioka, Maki ; Shibata, Takashi ; Yamada, Kazuhiko ; Asahina, Hajime ; Kawata, Toshio ; Shi, Xiaojin ; Tamura, Tomohide
Publisher:Oxford, UK: Blackwell Publishing Ltd
Journal title:Cancer science, 2012-03, Vol.103 (3), p.504-509
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Safety and tolerability of the poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib (AZD2281) in combination with topotecan for the treatment of patients with advanced solid tumors: a phase I study
Author / Creator:Samol, Jens ; Ranson, Malcolm ; Scott, Edwina ; Macpherson, Euan ; Carmichael, James ; Thomas, Anne ; Cassidy, James
Publisher:Boston: Springer US
Journal title:Investigational new drugs, 2012-08, Vol.30 (4), p.1493-1500
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Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours
Author / Creator:Plummer, Ruth ; Swaisland, Helen ; Leunen, Karin ; van Herpen, Carla M. L. ; Jerusalem, Guy ; De Grève, Jacques ; Lolkema, Martijn P. ; Soetekouw, Patricia ; Mau-Sørensen, Morten ; Nielsen, Dorte ; Spicer, James ; Fielding, Anitra ; So, Karen ; Bannister, Wendy ; Molife, L. Rhoda
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer chemotherapy and pharmacology, 2015-10, Vol.76 (4), p.723-729
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A Phase I study of olaparib and irinotecan in patients with colorectal cancer: Canadian Cancer Trials Group IND 187
Author / Creator:Chen, Eric X. ; Jonker, Derek J. ; Siu, Lillian L. ; McKeever, Karyn ; Keller, Deborah ; Wells, Julie ; Hagerman, Linda ; Seymour, Lesley
Publisher:New York: Springer US
Journal title:Investigational new drugs, 2016-08, Vol.34 (4), p.450-457
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Pharmacokinetic effects of proton pump inhibitors on the novel PARP inhibitor fluzoparib: a single-arm, fixed-sequence trial in male healthy volunteers
Author / Creator:Li, Lei ; Xiang, Yu-xia ; Yang, Guo-ping ; Zhang, Xing-fei ; Yang, Xiao-yan ; Yang, Shuang ; Huang, Jie
Publisher:New York: Springer US
Journal title:Investigational new drugs, 2021-06, Vol.39 (3), p.796-802
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Pharmacokinetics and safety of olaparib tablets as monotherapy and in combination with paclitaxel: results of a Phase I study in Chinese patients with advanced solid tumours
Author / Creator:Yuan, Peng ; Shentu, Jianzhong ; Xu, Jianming ; Burke, Wendy ; Hsu, Kate ; Learoyd, Maria ; Zhu, Min ; Xu, Binghe
Publisher:Heidelberg: Springer Nature B.V
Journal title:Cancer chemotherapy and pharmacology, 2019-05, Vol.83 (5), p.963-974
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Evaluation of the pharmacodynamics and pharmacokinetics of the PARP inhibitor olaparib: a Phase I multicentre trial in patients scheduled for elective breast cancer surgery
Author / Creator:Bundred, Nigel ; Gardovskis, Janis ; Jaskiewicz, Janusz ; Eglitis, Janis ; Paramonov, Viktor ; McCormack, Peter ; Swaisland, Helen ; Cavallin, Maria ; Parry, Tony ; Carmichael, James ; Dixon, J. Michael
Publisher:Boston: Springer US
Journal title:Investigational new drugs, 2013-08, Vol.31 (4), p.949-958
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First‐In‐Human Dose Finding Study of Venadaparib (IDX‐1197), a Potent and Selective PARP Inhibitor, in Patients With Advanced Solid Tumors
Author / Creator:Kim, Sung‐Bae ; Bae, Kyun‐Seop ; Lee, Jae Lyun ; Lee, Won Sik ; Ock, Chan‐Young ; Lee, Myong‐Jae ; Bang, Jeongsook ; Hong, Min Ju ; Roh, Eun‐Jihn ; Ha, Kyoung Soo ; Lim, Jong‐Ha ; Kim, Yong‐Man
Publisher:United States: John Wiley & Sons, Inc
Journal title:Cancer medicine (Malden, MA), 2025-02, Vol.14 (4), p.e70576-n/a
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Phase 3 Study of Talazoparib Plus Enzalutamide Versus Placebo Plus Enzalutamide as First‐Line Treatment in Patients With Metastatic Castration‐Resistant Prostate Cancer: TALAPRO‐2 Japanese Subgroup An...
Author / Creator:Matsubara, Nobuaki ; Miyake, Hideaki ; Uemura, Hiroji ; Mizokami, Atsushi ; Kikukawa, Hiroaki ; Kosaka, Takeo ; Nishimura, Kazuo ; Nakamura, Motonobu ; Kobayashi, Kazuki ; Komaru, Atsushi ; Mori, Yuko ; Toyoizumi, Shigeyuki ; Hori, Natsuki ; Umeyama, Yoshiko ; Uemura, Hirotsugu
Publisher:United States: John Wiley & Sons, Inc
Journal title:Cancer medicine (Malden, MA), 2025-01, Vol.14 (1), p.e70333-n/a
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Showing 1 to 20 of 34 results

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Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers

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Pharmacokinetic drug–drug interaction between olaparib and apixaban: a case report

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Pharmacokinetics and Safety of Olaparib in Patients with Advanced Solid Tumours and Renal Impairment

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Evaluation of Anticancer Efficacy of D-α-Tocopheryl Polyethylene-Glycol Succinate and Soluplus® Mixed Micelles Loaded with Olaparib and Rapamycin Against Ovarian Cancer

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Effect of Itraconazole and Rifampin on the Pharmacokinetics of Olaparib in Patients With Advanced Solid Tumors: Results of Two Phase I Open-label Studies

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A phase 1, first-in-human study of AMG 900, an orally administered pan-Aurora kinase inhibitor, in adult patients with advanced solid tumors

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Quantitative determination of niraparib and olaparib tumor distribution by mass spectrometry imaging

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Evaluation of Olaparib Tablet Safety and Pharmacokinetics in Healthy Chinese Male Subjects

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A phase I dose-finding, pharmacokinetics and genotyping study of olaparib and lurbinectedin in patients with advanced solid tumors

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Phase I study to assess the safety and tolerability of olaparib in combination with bevacizumab in patients with advanced solid tumours

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Safety, pharmacokinetics, and preliminary efficacy of the PARP inhibitor talazoparib in Japanese patients with advanced solid tumors: phase 1 study

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A Phase I, dose‐finding and pharmacokinetic study of olaparib (AZD2281) in Japanese patients with advanced solid tumors

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Safety and tolerability of the poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib (AZD2281) in combination with topotecan for the treatment of patients with advanced solid tumors: a phase I study

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Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours

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A Phase I study of olaparib and irinotecan in patients with colorectal cancer: Canadian Cancer Trials Group IND 187

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Pharmacokinetic effects of proton pump inhibitors on the novel PARP inhibitor fluzoparib: a single-arm, fixed-sequence trial in male healthy volunteers

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Pharmacokinetics and safety of olaparib tablets as monotherapy and in combination with paclitaxel: results of a Phase I study in Chinese patients with advanced solid tumours

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Evaluation of the pharmacodynamics and pharmacokinetics of the PARP inhibitor olaparib: a Phase I multicentre trial in patients scheduled for elective breast cancer surgery

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First‐In‐Human Dose Finding Study of Venadaparib (IDX‐1197), a Potent and Selective PARP Inhibitor, in Patients With Advanced Solid Tumors

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Phase 3 Study of Talazoparib Plus Enzalutamide Versus Placebo Plus Enzalutamide as First‐Line Treatment in Patients With Metastatic Castration‐Resistant Prostate Cancer: TALAPRO‐2 Japanese Subgroup An...

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