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Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics
Author / Creator:Storck, Elisabeth M. ; Morales-Sanfrutos, Julia ; Serwa, Remigiusz A. ; Panyain, Nattawadee ; Lanyon-Hogg, Thomas ; Tolmachova, Tanya ; Ventimiglia, Leandro N. ; Martin-Serrano, Juan ; Seabra, Miguel C. ; Wojciak-Stothard, Beata ; Tate, Edward W.
Publisher:London: Nature Publishing Group UK
Journal title:Nature chemistry, 2019-06, Vol.11 (6), p.552-561
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Targeting protein prenylation for cancer therapy
Author / Creator:Berndt, Norbert ; Hamilton, Andrew D. ; Sebti, Saïd M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Cancer, 2011-11, Vol.11 (11), p.775-791
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Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking
Author / Creator:Kennedy, Kit ; Cobbold, Simon A ; Hanssen, Eric ; Birnbaum, Jakob ; Spillman, Natalie J ; McHugh, Emma ; Brown, Hannah ; Tilley, Leann ; Spielmann, Tobias ; McConville, Malcolm J ; Ralph, Stuart A
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2019-07, Vol.17 (7), p.e3000376-e3000376
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Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
Author / Creator:Konstantinopoulos, Panagiotis A. ; Karamouzis, Michalis V. ; Papavassiliou, Athanasios G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2007-07, Vol.6 (7), p.541-555
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The role of protein prenylation inhibition through targeting FPPS by zoledronic acid in the prevention of renal fibrosis in rats
Author / Creator:Mohamed, Reham Hussein ; Abdelrahim, Dina S. ; Hay, Nesma Hussein Abdel ; Fawzy, Nesma Mohamed ; M., Doaa Karem M. ; Yehia, Dalia Ahmed Yousef ; AbdelMaksoud, Omnia M. ; Tamim, Yomna M.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-08, Vol.14 (1), p.18283-14, Article 18283
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The Arabidopsis heat-intolerant 5 (hit5)/enhanced response to aba 1 (era1) mutant reveals the crucial role of protein farnesylation in plant responses to heat stress
Author / Creator:Wu, Jia‐Rong ; Wang, Lian‐Chin ; Lin, Yu‐Ru ; Weng, Chi‐Pei ; Yeh, Ching‐Hui ; Wu, Shaw‐Jye
Publisher:England: New Phytologist Trust
Journal title:The New phytologist, 2017-02, Vol.213 (3), p.1181-1193
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New Insights Into the Molecular Mechanisms of Action of Bisphosphonates
Author / Creator:Rogers, Michael J
Publisher:United Arab Emirates: Bentham Science Publishers Ltd
Journal title:Current pharmaceutical design, 2003-12, Vol.9 (32), p.2643-2658
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Inhibiting Farnesylation of Progerin Prevents the Characteristic Nuclear Blebbing of Hutchinson-Gilford Progeria Syndrome
Author / Creator:Capell, Brian C. ; Erdos, Michael R. ; Madigan, James P. ; Fiordalisi, James J. ; Varga, Renee ; Conneely, Karen N. ; Gordon, Leslie B. ; Der, Channing J. ; Cox, Adrienne D. ; Collins, Francis S.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2005-09, Vol.102 (36), p.12879-12884
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Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors
Author / Creator:Haney, Staci L ; Wills, Veronica S ; Wiemer, David F ; Holstein, Sarah A
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2017-05, Vol.22 (6), p.886
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Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages
Author / Creator:Munoz, Marcia A ; Fletcher, Emma K ; Skinner, Oliver P ; Jurczyluk, Julie ; Kristianto, Esther ; Hodson, Mark P ; Sun, Shuting ; Ebetino, Frank H ; Croucher, David R ; Hansbro, Philip M ; Center, Jacqueline R ; Rogers, Michael J
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2021-12, Vol.10
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Protein Farnesyltransferase Inhibitor Ameliorates Disease in a Mouse Model of Progeria
Author / Creator:Fong, Loren G ; Frost, David ; Meta, Margarita ; Qiao, Xin ; Yang, Shao H ; Coffinier, Catherine ; Young, Stephen G
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2006-03, Vol.311 (5767), p.1621-1623
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Combined HMG-COA reductase and prenylation inhibition in treatment of CCM
Author / Creator:Nishimura, Sayoko ; Mishra-Gorur, Ketu ; Park, JinSeok ; Surovtseva, Yulia V. ; Sebti, Said M. ; Levchenko, Andre ; Louvi, Angeliki ; Gunel, Murat
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-05, Vol.114 (21), p.5503-5508
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HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival
Author / Creator:Lacher, Sonja M ; Bruttger, Julia ; Kalt, Bettina ; Berthelet, Jean ; Rajalingam, Krishnaraj ; Wörtge, Simone ; Waisman, Ari
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2017-05, Vol.8 (5), p.e2824-e2824
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The Prenylated Rab GTPase Receptor PRA1.F4 Contributes to Protein Exit from the Golgi Apparatus
Author / Creator:Lee, Myoung Hui ; Yoo, Yun-Joo ; Kim, Dae Heon ; Hanh, Nguyen Hong ; Kwon, Yun ; Hwang, Inhwan
Publisher:United States: American Society of Plant Biologists
Journal title:Plant physiology (Bethesda), 2017-07, Vol.174 (3), p.1576-1594
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Therapeutic intervention based on protein prenylation and associated modifications
Author / Creator:Gelb, Michael H ; Brunsveld, Lucas ; Hrycyna, Christine A ; Michaelis, Susan ; Tamanoi, Fuyuhiko ; Van Voorhis, Wesley C ; Waldmann, Herbert
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2006-10, Vol.2 (10), p.518-528
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Inhibition of Protein Prenylation of GTPases Alters Endothelial Barrier Function
Author / Creator:Aslam, Muhammad ; Troidl, Christian ; Tanislav, Christian ; Rohrbach, Susanne ; Gündüz, Dursun ; Hamm, Christian W
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2019-12, Vol.21 (1), p.2
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ArticlesPeer ReviewedFull Text
Aminobisphosphonates Cause Osteoblast Apoptosis and Inhibit Bone Nodule Formation In Vitro
Author / Creator:Idris, Aymen I. ; Rojas, Javier ; Greig, Iain R. ; van’t Hof, Rob J. ; Ralston, Stuart H.
Publisher:New York: Springer-Verlag
Journal title:Calcified tissue international, 2008-03, Vol.82 (3), p.191-201
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Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic β-Cells
Author / Creator:Veluthakal, Rajakrishnan ; Arora, Daleep K. ; Goalstone, Marc L. ; Kowluru, Renu A. ; Kowluru, Anjaneyulu
Publisher:Basel, Switzerland: Cell Physiol Biochem Press GmbH & Co KG
Journal title:Cellular physiology and biochemistry, 2016-01, Vol.39 (6), p.2110-2120
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Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation
Author / Creator:Blondel, S ; Egesipe, A-L ; Picardi, P ; Jaskowiak, A-L ; Notarnicola, M ; Ragot, J ; Tournois, J ; Le Corf, A ; Brinon, B ; Poydenot, P ; Georges, P ; Navarro, C ; pitrez, P R ; Ferreira, L ; Bollot, G ; Bauvais, C ; Laustriat, D ; Mejat, A ; De Sandre-Giovannoli, A ; Levy, N ; Bifulco, M ; Peschanski, M ; Nissan, X
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2016-02, Vol.7 (2), p.e2105-e2105
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Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans
Author / Creator:Mörck, Catarina ; Olsen, Louise ; Kurth, Caroline ; Persson, Annelie ; Storm, Nadia Jin ; Svensson, Emma ; Jansson, John-Olov ; Hellqvist, Marika ; Enejder, Annika ; Faergeman, Nils J ; Pilon, Marc
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-10, Vol.106 (43), p.18285-18290
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Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics

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Targeting protein prenylation for cancer therapy

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Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking

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Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets

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The role of protein prenylation inhibition through targeting FPPS by zoledronic acid in the prevention of renal fibrosis in rats

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The Arabidopsis heat-intolerant 5 (hit5)/enhanced response to aba 1 (era1) mutant reveals the crucial role of protein farnesylation in plant responses to heat stress

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New Insights Into the Molecular Mechanisms of Action of Bisphosphonates

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Inhibiting Farnesylation of Progerin Prevents the Characteristic Nuclear Blebbing of Hutchinson-Gilford Progeria Syndrome

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Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors

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Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

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Protein Farnesyltransferase Inhibitor Ameliorates Disease in a Mouse Model of Progeria

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Combined HMG-COA reductase and prenylation inhibition in treatment of CCM

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HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival

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The Prenylated Rab GTPase Receptor PRA1.F4 Contributes to Protein Exit from the Golgi Apparatus

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Therapeutic intervention based on protein prenylation and associated modifications

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Inhibition of Protein Prenylation of GTPases Alters Endothelial Barrier Function

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Aminobisphosphonates Cause Osteoblast Apoptosis and Inhibit Bone Nodule Formation In Vitro

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Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic β-Cells

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Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation

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Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans

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