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ArticlesPeer ReviewedFull Text
ATP as a biological hydrotrope
Author / Creator:Patel, Avinash ; Malinovska, Liliana ; Saha, Shambaditya ; Wang, Jie ; Alberti, Simon ; Krishnan, Yamuna ; Hyman, Anthony A.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2017-05, Vol.356 (6339), p.753-756
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Metal Ion Effects on Aβ and Tau Aggregation
Author / Creator:Kim, Anne Claire ; Lim, Sungsu ; Kim, Yun Kyung
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2018-01, Vol.19 (1), p.128
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Structure-based inhibitors of tau aggregation
Author / Creator:Seidler, P. M. ; Boyer, D. R. ; Rodriguez, J. A. ; Sawaya, M. R. ; Cascio, D. ; Murray, K. ; Gonen, T. ; Eisenberg, D. S.
Publisher:London: Nature Publishing Group UK
Journal title:Nature chemistry, 2018-02, Vol.10 (2), p.170-176
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ArticlesPeer ReviewedFull Text
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
Author / Creator:Perni, Michele ; Galvagnion, Céline ; Maltsev, Alexander ; Meisl, Georg ; Müller, Martin B. D. ; Challa, Pavan K. ; Kirkegaard, Julius B. ; Flagmeier, Patrick ; Cohen, Samuel I. A. ; Cascella, Roberta ; Chen, Serene W. ; Limbocker, Ryan ; Sormanni, Pietro ; Heller, Gabriella T. ; Aprile, Francesco A. ; Cremades, Nunilo ; Cecchi, Cristina ; Chiti, Fabrizio ; Nollen, Ellen A. A. ; Knowles, Tuomas P. J. ; Vendruscolo, Michele ; Bax, Adriaan ; Zasloff, Michael ; Dobson, Christopher M.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-02, Vol.114 (6), p.E1009-E1017
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Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
Author / Creator:Linse, Sara ; Scheidt, Tom ; Bernfur, Katja ; Vendruscolo, Michele ; Dobson, Christopher M. ; Cohen, Samuel I. A. ; Sileikis, Eimantas ; Lundqvist, Martin ; Qian, Fang ; O’Malley, Tiernan ; Bussiere, Thierry ; Weinreb, Paul H. ; Xu, Catherine K. ; Meisl, Georg ; Devenish, Sean R. A. ; Knowles, Tuomas P. J. ; Hansson, Oskar
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2020-12, Vol.27 (12), p.1125-1133
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ArticlesPeer ReviewedFull Text
Lanosterol reverses protein aggregation in cataracts
Author / Creator:Zhao, Ling ; Chen, Xiang-Jun ; Zhu, Jie ; Xi, Yi-Bo ; Yang, Xu ; Hu, Li-Dan ; Ouyang, Hong ; Patel, Sherrina H. ; Jin, Xin ; Lin, Danni ; Wu, Frances ; Flagg, Ken ; Cai, Huimin ; Li, Gen ; Cao, Guiqun ; Lin, Ying ; Chen, Daniel ; Wen, Cindy ; Chung, Christopher ; Wang, Yandong ; Qiu, Austin ; Yeh, Emily ; Wang, Wenqiu ; Hu, Xun ; Grob, Seanna ; Abagyan, Ruben ; Su, Zhiguang ; Tjondro, Harry Christianto ; Zhao, Xi-Juan ; Luo, Hongrong ; Hou, Rui ; Jefferson, J. ; Perry, P. ; Gao, Weiwei ; Kozak, Igor ; Granet, David ; Li, Yingrui ; Sun, Xiaodong ; Wang, Jun ; Zhang, Liangfang ; Liu, Yizhi ; Yan, Yong-Bin ; Zhang, Kang
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-07, Vol.523 (7562), p.607-611
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ArticlesPeer ReviewedFull Text
TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation
Author / Creator:Jinn, Sarah ; Drolet, Robert E. ; Cramer, Paige E. ; Wong, Andus Hon-Kit ; Toolan, Dawn M. ; Gretzula, Cheryl A. ; Voleti, Bhavya ; Vassileva, Galya ; Disa, Jyoti ; Tadin-Strapps, Marija ; Stone, David J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-02, Vol.114 (9), p.2389-2394
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ArticlesPeer ReviewedFull Text
New mechanism of nerve injury in Alzheimer’s disease: β‐amyloid‐induced neuronal pyroptosis
Author / Creator:Han, Chenyang ; Yang, Yi ; Guan, Qiaobing ; Zhang, Xiaoling ; Shen, Heping ; Sheng, Yongjia ; Wang, Jin ; Zhou, Xiaohong ; Li, Wenyan ; Guo, Li ; Jiao, Qingcai
Publisher:England: John Wiley & Sons, Inc
Journal title:Journal of cellular and molecular medicine, 2020-07, Vol.24 (14), p.8078-8090
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ArticlesPeer ReviewedFull Text
Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms
Author / Creator:Giorgetti, Sofia ; Greco, Claudio ; Tortora, Paolo ; Aprile, Francesco Antonio
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2018-09, Vol.19 (9), p.2677
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ArticlesPeer ReviewedFull Text
Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer's Disease
Author / Creator:Loureiro, Joana A ; Andrade, Stephanie ; Duarte, Ana ; Neves, Ana Rute ; Queiroz, Joana Fontes ; Nunes, Cláudia ; Sevin, Emmanuel ; Fenart, Laurence ; Gosselet, Fabien ; Coelho, Manuel A N ; Pereira, Maria Carmo
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2017-02, Vol.22 (2), p.277-277
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ArticlesPeer ReviewedFull Text
Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach
Author / Creator:Nah, J., Seoul National University, Seoul, Republic of Korea ; Yuan, J., Harvard Medical School, Boston, USA ; Jung, Y.K., Seoul National University, Seoul, Republic of Korea
Publisher:Korean Society for Molecular and Cellular Biology
Journal title:Molecules and Cells, 2015, 38(5), , pp.381-389
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ArticlesPeer ReviewedFull Text
Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers
Author / Creator:Ruggeri, Francesco Simone ; Habchi, Johnny ; Chia, Sean ; Horne, Robert I. ; Vendruscolo, Michele ; Knowles, Tuomas P. J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-01, Vol.12 (1), p.688-9, Article 688
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ArticlesPeer ReviewedFull Text
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease
Author / Creator:Bengoa-Vergniory, Nora ; Faggiani, Emilie ; Ramos-Gonzalez, Paula ; Kirkiz, Ecem ; Connor-Robson, Natalie ; Brown, Liam V. ; Siddique, Ibrar ; Li, Zizheng ; Vingill, Siv ; Cioroch, Milena ; Cavaliere, Fabio ; Threlfell, Sarah ; Roberts, Bradley ; Schrader, Thomas ; Klärner, Frank-Gerrit ; Cragg, Stephanie ; Dehay, Benjamin ; Bitan, Gal ; Matute, Carlos ; Bezard, Erwan ; Wade-Martins, Richard
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-09, Vol.11 (1), p.4885-4885, Article 4885
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ArticlesPeer ReviewedFull Text
Heavy metals and metalloids as a cause for protein misfolding and aggregation
Author / Creator:Tamás, Markus J ; Sharma, Sandeep K ; Ibstedt, Sebastian ; Jacobson, Therese ; Christen, Philipp
Publisher:Switzerland: MDPI AG
Journal title:Biomolecules (Basel, Switzerland), 2014-02, Vol.4 (1), p.252-267
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Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers
Author / Creator:Kedia, Niraja ; Arhzaouy, Khalid ; Pittman, Sara K. ; Sun, Yuanzi ; Batchelor, Mark ; Weihl, Conrad C. ; Bieschke, Jan
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-08, Vol.116 (34), p.16835-16840
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Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis
Author / Creator:Proctor, Elizabeth A. ; Fee, Lanette ; Tao, Yazhong ; Redler, Rachel L. ; Fay, James M. ; Zhang, Yuliang ; Lv, Zhengjian ; Mercer, Ian P. ; Deshmukh, Mohanish ; Lyubchenko, Yuri L. ; Dokholyan, Nikolay V.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-01, Vol.113 (3), p.614-619
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ArticlesPeer ReviewedFull Text
Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species
Author / Creator:González-Lizárraga, Florencia ; Socías, Sergio B. ; Ávila, César L. ; Torres-Bugeau, Clarisa M. ; Barbosa, Leandro R. S. ; Binolfi, Andres ; Sepúlveda-Díaz, Julia E. ; Del-Bel, Elaine ; Fernandez, Claudio O. ; Papy-Garcia, Dulce ; Itri, Rosangela ; Raisman-Vozari, Rita ; Chehín, Rosana N.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-02, Vol.7 (1), p.41755, Article 41755
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ArticlesPeer ReviewedFull Text
Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates
Author / Creator:García-Huerta, Paula ; Troncoso-Escudero, Paulina ; Wu, Di ; Thiruvalluvan, Arun ; Cisternas-Olmedo, Marisol ; Henríquez, Daniel R. ; Plate, Lars ; Chana-Cuevas, Pedro ; Saquel, Cristian ; Thielen, Peter ; Longo, Kenneth A. ; Geddes, Brad J. ; Lederkremer, Gerardo Z. ; Sharma, Neeraj ; Shenkman, Marina ; Naphade, Swati ; Sardi, S. Pablo ; Spichiger, Carlos ; Richter, Hans G. ; Court, Felipe A. ; Tshilenge, Kizito Tshitoko ; Ellerby, Lisa M. ; Wiseman, R. Luke ; Gonzalez-Billault, Christian ; Bergink, Steven ; Vidal, Rene L. ; Hetz, Claudio
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2020-11, Vol.140 (5), p.737-764
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ArticlesPeer ReviewedFull Text
Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer's Disease
Author / Creator:Uddin, Md Sahab ; Kabir, Md Tanvir ; Niaz, Kamal ; Jeandet, Philippe ; Clément, Christophe ; Mathew, Bijo ; Rauf, Abdur ; Rengasamy, Kannan R R ; Sobarzo-Sánchez, Eduardo ; Ashraf, Ghulam Md ; Aleya, Lotfi
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2020-03, Vol.25 (6), p.1267
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The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
Author / Creator:de Oliveira, Rita Machado ; Vicente Miranda, Hugo ; Francelle, Laetitia ; Pinho, Raquel ; Szegö, Éva M ; Martinho, Renato ; Munari, Francesca ; Lázaro, Diana F ; Moniot, Sébastien ; Guerreiro, Patrícia ; Fonseca-Ornelas, Luis ; Marijanovic, Zrinka ; Antas, Pedro ; Gerhardt, Ellen ; Enguita, Francisco Javier ; Fauvet, Bruno ; Penque, Deborah ; Pais, Teresa Faria ; Tong, Qiang ; Becker, Stefan ; Kügler, Sebastian ; Lashuel, Hilal Ahmed ; Steegborn, Clemens ; Zweckstetter, Markus ; Outeiro, Tiago Fleming
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2017-03, Vol.15 (3), p.e2000374
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Showing 1 to 20 of 284 results

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ATP as a biological hydrotrope

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Metal Ion Effects on Aβ and Tau Aggregation

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Structure-based inhibitors of tau aggregation

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A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

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Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

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Lanosterol reverses protein aggregation in cataracts

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TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation

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New mechanism of nerve injury in Alzheimer’s disease: β‐amyloid‐induced neuronal pyroptosis

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Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms

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Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer's Disease

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Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach

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Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers

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CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease

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Heavy metals and metalloids as a cause for protein misfolding and aggregation

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Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers

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Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis

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Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species

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Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates

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Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer's Disease

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The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

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