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8,227 results for Protein+Serine-Threonine+Kinases+-+genetics

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ArticlesPeer ReviewedFull Text
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
Author / Creator:Kottakis, Filippos ; Nicolay, Brandon N. ; Roumane, Ahlima ; Karnik, Rahul ; Gu, Hongcang ; Nagle, Julia M. ; Boukhali, Myriam ; Hayward, Michele C. ; Li, Yvonne Y. ; Chen, Ting ; Liesa, Marc ; Hammerman, Peter S. ; Wong, Kwok Kin ; Hayes, D. Neil ; Shirihai, Orian S. ; Dyson, Nicholas J. ; Haas, Wilhelm ; Meissner, Alexander ; Bardeesy, Nabeel
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2016-11, Vol.539 (7629), p.390-395
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Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity
Author / Creator:Geng, Jing ; Sun, Xiufeng ; Wang, Ping ; Zhang, Shihao ; Wang, Xiaozhen ; Wu, Hongtan ; Hong, Lixin ; Xie, Changchuan ; Li, Xun ; Zhao, Hao ; Liu, Qingxu ; Jiang, Mingting ; Chen, Qinghua ; Zhang, Jinjia ; Li, Yang ; Song, Siyang ; Wang, Hong-Rui ; Zhou, Rongbin ; Johnson, Randy L ; Chien, Kun-Yi ; Lin, Sheng-Cai ; Han, Jiahuai ; Avruch, Joseph ; Chen, Lanfen ; Zhou, Dawang
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2015-11, Vol.16 (11), p.1142-1152
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The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis
Author / Creator:Günther, Claudia ; He, Gui-Wei ; Kremer, Andreas E. ; Murphy, James M. ; Petrie, Emma J. ; Amann, Kerstin ; Vandenabeele, Peter ; Linkermann, Andreas ; Poremba, Christopher ; Schleicher, Ulrike ; Dewitz, Christin ; Krautwald, Stefan ; Neurath, Markus F. ; Becker, Christoph ; Wirtz, Stefan
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2016-11, Vol.126 (11), p.4346-4360
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Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice
Author / Creator:Bhat, Neha ; Narayanan, Anand ; Fathzadeh, Mohsen ; Kahn, Mario ; Zhang, Dongyan ; Goedeke, Leigh ; Neogi, Arpita ; Cardone, Rebecca L. ; Kibbey, Richard G. ; Fernandez-Hernando, Carlos ; Ginsberg, Henry N. ; Jain, Dhanpat ; Shulman, Gerald I. ; Mani, Arya
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2022-02, Vol.132 (3), p.1-19
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Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells
Author / Creator:Chandrakesan, Parthasarathy ; Yao, Jiannan ; Qu, Dongfeng ; May, Randal ; Weygant, Nathaniel ; Ge, Yang ; Ali, Naushad ; Sureban, Sripathi M. ; Gude, Modhi ; Vega, Kenneth ; Bannerman-Menson, Eddie ; Xia, Lijun ; Bronze, Michael ; An, Guangyu ; Houchen, Courtney W.
Publisher:England: BioMed Central Ltd
Journal title:Molecular cancer, 2017-02, Vol.16 (1), p.30-30, Article 30
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Neural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression
Author / Creator:Le Grand, Jaclyn Nicole ; Gonzalez-Cano, Laura ; Pavlou, Maria Angeliki ; Schwamborn, Jens C
Publisher:Basel: Springer-Verlag
Journal title:Cellular and molecular life sciences : CMLS, 2015-02, Vol.72 (4), p.773-797
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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
Author / Creator:Majumder, Pradip K ; Febbo, Phillip G ; Bikoff, Rachel ; Berger, Raanan ; Xue, Qi ; McMahon, Louis M ; Manola, Judith ; Brugarolas, James ; McDonnell, Timothy J ; Golub, Todd R ; Loda, Massimo ; Lane, Heidi A ; Sellers, William R
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2004-06, Vol.10 (6), p.594-601
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Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3
Author / Creator:Lui, Pak-Yin ; Wong, Lok-Yin Roy ; Fung, Cheuk-Lai ; Siu, Kam-Leung ; Yeung, Man-Lung ; Yuen, Kit-San ; Chan, Chi-Ping ; Woo, Patrick Chiu-Yat ; Yuen, Kwok-Yung ; Jin, Dong-Yan
Publisher:United States: Taylor & Francis Ltd
Journal title:Emerging microbes & infections, 2016-04, Vol.5 (1), p.1-9
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ArticlesPeer ReviewedFull Text
LKB1; linking cell structure and tumor suppression
Author / Creator:Hezel, A F ; Bardeesy, N
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2008-11, Vol.27 (55), p.6908-6919
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ArticlesPeer ReviewedFull Text
Effects of intermittent hypoxia training on leukocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and blood insulin level in prediabetes patients
Author / Creator:Serebrovska, Tetiana V. ; Portnychenko, Alla G. ; Portnichenko, Vladimir I. ; Xi, Lei ; Egorov, Egor ; Antoniuk-Shcheglova, Ivanna ; Naskalova, Svitlana ; Shatylo, Valeriy B.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:European journal of applied physiology, 2019-03, Vol.119 (3), p.813-823
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ArticlesPeer ReviewedFull Text
LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
Author / Creator:Taymans, Jean-Marc ; Vancraenenbroeck, Renée ; Ollikainen, Petri ; Beilina, Alexandra ; Lobbestael, Evy ; De Maeyer, Marc ; Baekelandt, Veerle ; Cookson, Mark R.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2011-08, Vol.6 (8), p.e23207
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ArticlesPeer ReviewedFull Text
Lkb1 and Pten Synergise to Suppress mTOR-Mediated Tumorigenesis and Epithelial-Mesenchymal Transition in the Mouse Bladder
Author / Creator:Shorning, Boris Y. ; Griffiths, David ; Clarke, Alan R.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2011-01, Vol.6 (1), p.e16209
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ArticlesPeer ReviewedFull Text
Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional
Author / Creator:Lossaint, G ; Besnard, E ; Fisher, D ; Piette, J ; Dulić, V
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2011-10, Vol.30 (41), p.4261-4274
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ArticlesPeer ReviewedFull Text
Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development
Author / Creator:Burchert, A ; Wang, Y ; Cai, D ; von Bubnoff, N ; Paschka, P ; Müller-Brüsselbach, S ; Ottmann, O G ; Duyster, J ; Hochhaus, A ; Neubauer, A
Publisher:London: Nature Publishing
Journal title:Leukemia, 2005-10, Vol.19 (10), p.1774-1782
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Genome-wide surveys reveal polarity and cytoskeletal regulators mediate LKB1-associated germline stem cell quiescence
Author / Creator:Kadekar, Pratik ; Chaouni, Rita ; Clark, Emily ; Kazanets, Anna ; Roy, Richard
Publisher:England: BioMed Central Ltd
Journal title:BMC genomics, 2018-06, Vol.19 (1), p.462-462, Article 462
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ArticlesPeer ReviewedFull Text
Serine/Threonine Kinase 17A Is a Novel Candidate for Therapeutic Targeting in Glioblastoma
Author / Creator:Mao, Pingping ; Hever-Jardine, Mary P. ; Rahme, Gilbert J. ; Yang, Eric ; Tam, Janice ; Kodali, Anita ; Biswal, Bijesh ; Fadul, Camilo E. ; Gaur, Arti ; Israel, Mark A. ; Spinella, Michael J.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-11, Vol.8 (11), p.e81803
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ArticlesPeer ReviewedFull Text
Cell Morphogenesis Proteins Are Translationally Controlled through UTRs by the Ndr/LATS Target Ssd1
Author / Creator:Wanless, Antony G. ; Lin, Yuan ; Weiss, Eric L.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-01, Vol.9 (1), p.e85212-e85212
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ArticlesPeer ReviewedFull Text
Clk/STY (cdc2-Like Kinase 1) and Akt Regulate Alternative Splicing and Adipogenesis in 3T3-L1 Pre-Adipocytes
Author / Creator:Li, Pengfei ; Carter, Gay ; Romero, Jacqueline ; Gower, Kathryn M. ; Watson, James ; Patel, Niketa A. ; Cooper, Denise R.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-01, Vol.8 (1), p.e53268-e53268
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ArticlesPeer ReviewedFull Text
Kalirin: a novel genetic risk factor for ischemic stroke
Author / Creator:Krug, Tiago ; Manso, Helena ; Gouveia, Liliana ; Sobral, João ; Xavier, Joana M ; Albergaria, Isabel ; Gaspar, Gisela ; Correia, Manuel ; Viana-Baptista, Miguel ; Simões, Rita Moiron ; Pinto, Amélia Nogueira ; Taipa, Ricardo ; Ferreira, Carla ; Fontes, João Ramalho ; Silva, Mário Rui ; Gabriel, João Paulo ; Matos, Ilda ; Lopes, Gabriela ; Ferro, José M ; Vicente, Astrid M ; Oliveira, Sofia A
Publisher:Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
Journal title:Human genetics, 2010-05, Vol.127 (5), p.513-523
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ArticlesPeer ReviewedFull Text
The Tumor Suppressor Gene TUSC2 (FUS1) Sensitizes NSCLC to the AKT Inhibitor MK2206 in LKB1-dependent Manner
Author / Creator:Meng, Jieru ; Majidi, Mourad ; Fang, Bingliang ; Ji, Lin ; Bekele, B. Nebiyou ; Minna, John D. ; Roth, Jack A.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-10, Vol.8 (10), p.e77067-e77067
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LKB1 loss links serine metabolism to DNA methylation and tumorigenesis

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Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

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The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

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Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice

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Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells

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Neural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

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Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3

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LKB1; linking cell structure and tumor suppression

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Effects of intermittent hypoxia training on leukocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and blood insulin level in prediabetes patients

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LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding

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Lkb1 and Pten Synergise to Suppress mTOR-Mediated Tumorigenesis and Epithelial-Mesenchymal Transition in the Mouse Bladder

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Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional

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Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development

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Genome-wide surveys reveal polarity and cytoskeletal regulators mediate LKB1-associated germline stem cell quiescence

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Serine/Threonine Kinase 17A Is a Novel Candidate for Therapeutic Targeting in Glioblastoma

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Cell Morphogenesis Proteins Are Translationally Controlled through UTRs by the Ndr/LATS Target Ssd1

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Clk/STY (cdc2-Like Kinase 1) and Akt Regulate Alternative Splicing and Adipogenesis in 3T3-L1 Pre-Adipocytes

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Kalirin: a novel genetic risk factor for ischemic stroke

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The Tumor Suppressor Gene TUSC2 (FUS1) Sensitizes NSCLC to the AKT Inhibitor MK2206 in LKB1-dependent Manner

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